UI Index

Phase III trial comparing 3-6 months of adjuvant FOLFOX4/XELOX in stage II-III colon cancer: safety and compliance in the TOSCA trial.

Annals of oncology : official journal of the European Society for Medical Oncology

Lonardi S, Sobrero A, Rosati G, Di Bartolomeo M, Ronzoni M, Aprile G, Massida B, Scartozzi M, Banzi M, Zampino MG, Pasini F, Marchetti P, Cantore M, Zaniboni A, Rimassa L, Ciuffreda L, Ferrari D, Barni S, Zagonel V, Maiello E, Rulli E, Labianca R.
PMID: 28327986
Ann Oncol. 2017 Dec 01;28(12):3110. doi: 10.1093/annonc/mdx021.

No abstract available.

[No title available]

Frontiers in immunology

Pagliari M, Munari F, Toffoletto M, Lonardi S, Chemello F, Codolo G, Millino C, Della Bella C, Pacchioni B, Vermi W, Fassan M, de Bernard M, Cagnin S.
PMID: 29085364
Front Immunol. 2017 Oct 12;8:1288. doi: 10.3389/fimmu.2017.01288. eCollection 2017.

No abstract available.

slanDCs in carcinoma-draining lymph nodes.

Oncoimmunology

Vermi W, Lonardi S, Bugatti M, Calzetti F, Micheletti A, Cassatella MA.
PMID: 24843832
Oncoimmunology. 2014 Jan 01;3(3):e28246. doi: 10.4161/onci.28246. Epub 2014 Mar 17.

Dendritic cells (DCs) are known to initiate adaptive immune responses against malignant cells. However, the role in anticancer immunosurveillance of 6-sulfo LacNAc-expressing DCs (slanDCs), a distinct population of circulating and tissue-resident pro-inflammatory DCs, is unclear. We have recently demonstrated...

Ewe Ovarian Tissue Vitrification: A Model for the Study of Fertility Preservation in Women.

JBRA assisted reproduction

Lunardi FO, Bass CS, Bernuci MP, Chaves RN, Lima LF, Silva RF, Figueiredo JR, Rodrigues AP.
PMID: 27203200
JBRA Assist Reprod. 2015 Nov 01;19(4):241-51. doi: 10.5935/1518-0557.20150047.

Emergency in vitro fertilization followed by embryo vitrification is one feasible fertility preservation option for cancer patients. However, its clinical application has several limitations. Hormonal stimulation delays the initiation of oncotherapy and it is contraindicated in hormone-sensitive cancers or...

Anesthesia-induced developmental neurodegeneration: the role of neuronal organelles.

Frontiers in neurology

Jevtovic-Todorovic V, Boscolo A, Sanchez V, Lunardi N.
PMID: 23087668
Front Neurol. 2012 Oct 11;3:141. doi: 10.3389/fneur.2012.00141. eCollection 2012.

Exposure to general anesthetics (GAs) and antiepileptics during critical stages of brain development causes significant neurotoxicity to immature neurons. Many animal, and emerging human studies have shown long-term functional sequelae manifested as behavioral deficits and cognitive impairments. Since GAs...

Do personality traits predict individual differences in excitatory and inhibitory learning?.

Frontiers in psychology

He Z, Cassaday HJ, Bonardi C, Bibby PA.
PMID: 23658551
Front Psychol. 2013 May 08;4:245. doi: 10.3389/fpsyg.2013.00245. eCollection 2013.

Conditioned inhibition (CI) is demonstrated in classical conditioning when a stimulus is used to signal the omission of an otherwise expected outcome. This basic learning ability is involved in a wide range of normal behavior - and thus its...

Novel Gene Discovery in the Human Malaria Parasite using Nucleosome Positioning Data.

Computational systems bioinformatics. Computational Systems Bioinformatics Conference

Pokhriyal N, Ponts N, Harris EY, Le Roch KG, Lonardi S.
PMID: 25076982
Comput Syst Bioinformatics Conf. 2010 Aug;9:124-135.

Recent genome-wide studies on nucleosome positioning in model organisms have shown strong evidence that nucleosome landscapes in the proximity of protein-coding genes exhibit regular characteristic patterns. Here, we propose a computational framework to discover novel genes in the human...

Assessment of intratumor immune-microenvironment in colorectal cancers with extranodal extension of nodal metastases.

Cancer cell international

Fassan M, Vianello L, Sacchi D, Fanelli GN, Munari G, Scarpa M, Cappellesso R, Loupakis F, Lanza C, Salmaso R, Mescoli C, Valeri N, Agostini M, D'Angelo E, Lonardi S, Pucciarelli S, Veronese N, Luchini C, Rugge M.
PMID: 30202242
Cancer Cell Int. 2018 Sep 06;18:131. doi: 10.1186/s12935-018-0634-8. eCollection 2018.

BACKGROUND: No data is available on the molecular background of the extra-nodal extension (ENE) of lymph node metastasis (LN) in colorectal cancer (CRC).METHODS: A series of 22 ENE-positive CRCs was considered and three samples per case were selected (the...

PD-L1 expression heterogeneity in non-small cell lung cancer: evaluation of small biopsies reliability.

Oncotarget

Munari E, Zamboni G, Marconi M, Sommaggio M, Brunelli M, Martignoni G, Netto GJ, Moretta F, Mingari MC, Salgarello M, Terzi A, Picece V, Pomari C, Lunardi G, Cavazza A, Rossi G, Moretta L, Bogina G.
PMID: 29163815
Oncotarget. 2017 Oct 04;8(52):90123-90131. doi: 10.18632/oncotarget.21485. eCollection 2017 Oct 27.

Immunotherapy with checkpoint inhibitors, allowing recovery of effector cells function, has demonstrated to be highly effective in many tumor types and represents a true revolution in oncology. Recently, the anti-PD1 agent pembrolizumab was granted FDA approval for the first...

A Novel Missense Mutation of the NSD1 Gene Associated with Overgrowth in Three Generations of an Italian Family: Case Report, Differential Diagnosis, and Review of Mutations of NSD1 Gene in Familial Sotos Syndrome.

Frontiers in pediatrics

Laccetta G, Moscuzza F, Michelucci A, Guzzetta A, Lunardi S, Lorenzoni F, Ghirri P.
PMID: 29164086
Front Pediatr. 2017 Nov 07;5:236. doi: 10.3389/fped.2017.00236. eCollection 2017.

Sotos syndrome (SoS) is characterized by overgrowth of prenatal onset, learning disability, and characteristic facial appearance; it is usually due to haploinsufficiency of NSD1 gene at chromosome 5q35. An Italian child was born at 37 weeks of gestation (weight...

Vinorelbine in BRAF V600E mutated metastatic colorectal cancer: a prospective multicentre phase II clinical study.

ESMO open

Cremolini C, Pietrantonio F, Tomasello G, Dadduzio V, Moretto R, Morano F, Schirripa M, Antoniotti C, Fucà G, Bergamo F, Rossini D, Nichetti F, Ziampiri S, Ghidini M, Marmorino F, Prisciandaro M, Falcone A, De Braud F, Loupakis F, Lonardi S.
PMID: 29209533
ESMO Open. 2017 Aug 10;2(3):e000241. doi: 10.1136/esmoopen-2017-000241. eCollection 2017.

BACKGROUND: BRAF V600E mutation defines a specific colorectal cancer (CRC) subgroup with poor prognosis. Promising preclinical data showed synthetically lethal activity of mitotic spindle poisons on PATIENTS AND METHODS: Patients progressed to or not deemed eligible for standard treatments...

Author Correction: The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.

Nature communications

Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, di Cantogno LV, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P.
PMID: 29600801
Nat Commun. 2018 Mar 30;9:16203. doi: 10.1038/ncomms16203.

This corrects the article DOI: 10.1038/ncomms14797.