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Showing 1 to 12 of 12 entries
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[Distinctive morphological and functional changes in retinal ganglion cells associated with normal aging and early stage of glaucoma].

Vestnik oftalmologii

Zueva MV, Arapiev MU, Tsapenko IV, Lovpache DN, Maglakelidze NM, Lantukh EP.
PMID: 27030432
Vestn Oftalmol. 2016 Jan-Feb;132(1):36-42. doi: 10.17116/oftalma2016132136-42.

UNLABELLED: Early diagnosis of primary open-angle glaucoma (POAG) is closely connected with detection of normal age-related changes in the retina. It is also essential to develop reliable methods for quantitative evaluation of retinal nerve fiber layer (RNFL) thickness and...

Clinical and Immunologic Responses to a B-Cell Epitope Vaccine in Patients with HER2/neu-Overexpressing Advanced Gastric Cancer-Results from Phase Ib Trial IMU.ACS.001.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wiedermann U, Garner-Spitzer E, Chao Y, Maglakelidze M, Bulat I, Dechaphunkul A, Arpornwirat W, Charoentum C, Yen CJ, Yau TC, Tanasanvimon S, Maneechavakajorn J, Sookprasert A, Bai LY, Chou WC, Ungtrakul T, Drinic M, Tobias J, Zielinski CC, Chong L, Ede NJ, Marino MT, Good AJ.
PMID: 33879458
Clin Cancer Res. 2021 Jul 01;27(13):3649-3660. doi: 10.1158/1078-0432.CCR-20-3742. Epub 2021 Apr 20.

PURPOSE: HER2/neu is overexpressed in up to 30% of gastroesophageal adenocarcinomas (GEA) and linked to poor prognosis. Recombinant mAbs to treat HER2/neu-overexpressing cancers are effective with limitations, including resistance and toxicity. Therefore, we developed a therapeutic B-cell epitope vaccine...

A comparison of self-reported to cotinine-detected smoking status among adults in Georgia.

European journal of public health

Williams J, Rakovac I, Loyola E, Sturua L, Maglakelidze N, Gamkrelidze A, Mauer-Stender K, Mikkelsen B, Breda J.
PMID: 32951029
Eur J Public Health. 2020 Oct 01;30(5):1037. doi: 10.1093/eurpub/ckaa160.

No abstract available.

In vivo kinetics and nonradioactive imaging of rapidly proliferating cells in graft-versus-host disease.

JCI insight

Buxbaum NP, Farthing DE, Maglakelidze N, Lizak M, Merkle H, Carpenter AC, Oliver BU, Kapoor V, Castro E, Swan GA, Dos Santos LM, Bouladoux NJ, Bare CV, Flomerfelt FA, Eckhaus MA, Telford WG, Belkaid Y, Bosselut RJ, Gress RE.
PMID: 28614804
JCI Insight. 2017 Jun 15;2(12). doi: 10.1172/jci.insight.92851. eCollection 2017 Jun 15.

Hematopoietic stem cell transplantation (HSCT) offers a cure for cancers that are refractory to chemotherapy and radiation. Most HSCT recipients develop chronic graft-versus-host disease (cGVHD), a systemic alloimmune attack on host organs. Diagnosis is based on clinical signs and...

A combined opiate agonist and antagonist treatment reduces prolactin secreting pituitary tumor growth.

Journal of cell communication and signaling

Maglakelidze G, Wynne O, Sarkar DK.
PMID: 28144772
J Cell Commun Signal. 2017 Sep;11(3):227-232. doi: 10.1007/s12079-017-0374-x. Epub 2017 Jan 31.

Prolactin secreting pituitary adenomas (prolactinomas) is the most common pituitary tumors in humans. Animal studies have identified aggressive prolactinoma development in fetal alcohol exposed rats. We have recently identified a combination treatment of a μ opioid receptor antagonist naltrexone...

Unfriendly Fire: How the Tobacco Industry is Destroying the Future of Our Children.

Acta medica Lituanica

Bush A, Ferkol T, Valiulis A, Mazur A, Chkhaidze I, Maglakelidze T, Sargsyan S, Boyajyan G, Cirstea O, Doan S, Katilov O, Pokhylko V, Dubey L, Poluziorovienė E, Prokopčiuk N, Taminskienė V, Valiulis A.
PMID: 34393624
Acta Med Litu. 2021;28(1):6-18. doi: 10.15388/Amed.2020.28.1.6. Epub 2021 Feb 08.

Tobacco has long been known to be one of the greatest causes of morbidity and mortality in the adults, but the effects on the foetus and young children, which are lifelong, have been less well appreciated. Developing from this...

Myeloprotective Effects of Trilaciclib Among Patients with Small Cell Lung Cancer at Increased Risk of Chemotherapy-Induced Myelosuppression: Pooled Results from Three Phase 2, Randomized, Double-Blind, Placebo-Controlled Studies.

Cancer management and research

Hussein M, Maglakelidze M, Richards DA, Sabatini M, Gersten TA, Lerro K, Sinielnikov I, Spira A, Pritchett Y, Antal JM, Malik R, Beck JT.
PMID: 34408488
Cancer Manag Res. 2021 Aug 09;13:6207-6218. doi: 10.2147/CMAR.S313045. eCollection 2021.

PURPOSE: Trilaciclib is an intravenous cyclin-dependent kinase 4/6 inhibitor indicated to decrease the incidence of chemotherapy-induced myelosuppression (CIM) by protecting hematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myeloprotection). Here, we investigated the myeloprotective effects...

Helsinki by nature: The Nature Step to Respiratory Health.

Clinical and translational allergy

Haahtela T, von Hertzen L, Anto JM, Bai C, Baigenzhin A, Bateman ED, Behera D, Bennoor K, Camargos P, Chavannes N, de Sousa JC, Cruz A, Do Céu Teixeira M, Erhola M, Furman E, Gemicioğlu B, Gonzalez Diaz S, Hellings PW, Jousilahti P, Khaltaev N, Kolek V, Kuna P, La Grutta S, Lan LTT, Maglakelidze T, Masjedi MR, Mihaltan F, Mohammad Y, Nunes E, Nyberg A, Quel J, Rosado-Pinto J, Sagara H, Samolinski B, Schraufnagel D, Sooronbaev T, Tag Eldin M, To T, Valiulis A, Varghese C, Vasankari T, Viegi G, Winders T, Yañez A, Yorgancioğlu A, Yusuf O, Bousquet J, Billo NE.
PMID: 31695865
Clin Transl Allergy. 2019 Oct 30;9:57. doi: 10.1186/s13601-019-0295-2. eCollection 2019.

RESULTS: The concept of the Nature Step has evolved from innovative research indicating, how changed lifestyle in urban surroundings reduces contact with biodiverse environments, impoverishes microbiota, affects immune regulation and increases risk of NCDs. The Nature Step calls for...

Accuracy and cost-effectiveness of different screening strategies for identifying undiagnosed COPD among primary care patients (≥40 years) in China: a cross-sectional screening test accuracy study: findings from the Breathe Well group.

BMJ open

Pan Z, Dickens AP, Chi C, Kong X, Enocson A, G Cooper B, Adab P, Cheng KK, Sitch AJ, Jowett S, Adams R, Correia-de-Sousa J, Farley A, Gale NK, Jolly K, Maglakelidze M, Maglakelidze T, M Martins S, Stavrikj K, Stelmach R, Turner AM, Williams S, E Jordan R.
PMID: 34556515
BMJ Open. 2021 Sep 23;11(9):e051811. doi: 10.1136/bmjopen-2021-051811.

OBJECTIVES: To examine the accuracy and cost-effectiveness of various chronic obstructive pulmonary disease (COPD) screening tests and combinations within a Chinese primary care population.DESIGN: Screening test accuracy study.SETTING: Urban and rural community health centres in four municipalities of China:...

A Review: Does Complement or the Contact System Have a Role in Protection or Pathogenesis of COVID-19?.

Pulmonary therapy

Maglakelidze N, Manto KM, Craig TJ.
PMID: 32405877
Pulm Ther. 2020 Dec;6(2):169-176. doi: 10.1007/s41030-020-00118-5. Epub 2020 May 13.

INTRODUCTION: COVID-19 presentation may include a profound increase in cytokines and associated pneumonia, rapidly progressing to acute respiratory distress syndrome (ARDS). This so-called cytokine storm often leads to refractory edema, respiratory arrest, and death. At present, anti-IL-6, antiviral therapy,...

Clinical and Immunologic Responses to a B-Cell Epitope Vaccine in Patients with HER2/neu-Overexpressing Advanced Gastric Cancer-Results from Phase Ib Trial IMU.ACS.001.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wiedermann U, Garner-Spitzer E, Chao Y, Maglakelidze M, Bulat I, Dechaphunkul A, Arpornwirat W, Charoentum C, Yen CJ, Yau TC, Tanasanvimon S, Maneechavakajorn J, Sookprasert A, Bai LY, Chou WC, Ungtrakul T, Drinic M, Tobias J, Zielinski CC, Chong L, Ede NJ, Marino MT, Good AJ.
PMID: 33879458
Clin Cancer Res. 2021 Jul 01;27(13):3649-3660. doi: 10.1158/1078-0432.CCR-20-3742. Epub 2021 Apr 20.

PURPOSE: HER2/neu is overexpressed in up to 30% of gastroesophageal adenocarcinomas (GEA) and linked to poor prognosis. Recombinant mAbs to treat HER2/neu-overexpressing cancers are effective with limitations, including resistance and toxicity. Therefore, we developed a therapeutic B-cell epitope vaccine...

A planetary health blind spot: the untapped potential of women to safeguard nature and human resilience in LMICs.

The Lancet. Planetary health

de Paula N, Jung L, Mar K, Bowen K, Maglakelidze M, Fünderich M, Otieno M, El Omrani O, Baunach S, Gepp S.
PMID: 33691087
Lancet Planet Health. 2021 Mar;5(3):e109-e110. doi: 10.1016/S2542-5196(21)00007-3. Epub 2021 Mar 07.

No abstract available.

Showing 1 to 12 of 12 entries