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Showing 1 to 6 of 6 entries
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Aldo-Keto Reductases 1B in Adrenal Cortex Physiology.

Frontiers in endocrinology

Pastel E, Pointud JC, Martinez A, Lefrançois-Martinez AM.
PMID: 27499746
Front Endocrinol (Lausanne). 2016 Jul 22;7:97. doi: 10.3389/fendo.2016.00097. eCollection 2016.

Aldose reductase (AKR1B) proteins are monomeric enzymes, belonging to the aldo-keto reductase (AKR) superfamily. They perform oxidoreduction of carbonyl groups from a wide variety of substrates, such as aliphatic and aromatic aldehydes or ketones. Due to the involvement of...

Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.

The Journal of clinical investigation

Djari C, Sahut-Barnola I, Septier A, Plotton I, Montanier N, Dufour D, Levasseur A, Wilmouth J, Pointud JC, Faucz FR, Kamilaris C, Lopez AG, Guillou F, Swain A, Vainio SJ, Tauveron I, Val P, Lefebvre H, Stratakis CA, Martinez A, Lefrançois-Martinez AM.
PMID: 34850745
J Clin Invest. 2021 Dec 01;131(23). doi: 10.1172/JCI146910.

Large-cell calcifying Sertoli cell tumors (LCCSCTs) are among the most frequent lesions occurring in male Carney complex (CNC) patients. Although they constitute a key diagnostic criterion for this rare multiple neoplasia syndrome resulting from inactivating mutations of the tumor...

SF-1 a key player in the development and differentiation of steroidogenic tissues.

Nuclear receptor

Val P, Lefrançois-Martinez AM, Veyssière G, Martinez A.
PMID: 14594453
Nucl Recept. 2003 Sep 18;1(1):8. doi: 10.1186/1478-1336-1-8.

Since its discovery in the early 1990s, the orphan nuclear receptor SF-1 has been attributed a central role in the development and differentiation of steroidogenic tissues. SF-1 controls the expression of all the steroidogenic enzymes and cholesterol transporters required...

Aldo-Keto Reductases 1B in Endocrinology and Metabolism.

Frontiers in pharmacology

Pastel E, Pointud JC, Volat F, Martinez A, Lefrançois-Martinez AM.
PMID: 22876234
Front Pharmacol. 2012 Aug 02;3:148. doi: 10.3389/fphar.2012.00148. eCollection 2012.

The aldose reductase (AR; human AKR1B1/mouse Akr1b3) has been the focus of many research because of its role in diabetic complications. The starting point of these alterations is the massive entry of glucose in polyol pathway where it is...

Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?.

Frontiers in endocrinology

Leccia F, Batisse-Lignier M, Sahut-Barnola I, Val P, Lefrançois-Martinez AM, Martinez A.
PMID: 27471492
Front Endocrinol (Lausanne). 2016 Jul 15;7:93. doi: 10.3389/fendo.2016.00093. eCollection 2016.

Adrenal cortex tumors are divided into benign forms, such as primary hyperplasias and adrenocortical adenomas (ACAs), and malignant forms or adrenocortical carcinomas (ACCs). Primary hyperplasias are rare causes of adrenocorticotropin hormone-independent hypercortisolism. ACAs are the most common type of...

Protein kinase A drives paracrine crisis and WNT4-dependent testis tumor in Carney complex.

The Journal of clinical investigation

Djari C, Sahut-Barnola I, Septier A, Plotton I, Montanier N, Dufour D, Levasseur A, Wilmouth J, Pointud JC, Faucz FR, Kamilaris C, Lopez AG, Guillou F, Swain A, Vainio SJ, Tauveron I, Val P, Lefebvre H, Stratakis CA, Martinez A, Lefrançois-Martinez AM.
PMID: 34850745
J Clin Invest. 2021 Dec 01;131(23). doi: 10.1172/JCI146910.

Large-cell calcifying Sertoli cell tumors (LCCSCTs) are among the most frequent lesions occurring in male Carney complex (CNC) patients. Although they constitute a key diagnostic criterion for this rare multiple neoplasia syndrome resulting from inactivating mutations of the tumor...

Showing 1 to 6 of 6 entries