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Showing 1 to 12 of 36 entries
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chopBAI: BAM index reduction solves I/O bottlenecks in the joint analysis of large sequencing cohorts.

Bioinformatics (Oxford, England)

Kehr B, Melsted P.
PMID: 27153590
Bioinformatics. 2016 Jul 15;32(14):2202-4. doi: 10.1093/bioinformatics/btw149. Epub 2016 Mar 18.

UNLABELLED: Advances in sequencing capacity have led to the generation of unprecedented amounts of genomic data. The processing of this data frequently leads to I/O bottlenecks, e. g. when analyzing a small genomic region across a large number of...

Three overcrowded zinc(II) complexes with potentially hexadentate polypyridyl ligands.

Acta crystallographica. Section C, Crystal structure communications

Hazell A, Mønsted O, Rasmussen JC, Toftlund H.
PMID: 18451470
Acta Crystallogr C. 2008 May;64:m185-9. doi: 10.1107/S0108270108007014. Epub 2008 Apr 09.

In each of [N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine-kappa(6)N]zinc(II) bis(perchlorate) 0.67-hydrate, [Zn(C(26)H(28)N(6))](ClO(4))(2) x 0.67 H(2)O, (I), [N,N,N'-tris(2-pyridylmethyl)-N'-(2-quinolylmethyl)ethane-1,2-diamine-kappa(6)N]zinc(II) bis(perchlorate), [Zn(C(30)H(30)N(6))](ClO(4))(2), (II), and [N,N'-bis(2-pyridylmethyl)-N,N'-bis(2-quinolylmethyl)ethane-1,2-diamine-kappa(6)N]zinc(II) bis(perchlorate) monohydrate, [Zn(C(34)H(32)N(6))](ClO(4))(2) x H(2)O, (III), the Zn atom is coordinated to all six N atoms of the ligand. Compound (I) has...

Experiences with a researcher-centric ELN.

Chemical science

Badiola KA, Bird C, Brocklesby WS, Casson J, Chapman RT, Coles SJ, Cronshaw JR, Fisher A, Frey JG, Gloria D, Grossel MC, Hibbert DB, Knight N, Mapp LK, Marazzi L, Matthews B, Milsted A, Minns RS, Mueller KT, Murphy K, Parkinson T, Quinnell R, Robinson JS, Robertson MN, Robins M, Springate E, Tizzard G, Todd MH, Williamson AE, Willoughby C, Yang E, Ylioja PM.
PMID: 29308130
Chem Sci. 2015 Mar 01;6(3):1614-1629. doi: 10.1039/c4sc02128b. Epub 2014 Oct 20.

Electronic Laboratory Notebooks (ELNs) are progressively replacing traditional paper books in both commercial research establishments and academic institutions. University researchers require specific features from ELNs, given the need to promote cross-institutional collaborative working, to enable the sharing of procedures...

[Cr(III)8M(II)6](12+) Coordination Cubes (M(II)=Cu, Co).

Angewandte Chemie (International ed. in English)

Sanz S, O'Connor HM, Pineda EM, Pedersen KS, Nichol GS, Mønsted O, Weihe H, Piligkos S, McInnes EJ, Lusby PJ, Brechin EK.
PMID: 25891167
Angew Chem Int Ed Engl. 2015 Jun 01;54(23):6761-4. doi: 10.1002/anie.201501041. Epub 2015 Apr 17.

[Cr(III)8M(II)6](12+) (M(II) =Cu, Co) coordination cubes were constructed from a simple [Cr(III) L3 ] metalloligand and a "naked" M(II) salt. The flexibility in the design proffers the potential to tune the physical properties, as all the constituent parts of...

Lifestyle counselling as secondary prevention in patients with minor stroke and transient ischemic attack: study protocol for a randomized controlled pilot study.

Pilot and feasibility studies

Liljehult J, Molsted S, Møller T, Overgaard D, Adamsen L, Jarden M, Christensen T.
PMID: 32226634
Pilot Feasibility Stud. 2020 Mar 25;6:40. doi: 10.1186/s40814-020-00583-4. eCollection 2020.

BACKGROUND: Most patients with minor stroke or transient ischemic attack (TIA) are discharged with little or no specialised follow-up. Nonetheless, these patients have a high prevalence of cognitive impairments and a considerable risk of recurrent stroke. Smoking cessation, physical...

Large-scale integration of the plasma proteome with genetics and disease.

Nature genetics

Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL, Gunnarsdottir K, Helgason A, Oddsson A, Halldorsson BV, Jensson BO, Zink F, Halldorsson GH, Masson G, Arnadottir GA, Katrinardottir H, Juliusson K, Magnusson MK, Magnusson OT, Fridriksdottir R, Saevarsdottir S, Gudjonsson SA, Stacey SN, Rognvaldsson S, Eiriksdottir T, Olafsdottir TA, Steinthorsdottir V, Tragante V, Ulfarsson MO, Stefansson H, Jonsdottir I, Holm H, Rafnar T, Melsted P, Saemundsdottir J, Norddahl GL, Lund SH, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K.
PMID: 34857953
Nat Genet. 2021 Dec;53(12):1712-1721. doi: 10.1038/s41588-021-00978-w. Epub 2021 Dec 02.

The plasma proteome can help bridge the gap between the genome and diseases. Here we describe genome-wide association studies (GWASs) of plasma protein levels measured with 4,907 aptamers in 35,559 Icelanders. We found 18,084 associations between sequence variants and...

Effectiveness and acceptability of a pragmatic exercise intervention for patients with type 2 diabetes in specialized care.

Diabetes research and clinical practice

Nielsen SG, Danielsen JH, Jacobsen SS, Kristensen PL, Storgaard H, Molsted S, Vilsbøll T.
PMID: 34923022
Diabetes Res Clin Pract. 2021 Dec 16;183:109176. doi: 10.1016/j.diabres.2021.109176. Epub 2021 Dec 16.

AIMS: Physical activity improves glycaemic control in type 2 diabetes (T2D), but adherence is low, and diabetes complications are barriers towards adopting physical activity. We investigated adherence and effects of individualized supervised exercise.METHODS: Patients with intermediate (level 2) to...

Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: comparison of dental arch relationships and dental indices at 5, 8, and 10 years.

European journal of orthodontics

Heliövaara A, Küseler A, Skaare P, Bellardie H, Mølsted K, Karsten A, Marcusson A, Rizell S, Brinck E, Sæle P, Chalien MN, Mooney J, Eyres P, Shaw W, Semb G.
PMID: 34476476
Eur J Orthod. 2021 Sep 03; doi: 10.1093/ejo/cjab055. Epub 2021 Sep 03.

BACKGROUND AND TRIAL DESIGN: The Scandcleft intercentre study evaluates the outcomes of four surgical protocols (common method Arm A, and methods B, C, and D) for treatment of children with unilateral cleft lip and palate (UCLP) in a set...

Rare and intractable fibrodysplasia ossificans progressiva shows different PBMC phenotype possibly modulated by ascorbic acid and propranolol treatment.

Intractable & rare diseases research

Nascimento DR, Balaniuc SLB, Palhares DB, Underwood A, Palhares MG, Alves F, Vieira FO, Souza-Fagundes EM, Giuliani LR, Xavier PCN, Puerto HLD, Santos RAS, Milsted A, Brum JM, Silva IS, Martins AS.
PMID: 34466340
Intractable Rare Dis Res. 2021 Aug;10(3):179-189. doi: 10.5582/irdr.2021.01012.

Fibrodysplasia Ossificans Progressiva (FOP) is a rare congenital intractable disease associated with a mutation in

Conformal Fields and Operator Product Expansion in Critical Quantum Spin Chains.

Physical review letters

Zou Y, Milsted A, Vidal G.
PMID: 32058756
Phys Rev Lett. 2020 Jan 31;124(4):040604. doi: 10.1103/PhysRevLett.124.040604.

At a quantum critical point, the low-energy physics of a quantum spin chain is described by conformal field theory (CFT). Given the Hamiltonian of a critical spin chain, we propose a variational method to build an approximate lattice representation...

Inspiratory muscle strength and walking capacity in patients with COPD.

European clinical respiratory journal

Kofod LM, Hage T, Christiansen LH, Skalkam K, Martinez G, Godtfredsen NS, Molsted S.
PMID: 31853341
Eur Clin Respir J. 2019 Dec 09;7(1):1700086. doi: 10.1080/20018525.2019.1700086. eCollection 2020.

No abstract available.

Copper artifacts: correlation with source types of copper ores.

Science (New York, N.Y.)

Friedman AM, Conway M, Kastner M, Milsted J, Metta D, Fields PR, Olsen E.
PMID: 17788029
Science. 1966 Jun 10;152(3728):1504-6. doi: 10.1126/science.152.3728.1504.

Six out of eight minor chemical elements, determined by spectroscopic and neutron-activation techniques, were found to be critical in computing a probability that a given copper artifact was derived from one of three types of copper ore: native metal,...

Showing 1 to 12 of 36 entries