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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.

ACS medicinal chemistry letters

Mitchell LH, Drew AE, Ribich SA, Rioux N, Swinger KK, Jacques SL, Lingaraj T, Boriack-Sjodin PA, Waters NJ, Wigle TJ, Moradei O, Jin L, Riera T, Porter-Scott M, Moyer MP, Smith JJ, Chesworth R, Copeland RA.
PMID: 26101569
ACS Med Chem Lett. 2015 Apr 06;6(6):655-9. doi: 10.1021/acsmedchemlett.5b00071. eCollection 2015 Jun 11.

A novel aryl pyrazole series of arginine methyltransferase inhibitors has been identified. Synthesis of analogues within this series yielded the first potent, selective, small molecule PRMT6 inhibitor tool compound, EPZ020411. PRMT6 overexpression has been reported in several cancer types...

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Mitchell LH, Drew AE, Ribich SA, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett. 2015;6(6):655-9doi: 10.1021/acsmedchemlett.5b00071.
Mitchell, L. H., Drew, A. E., Ribich, S. A., Rioux, N., Swinger, K. K., Jacques, S. L., Lingaraj, T., Boriack-Sjodin, P. A., Waters, N. J., Wigle, T. J., Moradei, O., Jin, L., Riera, T., Porter-Scott, M., Moyer, M. P., Smith, J. J., Chesworth, R., & Copeland, R. A. (2015). Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS medicinal chemistry letters, 6(6), 655-9. https://doi.org/10.1021/acsmedchemlett.5b00071
Mitchell, Lorna H, et al. "Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound." ACS medicinal chemistry letters vol. 6,6 (2015): 655-9. doi: https://doi.org/10.1021/acsmedchemlett.5b00071
Mitchell LH, Drew AE, Ribich SA, Rioux N, Swinger KK, Jacques SL, Lingaraj T, Boriack-Sjodin PA, Waters NJ, Wigle TJ, Moradei O, Jin L, Riera T, Porter-Scott M, Moyer MP, Smith JJ, Chesworth R, Copeland RA. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound. ACS Med Chem Lett. 2015 Apr 06;6(6):655-9. doi: 10.1021/acsmedchemlett.5b00071. eCollection 2015 Jun 11. PMID: 26101569; PMCID: PMC4468411.
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Effect of Short-term-focused Training on a Phantom Model in Improving Operative Room Performance Among Surgical Residents: A Randomized Trial.

Surgical laparoscopy, endoscopy & percutaneous techniques

Lingaraj C, Rai SK, Asuri K, Prajapati OP, Kumar S, Bhattacharjee H, Bansal VK.
PMID: 34690339
Surg Laparosc Endosc Percutan Tech. 2021 Oct 22; doi: 10.1097/SLE.0000000000001016. Epub 2021 Oct 22.

BACKGROUND: Meta-analysis has shown the effectiveness of various training methods for the acquisition of laparoscopic skills in surgical training. However, there is very limited literature focusing on the translation of skill acquisition on training models into improved operating room...

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Lingaraj C, Rai SK, Asuri K, et al. Effect of Short-term-focused Training on a Phantom Model in Improving Operative Room Performance Among Surgical Residents: A Randomized Trial. Surg Laparosc Endosc Percutan Tech. 2021;doi: 10.1097/SLE.0000000000001016.
Lingaraj, C., Rai, S. K., Asuri, K., Prajapati, O. P., Kumar, S., Bhattacharjee, H., & Bansal, V. K. (2021). Effect of Short-term-focused Training on a Phantom Model in Improving Operative Room Performance Among Surgical Residents: A Randomized Trial. Surgical laparoscopy, endoscopy & percutaneous techniques, . https://doi.org/10.1097/SLE.0000000000001016
Lingaraj, Chaitra, et al. "Effect of Short-term-focused Training on a Phantom Model in Improving Operative Room Performance Among Surgical Residents: A Randomized Trial." Surgical laparoscopy, endoscopy & percutaneous techniques vol. (2021). doi: https://doi.org/10.1097/SLE.0000000000001016
Lingaraj C, Rai SK, Asuri K, Prajapati OP, Kumar S, Bhattacharjee H, Bansal VK. Effect of Short-term-focused Training on a Phantom Model in Improving Operative Room Performance Among Surgical Residents: A Randomized Trial. Surg Laparosc Endosc Percutan Tech. 2021 Oct 22; doi: 10.1097/SLE.0000000000001016. Epub 2021 Oct 22. PMID: 34690339.
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Method Development and Validation for the Determination of Caffeine: An Alkaloid from .

Pharmacognosy research

Naveen P, Lingaraju HB, Deepak M, Medhini B, Prasad KS.
PMID: 29568193
Pharmacognosy Res. 2018 Jan-Mar;10(1):88-91. doi: 10.4103/pr.pr_79_17.

OBJECTIVE: The present study was investigated to develop and validate a reversed phase high performance liquid chromatography method for the determination of caffeine from bean material of Coffee arabica.MATERIALS AND METHODS: The separation was achieved on a reversed-phase C18...

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Naveen P, Lingaraju HB, Deepak M, et al. Method Development and Validation for the Determination of Caffeine: An Alkaloid from . Pharmacognosy Res. 2018;10(1):88-91doi: 10.4103/pr.pr_79_17.
Naveen, P., Lingaraju, H. B., Deepak, M., Medhini, B., & Prasad, K. S. (2018). Method Development and Validation for the Determination of Caffeine: An Alkaloid from . Pharmacognosy research, 10(1), 88-91. https://doi.org/10.4103/pr.pr_79_17
Naveen, P, et al. "Method Development and Validation for the Determination of Caffeine: An Alkaloid from ." Pharmacognosy research vol. 10,1 (2018): 88-91. doi: https://doi.org/10.4103/pr.pr_79_17
Naveen P, Lingaraju HB, Deepak M, Medhini B, Prasad KS. Method Development and Validation for the Determination of Caffeine: An Alkaloid from . Pharmacognosy Res. 2018 Jan-Mar;10(1):88-91. doi: 10.4103/pr.pr_79_17. PMID: 29568193; PMCID: PMC5855379.
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Opportunistic infections in a renal transplant recipient.

Infectious disease reports

Mysorekar VV, Eshwarappa M, Lingaraj U.
PMID: 24470938
Infect Dis Rep. 2012 Jan 05;4(1):e8. doi: 10.4081/idr.2012.e8. eCollection 2012 Jan 02.

With the present progress in transplantation procedures, there is an improvement in patient and allograft survival. However, the immunosuppression necessary to sustain the allograft predisposes these transplant recipients to infection, which is now a significant cause of morbidity and...

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Mysorekar VV, Eshwarappa M, Lingaraj U. Opportunistic infections in a renal transplant recipient. Infect Dis Rep. 2012;4(1):e8doi: 10.4081/idr.2012.e8.
Mysorekar, V. V., Eshwarappa, M., & Lingaraj, U. (2012). Opportunistic infections in a renal transplant recipient. Infectious disease reports, 4(1), e8. https://doi.org/10.4081/idr.2012.e8
Mysorekar, Vijaya V, et al. "Opportunistic infections in a renal transplant recipient." Infectious disease reports vol. 4,1 (2012): e8. doi: https://doi.org/10.4081/idr.2012.e8
Mysorekar VV, Eshwarappa M, Lingaraj U. Opportunistic infections in a renal transplant recipient. Infect Dis Rep. 2012 Jan 05;4(1):e8. doi: 10.4081/idr.2012.e8. eCollection 2012 Jan 02. PMID: 24470938; PMCID: PMC3892655.
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Healing assessment of osseous defects of periapical lesions with use of freeze dried bone allograft.

Journal of maxillofacial and oral surgery

Lingaraj JB, Kotrashetti SM, Gupta N.
PMID: 23139544
J Maxillofac Oral Surg. 2009 Dec;8(4):362-5. doi: 10.1007/s12663-009-0086-8. Epub 2010 Apr 24.

OBJECTIVES: The aim of this study was to save endodontically failed teeth with periapical pathosis by surgery. Elimination of the periapical pathology and to evaluate the clinical and radiological efficiency of freeze dried bone allograft in bony defects.MATERIALS AND...

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Lingaraj JB, Kotrashetti SM, Gupta N. Healing assessment of osseous defects of periapical lesions with use of freeze dried bone allograft. J Maxillofac Oral Surg. 2010;8(4):362-5doi: 10.1007/s12663-009-0086-8.
Lingaraj, J. B., Kotrashetti, S. M., & Gupta, N. (2009). Healing assessment of osseous defects of periapical lesions with use of freeze dried bone allograft. Journal of maxillofacial and oral surgery, 8(4), 362-5. https://doi.org/10.1007/s12663-009-0086-8
Lingaraj, J B, et al. "Healing assessment of osseous defects of periapical lesions with use of freeze dried bone allograft." Journal of maxillofacial and oral surgery vol. 8,4 (2009): 362-5. doi: https://doi.org/10.1007/s12663-009-0086-8
Lingaraj JB, Kotrashetti SM, Gupta N. Healing assessment of osseous defects of periapical lesions with use of freeze dried bone allograft. J Maxillofac Oral Surg. 2009 Dec;8(4):362-5. doi: 10.1007/s12663-009-0086-8. Epub 2010 Apr 24. PMID: 23139544; PMCID: PMC3454090.
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Quantum frequency combs and Hong-Ou-Mandel interferometry: the role of spectral phase coherence.

Optics express

Lingaraju NB, Lu HH, Seshadri S, Imany P, Leaird DE, Lukens JM, Weiner AM.
PMID: 31878631
Opt Express. 2019 Dec 23;27(26):38683-38697. doi: 10.1364/OE.379749.

The Hong-Ou-Mandel interferometer is a versatile tool for analyzing the joint properties of photon pairs, relying on a truly quantum interference effect between two-photon probability amplitudes. While the theory behind this form of two-photon interferometry is well established, the...

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Lingaraju NB, Lu HH, Seshadri S, et al. Quantum frequency combs and Hong-Ou-Mandel interferometry: the role of spectral phase coherence. Opt Express. 2019;27(26):38683-38697doi: 10.1364/OE.379749.
Lingaraju, N. B., Lu, H. H., Seshadri, S., Imany, P., Leaird, D. E., Lukens, J. M., & Weiner, A. M. (2019). Quantum frequency combs and Hong-Ou-Mandel interferometry: the role of spectral phase coherence. Optics express, 27(26), 38683-38697. https://doi.org/10.1364/OE.379749
Lingaraju, Navin B, et al. "Quantum frequency combs and Hong-Ou-Mandel interferometry: the role of spectral phase coherence." Optics express vol. 27,26 (2019): 38683-38697. doi: https://doi.org/10.1364/OE.379749
Lingaraju NB, Lu HH, Seshadri S, Imany P, Leaird DE, Lukens JM, Weiner AM. Quantum frequency combs and Hong-Ou-Mandel interferometry: the role of spectral phase coherence. Opt Express. 2019 Dec 23;27(26):38683-38697. doi: 10.1364/OE.379749. PMID: 31878631.
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A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins.

Journal of food biochemistry

Sudeep HV, Venkatakrishna K, Amritharaj, Gouthamchandra K, Reethi B, Naveen P, Lingaraju HB, Shyamprasad K.
PMID: 34778972
J Food Biochem. 2021 Dec;45(12):e13994. doi: 10.1111/jfbc.13994. Epub 2021 Nov 14.

β-caryophyllene (BCP), a natural sesquiterpene present in plants, is a selective agonist of cannabinoid receptor type-2 (CB2) of the endocannabinoid system. In this study, we have prepared an extract from Piper nigrum (black pepper) seeds using supercritical fluid extraction,...

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Sudeep HV, Venkatakrishna K, Amritharaj, et al. A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins. J Food Biochem. 2021;45(12):e13994doi: 10.1111/jfbc.13994.
Sudeep, H. V., Venkatakrishna, K., Amritharaj, Gouthamchandra, K., Reethi, B., Naveen, P., Lingaraju, H. B., & Shyamprasad, K. (2021). A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins. Journal of food biochemistry, 45(12), e13994. https://doi.org/10.1111/jfbc.13994
Sudeep, H V, et al. "A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins." Journal of food biochemistry vol. 45,12 (2021): e13994. doi: https://doi.org/10.1111/jfbc.13994
Sudeep HV, Venkatakrishna K, Amritharaj, Gouthamchandra K, Reethi B, Naveen P, Lingaraju HB, Shyamprasad K. A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins. J Food Biochem. 2021 Dec;45(12):e13994. doi: 10.1111/jfbc.13994. Epub 2021 Nov 14. PMID: 34778972.
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Necrotizing cervical fasciitis: a case report and review of literature.

Journal of maxillofacial and oral surgery

Lingaraj JB, Rao S, Kotrashetti SM, Narad C.
PMID: 23139568
J Maxillofac Oral Surg. 2010 Mar;9(1):54-6. doi: 10.1007/s12663-010-0015-x. Epub 2010 Jun 04.

Necrotizing cervical fasciitis is a rare, fulminating infection causing extensive necrosis of the subcutaneous tissue and fascial planes with resultant skin gangrene. To reduce the morbitity and mortality from this condition, it requires early recognition and aggressive surgical debridment...

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Lingaraj JB, Rao S, Kotrashetti SM, et al. Necrotizing cervical fasciitis: a case report and review of literature. J Maxillofac Oral Surg. 2010;9(1):54-6doi: 10.1007/s12663-010-0015-x.
Lingaraj, J. B., Rao, S., Kotrashetti, S. M., & Narad, C. (2010). Necrotizing cervical fasciitis: a case report and review of literature. Journal of maxillofacial and oral surgery, 9(1), 54-6. https://doi.org/10.1007/s12663-010-0015-x
Lingaraj, J B, et al. "Necrotizing cervical fasciitis: a case report and review of literature." Journal of maxillofacial and oral surgery vol. 9,1 (2010): 54-6. doi: https://doi.org/10.1007/s12663-010-0015-x
Lingaraj JB, Rao S, Kotrashetti SM, Narad C. Necrotizing cervical fasciitis: a case report and review of literature. J Maxillofac Oral Surg. 2010 Mar;9(1):54-6. doi: 10.1007/s12663-010-0015-x. Epub 2010 Jun 04. PMID: 23139568; PMCID: PMC3453688.
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Predebridement wound culture in open fractures does not predict postoperative wound infection: A pilot study.

Journal of natural science, biology, and medicine

Lingaraj R, Santoshi JA, Devi S, Najimudeen S, Gnanadoss JJ, Kanagasabai R, Kanungo R.
PMID: 26604622
J Nat Sci Biol Med. 2015 Aug;6:S63-8. doi: 10.4103/0976-9668.166088.

BACKGROUND: There is confusion in the current literature regarding the value of obtaining predebridement wound cultures in the management of open fractures with several studies reporting contrasting results. We undertook a pilot study to determine the initial bacterial flora...

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Lingaraj R, Santoshi JA, Devi S, et al. Predebridement wound culture in open fractures does not predict postoperative wound infection: A pilot study. J Nat Sci Biol Med. 2015;6:S63-8doi: 10.4103/0976-9668.166088.
Lingaraj, R., Santoshi, J. A., Devi, S., Najimudeen, S., Gnanadoss, J. J., Kanagasabai, R., & Kanungo, R. (2015). Predebridement wound culture in open fractures does not predict postoperative wound infection: A pilot study. Journal of natural science, biology, and medicine, 6S63-8. https://doi.org/10.4103/0976-9668.166088
Lingaraj, Reddy, et al. "Predebridement wound culture in open fractures does not predict postoperative wound infection: A pilot study." Journal of natural science, biology, and medicine vol. 6 (2015): S63-8. doi: https://doi.org/10.4103/0976-9668.166088
Lingaraj R, Santoshi JA, Devi S, Najimudeen S, Gnanadoss JJ, Kanagasabai R, Kanungo R. Predebridement wound culture in open fractures does not predict postoperative wound infection: A pilot study. J Nat Sci Biol Med. 2015 Aug;6:S63-8. doi: 10.4103/0976-9668.166088. PMID: 26604622; PMCID: PMC4630766.
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Assessment of primary stability of the implant placed in prepared infected extraction sockets.

Journal of oral biology and craniofacial research

Narad C, Lingraj JB, Aulakh KK, Handa K, Kotrashetti SM, Pinto PX.
PMID: 30191099
J Oral Biol Craniofac Res. 2018 Sep-Dec;8(3):154-157. doi: 10.1016/j.jobcr.2016.10.002. Epub 2016 Nov 02.

BACKGROUND: Dental conditions like periodontal, periapical pathologies and failed endodontically treated teeth are one of the commonest reasons for tooth removal. These conditions also contraindicate replacement of such teeth with immediate implant procedures.AIM: This study aimed to evaluate the...

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Narad C, Lingraj JB, Aulakh KK, et al. Assessment of primary stability of the implant placed in prepared infected extraction sockets. J Oral Biol Craniofac Res. 2016;8(3):154-157doi: 10.1016/j.jobcr.2016.10.002.
Narad, C., Lingraj, J. B., Aulakh, K. K., Handa, K., Kotrashetti, S. M., & Pinto, P. X. (2018). Assessment of primary stability of the implant placed in prepared infected extraction sockets. Journal of oral biology and craniofacial research, 8(3), 154-157. https://doi.org/10.1016/j.jobcr.2016.10.002
Narad, Chintan, et al. "Assessment of primary stability of the implant placed in prepared infected extraction sockets." Journal of oral biology and craniofacial research vol. 8,3 (2018): 154-157. doi: https://doi.org/10.1016/j.jobcr.2016.10.002
Narad C, Lingraj JB, Aulakh KK, Handa K, Kotrashetti SM, Pinto PX. Assessment of primary stability of the implant placed in prepared infected extraction sockets. J Oral Biol Craniofac Res. 2018 Sep-Dec;8(3):154-157. doi: 10.1016/j.jobcr.2016.10.002. Epub 2016 Nov 02. PMID: 30191099; PMCID: PMC6107909.
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Rapid Development and Validation of Improved Reversed-Phase High-performance Liquid Chromatography Method for the Quantification of Mangiferin, a Polyphenol Xanthone Glycoside in .

Pharmacognosy research

Naveen P, Lingaraju HB, Prasad KS.
PMID: 28539748
Pharmacognosy Res. 2017 Apr-Jun;9(2):215-219. doi: 10.4103/0974-8490.204652.

Mangiferin, a polyphenolic xanthone glycoside from SUMMARY: The present study was intended to develop and validate an RP-HPLC method for the quantification of mangiferin from the bark extract of

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Naveen P, Lingaraju HB, Prasad KS. Rapid Development and Validation of Improved Reversed-Phase High-performance Liquid Chromatography Method for the Quantification of Mangiferin, a Polyphenol Xanthone Glycoside in . Pharmacognosy Res. 2017;9(2):215-219doi: 10.4103/0974-8490.204652.
Naveen, P., Lingaraju, H. B., & Prasad, K. S. (2017). Rapid Development and Validation of Improved Reversed-Phase High-performance Liquid Chromatography Method for the Quantification of Mangiferin, a Polyphenol Xanthone Glycoside in . Pharmacognosy research, 9(2), 215-219. https://doi.org/10.4103/0974-8490.204652
Naveen, P, et al. "Rapid Development and Validation of Improved Reversed-Phase High-performance Liquid Chromatography Method for the Quantification of Mangiferin, a Polyphenol Xanthone Glycoside in ." Pharmacognosy research vol. 9,2 (2017): 215-219. doi: https://doi.org/10.4103/0974-8490.204652
Naveen P, Lingaraju HB, Prasad KS. Rapid Development and Validation of Improved Reversed-Phase High-performance Liquid Chromatography Method for the Quantification of Mangiferin, a Polyphenol Xanthone Glycoside in . Pharmacognosy Res. 2017 Apr-Jun;9(2):215-219. doi: 10.4103/0974-8490.204652. PMID: 28539748; PMCID: PMC5424565.
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Simultaneous determination of rutin, isoquercetin, and quercetin flavonoids in .

International journal of pharmaceutical investigation

Naveen P, Lingaraju HB, Anitha, Prasad KS.
PMID: 28929052
Int J Pharm Investig. 2017 Apr-Jun;7(2):94-100. doi: 10.4103/jphi.JPHI_33_17.

OBJECTIVE: The present study was investigated to provide a documentary evidence for the determination of rutin, isoquercetin, and quercetin flavonoids from the flora of MATERIALS AND METHODS: RP-HPLC analysis was performed by gradient elution with a low-pressure gradient using...

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Naveen P, Lingaraju HB, Anitha, et al. Simultaneous determination of rutin, isoquercetin, and quercetin flavonoids in . Int J Pharm Investig. 2017;7(2):94-100doi: 10.4103/jphi.JPHI_33_17.
Naveen, P., Lingaraju, H. B., Anitha, & Prasad, K. S. (2017). Simultaneous determination of rutin, isoquercetin, and quercetin flavonoids in . International journal of pharmaceutical investigation, 7(2), 94-100. https://doi.org/10.4103/jphi.JPHI_33_17
Naveen, P, et al. "Simultaneous determination of rutin, isoquercetin, and quercetin flavonoids in ." International journal of pharmaceutical investigation vol. 7,2 (2017): 94-100. doi: https://doi.org/10.4103/jphi.JPHI_33_17
Naveen P, Lingaraju HB, Anitha, Prasad KS. Simultaneous determination of rutin, isoquercetin, and quercetin flavonoids in . Int J Pharm Investig. 2017 Apr-Jun;7(2):94-100. doi: 10.4103/jphi.JPHI_33_17. PMID: 28929052; PMCID: PMC5553270.
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