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Showing 1 to 9 of 9 entries
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Longitudinal Imaging Using PET/CT with Collagen-I PET-Tracer and MRI for Assessment of Fibrotic and Inflammatory Lesions in a Rat Lung Injury Model.

Journal of clinical medicine

Mahmutovic Persson I, Fransén Pettersson N, Liu J, Falk Håkansson H, Örbom A, In 't Zandt R, Gidlöf R, Sydoff M, von Wachenfeldt K, Olsson LE.
PMID: 33218212
J Clin Med. 2020 Nov 18;9(11). doi: 10.3390/jcm9113706.

Non-invasive imaging biomarkers (IBs) are warranted to enable improved diagnostics and follow-up monitoring of interstitial lung disease (ILD) including drug-induced ILD (DIILD). Of special interest are IB, which can characterize and differentiate acute inflammation from fibrosis. The aim of...

Early Career Members at the ERS Lung Science Conference: cell-matrix interactions in lung disease and regeneration: Early career forum.

Breathe (Sheffield, England)

Almendros I, Alsafadi HN, Bölükbas D, Collins JJP, Duch P, Garrido-Martin EM, Kahn N, Karampitsakos T, Mahmutovic Persson I, Tzouvelekis A, Uhl FE, Bartel S.
PMID: 30131840
Breathe (Sheff). 2018 Jun;14(2):e78-e83. doi: 10.1183/20734735.016818.

No abstract available.

Imaging Biomarkers in Animal Models of Drug-Induced Lung Injury: A Systematic Review.

Journal of clinical medicine

Mahmutovic Persson I, von Wachenfeldt K, Waterton JC, Olsson LE, On Behalf Of The Tristan Consortium.
PMID: 33396865
J Clin Med. 2020 Dec 30;10(1). doi: 10.3390/jcm10010107.

For drug-induced interstitial lung disease (DIILD) translational imaging biomarkers are needed to improve detection and management of lung injury and drug-toxicity. Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung...

Early Career Members at the ERS Lung Science Conference 2020: metabolic alterations in lung ageing and disease.

Breathe (Sheffield, England)

Ogger PP, Silva JD, Aghapour M, Mahmutovic Persson I, Tulen C, Jurkowska R, Ubags ND.
PMID: 33447269
Breathe (Sheff). 2020 Sep;16(3):200063. doi: 10.1183/20734735.0063-2020.

No abstract available.

NFκB1 Dichotomously Regulates Pro-Inflammatory and Antiviral Responses in Asthma.

Journal of innate immunity

Menzel M, Akbarshahi H, Mahmutovic Persson I, Andersson C, Puthia M, Uller L.
PMID: 34350857
J Innate Immun. 2021 Jul 28;1-10. doi: 10.1159/000517847. Epub 2021 Jul 28.

Asthma exacerbations are commonly triggered by rhinovirus infections. Viruses can activate the NFκB pathway resulting in airway inflammation and increased Th2 cytokine expression. NFκB signaling is also involved in early activation of IFNβ, which is a central mediator of...

NFκB1 Dichotomously Regulates Pro-Inflammatory and Antiviral Responses in Asthma.

Journal of innate immunity

Menzel M, Akbarshahi H, Mahmutovic Persson I, Andersson C, Puthia M, Uller L.
PMID: 34350857
J Innate Immun. 2021 Jul 28;1-10. doi: 10.1159/000517847. Epub 2021 Jul 28.

Asthma exacerbations are commonly triggered by rhinovirus infections. Viruses can activate the NFκB pathway resulting in airway inflammation and increased Th2 cytokine expression. NFκB signaling is also involved in early activation of IFNβ, which is a central mediator of...

Early Career Members at the Lung Science Conference and the Sleep and Breathing Conference 2019.

Breathe (Sheffield, England)

Almendros I, El-Merhie N, Jha A, Keir HR, Lykouras D, Mahmutovic Persson I, Ubags ND, Bartel S.
PMID: 31508161
Breathe (Sheff). 2019 Sep;15(3):234-240. doi: 10.1183/20734735.0203-2019.

No abstract available.

Caspase-1 deficiency reduces eosinophilia and interleukin-33 in an asthma exacerbation model.

ERJ open research

Menzel M, Akbarshahi H, Mahmutovic Persson I, Puthia M, Bjermer L, Uller L.
PMID: 29204432
ERJ Open Res. 2017 Oct 16;3(4). doi: 10.1183/23120541.00047-2017. eCollection 2017 Oct.

Rhinovirus infections are common triggers of asthma exacerbations. Viruses can activate the inflammasome, resulting in processing and activation of caspase-1. This recruitment triggers production of interleukin (IL)-1β and IL-18, which have been implicated in asthma. Elucidating the involvement of...

Imaging Biomarkers and Pathobiological Profiling in a Rat Model of Drug-Induced Interstitial Lung Disease Induced by Bleomycin.

Frontiers in physiology

Mahmutovic Persson I, Falk Håkansson H, Örbom A, Liu J, von Wachenfeldt K, Olsson LE.
PMID: 32636756
Front Physiol. 2020 Jun 19;11:584. doi: 10.3389/fphys.2020.00584. eCollection 2020.

A large number of systemically administered drugs have the potential to cause drug-induced interstitial lung disease (DIILD). We aim to characterize a model of DIILD in the rat and develop imaging biomarkers (IBs) for detection and quantification of DIILD....

Showing 1 to 9 of 9 entries