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Showing 1 to 12 of 18 entries
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Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates.

Organic letters

Mampuys P, Zhu Y, Sergeyev S, Ruijter E, Orru RV, Van Doorslaer S, Maes BU.
PMID: 27276236
Org Lett. 2016 Jun 17;18(12):2808-11. doi: 10.1021/acs.orglett.6b01023. Epub 2016 Jun 08.

A new method for the synthesis of secondary thiocarbamates from readily available isocyanides and thiosulfonates with broad functional group tolerance is reported. The reaction proceeds under mild reaction conditions in isopropanol and is catalyzed by inexpensive sodium iodide.

Synthesis of Secondary Amides from Thiocarbamates.

Organic letters

Mampuys P, Ruijter E, Orru RVA, Maes BUW.
PMID: 29975068
Org Lett. 2018 Jul 20;20(14):4235-4239. doi: 10.1021/acs.orglett.8b01654. Epub 2018 Jul 05.

The synthesis of secondary amides from readily accessible and bench-stable substituted S-phenyl thiocarbamates and Grignard reactants is reported. Oxidative workup allows recycling of the thiolate leaving group as diphenyl disulfide. Diphenyl disulfide can be transformed into S-phenyl benzenethiosulfonate, a...

Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion.

Organic letters

Collet JW, Morel B, Lin HC, Roose TR, Mampuys P, Orru RVA, Ruijter E, Maes BUW.
PMID: 31942797
Org Lett. 2020 Feb 07;22(3):914-919. doi: 10.1021/acs.orglett.9b04387. Epub 2020 Jan 16.

A robust nickel-catalyzed oxidative isocyanide insertion/C-H amination by reaction of readily available

C(sp.

Organic & biomolecular chemistry

Akulov AA, Varaksin MV, Mampuys P, Charushin VN, Chupakhin ON, Maes BUW.
PMID: 33026389
Org Biomol Chem. 2021 Jan 21;19(2):297-312. doi: 10.1039/d0ob01580f.

Direct C(sp2)-H functionalization of the endocyclic azomethine and aldonitrone moieties in non-aromatic azaheterocycles has established itself as a promising methodology over the last decade. Transition metal-catalyzed cross-coupling reactions, α-metalation-electrophile quenching protocols, and (metal-free) nucleophilic substitution of hydrogen reactions (SNH)...

Correction to: Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in "relapse prone" male rats.

Psychopharmacology

Kuhn BN, Campus P, Klumpner MS, Chang SE, Iglesias AG, Flagel SB.
PMID: 34286346
Psychopharmacology (Berl). 2021 Jul 21; doi: 10.1007/s00213-021-05919-3. Epub 2021 Jul 21.

No abstract available.

Low-volume walking HIIT: Efficient strategy to improve physical capacity and reduce the risk of cardiovascular disease in older women with type 2 diabetes.

Diabetes & metabolic syndrome

Marcotte-Chénard A, Tremblay D, Mony MM, Brochu M, Dionne IJ, Langlois MF, Mampuya W, Morais J, Tessier D, Riesco E.
PMID: 34364301
Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102233. doi: 10.1016/j.dsx.2021.102233. Epub 2021 Jul 30.

BACKGROUND AND AIMS: To compare the effect of a low-volume walking high-intensity interval training (HIIT) to moderate-intensity continuous training (MICT) on risk of cardiovascular diseases and physical capacity in older women with type 2 diabetes (T2D).METHODS: Thirty inactive older...

Functional and Dysfunctional Neuroplasticity in Learning to Cope with Stress.

Brain sciences

Cabib S, Campus P, Conversi D, Orsini C, Puglisi-Allegra S.
PMID: 32102272
Brain Sci. 2020 Feb 24;10(2). doi: 10.3390/brainsci10020127.

In this brief review, we present evidence of the primary role of learning-associated plasticity in the development of either adaptive or maladaptive coping strategies. Successful interactions with novel stressors foster plasticity within the neural circuits supporting acquisition, consolidation, retrieval,...

Stress-Induced Reduction of Dorsal Striatal D2 Dopamine Receptors Prevents Retention of a Newly Acquired Adaptive Coping Strategy.

Frontiers in pharmacology

Campus P, Canterini S, Orsini C, Fiorenza MT, Puglisi-Allegra S, Cabib S.
PMID: 28955227
Front Pharmacol. 2017 Sep 12;8:621. doi: 10.3389/fphar.2017.00621. eCollection 2017.

The inability to learn an adaptive coping strategy in a novel stressful condition leads to dysfunctional stress coping, a marker of mental disturbances. This study tested the involvement of dorsal striatal dopamine receptors in the dysfunctional coping with the...

Atenolol's Inferior Ability to Reduce Central vs Peripheral Blood Pressure Can Be Explained by the Combination of Its Heart Rate-Dependent and Heart Rate-Independent Effects.

International journal of hypertension

Teeäär T, Serg M, Paapstel K, Vähi M, Kals J, Cockcroft JR, Zilmer M, Eha J, Kampus P.
PMID: 32395337
Int J Hypertens. 2020 Apr 26;2020:4259187. doi: 10.1155/2020/4259187. eCollection 2020.

OBJECTIVE: Whether the inferior ability of atenolol to reduce central (aortic) compared to peripheral (brachial) blood pressure (BP) is related to its heart rate (HR)-dependent or -independent effects, or their combination, remains unclear. To provide further mechanistic insight into...

Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in "relapse prone" male rats.

Psychopharmacology

Kuhn BN, Campus P, Klumpner MS, Chang SE, Iglesias AG, Flagel SB.
PMID: 34181035
Psychopharmacology (Berl). 2021 Jun 28; doi: 10.1007/s00213-021-05894-9. Epub 2021 Jun 28.

RATIONALE: Relapse often occurs when individuals are exposed to stimuli or cues previously associated with the drug-taking experience. The ability of drug cues to trigger relapse is believed to be a consequence of incentive salience attribution, a process by...

Repetitive and Inflexible Active Coping and Addiction-like Neuroplasticity in Stressed Mice of a Helplessness-Resistant Inbred Strain.

Behavioral sciences (Basel, Switzerland)

Cabib S, Campus P, Latagliata EC, Orsini C, Tarmati V.
PMID: 34940109
Behav Sci (Basel). 2021 Dec 10;11(12). doi: 10.3390/bs11120174.

Dysfunctional coping styles are involved in the development, persistence, and relapse of psychiatric diseases. Passive coping with stress challenges (helplessness) is most commonly used in animal models of dysfunctional coping, although active coping strategies are associated with generalized anxiety...

Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats.

Diabetology & metabolic syndrome

Salum E, Butlin M, Kals J, Zilmer M, Eha J, Avolio AP, Arend A, Aunapuu M, Kampus P.
PMID: 24920962
Diabetol Metab Syndr. 2014 May 20;6:57. doi: 10.1186/1758-5996-6-57. eCollection 2014.

BACKGROUND: Prevention or attenuation of diabetic vascular complications includes anti-hypertensive treatment with renin-angiotensin system inhibitors on account of their protective effects beyond blood pressure reduction. The present study aimed to investigate the effects of telmisartan, an angiotensin II type...

Showing 1 to 12 of 18 entries