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Showing 1 to 12 of 16 entries
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Novel Gene Discovery in the Human Malaria Parasite using Nucleosome Positioning Data.

Computational systems bioinformatics. Computational Systems Bioinformatics Conference

Pokhriyal N, Ponts N, Harris EY, Le Roch KG, Lonardi S.
PMID: 25076982
Comput Syst Bioinformatics Conf. 2010 Aug;9:124-135.

Recent genome-wide studies on nucleosome positioning in model organisms have shown strong evidence that nucleosome landscapes in the proximity of protein-coding genes exhibit regular characteristic patterns. Here, we propose a computational framework to discover novel genes in the human...

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Pokhriyal N, Ponts N, Harris EY, et al. Novel Gene Discovery in the Human Malaria Parasite using Nucleosome Positioning Data. Comput Syst Bioinformatics Conf. 2010;9:124-135
Pokhriyal, N., Ponts, N., Harris, E. Y., Le Roch, K. G., & Lonardi, S. (2010). Novel Gene Discovery in the Human Malaria Parasite using Nucleosome Positioning Data. Computational systems bioinformatics. Computational Systems Bioinformatics Conference, 9124-135.
Pokhriyal, N, et al. "Novel Gene Discovery in the Human Malaria Parasite using Nucleosome Positioning Data." Computational systems bioinformatics. Computational Systems Bioinformatics Conference vol. 9 (2010): 124-135.
Pokhriyal N, Ponts N, Harris EY, Le Roch KG, Lonardi S. Novel Gene Discovery in the Human Malaria Parasite using Nucleosome Positioning Data. Comput Syst Bioinformatics Conf. 2010 Aug;9:124-135. PMID: 25076982; PMCID: PMC4112967.
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An Introduction to Functional Genomics and Systems Biology.

Advances in wound care

Bunnik EM, Le Roch KG.
PMID: 24527360
Adv Wound Care (New Rochelle). 2013 Nov;2(9):490-498. doi: 10.1089/wound.2012.0379.

OBJECTIVE: Over the past decade, the development of high-throughput technologies for DNA and protein analysis has revolutionized the ways in which cells can be studied. Within a relatively short time frame, research has changed from studying individual genes and...

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Bunnik EM, Le Roch KG. An Introduction to Functional Genomics and Systems Biology. Adv Wound Care (New Rochelle). 2013;2(9):490-498doi: 10.1089/wound.2012.0379.
Bunnik, E. M., & Le Roch, K. G. (2013). An Introduction to Functional Genomics and Systems Biology. Advances in wound care, 2(9), 490-498. https://doi.org/10.1089/wound.2012.0379
Bunnik, Evelien M, and Le Roch, Karine G. "An Introduction to Functional Genomics and Systems Biology." Advances in wound care vol. 2,9 (2013): 490-498. doi: https://doi.org/10.1089/wound.2012.0379
Bunnik EM, Le Roch KG. An Introduction to Functional Genomics and Systems Biology. Adv Wound Care (New Rochelle). 2013 Nov;2(9):490-498. doi: 10.1089/wound.2012.0379. PMID: 24527360; PMCID: PMC3816999.
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Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq.

Methods in molecular biology (Clifton, N.J.)

Hollin T, Abel S, Le Roch KG.
PMID: 34313988
Methods Mol Biol. 2021;2369:139-164. doi: 10.1007/978-1-0716-1681-9_9.

Over the last decades, identification of RNA-proteins complexes and their binding sites was challenging. Recently, techniques based on crosslinking, immunoprecipitation, and high-throughput sequencing have been developed. An optimized method, called eCLIP-seq, enables to identify precisely the targeted RNAs as...

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Hollin T, Abel S, Le Roch KG. Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq. Methods Mol Biol. 2021;2369:139-164doi: 10.1007/978-1-0716-1681-9_9.
Hollin, T., Abel, S., & Le Roch, K. G. (2021). Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq. Methods in molecular biology (Clifton, N.J.), 2369139-164. https://doi.org/10.1007/978-1-0716-1681-9_9
Hollin, Thomas, et al. "Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq." Methods in molecular biology (Clifton, N.J.) vol. 2369 (2021): 139-164. doi: https://doi.org/10.1007/978-1-0716-1681-9_9
Hollin T, Abel S, Le Roch KG. Genome-Wide Analysis of RNA-Protein Interactions in Plasmodium falciparum Using eCLIP-Seq. Methods Mol Biol. 2021;2369:139-164. doi: 10.1007/978-1-0716-1681-9_9. PMID: 34313988.
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Third-generation sequencing revises the molecular karyotype for .

Genome research

Xia J, Venkat A, Bainbridge RE, Reese ML, Le Roch KG, Ay F, Boyle JP.
PMID: 33906962
Genome Res. 2021 May;31(5):834-851. doi: 10.1101/gr.262816.120. Epub 2021 Apr 27.

No abstract available.

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Xia J, Venkat A, Bainbridge RE, et al. Third-generation sequencing revises the molecular karyotype for . Genome Res. 2021;31(5):834-851doi: 10.1101/gr.262816.120.
Xia, J., Venkat, A., Bainbridge, R. E., Reese, M. L., Le Roch, K. G., Ay, F., & Boyle, J. P. (2021). Third-generation sequencing revises the molecular karyotype for . Genome research, 31(5), 834-851. https://doi.org/10.1101/gr.262816.120
Xia, Jing, et al. "Third-generation sequencing revises the molecular karyotype for ." Genome research vol. 31,5 (2021): 834-851. doi: https://doi.org/10.1101/gr.262816.120
Xia J, Venkat A, Bainbridge RE, Reese ML, Le Roch KG, Ay F, Boyle JP. Third-generation sequencing revises the molecular karyotype for . Genome Res. 2021 May;31(5):834-851. doi: 10.1101/gr.262816.120. Epub 2021 Apr 27. PMID: 33906962; PMCID: PMC8092015.
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Visual Attention Saccadic Models Learn to Emulate Gaze Patterns From Childhood to Adulthood.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

Le Meur O, Coutrot A, Liu Z, Rama P, Le Roch A, Helo A.
PMID: 28682255
IEEE Trans Image Process. 2017 Oct;26(10):4777-4789. doi: 10.1109/TIP.2017.2722238. Epub 2017 Jun 30.

How people look at visual information reveals fundamental information about themselves, their interests and their state of mind. While previous visual attention models output static 2D saliency maps, saccadic models aim to predict not only where observers look at...

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Le Meur O, Coutrot A, Liu Z, et al. Visual Attention Saccadic Models Learn to Emulate Gaze Patterns From Childhood to Adulthood. IEEE Trans Image Process. 2017;26(10):4777-4789doi: 10.1109/TIP.2017.2722238.
Le Meur, O., Coutrot, A., Liu, Z., Rama, P., Le Roch, A., & Helo, A. (2017). Visual Attention Saccadic Models Learn to Emulate Gaze Patterns From Childhood to Adulthood. IEEE transactions on image processing : a publication of the IEEE Signal Processing Society, 26(10), 4777-4789. https://doi.org/10.1109/TIP.2017.2722238
Le Meur, Olivier, et al. "Visual Attention Saccadic Models Learn to Emulate Gaze Patterns From Childhood to Adulthood." IEEE transactions on image processing : a publication of the IEEE Signal Processing Society vol. 26,10 (2017): 4777-4789. doi: https://doi.org/10.1109/TIP.2017.2722238
Le Meur O, Coutrot A, Liu Z, Rama P, Le Roch A, Helo A. Visual Attention Saccadic Models Learn to Emulate Gaze Patterns From Childhood to Adulthood. IEEE Trans Image Process. 2017 Oct;26(10):4777-4789. doi: 10.1109/TIP.2017.2722238. Epub 2017 Jun 30. PMID: 28682255.
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Lessons learned evaluating the baby friendly spaces program for south Sudanese refugees in Gambella, Ethiopia: strengthening research and programmatic partnerships to address maternal and child health and psychosocial needs in humanitarian emergencies.

Conflict and health

Lasater ME, Woldeyes GM, Le Roch K, Phan X, Solomon-Osborne A, Murray SM.
PMID: 32724334
Confl Health. 2020 Jul 25;14:52. doi: 10.1186/s13031-020-00299-5. eCollection 2020.

BACKGROUND: During humanitarian crises, women and children are particularly vulnerable to morbidity and mortality. To address this problem, integrated child health interventions that include support for the well-being of mothers must be adapted and assessed in humanitarian settings. Baby...

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Lasater ME, Woldeyes GM, Le Roch K, et al. Lessons learned evaluating the baby friendly spaces program for south Sudanese refugees in Gambella, Ethiopia: strengthening research and programmatic partnerships to address maternal and child health and psychosocial needs in humanitarian emergencies. Confl Health. 2020;14:52doi: 10.1186/s13031-020-00299-5.
Lasater, M. E., Woldeyes, G. M., Le Roch, K., Phan, X., Solomon-Osborne, A., & Murray, S. M. (2020). Lessons learned evaluating the baby friendly spaces program for south Sudanese refugees in Gambella, Ethiopia: strengthening research and programmatic partnerships to address maternal and child health and psychosocial needs in humanitarian emergencies. Conflict and health, 1452. https://doi.org/10.1186/s13031-020-00299-5
Lasater, M E, et al. "Lessons learned evaluating the baby friendly spaces program for south Sudanese refugees in Gambella, Ethiopia: strengthening research and programmatic partnerships to address maternal and child health and psychosocial needs in humanitarian emergencies." Conflict and health vol. 14 (2020): 52. doi: https://doi.org/10.1186/s13031-020-00299-5
Lasater ME, Woldeyes GM, Le Roch K, Phan X, Solomon-Osborne A, Murray SM. Lessons learned evaluating the baby friendly spaces program for south Sudanese refugees in Gambella, Ethiopia: strengthening research and programmatic partnerships to address maternal and child health and psychosocial needs in humanitarian emergencies. Confl Health. 2020 Jul 25;14:52. doi: 10.1186/s13031-020-00299-5. eCollection 2020. PMID: 32724334; PMCID: PMC7382810.
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Ecological leads for natural product discovery: Novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp.

Tetrahedron

Lane AL, Mular L, Drenkard EJ, Shearer TL, Engel S, Fredericq S, Fairchild CR, Prudhomme J, Le Roch K, Hay ME, Aalbersberg W, Kubanek J.
PMID: 20661312
Tetrahedron. 2010 Jan 09;66(2):455-461. doi: 10.1016/j.tet.2009.11.042.

Pharmacologically-motivated marine natural product investigations have yielded a large variety of structurally unique compounds with interesting biomedical properties, but the natural roles of these molecules often remain unknown. While secondary metabolites may function as antimicrobial chemical defenses, few studies...

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Lane AL, Mular L, Drenkard EJ, et al. Ecological leads for natural product discovery: Novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp. Tetrahedron. 2010;66(2):455-461doi: 10.1016/j.tet.2009.11.042.
Lane, A. L., Mular, L., Drenkard, E. J., Shearer, T. L., Engel, S., Fredericq, S., Fairchild, C. R., Prudhomme, J., Le Roch, K., Hay, M. E., Aalbersberg, W., & Kubanek, J. (2010). Ecological leads for natural product discovery: Novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp. Tetrahedron, 66(2), 455-461. https://doi.org/10.1016/j.tet.2009.11.042
Lane, Amy L, et al. "Ecological leads for natural product discovery: Novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp." Tetrahedron vol. 66,2 (2010): 455-461. doi: https://doi.org/10.1016/j.tet.2009.11.042
Lane AL, Mular L, Drenkard EJ, Shearer TL, Engel S, Fredericq S, Fairchild CR, Prudhomme J, Le Roch K, Hay ME, Aalbersberg W, Kubanek J. Ecological leads for natural product discovery: Novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp. Tetrahedron. 2010 Jan 09;66(2):455-461. doi: 10.1016/j.tet.2009.11.042. PMID: 20661312; PMCID: PMC2908918.
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Pharmacokinetics, metabolism, and .

ACS medicinal chemistry letters

Teasdale ME, Prudhomme J, Torres M, Braley M, Cervantes S, Bhatia SC, La Clair JJ, Le Roch K, Kubanek J.
PMID: 24159368
ACS Med Chem Lett. 2013 Oct 10;4(10):989-993. doi: 10.1021/ml4002858.

A suite of pharmacokinetic and pharmacological studies show that bromophycolide A (

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Teasdale ME, Prudhomme J, Torres M, et al. Pharmacokinetics, metabolism, and . ACS Med Chem Lett. 2013;4(10):989-993doi: 10.1021/ml4002858.
Teasdale, M. E., Prudhomme, J., Torres, M., Braley, M., Cervantes, S., Bhatia, S. C., La Clair, J. J., Le Roch, K., & Kubanek, J. (2013). Pharmacokinetics, metabolism, and . ACS medicinal chemistry letters, 4(10), 989-993. https://doi.org/10.1021/ml4002858
Teasdale, Margaret E, et al. "Pharmacokinetics, metabolism, and ." ACS medicinal chemistry letters vol. 4,10 (2013): 989-993. doi: https://doi.org/10.1021/ml4002858
Teasdale ME, Prudhomme J, Torres M, Braley M, Cervantes S, Bhatia SC, La Clair JJ, Le Roch K, Kubanek J. Pharmacokinetics, metabolism, and . ACS Med Chem Lett. 2013 Oct 10;4(10):989-993. doi: 10.1021/ml4002858. PMID: 24159368; PMCID: PMC3804352.
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Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites.

Epigenetics insights

Lenz T, Le Roch KG.
PMID: 31633082
Epigenet Insights. 2019 Sep 29;12:2516865719879436. doi: 10.1177/2516865719879436. eCollection 2019.

Mounting evidence supports the idea that epigenetic, and the overall 3-dimensional (3D) architecture of the genome, plays an important role in gene expression for eukaryotic organisms. We recently used Hi-C methodologies to generate and compare the 3D genome of...

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Lenz T, Le Roch KG. Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites. Epigenet Insights. 2019;12:2516865719879436doi: 10.1177/2516865719879436.
Lenz, T., & Le Roch, K. G. (2019). Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites. Epigenetics insights, 122516865719879436. https://doi.org/10.1177/2516865719879436
Lenz, Todd, and Le Roch, Karine G. "Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites." Epigenetics insights vol. 12 (2019): 2516865719879436. doi: https://doi.org/10.1177/2516865719879436
Lenz T, Le Roch KG. Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites. Epigenet Insights. 2019 Sep 29;12:2516865719879436. doi: 10.1177/2516865719879436. eCollection 2019. PMID: 31633082; PMCID: PMC6769224.
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Leakage Current Non-Uniformity and Random Telegraph Signals in CMOS Image Sensor Floating Diffusions Used for In-Pixel Charge Storage.

Sensors (Basel, Switzerland)

Le Roch A, Goiffon V, Marcelot O, Paillet P, Pace F, Belloir JM, Magnan P, Virmontois C.
PMID: 31888151
Sensors (Basel). 2019 Dec 16;19(24). doi: 10.3390/s19245550.

The leakage current non-uniformity, as well as the leakage current random and discrete fluctuations sources, are investigated in pinned photodiode CMOS image sensor floating diffusions. Different bias configurations are studied to evaluate the electric field impacts on the FD...

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Le Roch A, Goiffon V, Marcelot O, et al. Leakage Current Non-Uniformity and Random Telegraph Signals in CMOS Image Sensor Floating Diffusions Used for In-Pixel Charge Storage. Sensors (Basel). 2019;19(24)doi: 10.3390/s19245550.
Le Roch, A., Goiffon, V., Marcelot, O., Paillet, P., Pace, F., Belloir, J. M., Magnan, P., & Virmontois, C. (2019). Leakage Current Non-Uniformity and Random Telegraph Signals in CMOS Image Sensor Floating Diffusions Used for In-Pixel Charge Storage. Sensors (Basel, Switzerland), 19(24), . https://doi.org/10.3390/s19245550
Le Roch, Alexandre, et al. "Leakage Current Non-Uniformity and Random Telegraph Signals in CMOS Image Sensor Floating Diffusions Used for In-Pixel Charge Storage." Sensors (Basel, Switzerland) vol. 19,24 (2019). doi: https://doi.org/10.3390/s19245550
Le Roch A, Goiffon V, Marcelot O, Paillet P, Pace F, Belloir JM, Magnan P, Virmontois C. Leakage Current Non-Uniformity and Random Telegraph Signals in CMOS Image Sensor Floating Diffusions Used for In-Pixel Charge Storage. Sensors (Basel). 2019 Dec 16;19(24). doi: 10.3390/s19245550. PMID: 31888151; PMCID: PMC6961015.
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Parallel supported synthesis of polyamine-imidazole conjugates.

Organic letters

Picard S, Le Roch M, Renault J, Uriac P.
PMID: 15575667
Org Lett. 2004 Dec 09;6(25):4711-4. doi: 10.1021/ol0480630.

[reaction: see text] A small collection of nine polyamine-imidazole conjugates, potentially acting as RNases A mimics, has been synthesized on SynPhase lanterns using amino alcohols and diamines as building blocks. Couplings were performed via S(N)2 alkylation of methanesulfonates with...

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Picard S, Le Roch M, Renault J, et al. Parallel supported synthesis of polyamine-imidazole conjugates. Org Lett. 2004;6(25):4711-4doi: 10.1021/ol0480630.
Picard, S., Le Roch, M., Renault, J., & Uriac, P. (2004). Parallel supported synthesis of polyamine-imidazole conjugates. Organic letters, 6(25), 4711-4. https://doi.org/10.1021/ol0480630
Picard, Sylvie, et al. "Parallel supported synthesis of polyamine-imidazole conjugates." Organic letters vol. 6,25 (2004): 4711-4. doi: https://doi.org/10.1021/ol0480630
Picard S, Le Roch M, Renault J, Uriac P. Parallel supported synthesis of polyamine-imidazole conjugates. Org Lett. 2004 Dec 09;6(25):4711-4. doi: 10.1021/ol0480630. PMID: 15575667.
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Synthesis of Highly Functionalized Triarylbismuthines by Functional Group Manipulation and Use in Palladium- and Copper-Catalyzed Arylation Reactions.

The Journal of organic chemistry

Hébert M, Petiot P, Benoit E, Dansereau J, Ahmad T, Le Roch A, Ottenwaelder X, Gagnon A.
PMID: 27231755
J Org Chem. 2016 Jul 01;81(13):5401-16. doi: 10.1021/acs.joc.6b00767. Epub 2016 Jun 13.

Organobismuthines are an attractive class of organometallic reagents that can be accessed from inexpensive and nontoxic bismuth salts. Triarylbismuthines are particularly interesting due to their air and moisture stability and high functional group tolerance. We report herein a detailed...

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Hébert M, Petiot P, Benoit E, et al. Synthesis of Highly Functionalized Triarylbismuthines by Functional Group Manipulation and Use in Palladium- and Copper-Catalyzed Arylation Reactions. J Org Chem. 2016;81(13):5401-16doi: 10.1021/acs.joc.6b00767.
Hébert, M., Petiot, P., Benoit, E., Dansereau, J., Ahmad, T., Le Roch, A., Ottenwaelder, X., & Gagnon, A. (2016). Synthesis of Highly Functionalized Triarylbismuthines by Functional Group Manipulation and Use in Palladium- and Copper-Catalyzed Arylation Reactions. The Journal of organic chemistry, 81(13), 5401-16. https://doi.org/10.1021/acs.joc.6b00767
Hébert, Martin, et al. "Synthesis of Highly Functionalized Triarylbismuthines by Functional Group Manipulation and Use in Palladium- and Copper-Catalyzed Arylation Reactions." The Journal of organic chemistry vol. 81,13 (2016): 5401-16. doi: https://doi.org/10.1021/acs.joc.6b00767
Hébert M, Petiot P, Benoit E, Dansereau J, Ahmad T, Le Roch A, Ottenwaelder X, Gagnon A. Synthesis of Highly Functionalized Triarylbismuthines by Functional Group Manipulation and Use in Palladium- and Copper-Catalyzed Arylation Reactions. J Org Chem. 2016 Jul 01;81(13):5401-16. doi: 10.1021/acs.joc.6b00767. Epub 2016 Jun 13. PMID: 27231755.
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Showing 1 to 12 of 16 entries