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Showing 1 to 12 of 232 entries
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Learning system design.

The Australasian nurses journal

Maclean CB, Knaggs SJ, Andrews HE, Spilker DD.
PMID: 1045966
Australas Nurses J. 1976 Jan;4(7):6, 16.

No abstract available.

Perioperative communication practices of anesthesiologists: A need to introspect and change.

Anesthesia, essays and researches

Hemanth Kumar VR, Jahagirdar SM, Ravishankar M, Athiraman UK, Maclean J, Parthasarathy S.
PMID: 27212751
Anesth Essays Res. 2016 May-Aug;10(2):223-6. doi: 10.4103/0259-1162.167848.

BACKGROUND: We conducted an audit of various communication practices during perioperative care among anesthesiology resident (R), faculties (F), and private practitioners (PP) in South India. We also documented the level of psycho-social support given to the patient and patient...

Assessing Visuospatial Abilities in Healthy Aging: A Novel Visuomotor Task.

Frontiers in aging neuroscience

de Bruin N, Bryant DC, MacLean JN, Gonzalez CL.
PMID: 26869918
Front Aging Neurosci. 2016 Feb 01;8:7. doi: 10.3389/fnagi.2016.00007. eCollection 2016.

This study examined the efficacy of a novel reaching-and-grasping task in determining visuospatial abilities across adulthood. The task required male and female young (18-25 years) and older adults (60-82 years) to replicate a series of complex models by locating...

Cellular population dynamics control the robustness of the stem cell niche.

Biology open

MacLean AL, Kirk PD, Stumpf MP.
PMID: 26453624
Biol Open. 2015 Oct 09;4(11):1420-6. doi: 10.1242/bio.013714.

Within populations of cells, fate decisions are controlled by an indeterminate combination of cell-intrinsic and cell-extrinsic factors. In the case of stem cells, the stem cell niche is believed to maintain 'stemness' through communication and interactions between the stem...

Epithelial-Mesenchymal Transition in Metastatic Cancer Cell Populations Affects Tumor Dormancy in a Simple Mathematical Model.

Biomedicines

MacLean AL, Harrington HA, Stumpf MPH, Hansen MDH.
PMID: 28548077
Biomedicines. 2014 Dec 09;2(4):384-402. doi: 10.3390/biomedicines2040384.

Signaling from the c-Met receptor tyrosine kinase is associated with progression and metastasis of epithelial tumors. c-Met, the receptor for hepatocyte growth factor, triggers epithelial-mesenchymal transition (EMT) of cultured cells, which is thought to drive migration of tumor cells...

An interactive, bilingual, culturally targeted website about living kidney donation and transplantation for hispanics: development and formative evaluation.

JMIR research protocols

Gordon EJ, Feinglass J, Carney P, Ramirez D, Olivero M, O'Connor K, MacLean J, Brucker J, Caicedo JC.
PMID: 25896143
JMIR Res Protoc. 2015 Apr 20;4(2):e42. doi: 10.2196/resprot.3838.

BACKGROUND: As the kidney shortage continues to grow, patients on the waitlist are increasingly turning to live kidney donors for transplantation. Despite having a disproportionately higher prevalence of end-stage kidney disease (ESKD), fewer waitlisted Hispanic patients received living donor...

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

ACS medicinal chemistry letters

Lim J, Altman MD, Baker J, Brubaker JD, Chen H, Chen Y, Fischmann T, Gibeau C, Kleinschek MA, Leccese E, Lesburg C, Maclean JK, Moy LY, Mulrooney EF, Presland J, Rakhilina L, Smith GF, Steinhuebel D, Yang R.
PMID: 26101574
ACS Med Chem Lett. 2015 Apr 20;6(6):683-8. doi: 10.1021/acsmedchemlett.5b00107. eCollection 2015 Jun 11.

Interleukin-1 receptor associated kinase 4 (IRAK4) is an essential signal transducer downstream of the IL-1R and TLR superfamily, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of inflammatory diseases. A...

Trends over time in enrollment in non-group health insurance plans by tobacco use in the United States.

Preventive medicine reports

Pesko MF, Maclean JC, Kaplan CM, Hill SC.
PMID: 28593122
Prev Med Rep. 2017 May 17;7:46-49. doi: 10.1016/j.pmedr.2017.05.010. eCollection 2017 Sep.

Healthcare.gov was created to facilitate the market for non-group insurance in states that did not establish their own marketplaces. In Healthcare.gov, families are asked to report their tobacco use status, and tobacco use surcharges of up to 50% may...

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

ACS medicinal chemistry letters

Hoyt SB, Park MK, London C, Xiong Y, Tata J, Bennett DJ, Cooke A, Cai J, Carswell E, Robinson J, MacLean J, Brown L, Belshaw S, Clarkson TR, Liu K, Liang GB, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Cai TQ, Stribling S, Pai LY, Ma X, Metzger J, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Buist N, Kuethe J, Rivera N, Clemas J, Zhou G, Gibson J, Maxwell CA, Lassman M, McLaughlin T, Castro-Perez J, Szeto D, Forrest G, Hajdu R, Rosenbach M, Ali A.
PMID: 26005536
ACS Med Chem Lett. 2015 Apr 07;6(5):573-8. doi: 10.1021/acsmedchemlett.5b00054. eCollection 2015 May 14.

We report the discovery of a benzimidazole series of CYP11B2 inhibitors. Hit-to-lead and lead optimization studies identified compounds such as 32, which displays potent CYP11B2 inhibition, high selectivity versus related CYP targets, and good pharmacokinetic properties in rat and...

High-Precision Half-Life Measurements for the Superallowed β^{+} Emitter ^{10}C: Implications for Weak Scalar Currents.

Physical review letters

Dunlop MR, Svensson CE, Ball GC, Grinyer GF, Leslie JR, Andreoiu C, Austin RA, Ballast T, Bender PC, Bildstein V, Diaz Varela A, Dunlop R, Garnsworthy AB, Garrett PE, Hackman G, Hadinia B, Jamieson DS, Laffoley AT, MacLean AD, Miller DM, Mills WJ, Park J, Radich AJ, Rajabali MM, Rand ET, Unsworth C, Valencik A, Wang ZM, Zganjar EF.
PMID: 27176517
Phys Rev Lett. 2016 Apr 29;116(17):172501. doi: 10.1103/PhysRevLett.116.172501. Epub 2016 Apr 28.

Precision measurements of superallowed Fermi β-decay transitions, particularly for the lightest superallowed emitters ^{10}C and ^{14}O, set stringent limits on possible scalar current contributions to the weak interaction. In the present work, a discrepancy between recent measurements of the...

It could be you.

BMJ (Clinical research ed.)

Maclean J.
PMID: 10669471
BMJ. 2000 Feb 12;320(7232):455.

No abstract available.

Association of angiotensin-converting enzyme inhibitor therapy and comorbidity in diabetes: results from the Vermont diabetes information system.

BMC endocrine disorders

Ramos-Nino ME, Maclean CD, Littenberg B.
PMID: 19061507
BMC Endocr Disord. 2008 Dec 05;8:17. doi: 10.1186/1472-6823-8-17.

BACKGROUND: Angiotensin converting enzyme inhibitors (ACE inhibitors) reduce peripheral vascular resistance via blockage of angiotensin converting enzyme (ACE). ACE inhibitors are commonly used to treat congestive heart failure and high blood pressure, but other effects have been reported. In...

Showing 1 to 12 of 232 entries