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Showing 1 to 12 of 111 entries
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Clinical characteristics and outcomes of end-stage renal disease patients with self-reported pruritus symptoms.

International journal of nephrology and renovascular disease

Ramakrishnan K, Bond TC, Claxton A, Sood VC, Kootsikas M, Agnese W, Sibbel S.
PMID: 24379689
Int J Nephrol Renovasc Dis. 2013 Dec 19;7:1-12. doi: 10.2147/IJNRD.S52985. eCollection 2013.

One of the most common conditions affecting end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) is pruritus. Studies report that itchy and dry skin, symptoms of pruritus, affect 40%-90% of ESRD patients. Yet, in clinical practice the condition is...

Some considerations of bioethics in geriatrics.

The Journal of the Florida Medical Association

Lawton AH.
PMID: 7108485
J Fla Med Assoc. 1982 Apr;69(4):310-3.

No abstract available.

The use of anti-ribosomal P antibodies in the diagnosis of cerebral lupus---superiority of western blotting over enzyme-linked immunosorbent assay.

Hong Kong medical journal = Xianggang yi xue za zhi

Chan EY, Ko OK, Lawton JW, Lau CS.
PMID: 11832566
Hong Kong Med J. 1998 Jun;4(2):145-150.

This study investigated the use of anti-ribosomal P antibodies in the diagnosis of cerebral complications of systemic lupus erythematosus using two different methods---western blotting and enzyme-linked immunosorbent assay. Anti-ribosomal P antibodies in patient serum were detected in both methods...

Modeling Transport and Flow Regulatory Mechanisms of the Kidney.

ISRN biomathematics

Layton AT.
PMID: 23914303
ISRN Biomath. 2012 Jul 12;2012(2012). doi: 10.5402/2012/170594.

The kidney plays an indispensable role in the regulation of whole-organism water balance, electrolyte balance, and acid-base balance, and in the excretion of metabolic wastes and toxins. In this paper, we review representative mathematical models that have been developed...

Survival and Failure Outcomes Predicted by Brain Metastasis Volumetric Kinetics in Melanoma Patients Following Upfront Treatment with Stereotactic Radiosurgery Alone.

Cureus

LeCompte MC, McTyre E, Henson A, Farris M, Okoukoni C, Cramer CK, Triozzi P, Ruiz J, Watabe K, Lo HW, Munley MT, Laxton AW, Tatter SB, Zhou X, Chan M.
PMID: 29464141
Cureus. 2017 Dec 11;9(12):e1934. doi: 10.7759/cureus.1934.

Introduction The roles of early whole brain radiotherapy (WBRT) and upfront stereotactic radiosurgery (SRS) alone in the treatment of melanoma patients with brain metastasis remain uncertain. We investigated the volumetric kinetics of brain metastasis development and associations with clinical...

Potential prognostic markers for survival and neurologic death in patients with breast cancer brain metastases who receive upfront SRS alone.

Journal of radiosurgery and SBRT

Shenker RF, Hughes RT, McTyre ER, Lanier C, Lo HW, Metheny-Barlow L, Su J, Thomas A, Brown DR, Avery T, Pasche B, Cramer CK, Laxton AW, Tatter SB, Watabe K, Chan MD.
PMID: 30538888
J Radiosurg SBRT. 2018;5(4):277-283.

PURPOSE/OBJECTIVES: Stereotactic radiosurgery (SRS) is used as a treatment option for breast cancer brain metastases. It is unclear what factors predict neurologic death for these patients.MATERIALS/METHODS: A total of 128 patients with breast cancer brain metastases were treated with...

Microorganisms

McLaughlin J, Watterson S, Layton AM, Bjourson AJ, Barnard E, McDowell A.
PMID: 31086023
Microorganisms. 2019 May 13;7(5). doi: 10.3390/microorganisms7050128.

The anaerobic bacterium

Visual Loss, Retinal Hemorrhages, and Optic Disc Edema Resulting From Thiamine Deficiency Following Bariatric Surgery Complicated by Prolonged Vomiting.

The Ochsner journal

Lawton AW, Frisard NE.
PMID: 28331457
Ochsner J. 2017;17(1):112-114.

BACKGROUND: Vision loss resulting from thiamine deficiency is a recognized complication of bariatric surgery. Most patients with such vision loss have Wernicke encephalopathy with characteristic changes seen on neuroimaging. Other patients may have retinal hemorrhages, optic disc edema, and...

Local control of brain metastases after stereotactic radiosurgery: the impact of whole brain radiotherapy and treatment paradigm.

Journal of radiosurgery and SBRT

Hughes RT, Black PJ, Page BR, Lucas JT, Qasem SA, Watabe K, Ruiz J, Laxton AW, Tatter SB, Debinski W, Chan MD.
PMID: 29296433
J Radiosurg SBRT. 2016;4(2):89-96.

PURPOSE: We investigate clinical, pathologic, and treatment paradigm-related factors affecting local control of brain metastases after stereotactic radiosurgery (SRS) with or without whole brain radiotherapy (WBRT).METHODS AND MATERIALS: Patients with brain metastases treated with SRS alone, before or after...

The challenge of recognising sepsis: Future nanotechnology solutions.

Journal of the Intensive Care Society

Claxton A, Papafilippou L, Hadjidemetriou M, Kostarelos K, Dark P.
PMID: 32782464
J Intensive Care Soc. 2020 Aug;21(3):241-246. doi: 10.1177/1751143719896554. Epub 2019 Dec 18.

The urgent need to start anti-infective therapeutic interventions in suspected sepsis, and the lack of specific time-critical diagnostic information often lead to the widespread administration of broad-spectrum antimicrobial therapies, increasing the risk of unwanted patient harms and contributing to...

Adaptive Changes in single-nephron GFR, Tubular Morphology, and Transport in a Pregnant Rat Nephron: Modeling and Analysis.

American journal of physiology. Renal physiology

Stadt M, Layton AT.
PMID: 34894726
Am J Physiol Renal Physiol. 2021 Dec 13; doi: 10.1152/ajprenal.00264.2021. Epub 2021 Dec 13.

Normal pregnancy is characterized by massive increases in plasma volume and electrolyte retention. Given that the kidneys regulate homeostasis of electrolytes and volume, the organ undergoes major adaptations in morphology, hemodynamics, and transport to achieve the volume and electrolyte...

Safety and immunogenicity of ChAd63-KH vaccine in post-kala-azar dermal leishmaniasis patients in Sudan.

Molecular therapy : the journal of the American Society of Gene Therapy

Younis BM, Osman M, Khalil EAG, Santoro F, Furini S, Wiggins R, Keding A, Carraro M, Musa AEA, Abdarahaman MAA, Mandefield L, Bland M, Aebischer T, Gabe R, Layton AM, Lacey CJN, Kaye PM, Musa AM.
PMID: 33781913
Mol Ther. 2021 Jul 07;29(7):2366-2377. doi: 10.1016/j.ymthe.2021.03.020. Epub 2021 Mar 27.

Post-kala-azar dermal leishmaniasis (PKDL) is a chronic, stigmatizing skin condition occurring frequently after apparent clinical cure from visceral leishmaniasis. Given an urgent need for new treatments, we conducted a phase IIa safety and immunogenicity trial of ChAd63-KH vaccine in...

Showing 1 to 12 of 111 entries