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Showing 1 to 12 of 47 entries
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The Effect of Nitric Oxide Inhibition in Spinal Cord Injured Humans with and without Preserved Sympathetic Control of the Vasculature.

Frontiers in neuroscience

Brown R, Celermajer D, Macefield V, Sander M.
PMID: 27013957
Front Neurosci. 2016 Mar 10;10:95. doi: 10.3389/fnins.2016.00095. eCollection 2016.

UNLABELLED: Systemic pharmacological inhibition of nitric oxide (NO) causes a hypertensive response, which has been attributed both to inhibition of peripheral NO-mediated vasodilatation and to inhibition of central nervous NO-production leading to a later onset sympathetic vasoconstriction. In the...

Sympathetic Responses to Noxious Stimulation of Muscle and Skin.

Frontiers in neurology

Burton AR, Fazalbhoy A, Macefield VG.
PMID: 27445972
Front Neurol. 2016 Jun 30;7:109. doi: 10.3389/fneur.2016.00109. eCollection 2016.

Acute pain triggers adaptive physiological responses that serve as protective mechanisms that prevent continuing damage to tissues and cause the individual to react to remove or escape the painful stimulus. However, an extension of the pain response beyond signaling...

Firing patterns of muscle vasoconstrictor neurons in respiratory disease.

Frontiers in physiology

Macefield VG.
PMID: 22654767
Front Physiol. 2012 May 23;3:153. doi: 10.3389/fphys.2012.00153. eCollection 2012.

Because the cardiovascular system and respiration are so intimately coupled, disturbances in respiratory control often lead to disturbances in cardiovascular control. Obstructive Sleep Apnea (OSA), Chronic Obstructive Pulmonary Disease (COPD), and Bronchiectasis (BE) are all associated with a greatly...

Vestibular Modulation of Sympathetic Nerve Activity to Muscle and Skin in Humans.

Frontiers in neurology

Hammam E, Macefield VG.
PMID: 28798718
Front Neurol. 2017 Jul 26;8:334. doi: 10.3389/fneur.2017.00334. eCollection 2017.

We review the existence of vestibulosympathetic reflexes in humans. While several methods to activate the human vestibular apparatus have been used, galvanic vestibular stimulation (GVS) is a means of selectively modulating vestibular afferent activity

The Stability and Repeatability of Spontaneous Sympathetic Baroreflex Sensitivity in Healthy Young Individuals.

Frontiers in neuroscience

Hissen SL, Sayed KE, Macefield VG, Brown R, Taylor CE.
PMID: 29962929
Front Neurosci. 2018 Jun 14;12:403. doi: 10.3389/fnins.2018.00403. eCollection 2018.

Spontaneous sympathetic baroreflex sensitivity (BRS) is a valuable tool for assessing how well the baroreflex buffers beat-to-beat changes in blood pressure. However, there has yet to be a study involving appropriate statistical tests to examine the stability of sympathetic...

Association of Short-term Heart Rate Variability and Sudden Unexpected Death in Epilepsy.

Neurology

Sivathamboo S, Friedman D, Laze J, Nightscales R, Chen Z, Kuhlmann L, Devore S, Macefield V, Kwan P, D'Souza W, Berkovic SF, Perucca P, O'Brien TJ, Devinsky O.
PMID: 34649884
Neurology. 2021 Dec 14;97(24):e2357-e2367. doi: 10.1212/WNL.0000000000012946. Epub 2021 Oct 14.

BACKGROUND AND OBJECTIVES: We compared heart rate variability (HRV) in sudden unexpected death in epilepsy (SUDEP) cases and living epilepsy controls.METHODS: This international, multicenter, retrospective, nested case-control study examined patients admitted for video-EEG monitoring (VEM) between January 1, 2003,...

Addressing Gender Equity in Senior Leadership Roles in Translational Science.

ACS pharmacology & translational science

Magliano DJ, Macefield VG, Ellis TM, Calkin AC.
PMID: 32832876
ACS Pharmacol Transl Sci. 2020 Jul 15;3(4):773-779. doi: 10.1021/acsptsci.0c00056. eCollection 2020 Aug 14.

Inequities for women exist across many leverage points of an academic career in science, technology, engineering, mathematics, and medicine (STEMM) disciplines, ranging from poorer success rates at promotion, reduced grant success, and a lower likelihood of invited conference presentations,...

The Role of Central Command in the Increase in Muscle Sympathetic Nerve Activity to Contracting Muscle During High Intensity Isometric Exercise.

Frontiers in neuroscience

Boulton D, Taylor CE, Green S, Macefield VG.
PMID: 34924937
Front Neurosci. 2021 Dec 02;15:770072. doi: 10.3389/fnins.2021.770072. eCollection 2021.

We previously demonstrated that muscle sympathetic nerve activity (MSNA) increases to contracting muscle as well as to non-contracting muscle, but this was only assessed during isometric exercise at ∼10% of maximum voluntary contraction (MVC). Given that high-intensity isometric contractions...

Brainstem Mechanisms of Pain Modulation: A within-Subjects 7T fMRI Study of Placebo Analgesic and Nocebo Hyperalgesic Responses.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Crawford LS, Mills EP, Hanson T, Macey PM, Glarin R, Macefield VG, Keay KA, Henderson LA.
PMID: 34697093
J Neurosci. 2021 Nov 24;41(47):9794-9806. doi: 10.1523/JNEUROSCI.0806-21.2021. Epub 2021 Oct 25.

Pain perception can be powerfully influenced by an individual's expectations and beliefs. Although the cortical circuitry responsible for pain modulation has been thoroughly investigated, the brainstem pathways involved in the modulatory phenomena of placebo analgesia and nocebo hyperalgesia remain...

A systematic review and in-depth analysis of outcome reporting in early phase studies of colorectal cancer surgical innovation.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Hoffmann C, Macefield RC, Wilson N, Blazeby JM, Avery KNL, Potter S, McNair AGK.
PMID: 32882087
Colorectal Dis. 2020 Dec;22(12):1862-1873. doi: 10.1111/codi.15347. Epub 2020 Oct 23.

AIM: Early phase studies are essential to evaluate new technologies prior to randomized evaluation. Evaluation is limited, however, by inconsistent measurement and reporting of outcomes. This study examines outcome reporting in studies of innovative colorectal cancer surgery.METHODS: Systematic searches...

Functional Imaging of the Human Brainstem during Somatosensory Input and Autonomic Output.

Frontiers in human neuroscience

Henderson LA, Macefield VG.
PMID: 24062670
Front Hum Neurosci. 2013 Sep 17;7:569. doi: 10.3389/fnhum.2013.00569.

Over the past half a century, many investigations in experimental animal have explored the functional roles of specific regions in the brainstem. Despite the accumulation of a considerable body of knowledge in, primarily, anesthetized preparations, relatively few studies have...

On the number of preganglionic neurons driving human postganglionic sympathetic neurons: a comparison of modeling and empirical data.

Frontiers in neuroscience

Macefield VG.
PMID: 22164130
Front Neurosci. 2011 Dec 06;5:132. doi: 10.3389/fnins.2011.00132. eCollection 2011.

Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per...

Showing 1 to 12 of 47 entries