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Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor.

ACS medicinal chemistry letters

Cho YS, Levell JR, Liu G, Caferro T, Sutton J, Shafer CM, Costales A, Manning JR, Zhao Q, Sendzik M, Shultz M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Kulathila R, Xie X, Dodd S, Gould T, Liang G, Heimbach T, Slocum K, Firestone B, Pu M, Pagliarini R, Growney JD.
PMID: 29057061
ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121. doi: 10.1021/acsmedchemlett.7b00342. eCollection 2017 Oct 12.

Inhibition of mutant IDH1 is being evaluated clinically as a promising treatment option for various cancers with hotspot mutation at Arg

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Cho YS, Levell JR, Liu G, et al. Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Med Chem Lett. 2017;8(10):1116-1121doi: 10.1021/acsmedchemlett.7b00342.
Cho, Y. S., Levell, J. R., Liu, G., Caferro, T., Sutton, J., Shafer, C. M., Costales, A., Manning, J. R., Zhao, Q., Sendzik, M., Shultz, M., Chenail, G., Dooley, J., Villalba, B., Farsidjani, A., Chen, J., Kulathila, R., Xie, X., Dodd, S., Gould, T., Liang, G., Heimbach, T., Slocum, K., Firestone, B., Pu, M., Pagliarini, R., & Growney, J. D. (2017). Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS medicinal chemistry letters, 8(10), 1116-1121. https://doi.org/10.1021/acsmedchemlett.7b00342
Cho, Young Shin, et al. "Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor." ACS medicinal chemistry letters vol. 8,10 (2017): 1116-1121. doi: https://doi.org/10.1021/acsmedchemlett.7b00342
Cho YS, Levell JR, Liu G, Caferro T, Sutton J, Shafer CM, Costales A, Manning JR, Zhao Q, Sendzik M, Shultz M, Chenail G, Dooley J, Villalba B, Farsidjani A, Chen J, Kulathila R, Xie X, Dodd S, Gould T, Liang G, Heimbach T, Slocum K, Firestone B, Pu M, Pagliarini R, Growney JD. Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Med Chem Lett. 2017 Sep 18;8(10):1116-1121. doi: 10.1021/acsmedchemlett.7b00342. eCollection 2017 Oct 12. PMID: 29057061; PMCID: PMC5641959.
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Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study.

Intractable & rare diseases research

Chamali B, Finnamore H, Manning R, Laffan MA, Hickson M, Whelan K, Shovlin CL.
PMID: 27195194
Intractable Rare Dis Res. 2016 May;5(2):109-13. doi: 10.5582/irdr.2016.01019.

Understanding potential provocations of haemorrhage is important in a range of clinical settings, and particularly for people with abnormal vasculature. Patients with hereditary haemorrhagic telangiectasia (HHT) can report haemorrhage from nasal telangiectasia in real time, and suggested dietary factors...

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Chamali B, Finnamore H, Manning R, et al. Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study. Intractable Rare Dis Res. 2016;5(2):109-13doi: 10.5582/irdr.2016.01019.
Chamali, B., Finnamore, H., Manning, R., Laffan, M. A., Hickson, M., Whelan, K., & Shovlin, C. L. (2016). Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study. Intractable & rare diseases research, 5(2), 109-13. https://doi.org/10.5582/irdr.2016.01019
Chamali, Basel, et al. "Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study." Intractable & rare diseases research vol. 5,2 (2016): 109-13. doi: https://doi.org/10.5582/irdr.2016.01019
Chamali B, Finnamore H, Manning R, Laffan MA, Hickson M, Whelan K, Shovlin CL. Dietary supplement use and nosebleeds in hereditary haemorrhagic telangiectasia - an observational study. Intractable Rare Dis Res. 2016 May;5(2):109-13. doi: 10.5582/irdr.2016.01019. PMID: 27195194; PMCID: PMC4869576.
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Group health coaching: strengths, challenges, and next steps.

Global advances in health and medicine

Armstrong C, Wolever RQ, Manning L, Elam R, Moore M, Frates EP, Duskey H, Anderson C, Curtis RL, Masemer S, Lawson K.
PMID: 24416678
Glob Adv Health Med. 2013 May;2(3):95-102. doi: 10.7453/gahmj.2013.019.

There is great need for cost effective approaches to increase patient engagement and improve health and well-being. Health and wellness coaching has recently demonstrated great promise, but the majority of studies to date have focused on individual coaching (ie,...

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Armstrong C, Wolever RQ, Manning L, et al. Group health coaching: strengths, challenges, and next steps. Glob Adv Health Med. 2013;2(3):95-102doi: 10.7453/gahmj.2013.019.
Armstrong, C., Wolever, R. Q., Manning, L., Elam, R., Moore, M., Frates, E. P., Duskey, H., Anderson, C., Curtis, R. L., Masemer, S., & Lawson, K. (2013). Group health coaching: strengths, challenges, and next steps. Global advances in health and medicine, 2(3), 95-102. https://doi.org/10.7453/gahmj.2013.019
Armstrong, Colin, et al. "Group health coaching: strengths, challenges, and next steps." Global advances in health and medicine vol. 2,3 (2013): 95-102. doi: https://doi.org/10.7453/gahmj.2013.019
Armstrong C, Wolever RQ, Manning L, Elam R, Moore M, Frates EP, Duskey H, Anderson C, Curtis RL, Masemer S, Lawson K. Group health coaching: strengths, challenges, and next steps. Glob Adv Health Med. 2013 May;2(3):95-102. doi: 10.7453/gahmj.2013.019. PMID: 24416678; PMCID: PMC3833535.
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Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression.

Cancers

O' Callaghan C, Fanning LJ, Barry OP.
PMID: 26512696
Cancers (Basel). 2015 Oct 23;7(4):2124-33. doi: 10.3390/cancers7040881.

The loss of tumour suppressor gene function is a hallmark of malignant transformation and can occur by a variety of genetic and/or epigenetic alterations. We have previously characterised p38δ mitogen-activated protein kinase (MAPK) as a tumour suppressor in oesophageal...

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O' Callaghan C, Fanning LJ, Barry OP. Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression. Cancers (Basel). 2015;7(4):2124-33doi: 10.3390/cancers7040881.
O' Callaghan, C., Fanning, L. J., & Barry, O. P. (2015). Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression. Cancers, 7(4), 2124-33. https://doi.org/10.3390/cancers7040881
O' Callaghan, Carol, et al. "Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression." Cancers vol. 7,4 (2015): 2124-33. doi: https://doi.org/10.3390/cancers7040881
O' Callaghan C, Fanning LJ, Barry OP. Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression. Cancers (Basel). 2015 Oct 23;7(4):2124-33. doi: 10.3390/cancers7040881. PMID: 26512696; PMCID: PMC4695881.
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Confirmatory Factor Analysis and Multiple Linear Regression of the Neck Disability Index: Assessment If Subscales Are Equally Relevant in Whiplash and Nonspecific Neck Pain.

Journal of chiropractic medicine

Croft AC, Milam B, Meylor J, Manning R.
PMID: 27330510
J Chiropr Med. 2016 Jun;15(2):87-94. doi: 10.1016/j.jcm.2016.04.010. Epub 2016 May 25.

OBJECTIVE: Because of previously published recommendations to modify the Neck Disability Index (NDI), we evaluated the responsiveness and dimensionality of the NDI within a population of adult whiplash-injured subjects. The purpose of the present study was to evaluate the...

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Croft AC, Milam B, Meylor J, et al. Confirmatory Factor Analysis and Multiple Linear Regression of the Neck Disability Index: Assessment If Subscales Are Equally Relevant in Whiplash and Nonspecific Neck Pain. J Chiropr Med. 2016;15(2):87-94doi: 10.1016/j.jcm.2016.04.010.
Croft, A. C., Milam, B., Meylor, J., & Manning, R. (2016). Confirmatory Factor Analysis and Multiple Linear Regression of the Neck Disability Index: Assessment If Subscales Are Equally Relevant in Whiplash and Nonspecific Neck Pain. Journal of chiropractic medicine, 15(2), 87-94. https://doi.org/10.1016/j.jcm.2016.04.010
Croft, Arthur C, et al. "Confirmatory Factor Analysis and Multiple Linear Regression of the Neck Disability Index: Assessment If Subscales Are Equally Relevant in Whiplash and Nonspecific Neck Pain." Journal of chiropractic medicine vol. 15,2 (2016): 87-94. doi: https://doi.org/10.1016/j.jcm.2016.04.010
Croft AC, Milam B, Meylor J, Manning R. Confirmatory Factor Analysis and Multiple Linear Regression of the Neck Disability Index: Assessment If Subscales Are Equally Relevant in Whiplash and Nonspecific Neck Pain. J Chiropr Med. 2016 Jun;15(2):87-94. doi: 10.1016/j.jcm.2016.04.010. Epub 2016 May 25. PMID: 27330510; PMCID: PMC4913116.
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Intermolecular O-H...O and C-H...pi(C5H5), and intramolecular C-H...O interactions in 2-(ferrocenyl)thiophene-3-carboxylic acid.

Acta crystallographica. Section C, Crystal structure communications

Gallagher JF, Hudson RD, Manning AR.
PMID: 11173386
Acta Crystallogr C. 2001 Jan;57:28-30. doi: 10.1107/s0108270100014360.

The title compound, [Fe(C5H5)(C10H7O2S)], an important precursor en route to organometallic donor-pi-acceptor systems, forms dimers in the solid state through cyclic intermolecular carboxylic acid O-H...O hydrogen bonds, graph set R2(2)(8) [O...O 2.661 (2) A and O-H...O 175 degrees ]....

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Gallagher JF, Hudson RD, Manning AR. Intermolecular O-H...O and C-H...pi(C5H5), and intramolecular C-H...O interactions in 2-(ferrocenyl)thiophene-3-carboxylic acid. Acta Crystallogr C. 2001;57:28-30doi: 10.1107/s0108270100014360.
Gallagher , J. F., Hudson , R. D., & Manning , A. R. (2001). Intermolecular O-H...O and C-H...pi(C5H5), and intramolecular C-H...O interactions in 2-(ferrocenyl)thiophene-3-carboxylic acid. Acta crystallographica. Section C, Crystal structure communications, 5728-30. https://doi.org/10.1107/s0108270100014360
Gallagher , J F, et al. "Intermolecular O-H...O and C-H...pi(C5H5), and intramolecular C-H...O interactions in 2-(ferrocenyl)thiophene-3-carboxylic acid." Acta crystallographica. Section C, Crystal structure communications vol. 57 (2001): 28-30. doi: https://doi.org/10.1107/s0108270100014360
Gallagher JF, Hudson RD, Manning AR. Intermolecular O-H...O and C-H...pi(C5H5), and intramolecular C-H...O interactions in 2-(ferrocenyl)thiophene-3-carboxylic acid. Acta Crystallogr C. 2001 Jan;57:28-30. doi: 10.1107/s0108270100014360. PMID: 11173386.
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The physical science behind climate change.

Scientific American

Collins W, Colman R, Haywood J, Manning MR, Mote P.
PMID: 17894174
Sci Am. 2007 Aug;297(2):64-73. doi: 10.1038/scientificamerican0807-64.

No abstract available.

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Collins W, Colman R, Haywood J, et al. The physical science behind climate change. Sci Am. 2007;297(2):64-73doi: 10.1038/scientificamerican0807-64.
Collins, W., Colman, R., Haywood, J., Manning, M. R., & Mote, P. (2007). The physical science behind climate change. Scientific American, 297(2), 64-73. https://doi.org/10.1038/scientificamerican0807-64
Collins, William, et al. "The physical science behind climate change." Scientific American vol. 297,2 (2007): 64-73. doi: https://doi.org/10.1038/scientificamerican0807-64
Collins W, Colman R, Haywood J, Manning MR, Mote P. The physical science behind climate change. Sci Am. 2007 Aug;297(2):64-73. doi: 10.1038/scientificamerican0807-64. PMID: 17894174.
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A SUPERVISED PSYCHOTHERAPY COURSE FOR PRACTICING PHYSICIANS.

Journal of medical education

ENELOW AJ, ADLER LM, MANNING PR.
PMID: 14121251
J Med Educ. 1964 Feb;39:140-6.

No abstract available.

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ENELOW AJ, ADLER LM, MANNING PR. A SUPERVISED PSYCHOTHERAPY COURSE FOR PRACTICING PHYSICIANS. J Med Educ. 1964;39:140-6
ENELOW, A. J., ADLER, L. M., & MANNING, P. R. (1964). A SUPERVISED PSYCHOTHERAPY COURSE FOR PRACTICING PHYSICIANS. Journal of medical education, 39140-6.
ENELOW, A J, et al. "A SUPERVISED PSYCHOTHERAPY COURSE FOR PRACTICING PHYSICIANS." Journal of medical education vol. 39 (1964): 140-6.
ENELOW AJ, ADLER LM, MANNING PR. A SUPERVISED PSYCHOTHERAPY COURSE FOR PRACTICING PHYSICIANS. J Med Educ. 1964 Feb;39:140-6. PMID: 14121251.
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Evaluating U.S. National Heritage Areas: theory, methods, and application.

Environmental management

Laven D, Ventriss C, Manning R, Mitchell N.
PMID: 20567857
Environ Manage. 2010 Aug;46(2):195-212. doi: 10.1007/s00267-010-9514-2. Epub 2010 Jun 22.

Like many governmental actors in recent decades, the U.S. National Park Service (NPS) has operated increasingly through partnerships with other state and federal agencies, non-governmental organizations (NGOs), community groups, and private sector corporations. Perhaps the most salient example of...

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Laven D, Ventriss C, Manning R, et al. Evaluating U.S. National Heritage Areas: theory, methods, and application. Environ Manage. 2010;46(2):195-212doi: 10.1007/s00267-010-9514-2.
Laven, D., Ventriss, C., Manning, R., & Mitchell, N. (2010). Evaluating U.S. National Heritage Areas: theory, methods, and application. Environmental management, 46(2), 195-212. https://doi.org/10.1007/s00267-010-9514-2
Laven, Daniel, et al. "Evaluating U.S. National Heritage Areas: theory, methods, and application." Environmental management vol. 46,2 (2010): 195-212. doi: https://doi.org/10.1007/s00267-010-9514-2
Laven D, Ventriss C, Manning R, Mitchell N. Evaluating U.S. National Heritage Areas: theory, methods, and application. Environ Manage. 2010 Aug;46(2):195-212. doi: 10.1007/s00267-010-9514-2. Epub 2010 Jun 22. PMID: 20567857.
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FMRI contributions to addressing autobiographical memory impairment in temporal lobe pathology.

World journal of radiology

Denkova EJ, Manning L.
PMID: 24778771
World J Radiol. 2014 Apr 28;6(4):93-105. doi: 10.4329/wjr.v6.i4.93.

Episodic autobiographical memory (AM) allows one, through the recollection of sensory-perceptual details, thoughts and feelings, to become aware of an event as belonging to one's own past as well as being able to project into one's future. Because AM...

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Denkova EJ, Manning L. FMRI contributions to addressing autobiographical memory impairment in temporal lobe pathology. World J Radiol. 2014;6(4):93-105doi: 10.4329/wjr.v6.i4.93.
Denkova, E. J., & Manning, L. (2014). FMRI contributions to addressing autobiographical memory impairment in temporal lobe pathology. World journal of radiology, 6(4), 93-105. https://doi.org/10.4329/wjr.v6.i4.93
Denkova, Ekaterina J, and Manning, Liliann. "FMRI contributions to addressing autobiographical memory impairment in temporal lobe pathology." World journal of radiology vol. 6,4 (2014): 93-105. doi: https://doi.org/10.4329/wjr.v6.i4.93
Denkova EJ, Manning L. FMRI contributions to addressing autobiographical memory impairment in temporal lobe pathology. World J Radiol. 2014 Apr 28;6(4):93-105. doi: 10.4329/wjr.v6.i4.93. PMID: 24778771; PMCID: PMC4000613.
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Improved laboratory capacity is required to respond better to future cholera outbreaks in Papua New Guinea.

Western Pacific surveillance and response journal : WPSAR

Greenhill A, Rosewell A, Kas M, Manning L, Latorre L, Siba P, Horwood P.
PMID: 23908909
Western Pac Surveill Response J. 2012 May 23;3(2):30-2. doi: 10.5365/WPSAR.2011.2.4.016. Print 2012 Apr.

No abstract available.

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Greenhill A, Rosewell A, Kas M, et al. Improved laboratory capacity is required to respond better to future cholera outbreaks in Papua New Guinea. Western Pac Surveill Response J. 2012;3(2):30-2doi: 10.5365/WPSAR.2011.2.4.016.
Greenhill, A., Rosewell, A., Kas, M., Manning, L., Latorre, L., Siba, P., & Horwood, P. (2012). Improved laboratory capacity is required to respond better to future cholera outbreaks in Papua New Guinea. Western Pacific surveillance and response journal : WPSAR, 3(2), 30-2. https://doi.org/10.5365/WPSAR.2011.2.4.016
Greenhill, Andrew, et al. "Improved laboratory capacity is required to respond better to future cholera outbreaks in Papua New Guinea." Western Pacific surveillance and response journal : WPSAR vol. 3,2 (2012): 30-2. doi: https://doi.org/10.5365/WPSAR.2011.2.4.016
Greenhill A, Rosewell A, Kas M, Manning L, Latorre L, Siba P, Horwood P. Improved laboratory capacity is required to respond better to future cholera outbreaks in Papua New Guinea. Western Pac Surveill Response J. 2012 May 23;3(2):30-2. doi: 10.5365/WPSAR.2011.2.4.016. Print 2012 Apr. PMID: 23908909; PMCID: PMC3729082.
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Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression.

Current behavioral neuroscience reports

Fanning JR, Keedy S, Berman ME, Lee R, Coccaro EF.
PMID: 29607288
Curr Behav Neurosci Rep. 2017 Jun;4(2):138-150. doi: 10.1007/s40473-017-0115-8. Epub 2017 May 20.

PURPOSE OF REVIEW: Aggressive behavior has adaptive value in many natural environments; however, it places substantial burden and costs on human society. For this reason, there has long been interest in understanding the neurobiological basis of aggression. This interest,...

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Fanning JR, Keedy S, Berman ME, et al. Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression. Curr Behav Neurosci Rep. 2017;4(2):138-150doi: 10.1007/s40473-017-0115-8.
Fanning, J. R., Keedy, S., Berman, M. E., Lee, R., & Coccaro, E. F. (2017). Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression. Current behavioral neuroscience reports, 4(2), 138-150. https://doi.org/10.1007/s40473-017-0115-8
Fanning, Jennifer R, et al. "Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression." Current behavioral neuroscience reports vol. 4,2 (2017): 138-150. doi: https://doi.org/10.1007/s40473-017-0115-8
Fanning JR, Keedy S, Berman ME, Lee R, Coccaro EF. Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression. Curr Behav Neurosci Rep. 2017 Jun;4(2):138-150. doi: 10.1007/s40473-017-0115-8. Epub 2017 May 20. PMID: 29607288; PMCID: PMC5875983.
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Showing 1 to 12 of 204 entries