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Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.

Parkinson's disease

Lange J, Lunde KA, Sletten C, Møller SG, Tysnes OB, Alves G, Larsen JP, Maple-Grødem J.
PMID: 26788404
Parkinsons Dis. 2015;2015:973298. doi: 10.1155/2015/973298. Epub 2015 Dec 14.

Background. Parkinson's disease (PD) and Alzheimer's disease (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), and genetic variations in the processing pathway genes have been found to increase...

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Lange J, Lunde KA, Sletten C, et al. Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population. Parkinsons Dis. 2015;2015:973298doi: 10.1155/2015/973298.
Lange, J., Lunde, K. A., Sletten, C., Møller, S. G., Tysnes, O. B., Alves, G., Larsen, J. P., & Maple-Grødem, J. (2015). Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population. Parkinson's disease, 2015973298. https://doi.org/10.1155/2015/973298
Lange, Johannes, et al. "Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population." Parkinson's disease vol. 2015 (2015): 973298. doi: https://doi.org/10.1155/2015/973298
Lange J, Lunde KA, Sletten C, Møller SG, Tysnes OB, Alves G, Larsen JP, Maple-Grødem J. Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population. Parkinsons Dis. 2015;2015:973298. doi: 10.1155/2015/973298. Epub 2015 Dec 14. PMID: 26788404; PMCID: PMC4691638.
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Early constipation predicts faster dementia onset in Parkinson's disease.

NPJ Parkinson's disease

Camacho M, Macleod AD, Maple-Grødem J, Evans JR, Breen DP, Cummins G, Wijeyekoon RS, Greenland JC, Alves G, Tysnes OB, Lawson RA, Barker RA, Williams-Gray CH.
PMID: 34039994
NPJ Parkinsons Dis. 2021 May 26;7(1):45. doi: 10.1038/s41531-021-00191-w.

Constipation is a common but not a universal feature in early PD, suggesting that gut involvement is heterogeneous and may be part of a distinct PD subtype with prognostic implications. We analysed data from the Parkinson's Incidence Cohorts Collaboration,...

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Camacho M, Macleod AD, Maple-Grødem J, et al. Early constipation predicts faster dementia onset in Parkinson's disease. NPJ Parkinsons Dis. 2021;7(1):45doi: 10.1038/s41531-021-00191-w.
Camacho, M., Macleod, A. D., Maple-Grødem, J., Evans, J. R., Breen, D. P., Cummins, G., Wijeyekoon, R. S., Greenland, J. C., Alves, G., Tysnes, O. B., Lawson, R. A., Barker, R. A., & Williams-Gray, C. H. (2021). Early constipation predicts faster dementia onset in Parkinson's disease. NPJ Parkinson's disease, 7(1), 45. https://doi.org/10.1038/s41531-021-00191-w
Camacho, M, et al. "Early constipation predicts faster dementia onset in Parkinson's disease." NPJ Parkinson's disease vol. 7,1 (2021): 45. doi: https://doi.org/10.1038/s41531-021-00191-w
Camacho M, Macleod AD, Maple-Grødem J, Evans JR, Breen DP, Cummins G, Wijeyekoon RS, Greenland JC, Alves G, Tysnes OB, Lawson RA, Barker RA, Williams-Gray CH. Early constipation predicts faster dementia onset in Parkinson's disease. NPJ Parkinsons Dis. 2021 May 26;7(1):45. doi: 10.1038/s41531-021-00191-w. PMID: 34039994; PMCID: PMC8154963.
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The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study.

Neuroscience letters

Chung J, Ushakova A, Doitsidou M, Tzoulis C, Tysnes OB, Dalen I, Pedersen KF, Alves G, Maple-Grødem J.
PMID: 34509566
Neurosci Lett. 2021 Nov 01;764:136243. doi: 10.1016/j.neulet.2021.136243. Epub 2021 Sep 10.

INTRODUCTION: Cognitive impairment is a common feature of Parkinson's disease and is a significant determinant of patients' quality of life and dependence. The pattern and progression of cognitive symptoms vary greatly between individuals, and genetic biomarkers may help to...

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Chung J, Ushakova A, Doitsidou M, et al. The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study. Neurosci Lett. 2021;764:136243doi: 10.1016/j.neulet.2021.136243.
Chung, J., Ushakova, A., Doitsidou, M., Tzoulis, C., Tysnes, O. B., Dalen, I., Pedersen, K. F., Alves, G., & Maple-Grødem, J. (2021). The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study. Neuroscience letters, 764136243. https://doi.org/10.1016/j.neulet.2021.136243
Chung, Janete, et al. "The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study." Neuroscience letters vol. 764 (2021): 136243. doi: https://doi.org/10.1016/j.neulet.2021.136243
Chung J, Ushakova A, Doitsidou M, Tzoulis C, Tysnes OB, Dalen I, Pedersen KF, Alves G, Maple-Grødem J. The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study. Neurosci Lett. 2021 Nov 01;764:136243. doi: 10.1016/j.neulet.2021.136243. Epub 2021 Sep 10. PMID: 34509566.
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Association of .

Frontiers in neurology

Szwedo AA, Pedersen CC, Ushakova A, Forsgren L, Tysnes OB, Counsell CE, Alves G, Lange J, Macleod AD, Maple-Grødem J.
PMID: 33643180
Front Neurol. 2021 Feb 10;11:620585. doi: 10.3389/fneur.2020.620585. eCollection 2020.

No abstract available.

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Szwedo AA, Pedersen CC, Ushakova A, et al. Association of . Front Neurol. 2021;11:620585doi: 10.3389/fneur.2020.620585.
Szwedo, A. A., Pedersen, C. C., Ushakova, A., Forsgren, L., Tysnes, O. B., Counsell, C. E., Alves, G., Lange, J., Macleod, A. D., & Maple-Grødem, J. (2020). Association of . Frontiers in neurology, 11620585. https://doi.org/10.3389/fneur.2020.620585
Szwedo, Aleksandra A, et al. "Association of ." Frontiers in neurology vol. 11 (2020): 620585. doi: https://doi.org/10.3389/fneur.2020.620585
Szwedo AA, Pedersen CC, Ushakova A, Forsgren L, Tysnes OB, Counsell CE, Alves G, Lange J, Macleod AD, Maple-Grødem J. Association of . Front Neurol. 2021 Feb 10;11:620585. doi: 10.3389/fneur.2020.620585. eCollection 2020. PMID: 33643180; PMCID: PMC7902914.
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Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts.

Journal of Parkinson's disease

Maple-Grødem J, Paul KC, Dalen I, Ngo KJ, Wong D, Macleod AD, Counsell CE, Bäckström D, Forsgren L, Tysnes OB, Kusters CDJ, Fogel BL, Bronstein JM, Ritz B, Alves G.
PMID: 34275908
J Parkinsons Dis. 2021;11(4):1569-1578. doi: 10.3233/JPD-212657.

BACKGROUND: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson's disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on lacking whether patients with GBA-associated PD differ in their risk of...

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Maple-Grødem J, Paul KC, Dalen I, et al. Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts. J Parkinsons Dis. 2021;11(4):1569-1578doi: 10.3233/JPD-212657.
Maple-Grødem, J., Paul, K. C., Dalen, I., Ngo, K. J., Wong, D., Macleod, A. D., Counsell, C. E., Bäckström, D., Forsgren, L., Tysnes, O. B., Kusters, C. D. J., Fogel, B. L., Bronstein, J. M., Ritz, B., & Alves, G. (2021). Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts. Journal of Parkinson's disease, 11(4), 1569-1578. https://doi.org/10.3233/JPD-212657
Maple-Grødem, Jodi, et al. "Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts." Journal of Parkinson's disease vol. 11,4 (2021): 1569-1578. doi: https://doi.org/10.3233/JPD-212657
Maple-Grødem J, Paul KC, Dalen I, Ngo KJ, Wong D, Macleod AD, Counsell CE, Bäckström D, Forsgren L, Tysnes OB, Kusters CDJ, Fogel BL, Bronstein JM, Ritz B, Alves G. Lack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts. J Parkinsons Dis. 2021;11(4):1569-1578. doi: 10.3233/JPD-212657. PMID: 34275908; PMCID: PMC8609705.
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The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study.

Neuroscience letters

Chung J, Ushakova A, Doitsidou M, Tzoulis C, Tysnes OB, Dalen I, Pedersen KF, Alves G, Maple-Grødem J.
PMID: 34509566
Neurosci Lett. 2021 Nov 01;764:136243. doi: 10.1016/j.neulet.2021.136243. Epub 2021 Sep 10.

INTRODUCTION: Cognitive impairment is a common feature of Parkinson's disease and is a significant determinant of patients' quality of life and dependence. The pattern and progression of cognitive symptoms vary greatly between individuals, and genetic biomarkers may help to...

Cite
Chung J, Ushakova A, Doitsidou M, et al. The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study. Neurosci Lett. 2021;764:136243doi: 10.1016/j.neulet.2021.136243.
Chung, J., Ushakova, A., Doitsidou, M., Tzoulis, C., Tysnes, O. B., Dalen, I., Pedersen, K. F., Alves, G., & Maple-Grødem, J. (2021). The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study. Neuroscience letters, 764136243. https://doi.org/10.1016/j.neulet.2021.136243
Chung, Janete, et al. "The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study." Neuroscience letters vol. 764 (2021): 136243. doi: https://doi.org/10.1016/j.neulet.2021.136243
Chung J, Ushakova A, Doitsidou M, Tzoulis C, Tysnes OB, Dalen I, Pedersen KF, Alves G, Maple-Grødem J. The impact of common genetic variants in cognitive decline in the first seven years of Parkinson's disease: A longitudinal observational study. Neurosci Lett. 2021 Nov 01;764:136243. doi: 10.1016/j.neulet.2021.136243. Epub 2021 Sep 10. PMID: 34509566.
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Genetic risk scores and hallucinations in patients with Parkinson disease.

Neurology. Genetics

Kusters CDJ, Paul KC, Duarte Folle A, Keener AM, Bronstein JM, Dobricic V, Tysnes OB, Bertram L, Alves G, Sinsheimer JS, Lill CM, Maple-Grødem J, Ritz BR.
PMID: 32802953
Neurol Genet. 2020 Jul 20;6(5):e492. doi: 10.1212/NXG.0000000000000492. eCollection 2020 Oct.

OBJECTIVE: We examine the hypothesized overlap of genetic architecture for Alzheimer disease (AD), schizophrenia (SZ), and Parkinson disease (PD) through the use of polygenic risk scores (PRSs) with the occurrence of hallucinations in PD.METHODS: We used 2 population-based studies...

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Kusters CDJ, Paul KC, Duarte Folle A, et al. Genetic risk scores and hallucinations in patients with Parkinson disease. Neurol Genet. 2020;6(5):e492doi: 10.1212/NXG.0000000000000492.
Kusters, C. D. J., Paul, K. C., Duarte Folle, A., Keener, A. M., Bronstein, J. M., Dobricic, V., Tysnes, O. B., Bertram, L., Alves, G., Sinsheimer, J. S., Lill, C. M., Maple-Grødem, J., & Ritz, B. R. (2020). Genetic risk scores and hallucinations in patients with Parkinson disease. Neurology. Genetics, 6(5), e492. https://doi.org/10.1212/NXG.0000000000000492
Kusters, Cynthia D J, et al. "Genetic risk scores and hallucinations in patients with Parkinson disease." Neurology. Genetics vol. 6,5 (2020): e492. doi: https://doi.org/10.1212/NXG.0000000000000492
Kusters CDJ, Paul KC, Duarte Folle A, Keener AM, Bronstein JM, Dobricic V, Tysnes OB, Bertram L, Alves G, Sinsheimer JS, Lill CM, Maple-Grødem J, Ritz BR. Genetic risk scores and hallucinations in patients with Parkinson disease. Neurol Genet. 2020 Jul 20;6(5):e492. doi: 10.1212/NXG.0000000000000492. eCollection 2020 Oct. PMID: 32802953; PMCID: PMC7413629.
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Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease.

Frontiers in neurology

Erga AH, Dalen I, Ushakova A, Chung J, Tzoulis C, Tysnes OB, Alves G, Pedersen KF, Maple-Grødem J.
PMID: 29541058
Front Neurol. 2018 Feb 28;9:109. doi: 10.3389/fneur.2018.00109. eCollection 2018.

INTRODUCTION: Impulse control disorders (ICDs) are frequent non-motor symptoms in Parkinson's disease (PD), with potential negative effects on the quality of life and social functioning. ICDs are closely associated with dopaminergic therapy, and genetic polymorphisms in several neurotransmitter pathways...

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Erga AH, Dalen I, Ushakova A, et al. Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease. Front Neurol. 2018;9:109doi: 10.3389/fneur.2018.00109.
Erga, A. H., Dalen, I., Ushakova, A., Chung, J., Tzoulis, C., Tysnes, O. B., Alves, G., Pedersen, K. F., & Maple-Grødem, J. (2018). Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease. Frontiers in neurology, 9109. https://doi.org/10.3389/fneur.2018.00109
Erga, Aleksander H, et al. "Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease." Frontiers in neurology vol. 9 (2018): 109. doi: https://doi.org/10.3389/fneur.2018.00109
Erga AH, Dalen I, Ushakova A, Chung J, Tzoulis C, Tysnes OB, Alves G, Pedersen KF, Maple-Grødem J. Dopaminergic and Opioid Pathways Associated with Impulse Control Disorders in Parkinson's Disease. Front Neurol. 2018 Feb 28;9:109. doi: 10.3389/fneur.2018.00109. eCollection 2018. PMID: 29541058; PMCID: PMC5835501.
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A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease.

NPJ Parkinson's disease

Pedersen CC, Lange J, Førland MGG, Macleod AD, Alves G, Maple-Grødem J.
PMID: 34210990
NPJ Parkinsons Dis. 2021 Jul 01;7(1):54. doi: 10.1038/s41531-021-00196-5.

There is great heterogeneity in both the clinical presentation and rate of disease progression among patients with Parkinson's disease (PD). This can pose prognostic difficulties in a clinical setting, and a greater understanding of the risk factors that contribute...

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Pedersen CC, Lange J, Førland MGG, et al. A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease. NPJ Parkinsons Dis. 2021;7(1):54doi: 10.1038/s41531-021-00196-5.
Pedersen, C. C., Lange, J., Førland, M. G. G., Macleod, A. D., Alves, G., & Maple-Grødem, J. (2021). A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease. NPJ Parkinson's disease, 7(1), 54. https://doi.org/10.1038/s41531-021-00196-5
Pedersen, Camilla Christina, et al. "A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease." NPJ Parkinson's disease vol. 7,1 (2021): 54. doi: https://doi.org/10.1038/s41531-021-00196-5
Pedersen CC, Lange J, Førland MGG, Macleod AD, Alves G, Maple-Grødem J. A systematic review of associations between common SNCA variants and clinical heterogeneity in Parkinson's disease. NPJ Parkinsons Dis. 2021 Jul 01;7(1):54. doi: 10.1038/s41531-021-00196-5. PMID: 34210990; PMCID: PMC8249472.
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Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection.

Frontiers in neurology

Gjerstad MD, Alves G, Maple-Grødem J.
PMID: 30487775
Front Neurol. 2018 Nov 14;9:961. doi: 10.3389/fneur.2018.00961. eCollection 2018.

Sleep contributes to the consolidation of our memory and facilitates learning. Short term sleep deprivation temporarily reduces mnestic capacity, whereas long lasting sleep deprivation is associated with structural changes in the hippocampus and cortical areas. However, it is unknown...

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Gjerstad MD, Alves G, Maple-Grødem J. Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection. Front Neurol. 2018;9:961doi: 10.3389/fneur.2018.00961.
Gjerstad, M. D., Alves, G., & Maple-Grødem, J. (2018). Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection. Frontiers in neurology, 9961. https://doi.org/10.3389/fneur.2018.00961
Gjerstad, Michaela D, et al. "Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection." Frontiers in neurology vol. 9 (2018): 961. doi: https://doi.org/10.3389/fneur.2018.00961
Gjerstad MD, Alves G, Maple-Grødem J. Excessive Daytime Sleepiness and REM Sleep Behavior Disorders in Parkinson's Disease: A Narrative Review on Early Intervention With Implications to Neuroprotection. Front Neurol. 2018 Nov 14;9:961. doi: 10.3389/fneur.2018.00961. eCollection 2018. PMID: 30487775; PMCID: PMC6246656.
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First delirium episode in Parkinson's disease and parkinsonism: incidence, predictors, and outcomes.

NPJ Parkinson's disease

Green S, Perrott SL, McCleary A, Sleeman I, Maple-Grødem J, Counsell CE, Macleod AD.
PMID: 34635668
NPJ Parkinsons Dis. 2021 Oct 11;7(1):92. doi: 10.1038/s41531-021-00234-2.

To define the incidence, predictors and prognosis of the first hospital delirium episode in Parkinson's disease (PD) and atypical parkinsonism (AP), we identified the first hospital episode of delirium after diagnosis in the Parkinsonism Incidence in North-East Scotland (PINE)...

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Green S, Perrott SL, McCleary A, et al. First delirium episode in Parkinson's disease and parkinsonism: incidence, predictors, and outcomes. NPJ Parkinsons Dis. 2021;7(1):92doi: 10.1038/s41531-021-00234-2.
Green, S., Perrott, S. L., McCleary, A., Sleeman, I., Maple-Grødem, J., Counsell, C. E., & Macleod, A. D. (2021). First delirium episode in Parkinson's disease and parkinsonism: incidence, predictors, and outcomes. NPJ Parkinson's disease, 7(1), 92. https://doi.org/10.1038/s41531-021-00234-2
Green, Samantha, et al. "First delirium episode in Parkinson's disease and parkinsonism: incidence, predictors, and outcomes." NPJ Parkinson's disease vol. 7,1 (2021): 92. doi: https://doi.org/10.1038/s41531-021-00234-2
Green S, Perrott SL, McCleary A, Sleeman I, Maple-Grødem J, Counsell CE, Macleod AD. First delirium episode in Parkinson's disease and parkinsonism: incidence, predictors, and outcomes. NPJ Parkinsons Dis. 2021 Oct 11;7(1):92. doi: 10.1038/s41531-021-00234-2. PMID: 34635668; PMCID: PMC8505483.
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DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis.

Human molecular genetics

Piston D, Alvarez-Erviti L, Bansal V, Gargano D, Yao Z, Szabadkai G, Odell M, Puno MR, Björkblom B, Maple-Grødem J, Breuer P, Kaut O, Larsen JP, Bonn S, Møller SG, Wüllner U, Schapira AHV, Gegg ME.
PMID: 29309579
Hum Mol Genet. 2018 Feb 01;27(3):576. doi: 10.1093/hmg/ddx425.

No abstract available.

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Piston D, Alvarez-Erviti L, Bansal V, et al. DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis. Hum Mol Genet. 2018;27(3):576doi: 10.1093/hmg/ddx425.
Piston, D., Alvarez-Erviti, L., Bansal, V., Gargano, D., Yao, Z., Szabadkai, G., Odell, M., Puno, M. R., Björkblom, B., Maple-Grødem, J., Breuer, P., Kaut, O., Larsen, J. P., Bonn, S., Møller, S. G., Wüllner, U., Schapira, A. H. V., & Gegg, M. E. (2018). DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis. Human molecular genetics, 27(3), 576. https://doi.org/10.1093/hmg/ddx425
Piston, Dominik, et al. "DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis." Human molecular genetics vol. 27,3 (2018): 576. doi: https://doi.org/10.1093/hmg/ddx425
Piston D, Alvarez-Erviti L, Bansal V, Gargano D, Yao Z, Szabadkai G, Odell M, Puno MR, Björkblom B, Maple-Grødem J, Breuer P, Kaut O, Larsen JP, Bonn S, Møller SG, Wüllner U, Schapira AHV, Gegg ME. DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis. Hum Mol Genet. 2018 Feb 01;27(3):576. doi: 10.1093/hmg/ddx425. PMID: 29309579; PMCID: PMC5886203.
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