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Showing 1 to 12 of 27 entries
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The Newcastle exercise project. Key messages are misleading and conclusions are not evidence based.

BMJ (Clinical research ed.)

Mutrie N, Woods C, Lowther M, Blamey A, Loughlan C.
PMID: 10877563
BMJ. 2000 May 27;320(7247):1471-2; author reply 1473-4.

No abstract available.

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.

EBioMedicine

Oyong DA, Loughland JR, Soon MSF, Chan JA, Andrew D, Wines BD, Hogarth PM, Olver SD, Collinge AD, Varelias A, Beeson JG, Kenangalem E, Price RN, Anstey NM, Minigo G, Boyle MJ.
PMID: 34968760
EBioMedicine. 2021 Dec 27;75:103784. doi: 10.1016/j.ebiom.2021.103784. Epub 2021 Dec 27.

BACKGROUND: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells have key roles in inducing antibodies, with Th2-Tfh cell...

Synaptic targets of photoreceptors specialized to detect color and skylight polarization in .

eLife

Kind E, Longden KD, Nern A, Zhao A, Sancer G, Flynn MA, Laughland CW, Gezahegn B, Ludwig HD, Thomson AG, Obrusnik T, Alarcón PG, Dionne H, Bock DD, Rubin GM, Reiser MB, Wernet MF.
PMID: 34913436
Elife. 2021 Dec 16;10. doi: 10.7554/eLife.71858. Epub 2021 Dec 16.

Color and polarization provide complementary information about the world and are detected by specialized photoreceptors. However, the downstream neural circuits that process these distinct modalities are incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed the...

Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells.

The Journal of infectious diseases

Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA.
PMID: 32809013
J Infect Dis. 2021 Apr 08;223(7):1284-1294. doi: 10.1093/infdis/jiaa513.

BACKGROUND: Varicella zoster virus (VZV) vasculopathy is characterized by persistent arterial inflammation leading to stroke. Studies show that VZV induces amyloid formation that may aggravate vasculitis. Thus, we determined if VZV central nervous system infection produces amyloid.METHODS: Aβ peptides,...

Safety and efficacy of sargramostim (GM-CSF) in the treatment of Alzheimer's disease.

Alzheimer's & dementia (New York, N. Y.)

Potter H, Woodcock JH, Boyd TD, Coughlan CM, O'Shaughnessy JR, Borges MT, Thaker AA, Raj BA, Adamszuk K, Scott D, Adame V, Anton P, Chial HJ, Gray H, Daniels J, Stocker ME, Sillau SH.
PMID: 33778150
Alzheimers Dement (N Y). 2021 Mar 24;7(1):e12158. doi: 10.1002/trc2.12158. eCollection 2021.

INTRODUCTION: Inflammatory markers have long been observed in the brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients, suggesting that inflammation contributes to AD and might be a therapeutic target. However, non-steroidal anti-inflammatory drug trials in AD...

Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent .

Clinical & translational immunology

Loughland JR, Woodberry T, Field M, Andrew DW, SheelaNair A, Dooley NL, Piera KA, Amante FH, Kenangalem E, Price RN, Engwerda CR, Anstey NM, McCarthy JS, Boyle MJ, Minigo G.
PMID: 32566226
Clin Transl Immunology. 2020 Jun 18;9(6):e1144. doi: 10.1002/cti2.1144. eCollection 2020.

OBJECTIVES: Malaria, caused by METHODS: The transcriptional and functional profiles of monocytes were examined in controlled human malaria infection with RESULTS: In subpatent primary infection, the monocyte transcriptional profile was dominated by an interferon (IFN) molecular signature. Pathways enriched...

Synaptic targets of photoreceptors specialized to detect color and skylight polarization in .

eLife

Kind E, Longden KD, Nern A, Zhao A, Sancer G, Flynn MA, Laughland CW, Gezahegn B, Ludwig HD, Thomson AG, Obrusnik T, Alarcón PG, Dionne H, Bock DD, Rubin GM, Reiser MB, Wernet MF.
PMID: 34913436
Elife. 2021 Dec 16;10. doi: 10.7554/eLife.71858. Epub 2021 Dec 16.

Color and polarization provide complementary information about the world and are detected by specialized photoreceptors. However, the downstream neural circuits that process these distinct modalities are incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed the...

Does ComPsych Communication Skills Training Alter Trainee Self-Efficacy?.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

Ditton-Phare P, Sandhu H, Kelly B, Loughland C.
PMID: 34553322
Acad Psychiatry. 2021 Sep 22; doi: 10.1007/s40596-021-01517-9. Epub 2021 Sep 22.

OBJECTIVE: ComPsych communication skills training is designed to teach psychiatry trainees effective skills and strategies for undertaking key communication tasks relating to mental illness, such as schizophrenia, with patients and their families/carers. This study examined the program's feasibility, utility,...

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during .

Cell reports. Medicine

Chan JA, Loughland JR, de Labastida Rivera F, SheelaNair A, Andrew DW, Dooley NL, Wines BD, Amante FH, Webb L, Hogarth PM, McCarthy JS, Beeson JG, Engwerda CR, Boyle MJ.
PMID: 33377128
Cell Rep Med. 2020 Dec 22;1(9):100157. doi: 10.1016/j.xcrm.2020.100157. eCollection 2020 Dec 22.

CD4

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.

EBioMedicine

Oyong DA, Loughland JR, Soon MSF, Chan JA, Andrew D, Wines BD, Hogarth PM, Olver SD, Collinge AD, Varelias A, Beeson JG, Kenangalem E, Price RN, Anstey NM, Minigo G, Boyle MJ.
PMID: 34968760
EBioMedicine. 2021 Dec 27;75:103784. doi: 10.1016/j.ebiom.2021.103784. Epub 2021 Dec 27.

BACKGROUND: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells have key roles in inducing antibodies, with Th2-Tfh cell...

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.

EBioMedicine

Oyong DA, Loughland JR, Soon MSF, Chan JA, Andrew D, Wines BD, Hogarth PM, Olver SD, Collinge AD, Varelias A, Beeson JG, Kenangalem E, Price RN, Anstey NM, Minigo G, Boyle MJ.
PMID: 34968760
EBioMedicine. 2021 Dec 27;75:103784. doi: 10.1016/j.ebiom.2021.103784. Epub 2021 Dec 27.

BACKGROUND: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells have key roles in inducing antibodies, with Th2-Tfh cell...

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.

EBioMedicine

Oyong DA, Loughland JR, Soon MSF, Chan JA, Andrew D, Wines BD, Hogarth PM, Olver SD, Collinge AD, Varelias A, Beeson JG, Kenangalem E, Price RN, Anstey NM, Minigo G, Boyle MJ.
PMID: 34968760
EBioMedicine. 2021 Dec 27;75:103784. doi: 10.1016/j.ebiom.2021.103784. Epub 2021 Dec 27.

BACKGROUND: Protective malarial antibodies are acquired more rapidly in adults than children, independently of cumulative exposure, however the cellular responses mediating these differences are unknown. CD4 T-follicular helper (Tfh) cells have key roles in inducing antibodies, with Th2-Tfh cell...

Showing 1 to 12 of 27 entries