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Showing 1 to 12 of 60 entries
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Erratum to: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study.

Journal of translational medicine

White SH, McDermott MM, Sufit RL, Kosmac K, Bugg AW, Gonzalez-Freire M, Ferrucci L, Tian L, Zhao L, Gao Y, Kibbe MR, Criqui MH, Leeuwenburgh C, Peterson CA.
PMID: 28241774
J Transl Med. 2017 Feb 23;15(1):45. doi: 10.1186/s12967-017-1127-6.

No abstract available.

Radical cyclization of sugar-derived beta-(alkynyloxy)acrylates: synthesis of novel fused ethers.

Organic letters

Leeuwenburgh MA, Litjens RE, Codee JD, Overkleeft HS, van der Marel GA, van Boom JH.
PMID: 10810726
Org Lett. 2000 May 04;2(9):1275-7. doi: 10.1021/ol0000408.

[formula: see text] Tributyltin radical mediated cyclization of carbohydrate-derived beta-(alkynyloxy)acrylates leading to highly functionalized cis- and trans-fused bicyclic ethers of various ring sizes is described. The efficacy of the radical cyclization is nicely illustrated in the iterative construction of...

Changes in lipid distribution during aging and its modulation by calorie restriction.

Age (Dordrecht, Netherlands)

Kim JY, Kim DH, Choi J, Park JK, Jeong KS, Leeuwenburgh C, Yu BP, Chung HY.
PMID: 19277901
Age (Dordr). 2009 Jun;31(2):127-42. doi: 10.1007/s11357-009-9089-0. Epub 2009 Mar 11.

Adipogenesis and ectopic lipid accumulation during aging have a great impact on the aging process and the pathogenesis of chronic diseases with age. However, at present, information on the age-related molecular changes in lipid redistribution patterns and their potential...

High-order harmonic generation spectroscopy of correlation-driven electron hole dynamics.

Physical review letters

Leeuwenburgh J, Cooper B, Averbukh V, Marangos JP, Ivanov M.
PMID: 24093256
Phys Rev Lett. 2013 Sep 20;111(12):123002. doi: 10.1103/PhysRevLett.111.123002. Epub 2013 Sep 20.

We show how high-order harmonic generation spectroscopy can be used to follow correlation-driven electron hole dynamics with attosecond time resolution. The technique is applicable both to normal Auger transitions and to electron hole migration processes that do not lead...

Highly Elastic and Self-Healing Composite Colloidal Gels.

Advanced materials (Deerfield Beach, Fla.)

Diba M, Wang H, Kodger TE, Parsa S, Leeuwenburgh SC.
PMID: 28067959
Adv Mater. 2017 Mar;29(11). doi: 10.1002/adma.201604672. Epub 2017 Jan 09.

Composite colloidal gels are formed by the pH-induced electrostatic assembly of silica and gelatin nanoparticles. These injectable and moldable colloidal gels are able to withstand substantial compressive and tensile loads, and exhibit a remarkable self-healing efficiency. This study provides...

Regenerating Critical Size Rat Segmental Bone Defects with a Self-Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP-2 Incorporation.

Macromolecular bioscience

van Houdt CIA, Koolen MKE, Lopez-Perez PM, Ulrich DJO, Jansen JA, Leeuwenburgh SCG, Weinans HH, van den Beucken JJJP.
PMID: 34117838
Macromol Biosci. 2021 Aug;21(8):e2100088. doi: 10.1002/mabi.202100088. Epub 2021 Jun 12.

The aim of the current study is to assess the biological performance of self-healing hydrogels based on calcium phosphate (CaP) nanoparticles and bisphosphonate (BP) conjugated hyaluronan (HA) in a critical size segmental femoral bone defect model in rats. Additionally,...

Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors.

Journal of clinical medicine

Darden DB, Ghita GL, Wang Z, Stortz JA, Lopez MC, Cox MC, Hawkins RB, Rincon JC, Kelly LS, Fenner BP, Ozrazgat-Baslanti T, Leeuwenburgh C, Bihorac A, Loftus TJ, Moore FA, Brakenridge SC, Baker HV, Bacher R, Mohr AM, Moldawer LL, Efron PA.
PMID: 34361995
J Clin Med. 2021 Jul 21;10(15). doi: 10.3390/jcm10153211.

Surgical sepsis has evolved into two major subpopulations: patients who rapidly recover, and those who develop chronic critical illness (CCI). Our primary aim was to determine whether CCI sepsis survivors manifest unique blood leukocyte transcriptomes in late sepsis that...

New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironments.

APL bioengineering

Oliveira CS, Leeuwenburgh S, Mano JF.
PMID: 34765857
APL Bioeng. 2021 Nov 03;5(4):041507. doi: 10.1063/5.0065152. eCollection 2021 Dec.

The bone microenvironment is characterized by an intricate interplay between cellular and noncellular components, which controls bone remodeling and repair. Its highly hierarchical architecture and dynamic composition provide a unique microenvironment as source of inspiration for the design of...

The COVID-19 pandemic and physical activity.

Sports medicine and health science

Woods JA, Hutchinson NT, Powers SK, Roberts WO, Gomez-Cabrera MC, Radak Z, Berkes I, Boros A, Boldogh I, Leeuwenburgh C, Coelho-Júnior HJ, Marzetti E, Cheng Y, Liu J, Durstine JL, Sun J, Ji LL.
PMID: 34189484
Sports Med Health Sci. 2020 Jun;2(2):55-64. doi: 10.1016/j.smhs.2020.05.006. Epub 2020 May 30.

The SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health, economy, and lifestyle. Although the virus usually first invades and infects the lung and respiratory track tissue, in extreme cases, almost all...

Bone-Adhesive Hydrogels Based on Dual Crosslinked Poly(2-oxazoline)s.

Macromolecular bioscience

Sánchez-Fernández MJ, Rutjes J, Félix Lanao RP, Bender JCME, van Hest JCM, Leeuwenburgh SCG.
PMID: 34569720
Macromol Biosci. 2021 Dec;21(12):e2100257. doi: 10.1002/mabi.202100257. Epub 2021 Oct 05.

The development of bone glues based on bone-adhesive hydrogels to allow for facile bone fracture fixation remains a major challenge. Herein, dual crosslinked hydrogels that combine tunable stiffness, ductility, and self-healing capacity are successfully synthesized. The resulting double network...

Top-Down Approach for the Preparation of Highly Porous PLLA Microcylinders.

ACS biomaterials science & engineering

Castro AGB, Lo Giudice MC, Vermonden T, Leeuwenburgh SCG, Jansen JA, van den Beucken JJJP, Yang F.
PMID: 33440545
ACS Biomater Sci Eng. 2016 Nov 14;2(11):2099-2107. doi: 10.1021/acsbiomaterials.6b00522. Epub 2016 Oct 04.

A wide range of particles have been developed for different applications in drug-delivery, tissue engineering, or regenerative medicine. In contrast to traditional spherical particles, nonspherical (e.g., cylindrical) particles possess several structural and morphological advantages that make them attractive for...

G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment.

Journal for immunotherapy of cancer

Martinez Sanz P, van Rees DJ, van Zogchel LMJ, Klein B, Bouti P, Olsman H, Schornagel K, Kok I, Sunak A, Leeuwenburg K, Timmerman I, Dierselhuis MP, Kholosy WM, Molenaar JJ, van Bruggen R, van den Berg TK, Kuijpers TW, Matlung HL, Tytgat GAM, Franke K.
PMID: 34049929
J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2020-002259.

BACKGROUND: Current immunotherapy for patients with high-risk neuroblastoma involves the therapeutic antibody dinutuximab that targets GD2, a ganglioside expressed on the majority of neuroblastoma tumors. Opsonized tumor cells are killed through antibody-dependent cellular cytotoxicity (ADCC), a process mediated by...

Showing 1 to 12 of 60 entries