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Showing 1 to 12 of 22 entries
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Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts.

Oncotarget

Trerotola M, Ganguly KK, Fazli L, Fedele C, Lu H, Dutta A, Liu Q, De Angelis T, Riddell LW, Riobo NA, Gleave ME, Zoubeidi A, Pestell RG, Altieri DC, Languino LR.
PMID: 26513314
Oncotarget. 2015 Oct 20;6(32):34038. doi: 10.18632/oncotarget.6187.

No abstract available.

Corrigendum: Landscape of the mitochondrial Hsp90 metabolome in tumours.

Nature communications

Chae YC, Angelin A, Lisanti S, Kossenkov AV, Speicher KD, Wang H, Powers JF, Tischler AS, Pacak K, Fliedner S, Michalek RD, Karoly ED, Wallace DC, Languino LR, Speicher DW, Altieri DC.
PMID: 26085380
Nat Commun. 2015 Jun 18;6:7605. doi: 10.1038/ncomms8605.

No abstract available.

Integrin signaling aberrations in prostate cancer.

American journal of translational research

Goel HL, Alam N, Johnson IN, Languino LR.
PMID: 19956432
Am J Transl Res. 2009 Apr 20;1(3):211-20.

Integrins are cell surface receptors for extracellular matrix proteins and play a key role in cell survival, proliferation, migration and gene expression. Integrin signaling has been shown to be deregulated in several types of cancer, including prostate cancer. This...

CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells.

American journal of translational research

Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR.
PMID: 20407603
Am J Transl Res. 2010 Mar 15;2(2):135-44.

Cancer stem cells (CSCs) play a key role in initiation and development of cancer and are attractive targets for therapy. The identification of CSC surface receptors to be used as therapeutic targets in vivo remains a difficult task. In...

α(V)β(6) integrin expression is induced in the POET and Pten(pc-/-) mouse models of prostatic inflammation and prostatic adenocarcinoma.

American journal of translational research

Garlick DS, Li J, Sansoucy B, Wang T, Griffith L, Fitzgerald T, Butterfield J, Charbonneau B, Violette SM, Weinreb PH, Ratliff TL, Liao CP, Roy-Burman P, Vietri M, Lian JB, Stein GS, Altieri DC, Languino LR.
PMID: 22611469
Am J Transl Res. 2012;4(2):165-74. Epub 2012 Apr 10.

Chronic inflammation is proposed to prime the development of prostate cancer. However, the mechanisms of prostate cancer initiation and development are not completely understood. The α(v)β(6) integrin has been shown to play a role in epithelial development, wound healing...

Hitting the Bullseye: Are extracellular vesicles on target?.

Journal of extracellular vesicles

Noren Hooten N, Yáñez-Mó M, DeRita R, Russell A, Quesenberry P, Ramratnam B, Robbins PD, Di Vizio D, Wen S, Witwer KW, Languino LR.
PMID: 33708359
J Extracell Vesicles. 2020 Nov;10(1):e12032. doi: 10.1002/jev2.12032. Epub 2020 Nov 29.

No abstract available.

IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles.

The Biochemical journal

Naranjo NM, Salem I, Harris MA, Languino LR.
PMID: 34622927
Biochem J. 2021 Nov 12;478(21):3905-3921. doi: 10.1042/BCJ20210580.

We have previously shown that the αvβ6 integrin plays a key role in promoting prostate cancer (PrCa) and it can be transferred to recipient cells via small extracellular vesicles (sEVs). Furthermore, we have reported in a proteomic analysis that...

Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth.

iScience

DeRita RM, Sayeed A, Garcia V, Krishn SR, Shields CD, Sarker S, Friedman A, McCue P, Molugu SK, Rodeck U, Dicker AP, Languino LR.
PMID: 30981115
iScience. 2019 Apr 26;14:199-209. doi: 10.1016/j.isci.2019.03.022. Epub 2019 Mar 27.

The β1 integrins, known to promote cancer progression, are abundant in extracellular vesicles (EVs). We investigated whether prostate cancer (PrCa) EVs affect anchorage-independent growth and whether β1 integrins are required for this effect. Specifically using a cell-line-based genetic rescue...

Current trends in economy, sustainable development, and energy: a circular economy view.

Environmental science and pollution research international

Sanguino R, Barroso A, Fernández-Rodríguez S, Sánchez-Hernández MI.
PMID: 31912387
Environ Sci Pollut Res Int. 2020 Jan;27(1):1-7. doi: 10.1007/s11356-019-07074-x.

No abstract available.

Methods for extracellular vesicle isolation from cancer cells.

Cancer drug resistance (Alhambra, Calif.)

Salem I, Naranjo NM, Singh A, DeRita R, Krishn SR, Sirman LS, Quaglia F, Duffy A, Bowler N, Sayeed A, Languino LR.
PMID: 33062957
Cancer Drug Resist. 2020;3:371-384. doi: 10.20517/cdr.2019.118. Epub 2020 Apr 25.

Cells are known to release different types of vesicles such as small extracellular vesicles (sEVs) and large extracellular vesicles (LEVs). sEVs and LEVs play important roles in intercellular communication, pre-metastatic niche formation, and disease progression; both can be detected...

The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis.

Journal of extracellular vesicles

Krishn SR, Salem I, Quaglia F, Naranjo NM, Agarwal E, Liu Q, Sarker S, Kopenhaver J, McCue PA, Weinreb PH, Violette SM, Altieri DC, Languino LR.
PMID: 32595914
J Extracell Vesicles. 2020 May 20;9(1):1763594. doi: 10.1080/20013078.2020.1763594. eCollection 2020.

Prostate cancer (PrCa) cells crosstalk with the tumour microenvironment by releasing small extracellular vesicles (sEVs). sEVs, as well as large extracellular vesicles (LEVs), isolated via iodixanol density gradients from PrCa cell culture media, express the epithelial-specific αvβ6 integrin, which...

Measurement of quality of life among patient undergoing arthroplasty of the thumb to treat CMC arthritis.

Revista brasileira de ortopedia

Aita MA, Alves RS, Longuino LF, Ferreira CH, Ikeuti DH, Rodrigues LM.
PMID: 27517022
Rev Bras Ortop. 2016 Jun 06;51(4):431-6. doi: 10.1016/j.rboe.2016.06.003. eCollection 2016.

OBJECTIVE: To present the clinical and functional results, including measurement of quality of life, of patients undergoing trapeziometacarpal arthroplasty.METHOD: This was a prospective evaluation on 45 patients (53 thumbs) with a diagnosis of idiopathic rhizarthrosis who underwent resection arthroplasty...

Showing 1 to 12 of 22 entries