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Showing 1 to 12 of 17 entries
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Oxidized cholesterol as the driving force behind the development of Alzheimer's disease.

Frontiers in aging neuroscience

Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G.
PMID: 26150787
Front Aging Neurosci. 2015 Jun 19;7:119. doi: 10.3389/fnagi.2015.00119. eCollection 2015.

Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, is typified by the pathological accumulation of amyloid Aβ peptides and neurofibrillary tangles (NFT) within the brain. Considerable evidence indicates that many events contribute to AD progression, including...

Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review).

The Journal of nutritional biochemistry

Leonarduzzi G, Sottero B, Poli G.
PMID: 12550054
J Nutr Biochem. 2002 Dec;13(12):700-710. doi: 10.1016/s0955-2863(02)00222-x.

Cholesterol oxidation products, termed oxysterols, are increasingly considered of potential interest in the pathogenesis of atherosclerotic lesions. Of dietary or endogenous origin, oxysterols may occur in significant amounts in low density lipoprotein (LDL) particles, especially in hypercholesterolemic subjects. They...

Cholesterol Dysmetabolism in Alzheimer's Disease: A Starring Role for Astrocytes?.

Antioxidants (Basel, Switzerland)

Staurenghi E, Giannelli S, Testa G, Sottero B, Leonarduzzi G, Gamba P.
PMID: 34943002
Antioxidants (Basel). 2021 Nov 26;10(12). doi: 10.3390/antiox10121890.

In recent decades, the impairment of cholesterol metabolism in the pathogenesis of Alzheimer's disease (AD) has been intensively investigated, and it has been recognized to affect amyloid β (Aβ) production and clearance, tau phosphorylation, neuroinflammation and degeneration. In particular,...

Pendred Syndrome, or Not Pendred Syndrome? That Is the Question.

Genes

Tesolin P, Fiorino S, Lenarduzzi S, Rubinato E, Cattaruzzi E, Ammar L, Castro V, Orzan E, Granata C, Dell'Orco D, Morgan A, Girotto G.
PMID: 34680964
Genes (Basel). 2021 Oct 01;12(10). doi: 10.3390/genes12101569.

Pendred syndrome (PDS) is the most common form of syndromic Hearing Loss (HL), characterized by sensorineural HL, inner ear malformations, and goiter, with or without hypothyroidism.

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease.

Antioxidants (Basel, Switzerland)

Gamba P, Giannelli S, Staurenghi E, Testa G, Sottero B, Biasi F, Poli G, Leonarduzzi G.
PMID: 34067119
Antioxidants (Basel). 2021 May 07;10(5). doi: 10.3390/antiox10050740.

The development of Alzheimer's disease (AD) is influenced by several events, among which the dysregulation of cholesterol metabolism in the brain plays a major role. Maintenance of brain cholesterol homeostasis is essential for neuronal functioning and brain development. To...

A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer's Disease.

Frontiers in neuroscience

Gamba P, Staurenghi E, Testa G, Giannelli S, Sottero B, Leonarduzzi G.
PMID: 31213973
Front Neurosci. 2019 May 31;13:556. doi: 10.3389/fnins.2019.00556. eCollection 2019.

In Alzheimer's disease (AD), both cholesterol and glucose dysmetabolism precede the onset of memory deficit and contribute to the disease's progression. It is indeed now believed that oxidized cholesterol in the form of oxysterols and altered glucose uptake are...

Pendred Syndrome, or Not Pendred Syndrome? That Is the Question.

Genes

Tesolin P, Fiorino S, Lenarduzzi S, Rubinato E, Cattaruzzi E, Ammar L, Castro V, Orzan E, Granata C, Dell'Orco D, Morgan A, Girotto G.
PMID: 34680964
Genes (Basel). 2021 Oct 01;12(10). doi: 10.3390/genes12101569.

Pendred syndrome (PDS) is the most common form of syndromic Hearing Loss (HL), characterized by sensorineural HL, inner ear malformations, and goiter, with or without hypothyroidism.

[Radiography of marble kidney].

Annali di radiologia diagnostica

Lenarduzzi G, Marigo A.
PMID: 5524887
Ann Radiol Diagn (Bologna). 1970 Sep;43(4):397.

No abstract available.

Pendred Syndrome, or Not Pendred Syndrome? That Is the Question.

Genes

Tesolin P, Fiorino S, Lenarduzzi S, Rubinato E, Cattaruzzi E, Ammar L, Castro V, Orzan E, Granata C, Dell'Orco D, Morgan A, Girotto G.
PMID: 34680964
Genes (Basel). 2021 Oct 01;12(10). doi: 10.3390/genes12101569.

Pendred syndrome (PDS) is the most common form of syndromic Hearing Loss (HL), characterized by sensorineural HL, inner ear malformations, and goiter, with or without hypothyroidism.

Cholesterol Dysmetabolism in Alzheimer's Disease: A Starring Role for Astrocytes?.

Antioxidants (Basel, Switzerland)

Staurenghi E, Giannelli S, Testa G, Sottero B, Leonarduzzi G, Gamba P.
PMID: 34943002
Antioxidants (Basel). 2021 Nov 26;10(12). doi: 10.3390/antiox10121890.

In recent decades, the impairment of cholesterol metabolism in the pathogenesis of Alzheimer's disease (AD) has been intensively investigated, and it has been recognized to affect amyloid β (Aβ) production and clearance, tau phosphorylation, neuroinflammation and degeneration. In particular,...

Cholesterol Dysmetabolism in Alzheimer's Disease: A Starring Role for Astrocytes?.

Antioxidants (Basel, Switzerland)

Staurenghi E, Giannelli S, Testa G, Sottero B, Leonarduzzi G, Gamba P.
PMID: 34943002
Antioxidants (Basel). 2021 Nov 26;10(12). doi: 10.3390/antiox10121890.

In recent decades, the impairment of cholesterol metabolism in the pathogenesis of Alzheimer's disease (AD) has been intensively investigated, and it has been recognized to affect amyloid β (Aβ) production and clearance, tau phosphorylation, neuroinflammation and degeneration. In particular,...

Development of a synchronous fluorescence imaging system and data analysis methods.

Optics express

Liu Q, Chen K, Martin M, Wintenberg A, Lenarduzzi R, Panjehpour M, Overholt BF, Vo-Dinh T.
PMID: 19550526
Opt Express. 2007 Oct 01;15(20):12583-94. doi: 10.1364/oe.15.012583.

Although conventional autofluorescence spectroscopy, in which fluorescence emission spectra are recorded for fixed excitation wavelengths, has demonstrated good performance in tissue diagnosis, it suffers from prolonged data acquisition time and broad-band fluorescence features. Synchronous spectroscopy has been proposed to...

Showing 1 to 12 of 17 entries