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Showing 1 to 12 of 134 entries
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CytoJournal

De Luca C, Vigliar E, d'Anna M, Pisapia P, Bellevicine C, Malapelle U, Troncone G.
PMID: 28331530
Cytojournal. 2017 Feb 24;14:5. doi: 10.4103/1742-6413.200936. eCollection 2017.

BACKGROUND: Molecular techniques are relevant to modern cytopathology, but their implementation is difficult without molecular expertise and infrastructure. The assessment of MATERIALS AND METHODS: This study aims to validate this methodology to detect RESULTS: The same 11 mutations (CONCLUSION:...

Detection of epidermal growth factor receptor mutations in circulating tumor DNA: reviewing BENEFIT clinical trial.

Journal of thoracic disease

Malapelle U, Raez LE, Serrano MJ, Rolfo C.
PMID: 30746171
J Thorac Dis. 2018 Dec;10(12):6388-6391. doi: 10.21037/jtd.2018.11.22.

No abstract available.

The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice.

Critical reviews in oncology/hematology

De Maglio G, Pasello G, Dono M, Fiorentino M, Follador A, Sciortino M, Malapelle U, Tiseo M.
PMID: 34856311
Crit Rev Oncol Hematol. 2021 Nov 29;169:103561. doi: 10.1016/j.critrevonc.2021.103561. Epub 2021 Nov 29.

The increasing number of approved drugs along with next generation sequencing (NGS) technologies look out as potential revolution of biomolecular characterization of non-small-cell lung cancer (NSCLC). Nevertheless, several aspects impact on success rate of NGS in clinical practice: a...

Moving towards a local testing solution for undetermined thyroid fine-needle aspirates: validation of a novel custom DNA-based NGS panel.

Journal of clinical pathology

Sgariglia R, Nacchio M, Migliatico I, Vigliar E, Malapelle U, Pisapia P, De Luca C, Iaccarino A, Salvatore D, Masone S, Troncone G, Bellevicine C.
PMID: 33789920
J Clin Pathol. 2021 Mar 31; doi: 10.1136/jclinpath-2021-207429. Epub 2021 Mar 31.

CONCLUSION: Our comparative analysis indicates that

TargetPlex FFPE-Direct DNA Library Preparation Kit for SiRe NGS panel: an international performance evaluation study.

Journal of clinical pathology

Malapelle U, Pepe F, Pisapia P, Sgariglia R, Nacchio M, Barberis M, Bilh M, Bubendorf L, Büttner R, Cabibi D, Castiglia M, De Andrea CE, de Biase D, Dumur CI, Fontanini G, Freire J, Gristina V, Hofman P, Ilie M, Lozano MD, Merkelbach-Bruse S, Pappesch R, Pelusi N, Roma G, Russo A, Savic S, Siemanowski J, Tallini G, Tischler V, Vander Borght S, Weynand B, Xu T, Troncone G.
PMID: 33766954
J Clin Pathol. 2021 Mar 25; doi: 10.1136/jclinpath-2021-207450. Epub 2021 Mar 25.

AIM: Next generation sequencing (NGS) represents a key diagnostic tool to identify clinically relevant gene alterations for treatment-decision making in cancer care. However, the complex manual workflow required for NGS has limited its implementation in routine clinical practice. In...

Performance evaluation of a fully closed real-time PCR platform for the detection of KRAS p.G12C mutations in liquid biopsy of patients with non-small cell lung cancer.

Journal of clinical pathology

Gragnano G, Nacchio M, Sgariglia R, Conticelli F, Iaccarino A, De Luca C, Troncone G, Malapelle U.
PMID: 33649142
J Clin Pathol. 2021 Mar 01; doi: 10.1136/jclinpath-2021-207416. Epub 2021 Mar 01.

Whenever tissue sample is not available, non-small cell lung cancer (NSCLC) biomarker testing is performed with liquid biopsy. The Kirsten rat sarcoma viral oncogene homolog (

Next Generation Sequencing in Cytopathology: Focus on Non-Small Cell Lung Cancer.

Frontiers in medicine

Pisapia P, Pepe F, Iaccarino A, Sgariglia R, Nacchio M, Conticelli F, Salatiello M, Tufano R, Russo G, Gragnano G, Girolami I, Eccher A, Malapelle U, Troncone G.
PMID: 33644101
Front Med (Lausanne). 2021 Feb 11;8:633923. doi: 10.3389/fmed.2021.633923. eCollection 2021.

Molecular cytopathology is a rapidly evolving field embracing both conventional microscopy and molecular pathology. Its growing popularity stems from the fact that in many types of advanced cancers, including non small cell lung cancer (NSCLC), cytological samples often constitute...

The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies.

Critical reviews in oncology/hematology

Russo A, Incorvaia L, Capoluongo E, Tagliaferri P, Galvano A, Del Re M, Malapelle U, Chiari R, Conte P, Danesi R, Fassan M, Ferrara R, Genuardi M, Ghiorzo P, Gori S, Guadagni F, Marchetti A, Marchetti P, Midiri M, Normanno N, Passiglia F, Pinto C, Silvestris N, Tallini G, Vatrano S, Vincenzi B, Cinieri S, Beretta G.
PMID: 34896250
Crit Rev Oncol Hematol. 2021 Dec 08;169:103567. doi: 10.1016/j.critrevonc.2021.103567. Epub 2021 Dec 08.

The development of innovative technologies and the advances in the genetics and genomics, have offered new opportunities for personalized treatment in oncology. Although the selection of the patient based on the molecular characteristics of the neoplasm has the potential...

The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice.

Critical reviews in oncology/hematology

De Maglio G, Pasello G, Dono M, Fiorentino M, Follador A, Sciortino M, Malapelle U, Tiseo M.
PMID: 34856311
Crit Rev Oncol Hematol. 2021 Nov 29;169:103561. doi: 10.1016/j.critrevonc.2021.103561. Epub 2021 Nov 29.

The increasing number of approved drugs along with next generation sequencing (NGS) technologies look out as potential revolution of biomolecular characterization of non-small-cell lung cancer (NSCLC). Nevertheless, several aspects impact on success rate of NGS in clinical practice: a...

BRCA1/2 NGS Somatic Testing in Clinical Practice: A Short Report.

Genes

Pepe F, Pisapia P, Russo G, Nacchio M, Pallante P, Vigliar E, De Angelis C, Insabato L, Bellevicine C, De Placido S, Troncone G, Malapelle U.
PMID: 34946865
Genes (Basel). 2021 Nov 28;12(12). doi: 10.3390/genes12121917.

High-grade serous ovarian carcinoma (HGSOC) is the most common subtype of all ovarian carcinomas. HGSOC harboring

Harmonization of Next-Generation Sequencing Procedure in Italian Laboratories: A Multi-Institutional Evaluation of the SiRe® Panel.

Frontiers in oncology

Malapelle U, Pepe F, Pisapia P, Sgariglia R, Nacchio M, De Luca C, Lacalamita R, Tommasi S, Pinto R, Palomba G, Palmieri G, Vacirca D, Barberis M, Bottillo I, Grammatico P, Grillo LR, Costa V, Smeraglio R, Bruzzese D, Troncone G.
PMID: 32219061
Front Oncol. 2020 Mar 11;10:236. doi: 10.3389/fonc.2020.00236. eCollection 2020.

No abstract available.

Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study.

Critical reviews in oncology/hematology

Pisapia P, Pepe F, Baggi A, Barberis M, Galvano A, Gristina V, Mastrilli F, Novello S, Pagni F, Pasini S, Perrone G, Righi D, Russo A, Troncone G, Malapelle U.
PMID: 34813925
Crit Rev Oncol Hematol. 2021 Nov 20;169:103525. doi: 10.1016/j.critrevonc.2021.103525. Epub 2021 Nov 20.

AIMS: The KWAY project aims to investigate the economic sustainability of the up-front NGS technologies adoption in the analysis of clinically relevant molecular alterations in NSCLC patients.METHODS: The diagnostic workflow and the related sustained costs of five Italian referral...

Showing 1 to 12 of 134 entries