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Showing 1 to 12 of 14 entries
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BAIT: Organizing genomes and mapping rearrangements in single cells.

Genome medicine

Hills M, O'Neill K, Falconer E, Brinkman R, Lansdorp PM.
PMID: 24028793
Genome Med. 2013 Sep 13;5(9):82. doi: 10.1186/gm486. eCollection 2013.

Strand-seq is a single-cell sequencing technique to finely map sister chromatid exchanges (SCEs) and other rearrangements. To analyze these data, we introduce BAIT, software which assigns templates and identifies and localizes SCEs. We demonstrate BAIT can refine completed reference...

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Hills M, O'Neill K, Falconer E, et al. BAIT: Organizing genomes and mapping rearrangements in single cells. Genome Med. 2013;5(9):82doi: 10.1186/gm486.
Hills, M., O'Neill, K., Falconer, E., Brinkman, R., & Lansdorp, P. M. (2013). BAIT: Organizing genomes and mapping rearrangements in single cells. Genome medicine, 5(9), 82. https://doi.org/10.1186/gm486
Hills, Mark, et al. "BAIT: Organizing genomes and mapping rearrangements in single cells." Genome medicine vol. 5,9 (2013): 82. doi: https://doi.org/10.1186/gm486
Hills M, O'Neill K, Falconer E, Brinkman R, Lansdorp PM. BAIT: Organizing genomes and mapping rearrangements in single cells. Genome Med. 2013 Sep 13;5(9):82. doi: 10.1186/gm486. eCollection 2013. PMID: 24028793; PMCID: PMC3971352.
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Fat metabolism is associated with telomere length in six population-based studies.

Human molecular genetics

van der Spek A, Karamujić-Čomić H, Pool R, Bot M, Beekman M, Garmaeva S, Arp PP, Henkelman S, Liu J, Alves AC, Willemsen G, van Grootheest G, Aubert G, Ikram MA, Jarvelin MR, Lansdorp P, Uitterlinden AG, Zhernakova A, Slagboom PE, Penninx BWJH, Boomsma DI, Amin N, van Duijn CM.
PMID: 34875050
Hum Mol Genet. 2021 Dec 07; doi: 10.1093/hmg/ddab281. Epub 2021 Dec 07.

Telomeres are repetitive DNA sequences located at the end of chromosomes, which are associated to biological aging, cardiovascular disease, cancer, and mortality. Lipid and fatty acid metabolism have been associated with telomere shortening. We have conducted an in-depth study...

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van der Spek A, Karamujić-Čomić H, Pool R, et al. Fat metabolism is associated with telomere length in six population-based studies. Hum Mol Genet. 2021;doi: 10.1093/hmg/ddab281.
van der Spek, A., Karamujić-Čomić, H., Pool, R., Bot, M., Beekman, M., Garmaeva, S., Arp, P. P., Henkelman, S., Liu, J., Alves, A. C., Willemsen, G., van Grootheest, G., Aubert, G., Ikram, M. A., Jarvelin, M. R., Lansdorp, P., Uitterlinden, A. G., Zhernakova, A., Slagboom, P. E., Penninx, B. W. J. H., Boomsma, D. I., Amin, N., & van Duijn, C. M. (2021). Fat metabolism is associated with telomere length in six population-based studies. Human molecular genetics, . https://doi.org/10.1093/hmg/ddab281
van der Spek, Ashley, et al. "Fat metabolism is associated with telomere length in six population-based studies." Human molecular genetics vol. (2021). doi: https://doi.org/10.1093/hmg/ddab281
van der Spek A, Karamujić-Čomić H, Pool R, Bot M, Beekman M, Garmaeva S, Arp PP, Henkelman S, Liu J, Alves AC, Willemsen G, van Grootheest G, Aubert G, Ikram MA, Jarvelin MR, Lansdorp P, Uitterlinden AG, Zhernakova A, Slagboom PE, Penninx BWJH, Boomsma DI, Amin N, van Duijn CM. Fat metabolism is associated with telomere length in six population-based studies. Hum Mol Genet. 2021 Dec 07; doi: 10.1093/hmg/ddab281. Epub 2021 Dec 07. PMID: 34875050.
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Ihor Lemischka (1953-2017).

Stem cell reports

Lansdorp P.
PMID: 33248031
Stem Cell Reports. 2018 Feb 13;10(2):329-330. doi: 10.1016/j.stemcr.2018.01.035. Epub 2018 Feb 13.

No abstract available.

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Lansdorp P. Ihor Lemischka (1953-2017). Stem Cell Reports. 2018;10(2):329-330doi: 10.1016/j.stemcr.2018.01.035.
Lansdorp, P. (2018). Ihor Lemischka (1953-2017). Stem cell reports, 10(2), 329-330. https://doi.org/10.1016/j.stemcr.2018.01.035
Lansdorp, Peter. "Ihor Lemischka (1953-2017)." Stem cell reports vol. 10,2 (2018): 329-330. doi: https://doi.org/10.1016/j.stemcr.2018.01.035
Lansdorp P. Ihor Lemischka (1953-2017). Stem Cell Reports. 2018 Feb 13;10(2):329-330. doi: 10.1016/j.stemcr.2018.01.035. Epub 2018 Feb 13. PMID: 33248031; PMCID: PMC8486941.
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Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons.

Genome biology

van den Bos H, Spierings DC, Taudt A, Bakker B, Porubský D, Falconer E, Novoa C, Halsema N, Kazemier HG, Hoekstra-Wakker K, Guryev V, den Dunnen WF, Foijer F, Colomé-Tatché M, Boddeke HW, Landsdorp PM.
PMID: 27363435
Genome Biol. 2016 Jun 30;17(1):143. doi: 10.1186/s13059-016-1015-z.

No abstract available.

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van den Bos H, Spierings DC, Taudt A, et al. Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons. Genome Biol. 2016;17(1):143doi: 10.1186/s13059-016-1015-z.
van den Bos, H., Spierings, D. C., Taudt, A., Bakker, B., Porubský, D., Falconer, E., Novoa, C., Halsema, N., Kazemier, H. G., Hoekstra-Wakker, K., Guryev, V., den Dunnen, W. F., Foijer, F., Colomé-Tatché, M., Boddeke, H. W., & Landsdorp, P. M. (2016). Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons. Genome biology, 17(1), 143. https://doi.org/10.1186/s13059-016-1015-z
van den Bos, Hilda, et al. "Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons." Genome biology vol. 17,1 (2016): 143. doi: https://doi.org/10.1186/s13059-016-1015-z
van den Bos H, Spierings DC, Taudt A, Bakker B, Porubský D, Falconer E, Novoa C, Halsema N, Kazemier HG, Hoekstra-Wakker K, Guryev V, den Dunnen WF, Foijer F, Colomé-Tatché M, Boddeke HW, Landsdorp PM. Erratum to: Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons. Genome Biol. 2016 Jun 30;17(1):143. doi: 10.1186/s13059-016-1015-z. PMID: 27363435; PMCID: PMC4928312.
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Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn's disease: results of the HOT-REVA pilot study.

BJS open

Lansdorp CA, Buskens CJ, Gecse KB, D'Haens GRAM, van Hulst RA.
PMID: 34046674
BJS Open. 2021 May 07;5(3). doi: 10.1093/bjsopen/zrab042.

BACKGROUND: Positive effects of hyperbaric oxygen (HBO) on perianal fistulas in Crohn's disease (CD) have been described, but the effect on rectovaginal fistulas (RVFs) has not yet been studied. The aim was to investigate the efficacy, safety and feasibility...

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Lansdorp CA, Buskens CJ, Gecse KB, et al. Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn's disease: results of the HOT-REVA pilot study. BJS Open. 2021;5(3)doi: 10.1093/bjsopen/zrab042.
Lansdorp, C. A., Buskens, C. J., Gecse, K. B., D'Haens, G. R. A. M., & van Hulst, R. A. (2021). Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn's disease: results of the HOT-REVA pilot study. BJS open, 5(3), . https://doi.org/10.1093/bjsopen/zrab042
Lansdorp, C A, et al. "Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn's disease: results of the HOT-REVA pilot study." BJS open vol. 5,3 (2021). doi: https://doi.org/10.1093/bjsopen/zrab042
Lansdorp CA, Buskens CJ, Gecse KB, D'Haens GRAM, van Hulst RA. Hyperbaric oxygen therapy for the treatment of rectovaginal fistulas in patients with Crohn's disease: results of the HOT-REVA pilot study. BJS Open. 2021 May 07;5(3). doi: 10.1093/bjsopen/zrab042. PMID: 34046674; PMCID: PMC8160532.
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Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival.

British journal of cancer

Tamminga M, Andree KC, van den Bos H, Hiltermann TJN, Mentink A, Spierings DCJ, Lansdorp P, Timens W, Schuuring E, Terstappen LWMM, Groen HJM.
PMID: 34848855
Br J Cancer. 2021 Nov 30; doi: 10.1038/s41416-021-01634-0. Epub 2021 Nov 30.

BACKGROUND: Circulating tumour cells (CTCs) can be used to monitor cancer longitudinally, but their use in non-small cell lung cancer (NSCLC) is limited due to low numbers in the peripheral blood. Through diagnostic leukapheresis (DLA) CTCs can be obtained...

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Tamminga M, Andree KC, van den Bos H, et al. Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival. Br J Cancer. 2021;doi: 10.1038/s41416-021-01634-0.
Tamminga, M., Andree, K. C., van den Bos, H., Hiltermann, T. J. N., Mentink, A., Spierings, D. C. J., Lansdorp, P., Timens, W., Schuuring, E., Terstappen, L. W. M. M., & Groen, H. J. M. (2021). Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival. British journal of cancer, . https://doi.org/10.1038/s41416-021-01634-0
Tamminga, Menno, et al. "Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival." British journal of cancer vol. (2021). doi: https://doi.org/10.1038/s41416-021-01634-0
Tamminga M, Andree KC, van den Bos H, Hiltermann TJN, Mentink A, Spierings DCJ, Lansdorp P, Timens W, Schuuring E, Terstappen LWMM, Groen HJM. Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival. Br J Cancer. 2021 Nov 30; doi: 10.1038/s41416-021-01634-0. Epub 2021 Nov 30. PMID: 34848855.
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Flow cytometry and immunoselection of human stem cells.

Methods in molecular medicine

Thomas TE, Abraham SJ, Lansdorp PM.
PMID: 21437799
Methods Mol Med. 2002;63:29-57. doi: 10.1385/1-59259-140-X:029.

Human hematopoietic stem cells (HSCs) can be obtained from a variety of hematopoietic tissues, including bone marrow, blood, cord blood, and fetal liver. Various techniques have been used to fractionate hematopoietic cell populations based on differences in size and...

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Thomas TE, Abraham SJ, Lansdorp PM. Flow cytometry and immunoselection of human stem cells. Methods Mol Med. 2002;63:29-57doi: 10.1385/1-59259-140-X:029.
Thomas, T. E., Abraham, S. J., & Lansdorp, P. M. (2002). Flow cytometry and immunoselection of human stem cells. Methods in molecular medicine, 6329-57. https://doi.org/10.1385/1-59259-140-X:029
Thomas, Terry E, et al. "Flow cytometry and immunoselection of human stem cells." Methods in molecular medicine vol. 63 (2002): 29-57. doi: https://doi.org/10.1385/1-59259-140-X:029
Thomas TE, Abraham SJ, Lansdorp PM. Flow cytometry and immunoselection of human stem cells. Methods Mol Med. 2002;63:29-57. doi: 10.1385/1-59259-140-X:029. PMID: 21437799.
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Detection of G-quadruplex DNA in mammalian cells.

Nucleic acids research

Henderson A, Wu Y, Huang YC, Chavez EA, Platt J, Johnson FB, Brosh RM, Sen D, Lansdorp PM.
PMID: 28449109
Nucleic Acids Res. 2017 Jun 02;45(10):6252. doi: 10.1093/nar/gkx300.

No abstract available.

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Henderson A, Wu Y, Huang YC, et al. Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res. 2017;45(10):6252doi: 10.1093/nar/gkx300.
Henderson, A., Wu, Y., Huang, Y. C., Chavez, E. A., Platt, J., Johnson, F. B., Brosh, R. M., Sen, D., & Lansdorp, P. M. (2017). Detection of G-quadruplex DNA in mammalian cells. Nucleic acids research, 45(10), 6252. https://doi.org/10.1093/nar/gkx300
Henderson, Alexander, et al. "Detection of G-quadruplex DNA in mammalian cells." Nucleic acids research vol. 45,10 (2017): 6252. doi: https://doi.org/10.1093/nar/gkx300
Henderson A, Wu Y, Huang YC, Chavez EA, Platt J, Johnson FB, Brosh RM, Sen D, Lansdorp PM. Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res. 2017 Jun 02;45(10):6252. doi: 10.1093/nar/gkx300. PMID: 28449109; PMCID: PMC5449604.
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Detection of Circulating Tumor Cells in the Diagnostic Leukapheresis Product of Non-Small-Cell Lung Cancer Patients Comparing CellSearch.

Cancers

Tamminga M, Andree KC, Hiltermann TJN, Jayat M, Schuuring E, van den Bos H, Spierings DCJ, Lansdorp PM, Timens W, Terstappen LWMM, Groen HJM.
PMID: 32272669
Cancers (Basel). 2020 Apr 07;12(4). doi: 10.3390/cancers12040896.

Circulating tumor cells (CTCs) detected by CellSearch are prognostic in non-small-cell lung cancer (NSCLC), but rarely found. CTCs can be extracted from the blood together with mononuclear cell populations by diagnostic leukapheresis (DLA), therefore concentrating them. However, CellSearch can...

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Tamminga M, Andree KC, Hiltermann TJN, et al. Detection of Circulating Tumor Cells in the Diagnostic Leukapheresis Product of Non-Small-Cell Lung Cancer Patients Comparing CellSearch. Cancers (Basel). 2020;12(4)doi: 10.3390/cancers12040896.
Tamminga, M., Andree, K. C., Hiltermann, T. J. N., Jayat, M., Schuuring, E., van den Bos, H., Spierings, D. C. J., Lansdorp, P. M., Timens, W., Terstappen, L. W. M. M., & Groen, H. J. M. (2020). Detection of Circulating Tumor Cells in the Diagnostic Leukapheresis Product of Non-Small-Cell Lung Cancer Patients Comparing CellSearch. Cancers, 12(4), . https://doi.org/10.3390/cancers12040896
Tamminga, Menno, et al. "Detection of Circulating Tumor Cells in the Diagnostic Leukapheresis Product of Non-Small-Cell Lung Cancer Patients Comparing CellSearch." Cancers vol. 12,4 (2020). doi: https://doi.org/10.3390/cancers12040896
Tamminga M, Andree KC, Hiltermann TJN, Jayat M, Schuuring E, van den Bos H, Spierings DCJ, Lansdorp PM, Timens W, Terstappen LWMM, Groen HJM. Detection of Circulating Tumor Cells in the Diagnostic Leukapheresis Product of Non-Small-Cell Lung Cancer Patients Comparing CellSearch. Cancers (Basel). 2020 Apr 07;12(4). doi: 10.3390/cancers12040896. PMID: 32272669; PMCID: PMC7226321.
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Sperm DNA damage causes genomic instability in early embryonic development.

Science advances

Middelkamp S, van Tol HTA, Spierings DCJ, Boymans S, Guryev V, Roelen BAJ, Lansdorp PM, Cuppen E, Kuijk EW.
PMID: 32494621
Sci Adv. 2020 Apr 15;6(16):eaaz7602. doi: 10.1126/sciadv.aaz7602. eCollection 2020 Apr.

Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, we examined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of individual blastomeres from bovine embryos produced with...

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Middelkamp S, van Tol HTA, Spierings DCJ, et al. Sperm DNA damage causes genomic instability in early embryonic development. Sci Adv. 2020;6(16):eaaz7602doi: 10.1126/sciadv.aaz7602.
Middelkamp, S., van Tol, H. T. A., Spierings, D. C. J., Boymans, S., Guryev, V., Roelen, B. A. J., Lansdorp, P. M., Cuppen, E., & Kuijk, E. W. (2020). Sperm DNA damage causes genomic instability in early embryonic development. Science advances, 6(16), eaaz7602. https://doi.org/10.1126/sciadv.aaz7602
Middelkamp, Sjors, et al. "Sperm DNA damage causes genomic instability in early embryonic development." Science advances vol. 6,16 (2020): eaaz7602. doi: https://doi.org/10.1126/sciadv.aaz7602
Middelkamp S, van Tol HTA, Spierings DCJ, Boymans S, Guryev V, Roelen BAJ, Lansdorp PM, Cuppen E, Kuijk EW. Sperm DNA damage causes genomic instability in early embryonic development. Sci Adv. 2020 Apr 15;6(16):eaaz7602. doi: 10.1126/sciadv.aaz7602. eCollection 2020 Apr. PMID: 32494621; PMCID: PMC7159919.
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Guanine quadruplex structures localize to heterochromatin.

Nucleic acids research

Hoffmann RF, Moshkin YM, Mouton S, Grzeschik NA, Kalicharan RD, Kuipers J, Wolters AHG, Nishida K, Romashchenko AV, Postberg J, Lipps H, Berezikov E, Sibon OCM, Giepmans BNG, Lansdorp PM.
PMID: 28449026
Nucleic Acids Res. 2017 Jun 02;45(10):6253. doi: 10.1093/nar/gkx301.

No abstract available.

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Hoffmann RF, Moshkin YM, Mouton S, et al. Guanine quadruplex structures localize to heterochromatin. Nucleic Acids Res. 2017;45(10):6253doi: 10.1093/nar/gkx301.
Hoffmann, R. F., Moshkin, Y. M., Mouton, S., Grzeschik, N. A., Kalicharan, R. D., Kuipers, J., Wolters, A. H. G., Nishida, K., Romashchenko, A. V., Postberg, J., Lipps, H., Berezikov, E., Sibon, O. C. M., Giepmans, B. N. G., & Lansdorp, P. M. (2017). Guanine quadruplex structures localize to heterochromatin. Nucleic acids research, 45(10), 6253. https://doi.org/10.1093/nar/gkx301
Hoffmann, Roland F, et al. "Guanine quadruplex structures localize to heterochromatin." Nucleic acids research vol. 45,10 (2017): 6253. doi: https://doi.org/10.1093/nar/gkx301
Hoffmann RF, Moshkin YM, Mouton S, Grzeschik NA, Kalicharan RD, Kuipers J, Wolters AHG, Nishida K, Romashchenko AV, Postberg J, Lipps H, Berezikov E, Sibon OCM, Giepmans BNG, Lansdorp PM. Guanine quadruplex structures localize to heterochromatin. Nucleic Acids Res. 2017 Jun 02;45(10):6253. doi: 10.1093/nar/gkx301. PMID: 28449026; PMCID: PMC5449592.
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RECQL5 at the .

Frontiers in cell and developmental biology

Hamadeh Z, Lansdorp P.
PMID: 32523948
Front Cell Dev Biol. 2020 May 25;8:324. doi: 10.3389/fcell.2020.00324. eCollection 2020.

Maintenance of genome stability is essential to prevent the accumulation of DNA mutations that can initiate oncogenesis and facilitate tumor progression. Studies of DNA repair genes have revealed a highly dynamic and redundant network of genes and proteins responsible...

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Hamadeh Z, Lansdorp P. RECQL5 at the . Front Cell Dev Biol. 2020;8:324doi: 10.3389/fcell.2020.00324.
Hamadeh, Z., & Lansdorp, P. (2020). RECQL5 at the . Frontiers in cell and developmental biology, 8324. https://doi.org/10.3389/fcell.2020.00324
Hamadeh, Zeid, and Lansdorp, Peter. "RECQL5 at the ." Frontiers in cell and developmental biology vol. 8 (2020): 324. doi: https://doi.org/10.3389/fcell.2020.00324
Hamadeh Z, Lansdorp P. RECQL5 at the . Front Cell Dev Biol. 2020 May 25;8:324. doi: 10.3389/fcell.2020.00324. eCollection 2020. PMID: 32523948; PMCID: PMC7262407.
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