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Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination.

Oncoimmunology

Bol KF, Aarntzen EH, Hout FE, Schreibelt G, Creemers JH, Lesterhuis WJ, Gerritsen WR, Grunhagen DJ, Verhoef C, Punt CJ, Bonenkamp JJ, de Wilt JH, Figdor CG, de Vries IJ.
PMID: 26942068
Oncoimmunology. 2015 Jun 05;5(1):e1057673. doi: 10.1080/2162402X.2015.1057673. eCollection 2016.

Melanoma patients with regional metastatic disease are at high risk for recurrence and metastatic disease, despite radical lymph node dissection (RLND). We investigated the immunologic response and clinical outcome to adjuvant dendritic cell (DC) vaccination in melanoma patients with...

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Bol KF, Aarntzen EH, Hout FE, et al. Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination. Oncoimmunology. 2015;5(1):e1057673doi: 10.1080/2162402X.2015.1057673.
Bol, K. F., Aarntzen, E. H., Hout, F. E., Schreibelt, G., Creemers, J. H., Lesterhuis, W. J., Gerritsen, W. R., Grunhagen, D. J., Verhoef, C., Punt, C. J., Bonenkamp, J. J., de Wilt, J. H., Figdor, C. G., & de Vries, I. J. (2016). Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination. Oncoimmunology, 5(1), e1057673. https://doi.org/10.1080/2162402X.2015.1057673
Bol, Kalijn F, et al. "Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination." Oncoimmunology vol. 5,1 (2016): e1057673. doi: https://doi.org/10.1080/2162402X.2015.1057673
Bol KF, Aarntzen EH, Hout FE, Schreibelt G, Creemers JH, Lesterhuis WJ, Gerritsen WR, Grunhagen DJ, Verhoef C, Punt CJ, Bonenkamp JJ, de Wilt JH, Figdor CG, de Vries IJ. Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination. Oncoimmunology. 2015 Jun 05;5(1):e1057673. doi: 10.1080/2162402X.2015.1057673. eCollection 2016. PMID: 26942068; PMCID: PMC4760342.
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Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen.

Oncoimmunology

Creaney J, Ma S, Sneddon SA, Tourigny MR, Dick IM, Leon JS, Khong A, Fisher SA, Lake RA, Lesterhuis WJ, Nowak AK, Leary S, Watson MW, Robinson BW.
PMID: 26140232
Oncoimmunology. 2015 May 11;4(7):e1011492. doi: 10.1080/2162402X.2015.1011492. eCollection 2015 Jul.

A key to improving cancer immunotherapy will be the identification of tumor-specific "neoantigens" that arise from mutations and augment the resultant host immune response. In this study we identified single nucleotide variants (SNVs) by RNA sequencing of asbestos-induced murine...

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Creaney J, Ma S, Sneddon SA, et al. Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen. Oncoimmunology. 2015;4(7):e1011492doi: 10.1080/2162402X.2015.1011492.
Creaney, J., Ma, S., Sneddon, S. A., Tourigny, M. R., Dick, I. M., Leon, J. S., Khong, A., Fisher, S. A., Lake, R. A., Lesterhuis, W. J., Nowak, A. K., Leary, S., Watson, M. W., & Robinson, B. W. (2015). Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen. Oncoimmunology, 4(7), e1011492. https://doi.org/10.1080/2162402X.2015.1011492
Creaney, Jenette, et al. "Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen." Oncoimmunology vol. 4,7 (2015): e1011492. doi: https://doi.org/10.1080/2162402X.2015.1011492
Creaney J, Ma S, Sneddon SA, Tourigny MR, Dick IM, Leon JS, Khong A, Fisher SA, Lake RA, Lesterhuis WJ, Nowak AK, Leary S, Watson MW, Robinson BW. Strong spontaneous tumor neoantigen responses induced by a natural human carcinogen. Oncoimmunology. 2015 May 11;4(7):e1011492. doi: 10.1080/2162402X.2015.1011492. eCollection 2015 Jul. PMID: 26140232; PMCID: PMC4485777.
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Myocardial infarction in a patient with sickle cell trait. Treatment dilemmas and imaging findings at follow-up.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

van Mieghem C, Ramcharitar S, Barlis P, Oosterhuis W, Kik C, de Feyter P, Serruys PW.
PMID: 19608492
EuroIntervention. 2008 Mar;3(5):627-34. doi: 10.4244/eijv3i5a112.

BACKGROUND: A 43-year-old woman with a 2-hour history of chest pain presented with an anterior infarction and was referred for primary percutaneous coronary intervention.INVESTIGATIONS: Physical examination, electrocardiography, laboratory tests, coronary angiography, abdominal angiography, cardiac CT, histology, immunohistochemistry, intravascular ultrasound.DIAGNOSIS:...

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van Mieghem C, Ramcharitar S, Barlis P, et al. Myocardial infarction in a patient with sickle cell trait. Treatment dilemmas and imaging findings at follow-up. EuroIntervention. 2008;3(5):627-34doi: 10.4244/eijv3i5a112.
van Mieghem, C., Ramcharitar, S., Barlis, P., Oosterhuis, W., Kik, C., de Feyter, P., & Serruys, P. W. (2008). Myocardial infarction in a patient with sickle cell trait. Treatment dilemmas and imaging findings at follow-up. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 3(5), 627-34. https://doi.org/10.4244/eijv3i5a112
van Mieghem, Carlos, et al. "Myocardial infarction in a patient with sickle cell trait. Treatment dilemmas and imaging findings at follow-up." EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology vol. 3,5 (2008): 627-34. doi: https://doi.org/10.4244/eijv3i5a112
van Mieghem C, Ramcharitar S, Barlis P, Oosterhuis W, Kik C, de Feyter P, Serruys PW. Myocardial infarction in a patient with sickle cell trait. Treatment dilemmas and imaging findings at follow-up. EuroIntervention. 2008 Mar;3(5):627-34. doi: 10.4244/eijv3i5a112. PMID: 19608492.
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Psychoeducation for patients with a psychotic disorder: effects on knowledge and coping.

The primary care companion for CNS disorders

Bossema ER, de Haar CA, Westerhuis W, Beenackers BP, Blom BC, Appels MC, van Oeveren CJ.
PMID: 22132352
Prim Care Companion CNS Disord. 2011;13(4). doi: 10.4088/PCC.10m01116.

OBJECTIVE: Psychoeducation is an essential and promising element in the nonpharmacologic treatment of patients with a psychotic disorder. This study examined the effects of patient-directed psychoeducation on knowledge and coping.METHOD: This study included 99 primary care patients with a...

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Bossema ER, de Haar CA, Westerhuis W, et al. Psychoeducation for patients with a psychotic disorder: effects on knowledge and coping. Prim Care Companion CNS Disord. 2011;13(4)doi: 10.4088/PCC.10m01116.
Bossema, E. R., de Haar, C. A., Westerhuis, W., Beenackers, B. P., Blom, B. C., Appels, M. C., & van Oeveren, C. J. (2011). Psychoeducation for patients with a psychotic disorder: effects on knowledge and coping. The primary care companion for CNS disorders, 13(4), . https://doi.org/10.4088/PCC.10m01116
Bossema, Ercolie R, et al. "Psychoeducation for patients with a psychotic disorder: effects on knowledge and coping." The primary care companion for CNS disorders vol. 13,4 (2011). doi: https://doi.org/10.4088/PCC.10m01116
Bossema ER, de Haar CA, Westerhuis W, Beenackers BP, Blom BC, Appels MC, van Oeveren CJ. Psychoeducation for patients with a psychotic disorder: effects on knowledge and coping. Prim Care Companion CNS Disord. 2011;13(4). doi: 10.4088/PCC.10m01116. PMID: 22132352; PMCID: PMC3219515.
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Adding clinical utility to the laboratory reports: automation of interpretative comments.

Clinical chemistry and laboratory medicine

Oosterhuis W.
PMID: 30367781
Clin Chem Lab Med. 2019 Feb 25;57(3):365-370. doi: 10.1515/cclm-2018-0623.

In laboratory medicine, consultation by adding interpretative comments to reports has long been recognized as one of the activities that help to improve patient treatment outcomes and strengthen the position of our profession. Interpretation and understanding of laboratory test...

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Oosterhuis W. Adding clinical utility to the laboratory reports: automation of interpretative comments. Clin Chem Lab Med. 2019;57(3):365-370doi: 10.1515/cclm-2018-0623.
Oosterhuis, W. (2019). Adding clinical utility to the laboratory reports: automation of interpretative comments. Clinical chemistry and laboratory medicine, 57(3), 365-370. https://doi.org/10.1515/cclm-2018-0623
Oosterhuis, Wytze. "Adding clinical utility to the laboratory reports: automation of interpretative comments." Clinical chemistry and laboratory medicine vol. 57,3 (2019): 365-370. doi: https://doi.org/10.1515/cclm-2018-0623
Oosterhuis W. Adding clinical utility to the laboratory reports: automation of interpretative comments. Clin Chem Lab Med. 2019 Feb 25;57(3):365-370. doi: 10.1515/cclm-2018-0623. PMID: 30367781.
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Publisher Correction: Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus.

Scientific reports

Westerhuis B, Ten Hulscher H, Jacobi R, van Beek J, Koopmans M, Rimmelzwaan G, Meijer A, van Binnendijk R.
PMID: 32198442
Sci Rep. 2020 Mar 20;10(1):5458. doi: 10.1038/s41598-020-62303-5.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Westerhuis B, Ten Hulscher H, Jacobi R, et al. Publisher Correction: Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus. Sci Rep. 2020;10(1):5458doi: 10.1038/s41598-020-62303-5.
Westerhuis, B., Ten Hulscher, H., Jacobi, R., van Beek, J., Koopmans, M., Rimmelzwaan, G., Meijer, A., & van Binnendijk, R. (2020). Publisher Correction: Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus. Scientific reports, 10(1), 5458. https://doi.org/10.1038/s41598-020-62303-5
Westerhuis, Brenda, et al. "Publisher Correction: Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus." Scientific reports vol. 10,1 (2020): 5458. doi: https://doi.org/10.1038/s41598-020-62303-5
Westerhuis B, Ten Hulscher H, Jacobi R, van Beek J, Koopmans M, Rimmelzwaan G, Meijer A, van Binnendijk R. Publisher Correction: Specific memory B cell response in humans upon infection with highly pathogenic H7N7 avian influenza virus. Sci Rep. 2020 Mar 20;10(1):5458. doi: 10.1038/s41598-020-62303-5. PMID: 32198442; PMCID: PMC7083889.
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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.

iScience

Orozco Morales ML, Rinaldi CA, de Jong E, Lansley SM, Gummer JPA, Olasz B, Nambiar S, Hope DE, Casey TH, Lee YCG, Leslie C, Nealon G, Shackleford DM, Powell AK, Grimaldi M, Balaguer P, Zemek RM, Bosco A, Piggott MJ, Vrielink A, Lake RA, Lesterhuis WJ.
PMID: 34984327
iScience. 2021 Dec 04;25(1):103571. doi: 10.1016/j.isci.2021.103571. eCollection 2022 Jan 21.

Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the...

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Orozco Morales ML, Rinaldi CA, de Jong E, et al. PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective. iScience. 2021;25(1):103571doi: 10.1016/j.isci.2021.103571.
Orozco Morales, M. L., Rinaldi, C. A., de Jong, E., Lansley, S. M., Gummer, J. P. A., Olasz, B., Nambiar, S., Hope, D. E., Casey, T. H., Lee, Y. C. G., Leslie, C., Nealon, G., Shackleford, D. M., Powell, A. K., Grimaldi, M., Balaguer, P., Zemek, R. M., Bosco, A., Piggott, M. J., Vrielink, A., Lake, R. A., & Lesterhuis, W. J. (2022). PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective. iScience, 25(1), 103571. https://doi.org/10.1016/j.isci.2021.103571
Orozco Morales, M Lizeth, et al. "PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective." iScience vol. 25,1 (2022): 103571. doi: https://doi.org/10.1016/j.isci.2021.103571
Orozco Morales ML, Rinaldi CA, de Jong E, Lansley SM, Gummer JPA, Olasz B, Nambiar S, Hope DE, Casey TH, Lee YCG, Leslie C, Nealon G, Shackleford DM, Powell AK, Grimaldi M, Balaguer P, Zemek RM, Bosco A, Piggott MJ, Vrielink A, Lake RA, Lesterhuis WJ. PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective. iScience. 2021 Dec 04;25(1):103571. doi: 10.1016/j.isci.2021.103571. eCollection 2022 Jan 21. PMID: 34984327; PMCID: PMC8692993.
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A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery.

Journal for immunotherapy of cancer

Creemers JHA, Lesterhuis WJ, Mehra N, Gerritsen WR, Figdor CG, de Vries IJM, Textor J.
PMID: 34059522
J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2020-002032.

BACKGROUND: Predicting treatment response or survival of cancer patients remains challenging in immuno-oncology. Efforts to overcome these challenges focus, among others, on the discovery of new biomarkers. Despite advances in cellular and molecular approaches, only a limited number of...

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Creemers JHA, Lesterhuis WJ, Mehra N, et al. A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery. J Immunother Cancer. 2021;9(5)doi: 10.1136/jitc-2020-002032.
Creemers, J. H. A., Lesterhuis, W. J., Mehra, N., Gerritsen, W. R., Figdor, C. G., de Vries, I. J. M., & Textor, J. (2021). A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery. Journal for immunotherapy of cancer, 9(5), . https://doi.org/10.1136/jitc-2020-002032
Creemers, Jeroen H A, et al. "A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery." Journal for immunotherapy of cancer vol. 9,5 (2021). doi: https://doi.org/10.1136/jitc-2020-002032
Creemers JHA, Lesterhuis WJ, Mehra N, Gerritsen WR, Figdor CG, de Vries IJM, Textor J. A tipping point in cancer-immune dynamics leads to divergent immunotherapy responses and hampers biomarker discovery. J Immunother Cancer. 2021 May;9(5). doi: 10.1136/jitc-2020-002032. PMID: 34059522; PMCID: PMC8169479.
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Co-Creation of a Multi-Component Health Literacy Intervention Targeting Both Patients with Mild to Severe Chronic Kidney Disease and Health Care Professionals.

International journal of environmental research and public health

Boonstra MD, Reijneveld SA, Navis G, Westerhuis R, de Winter AF.
PMID: 34948960
Int J Environ Res Public Health. 2021 Dec 18;18(24). doi: 10.3390/ijerph182413354.

Limited health literacy (LHL) is common in chronic kidney disease (CKD) patients and frequently associated with worse self-management. Multi-component interventions targeted at patients and healthcare professionals (HCPs) are recommended, but evidence is limited. Therefore, this study aims to determine...

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Boonstra MD, Reijneveld SA, Navis G, et al. Co-Creation of a Multi-Component Health Literacy Intervention Targeting Both Patients with Mild to Severe Chronic Kidney Disease and Health Care Professionals. Int J Environ Res Public Health. 2021;18(24)doi: 10.3390/ijerph182413354.
Boonstra, M. D., Reijneveld, S. A., Navis, G., Westerhuis, R., & de Winter, A. F. (2021). Co-Creation of a Multi-Component Health Literacy Intervention Targeting Both Patients with Mild to Severe Chronic Kidney Disease and Health Care Professionals. International journal of environmental research and public health, 18(24), . https://doi.org/10.3390/ijerph182413354
Boonstra, Marco D, et al. "Co-Creation of a Multi-Component Health Literacy Intervention Targeting Both Patients with Mild to Severe Chronic Kidney Disease and Health Care Professionals." International journal of environmental research and public health vol. 18,24 (2021). doi: https://doi.org/10.3390/ijerph182413354
Boonstra MD, Reijneveld SA, Navis G, Westerhuis R, de Winter AF. Co-Creation of a Multi-Component Health Literacy Intervention Targeting Both Patients with Mild to Severe Chronic Kidney Disease and Health Care Professionals. Int J Environ Res Public Health. 2021 Dec 18;18(24). doi: 10.3390/ijerph182413354. PMID: 34948960; PMCID: PMC8704507.
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Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients.

Clinical nutrition (Edinburgh, Scotland)

Post A, Groothof D, Schutten JC, Kelly D, Swarte JC, Flores-Guerrero JL, van der Veen Y, Kema IP, Ozyilmaz A, Enya A, Westerhuis R, Bakker SJL, Franssen CFM.
PMID: 33589239
Clin Nutr. 2021 Jun;40(6):4216-4224. doi: 10.1016/j.clnu.2021.01.036. Epub 2021 Feb 03.

INTRODUCTION: Protein energy wasting (PEW) is the most important risk factor for morbidity and mortality in hemodialysis patients. Inadequate dietary protein intake is a frequent cause of PEW. Recent studies have identified fibroblast growth factor 21 (FGF21) as an...

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Post A, Groothof D, Schutten JC, et al. Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients. Clin Nutr. 2021;40(6):4216-4224doi: 10.1016/j.clnu.2021.01.036.
Post, A., Groothof, D., Schutten, J. C., Kelly, D., Swarte, J. C., Flores-Guerrero, J. L., van der Veen, Y., Kema, I. P., Ozyilmaz, A., Enya, A., Westerhuis, R., Bakker, S. J. L., & Franssen, C. F. M. (2021). Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients. Clinical nutrition (Edinburgh, Scotland), 40(6), 4216-4224. https://doi.org/10.1016/j.clnu.2021.01.036
Post, Adrian, et al. "Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients." Clinical nutrition (Edinburgh, Scotland) vol. 40,6 (2021): 4216-4224. doi: https://doi.org/10.1016/j.clnu.2021.01.036
Post A, Groothof D, Schutten JC, Kelly D, Swarte JC, Flores-Guerrero JL, van der Veen Y, Kema IP, Ozyilmaz A, Enya A, Westerhuis R, Bakker SJL, Franssen CFM. Fibroblast growth factor 21 and protein energy wasting in hemodialysis patients. Clin Nutr. 2021 Jun;40(6):4216-4224. doi: 10.1016/j.clnu.2021.01.036. Epub 2021 Feb 03. PMID: 33589239.
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The Effect of Renal Function and Hemodialysis Treatment on Plasma Vasopressin and Copeptin Levels.

Kidney international reports

Ettema EM, Heida J, Casteleijn NF, Boesten L, Westerhuis R, Gaillard CAJM, Gansevoort RT, Franssen CFM, Zittema D.
PMID: 29142968
Kidney Int Rep. 2017 Jan 23;2(3):410-419. doi: 10.1016/j.ekir.2017.01.006. eCollection 2017 May.

INTRODUCTION: Copeptin is increasingly used in epidemiological studies as a substitute for vasopressin. The effect of renal function METHODS: Copeptin and vasopressin levels were measured in 127 patients with various stages of chronic kidney disease, including 42 hemodialysis patients...

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Ettema EM, Heida J, Casteleijn NF, et al. The Effect of Renal Function and Hemodialysis Treatment on Plasma Vasopressin and Copeptin Levels. Kidney Int Rep. 2017;2(3):410-419doi: 10.1016/j.ekir.2017.01.006.
Ettema, E. M., Heida, J., Casteleijn, N. F., Boesten, L., Westerhuis, R., Gaillard, C. A. J. M., Gansevoort, R. T., Franssen, C. F. M., & Zittema, D. (2017). The Effect of Renal Function and Hemodialysis Treatment on Plasma Vasopressin and Copeptin Levels. Kidney international reports, 2(3), 410-419. https://doi.org/10.1016/j.ekir.2017.01.006
Ettema, Esmée M, et al. "The Effect of Renal Function and Hemodialysis Treatment on Plasma Vasopressin and Copeptin Levels." Kidney international reports vol. 2,3 (2017): 410-419. doi: https://doi.org/10.1016/j.ekir.2017.01.006
Ettema EM, Heida J, Casteleijn NF, Boesten L, Westerhuis R, Gaillard CAJM, Gansevoort RT, Franssen CFM, Zittema D. The Effect of Renal Function and Hemodialysis Treatment on Plasma Vasopressin and Copeptin Levels. Kidney Int Rep. 2017 Jan 23;2(3):410-419. doi: 10.1016/j.ekir.2017.01.006. eCollection 2017 May. PMID: 29142968; PMCID: PMC5678637.
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How to tackle health literacy problems in chronic kidney disease patients? A systematic review to identify promising intervention targets and strategies.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Boonstra MD, Reijneveld SA, Foitzik EM, Westerhuis R, Navis G, de Winter AF.
PMID: 33351936
Nephrol Dial Transplant. 2020 Dec 22; doi: 10.1093/ndt/gfaa273. Epub 2020 Dec 22.

BACKGROUND: Limited health literacy (LHL) is associated with multiple adverse health outcomes in chronic kidney disease (CKD). Interventions are needed to improve this situation, but evidence on intervention targets and strategies is lacking. This systematic review aims to identify...

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Boonstra MD, Reijneveld SA, Foitzik EM, et al. How to tackle health literacy problems in chronic kidney disease patients? A systematic review to identify promising intervention targets and strategies. Nephrol Dial Transplant. 2020;doi: 10.1093/ndt/gfaa273.
Boonstra, M. D., Reijneveld, S. A., Foitzik, E. M., Westerhuis, R., Navis, G., & de Winter, A. F. (2020). How to tackle health literacy problems in chronic kidney disease patients? A systematic review to identify promising intervention targets and strategies. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, . https://doi.org/10.1093/ndt/gfaa273
Boonstra, Marco D, et al. "How to tackle health literacy problems in chronic kidney disease patients? A systematic review to identify promising intervention targets and strategies." Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association vol. (2020). doi: https://doi.org/10.1093/ndt/gfaa273
Boonstra MD, Reijneveld SA, Foitzik EM, Westerhuis R, Navis G, de Winter AF. How to tackle health literacy problems in chronic kidney disease patients? A systematic review to identify promising intervention targets and strategies. Nephrol Dial Transplant. 2020 Dec 22; doi: 10.1093/ndt/gfaa273. Epub 2020 Dec 22. PMID: 33351936; PMCID: PMC8237988.
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