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Crystal structure of tert-butyl-N-phenyl-carbonitrilium tetra-chlorido-aluminate.

Acta crystallographica. Section E, Structure reports online

van Dijk T, Zant DW, Wolf R, Lammertsma K, Slootweg JC.
PMID: 25484737
Acta Crystallogr Sect E Struct Rep Online. 2014 Oct 11;70:331-3. doi: 10.1107/S1600536814022028. eCollection 2014 Nov 01.

In the title compound, (C11H14N)[AlCl4], the nitrilium (systematic name: 2,2-dimethyl-N-phenyl-propane-nitrilium) ion adopts a slightly distorted linear configuration [C-N C = 178.87 (16) and N C-C = 179.13 (17)°]. In the crystal, while there are no inter-molecular hydrogen bonds, pairs...

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van Dijk T, Zant DW, Wolf R, et al. Crystal structure of tert-butyl-N-phenyl-carbonitrilium tetra-chlorido-aluminate. Acta Crystallogr Sect E Struct Rep Online. 2014;70:331-3doi: 10.1107/S1600536814022028.
van Dijk, T., Zant, D. W., Wolf, R., Lammertsma, K., & Slootweg, J. C. (2014). Crystal structure of tert-butyl-N-phenyl-carbonitrilium tetra-chlorido-aluminate. Acta crystallographica. Section E, Structure reports online, 70331-3. https://doi.org/10.1107/S1600536814022028
van Dijk, Tom, et al. "Crystal structure of tert-butyl-N-phenyl-carbonitrilium tetra-chlorido-aluminate." Acta crystallographica. Section E, Structure reports online vol. 70 (2014): 331-3. doi: https://doi.org/10.1107/S1600536814022028
van Dijk T, Zant DW, Wolf R, Lammertsma K, Slootweg JC. Crystal structure of tert-butyl-N-phenyl-carbonitrilium tetra-chlorido-aluminate. Acta Crystallogr Sect E Struct Rep Online. 2014 Oct 11;70:331-3. doi: 10.1107/S1600536814022028. eCollection 2014 Nov 01. PMID: 25484737; PMCID: PMC4257323.
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Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC.

EJNMMI research

Bahce I, Yaqub M, Errami H, Schuit RC, Schober P, Thunnissen E, Windhorst AD, Lammertsma AA, Smit EF, Hendrikse NH.
PMID: 26857779
EJNMMI Res. 2016 Dec;6(1):10. doi: 10.1186/s13550-016-0169-8. Epub 2016 Feb 09.

BACKGROUND: In non-small cell lung cancer (NSCLC) patients off erlotinib therapy, positron emission tomography (PET) using [(11)C]erlotinib distinguished epidermal growth factor receptor (EGFR) mutations from wild-type EGFR. However, tumor uptake of [(11)C]erlotinib during erlotinib therapy is unknown. Therefore, the...

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Bahce I, Yaqub M, Errami H, et al. Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC. EJNMMI Res. 2016;6(1):10doi: 10.1186/s13550-016-0169-8.
Bahce, I., Yaqub, M., Errami, H., Schuit, R. C., Schober, P., Thunnissen, E., Windhorst, A. D., Lammertsma, A. A., Smit, E. F., & Hendrikse, N. H. (2016). Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC. EJNMMI research, 6(1), 10. https://doi.org/10.1186/s13550-016-0169-8
Bahce, Idris, et al. "Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC." EJNMMI research vol. 6,1 (2016): 10. doi: https://doi.org/10.1186/s13550-016-0169-8
Bahce I, Yaqub M, Errami H, Schuit RC, Schober P, Thunnissen E, Windhorst AD, Lammertsma AA, Smit EF, Hendrikse NH. Effects of erlotinib therapy on [(11)C]erlotinib uptake in EGFR mutated, advanced NSCLC. EJNMMI Res. 2016 Dec;6(1):10. doi: 10.1186/s13550-016-0169-8. Epub 2016 Feb 09. PMID: 26857779; PMCID: PMC4746207.
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Reaction of a complexed phosphinidene with 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene.

Chemistry (Weinheim an der Bergstrasse, Germany)

Vlaar MJ, Ehlers AW, Schakel M, Clendenning SB, Nixon JF, Lutz M, Spek AL, Lammertsma K.
PMID: 11560325
Chemistry. 2001 Aug 17;7(16):3545-50. doi: 10.1002/1521-3765(20010817)7:16<3545::aid-chem3545>3.0.co;2-0.

The terminal phosphinidene complex PhPW(CO)5 reacts with 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene to give two unexpected multicyclic organophosphorus compounds. One of them results from an initial 1,2-addition, followed by an intramolecular rearrangement. B3LYP/6-31G* calculations on simplified parent systems suggest that the reaction follows...

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Vlaar MJ, Ehlers AW, Schakel M, et al. Reaction of a complexed phosphinidene with 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene. Chemistry. 2001;7(16):3545-50doi: 10.1002/1521-3765(20010817)7:16<3545::aid-chem3545>3.0.co;2-0.
Vlaar, M. J., Ehlers, A. W., Schakel, M., Clendenning, S. B., Nixon, J. F., Lutz, M., Spek, A. L., & Lammertsma, K. (2001). Reaction of a complexed phosphinidene with 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene. Chemistry (Weinheim an der Bergstrasse, Germany), 7(16), 3545-50. https://doi.org/10.1002/1521-3765(20010817)7:16<3545::aid-chem3545>3.0.co;2-0
Vlaar, M J, et al. "Reaction of a complexed phosphinidene with 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 7,16 (2001): 3545-50. doi: https://doi.org/10.1002/1521-3765(20010817)7:16<3545::aid-chem3545>3.0.co;2-0
Vlaar MJ, Ehlers AW, Schakel M, Clendenning SB, Nixon JF, Lutz M, Spek AL, Lammertsma K. Reaction of a complexed phosphinidene with 2,4,6-tri-tert-butyl-1,3,5-triphosphabenzene. Chemistry. 2001 Aug 17;7(16):3545-50. doi: 10.1002/1521-3765(20010817)7:16<3545::aid-chem3545>3.0.co;2-0. PMID: 11560325.
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Addition of a phosphinidene complex to C=N bonds: P-ylides, azaphosphiridines, and 1,3-dipolar cycloadditions.

Chemistry (Weinheim an der Bergstrasse, Germany)

Vlaar MJ, Valkier P, de Kanter FJ, Schakel M, Ehlers AW, Spek AL, Lutz M, Lammertsma K.
PMID: 11560326
Chemistry. 2001 Aug 17;7(16):3551-7. doi: 10.1002/1521-3765(20010817)7:16<3551::aid-chem3551>3.0.co;2-m.

The terminal phosphinidene complex PhPW(CO)5 adds to the imine bond of PhHC=N-Ph to give 3-membered ring azaphosphiridines, which undergo ring-expansion with an additional imine to yield a set of four isomeric five-membered ring diazaphospholanes. Treatment with the diimines PhHC=N-(CH2)n-N=CHPh...

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Vlaar MJ, Valkier P, de Kanter FJ, et al. Addition of a phosphinidene complex to C=N bonds: P-ylides, azaphosphiridines, and 1,3-dipolar cycloadditions. Chemistry. 2001;7(16):3551-7doi: 10.1002/1521-3765(20010817)7:16<3551::aid-chem3551>3.0.co;2-m.
Vlaar, M. J., Valkier, P., de Kanter, F. J., Schakel, M., Ehlers, A. W., Spek, A. L., Lutz, M., & Lammertsma, K. (2001). Addition of a phosphinidene complex to C=N bonds: P-ylides, azaphosphiridines, and 1,3-dipolar cycloadditions. Chemistry (Weinheim an der Bergstrasse, Germany), 7(16), 3551-7. https://doi.org/10.1002/1521-3765(20010817)7:16<3551::aid-chem3551>3.0.co;2-m
Vlaar, M J, et al. "Addition of a phosphinidene complex to C=N bonds: P-ylides, azaphosphiridines, and 1,3-dipolar cycloadditions." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 7,16 (2001): 3551-7. doi: https://doi.org/10.1002/1521-3765(20010817)7:16<3551::aid-chem3551>3.0.co;2-m
Vlaar MJ, Valkier P, de Kanter FJ, Schakel M, Ehlers AW, Spek AL, Lutz M, Lammertsma K. Addition of a phosphinidene complex to C=N bonds: P-ylides, azaphosphiridines, and 1,3-dipolar cycloadditions. Chemistry. 2001 Aug 17;7(16):3551-7. doi: 10.1002/1521-3765(20010817)7:16<3551::aid-chem3551>3.0.co;2-m. PMID: 11560326.
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Vinylphosphirane-phospholene rearrangements: pericyclic [1,3]-sigmatropic shifts or not?.

Journal of the American Chemical Society

Bulo RE, Ehlers AW, Grimme S, Lammertsma K.
PMID: 12431122
J Am Chem Soc. 2002 Nov 20;124(46):13903-10. doi: 10.1021/ja027925u.

The conversion of "free" and Cr(CO)(5)-complexed 2-vinylphosphiranes into 3-phospholenes via [1,3]-sigmatropic shifts was studied with density functional theory and compared with the corresponding hydrocarbon system, that is, the vinylcyclopropane-cyclopentene rearrangement. All three systems behave similarly with subtle but important...

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Bulo RE, Ehlers AW, Grimme S, et al. Vinylphosphirane-phospholene rearrangements: pericyclic [1,3]-sigmatropic shifts or not?. J Am Chem Soc. 2002;124(46):13903-10doi: 10.1021/ja027925u.
Bulo, R. E., Ehlers, A. W., Grimme, S., & Lammertsma, K. (2002). Vinylphosphirane-phospholene rearrangements: pericyclic [1,3]-sigmatropic shifts or not?. Journal of the American Chemical Society, 124(46), 13903-10. https://doi.org/10.1021/ja027925u
Bulo, Rosa E, et al. "Vinylphosphirane-phospholene rearrangements: pericyclic [1,3]-sigmatropic shifts or not?." Journal of the American Chemical Society vol. 124,46 (2002): 13903-10. doi: https://doi.org/10.1021/ja027925u
Bulo RE, Ehlers AW, Grimme S, Lammertsma K. Vinylphosphirane-phospholene rearrangements: pericyclic [1,3]-sigmatropic shifts or not?. J Am Chem Soc. 2002 Nov 20;124(46):13903-10. doi: 10.1021/ja027925u. PMID: 12431122.
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Norbornadiene-Quadricyclane Valence Isomerism for a Tetraphosphorus Derivative The Netherlands Organization for Scientific Research (NOW/CW) is acknowledged for partial support (A.L.S., M.L., K.L.), as are the NSERC of Canada for a scholarship (S.B.C.), and EPSRC for funding phosphaorganometallic chemistry at Sussex University (J.F.N.). Dr. H. Zappey is thanked for the HR-MS spectra and J. C. Slootweg for his initiative. .

Angewandte Chemie (International ed. in English)

Vlaar MJ, Ehlers AW, Schakel M, Clendenning SB, Nixon JF, Lutz M, Spek AL, Lammertsma K.
PMID: 12404432
Angew Chem Int Ed Engl. 2001 Dec 03;40(23):4412-4415. doi: 10.1002/1521-3773(20011203)40:23<4412::aid-anie4412>3.0.co;2-i.

No abstract available.

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Vlaar MJ, Ehlers AW, Schakel M, et al. Norbornadiene-Quadricyclane Valence Isomerism for a Tetraphosphorus Derivative The Netherlands Organization for Scientific Research (NOW/CW) is acknowledged for partial support (A.L.S., M.L., K.L.), as are the NSERC of Canada for a scholarship (S.B.C.), and EPSRC for funding phosphaorganometallic chemistry at Sussex University (J.F.N.). Dr. H. Zappey is thanked for the HR-MS spectra and J. C. Slootweg for his initiative. . Angew Chem Int Ed Engl. 2001;40(23):4412-4415doi: 10.1002/1521-3773(20011203)40:23<4412::aid-anie4412>3.0.co;2-i.
Vlaar, M. J., Ehlers, A. W., Schakel, M., Clendenning, S. B., Nixon, J. F., Lutz, M., Spek, A. L., & Lammertsma, K. (2001). Norbornadiene-Quadricyclane Valence Isomerism for a Tetraphosphorus Derivative The Netherlands Organization for Scientific Research (NOW/CW) is acknowledged for partial support (A.L.S., M.L., K.L.), as are the NSERC of Canada for a scholarship (S.B.C.), and EPSRC for funding phosphaorganometallic chemistry at Sussex University (J.F.N.). Dr. H. Zappey is thanked for the HR-MS spectra and J. C. Slootweg for his initiative. . Angewandte Chemie (International ed. in English), 40(23), 4412-4415. https://doi.org/10.1002/1521-3773(20011203)40:23<4412::aid-anie4412>3.0.co;2-i
Vlaar, Mark J. M., et al. "Norbornadiene-Quadricyclane Valence Isomerism for a Tetraphosphorus Derivative The Netherlands Organization for Scientific Research (NOW/CW) is acknowledged for partial support (A.L.S., M.L., K.L.), as are the NSERC of Canada for a scholarship (S.B.C.), and EPSRC for funding phosphaorganometallic chemistry at Sussex University (J.F.N.). Dr. H. Zappey is thanked for the HR-MS spectra and J. C. Slootweg for his initiative. ." Angewandte Chemie (International ed. in English) vol. 40,23 (2001): 4412-4415. doi: https://doi.org/10.1002/1521-3773(20011203)40:23<4412::aid-anie4412>3.0.co;2-i
Vlaar MJ, Ehlers AW, Schakel M, Clendenning SB, Nixon JF, Lutz M, Spek AL, Lammertsma K. Norbornadiene-Quadricyclane Valence Isomerism for a Tetraphosphorus Derivative The Netherlands Organization for Scientific Research (NOW/CW) is acknowledged for partial support (A.L.S., M.L., K.L.), as are the NSERC of Canada for a scholarship (S.B.C.), and EPSRC for funding phosphaorganometallic chemistry at Sussex University (J.F.N.). Dr. H. Zappey is thanked for the HR-MS spectra and J. C. Slootweg for his initiative. . Angew Chem Int Ed Engl. 2001 Dec 03;40(23):4412-4415. doi: 10.1002/1521-3773(20011203)40:23<4412::aid-anie4412>3.0.co;2-i. PMID: 12404432.
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2-Phospha-4-silabicyclo[1.1.0]butane as a reactive intermediate.

Angewandte Chemie (International ed. in English)

Slootweg JC, De Kanter FJ, Schakel M, Ehlers AW, Gehrhus B, Lutz M, Mills AM, Spek AL, Lammertsma K.
PMID: 15221844
Angew Chem Int Ed Engl. 2004 Jun 28;43(26):3474-7. doi: 10.1002/anie.200454183.

No abstract available.

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Slootweg JC, De Kanter FJ, Schakel M, et al. 2-Phospha-4-silabicyclo[1.1.0]butane as a reactive intermediate. Angew Chem Int Ed Engl. 2004;43(26):3474-7doi: 10.1002/anie.200454183.
Slootweg, J. C., De Kanter, F. J., Schakel, M., Ehlers, A. W., Gehrhus, B., Lutz, M., Mills, A. M., Spek, A. L., & Lammertsma, K. (2004). 2-Phospha-4-silabicyclo[1.1.0]butane as a reactive intermediate. Angewandte Chemie (International ed. in English), 43(26), 3474-7. https://doi.org/10.1002/anie.200454183
Slootweg, J Chris, et al. "2-Phospha-4-silabicyclo[1.1.0]butane as a reactive intermediate." Angewandte Chemie (International ed. in English) vol. 43,26 (2004): 3474-7. doi: https://doi.org/10.1002/anie.200454183
Slootweg JC, De Kanter FJ, Schakel M, Ehlers AW, Gehrhus B, Lutz M, Mills AM, Spek AL, Lammertsma K. 2-Phospha-4-silabicyclo[1.1.0]butane as a reactive intermediate. Angew Chem Int Ed Engl. 2004 Jun 28;43(26):3474-7. doi: 10.1002/anie.200454183. PMID: 15221844.
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P-C dichotomy: divergent iron(-I)-mediated alkyne and phosphaalkyne cycloligomerisations.

Dalton transactions (Cambridge, England : 2003)

Wolf R, Ghavtadze N, Weber K, Schnöckelborg EM, de Bruin B, Ehlers AW, Lammertsma K.
PMID: 20104301
Dalton Trans. 2010 Feb 14;39(6):1453-6. doi: 10.1039/b923663p. Epub 2009 Dec 04.

In contrast to the recently reported cyclodimerisations of phosphaalkynes, alkynes preferably trimerise at the same low-valent iron(-I) centre.

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Wolf R, Ghavtadze N, Weber K, et al. P-C dichotomy: divergent iron(-I)-mediated alkyne and phosphaalkyne cycloligomerisations. Dalton Trans. 2009;39(6):1453-6doi: 10.1039/b923663p.
Wolf, R., Ghavtadze, N., Weber, K., Schnöckelborg, E. M., de Bruin, B., Ehlers, A. W., & Lammertsma, K. (2010). P-C dichotomy: divergent iron(-I)-mediated alkyne and phosphaalkyne cycloligomerisations. Dalton transactions (Cambridge, England : 2003), 39(6), 1453-6. https://doi.org/10.1039/b923663p
Wolf, Robert, et al. "P-C dichotomy: divergent iron(-I)-mediated alkyne and phosphaalkyne cycloligomerisations." Dalton transactions (Cambridge, England : 2003) vol. 39,6 (2010): 1453-6. doi: https://doi.org/10.1039/b923663p
Wolf R, Ghavtadze N, Weber K, Schnöckelborg EM, de Bruin B, Ehlers AW, Lammertsma K. P-C dichotomy: divergent iron(-I)-mediated alkyne and phosphaalkyne cycloligomerisations. Dalton Trans. 2010 Feb 14;39(6):1453-6. doi: 10.1039/b923663p. Epub 2009 Dec 04. PMID: 20104301.
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C-C bond insertion of a complexed phosphinidene into 1,6-methano[10]annulene.

Chemistry (Weinheim an der Bergstrasse, Germany)

Bulo RE, Trion L, Ehlers AW, de Kanter FJ, Schakel M, Lutz M, Spek AL, Lammertsma K.
PMID: 15390134
Chemistry. 2004 Oct 25;10(21):5332-7. doi: 10.1002/chem.200400519.

Reaction of electrophilic phosphinidene complex [MePW(CO)5] with 1,6-methano-[10]annulene results in the sole formation of the isomeric C-C insertion products 6 c (main) and 6 d (minor). The single-crystal X-ray structure of the complexed 1,7-methano-3-phospha[11]annulene (6 c) shows a syn-W(CO)5...

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Bulo RE, Trion L, Ehlers AW, et al. C-C bond insertion of a complexed phosphinidene into 1,6-methano[10]annulene. Chemistry. 2004;10(21):5332-7doi: 10.1002/chem.200400519.
Bulo, R. E., Trion, L., Ehlers, A. W., de Kanter, F. J., Schakel, M., Lutz, M., Spek, A. L., & Lammertsma, K. (2004). C-C bond insertion of a complexed phosphinidene into 1,6-methano[10]annulene. Chemistry (Weinheim an der Bergstrasse, Germany), 10(21), 5332-7. https://doi.org/10.1002/chem.200400519
Bulo, Rosa E, et al. "C-C bond insertion of a complexed phosphinidene into 1,6-methano[10]annulene." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 10,21 (2004): 5332-7. doi: https://doi.org/10.1002/chem.200400519
Bulo RE, Trion L, Ehlers AW, de Kanter FJ, Schakel M, Lutz M, Spek AL, Lammertsma K. C-C bond insertion of a complexed phosphinidene into 1,6-methano[10]annulene. Chemistry. 2004 Oct 25;10(21):5332-7. doi: 10.1002/chem.200400519. PMID: 15390134.
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Geminal phosphorus/aluminum-based frustrated lewis pairs: C−H versus C≡C activation and CO2 fixation.

Angewandte Chemie (International ed. in English)

Appelt C, Westenberg H, Bertini F, Ehlers AW, Slootweg JC, Lammertsma K, Uhl W.
PMID: 21425419
Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3925-8. doi: 10.1002/anie.201006901. Epub 2011 Mar 21.

No abstract available.

Cite
Appelt C, Westenberg H, Bertini F, et al. Geminal phosphorus/aluminum-based frustrated lewis pairs: C−H versus C≡C activation and CO2 fixation. Angew Chem Int Ed Engl. 2011;50(17):3925-8doi: 10.1002/anie.201006901.
Appelt, C., Westenberg, H., Bertini, F., Ehlers, A. W., Slootweg, J. C., Lammertsma, K., & Uhl, W. (2011). Geminal phosphorus/aluminum-based frustrated lewis pairs: C−H versus C≡C activation and CO2 fixation. Angewandte Chemie (International ed. in English), 50(17), 3925-8. https://doi.org/10.1002/anie.201006901
Appelt, Christian, et al. "Geminal phosphorus/aluminum-based frustrated lewis pairs: C−H versus C≡C activation and CO2 fixation." Angewandte Chemie (International ed. in English) vol. 50,17 (2011): 3925-8. doi: https://doi.org/10.1002/anie.201006901
Appelt C, Westenberg H, Bertini F, Ehlers AW, Slootweg JC, Lammertsma K, Uhl W. Geminal phosphorus/aluminum-based frustrated lewis pairs: C−H versus C≡C activation and CO2 fixation. Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3925-8. doi: 10.1002/anie.201006901. Epub 2011 Mar 21. PMID: 21425419.
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Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner.

EJNMMI research

Huisman MC, van Golen LW, Hoetjes NJ, Greuter HN, Schober P, Ijzerman RG, Diamant M, Lammertsma AA.
PMID: 23168248
EJNMMI Res. 2012 Nov 20;2(1):63. doi: 10.1186/2191-219X-2-63.

BACKGROUND: Positron emission tomography (PET) allows for the measurement of cerebral blood flow (CBF; based on [15O]H2O) and cerebral metabolic rate of glucose utilization (CMRglu; based on [18 F]-2-fluoro-2-deoxy-d-glucose ([18 F]FDG)). By using kinetic modeling, quantitative CBF and CMRglu...

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Huisman MC, van Golen LW, Hoetjes NJ, et al. Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner. EJNMMI Res. 2012;2(1):63doi: 10.1186/2191-219X-2-63.
Huisman, M. C., van Golen, L. W., Hoetjes, N. J., Greuter, H. N., Schober, P., Ijzerman, R. G., Diamant, M., & Lammertsma, A. A. (2012). Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner. EJNMMI research, 2(1), 63. https://doi.org/10.1186/2191-219X-2-63
Huisman, Marc C, et al. "Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner." EJNMMI research vol. 2,1 (2012): 63. doi: https://doi.org/10.1186/2191-219X-2-63
Huisman MC, van Golen LW, Hoetjes NJ, Greuter HN, Schober P, Ijzerman RG, Diamant M, Lammertsma AA. Cerebral blood flow and glucose metabolism in healthy volunteers measured using a high-resolution PET scanner. EJNMMI Res. 2012 Nov 20;2(1):63. doi: 10.1186/2191-219X-2-63. PMID: 23168248; PMCID: PMC3544653.
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Positron Emission Tomography as a Method for Measuring Drug Delivery to Tumors in vivo: The Example of [(11)C]docetaxel.

Frontiers in oncology

van der Veldt AA, Smit EF, Lammertsma AA.
PMID: 23986880
Front Oncol. 2013 Aug 13;3:208. doi: 10.3389/fonc.2013.00208. eCollection 2013.

Systemic anticancer treatments fail in a substantial number of patients. This may be caused by inadequate uptake and penetration of drugs in malignant tumors. Consequently, improvement of drug delivery to solid tumors may enhance its efficacy. Before evaluating strategies...

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van der Veldt AA, Smit EF, Lammertsma AA. Positron Emission Tomography as a Method for Measuring Drug Delivery to Tumors in vivo: The Example of [(11)C]docetaxel. Front Oncol. 2013;3:208doi: 10.3389/fonc.2013.00208.
van der Veldt, A. A., Smit, E. F., & Lammertsma, A. A. (2013). Positron Emission Tomography as a Method for Measuring Drug Delivery to Tumors in vivo: The Example of [(11)C]docetaxel. Frontiers in oncology, 3208. https://doi.org/10.3389/fonc.2013.00208
van der Veldt, Astrid A M, et al. "Positron Emission Tomography as a Method for Measuring Drug Delivery to Tumors in vivo: The Example of [(11)C]docetaxel." Frontiers in oncology vol. 3 (2013): 208. doi: https://doi.org/10.3389/fonc.2013.00208
van der Veldt AA, Smit EF, Lammertsma AA. Positron Emission Tomography as a Method for Measuring Drug Delivery to Tumors in vivo: The Example of [(11)C]docetaxel. Front Oncol. 2013 Aug 13;3:208. doi: 10.3389/fonc.2013.00208. eCollection 2013. PMID: 23986880; PMCID: PMC3742054.
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Showing 1 to 12 of 134 entries