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The role of androgens in metabolism, obesity, and diabetes in males and females

STEM and males

Allard C, Mauvais‐Jarvis F, Xu W.
GSID: d70eNxgIjX0J
G Navarro, C Allard, W Xu, F Mauvais‐Jarvis - Obesity, 2015 - Wiley Online Library

… that in males, testosterone has … in males is indirectly mediated via AR signaling in skeletal muscle. First, in vitro, testosterone stimulates the commitment of pluripotent mesenchymal stem …

[Future prospects for human contraception].

Journees annuelles de diabetologie de l'Hotel-Dieu

Mauvais-Jarvis P.
PMID: 6645140
Journ Annu Diabetol Hotel Dieu. 1983;263-71.

No abstract available.

Effect of menopausal hormone therapy on components of the metabolic syndrome.

Therapeutic advances in cardiovascular disease

Lovre D, Lindsey SH, Mauvais-Jarvis F.
PMID: 27234158
Ther Adv Cardiovasc Dis. 2016 May 27; doi: 10.1177/1753944716649358. Epub 2016 May 27.

The world population is aging, and women will spend an increasing share of their lives in a postmenopausal state that predisposes to metabolic dysfunction. Thus, the prevalence of metabolic syndrome (MetS) in women is likely to increase dramatically. This...

The D-Day of ghrelin.

Molecular metabolism

Tong J, Mauvais-Jarvis F.
PMID: 27408768
Mol Metab. 2016 May 20;5(7):433-434. doi: 10.1016/j.molmet.2016.05.007. eCollection 2016 Jul.

No abstract available.

Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion.

Journal of the Endocrine Society

Gautier JF, Fetita LS, Riveline JP, Ibrahim F, Porcher R, Abi Khalil C, Velho G, Choukem SP, Hadjadj S, Larger E, Roussel R, Boudou P, Marre M, Ravussin E, Mauvais-Jarvis F.
PMID: 29687090
J Endocr Soc. 2018 Mar 22;2(5):391-397. doi: 10.1210/js.2017-00482. eCollection 2018 May 01.

We previously showed that fetal exposure to maternal type 1 diabetes (T1D) is associated with altered glucose-stimulated insulin secretion in adult offspring. Here, we investigated whether this

Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19.

JAMA network open

Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R.
PMID: 34935924
JAMA Netw Open. 2021 Dec 01;4(12):e2140568. doi: 10.1001/jamanetworkopen.2021.40568.

IMPORTANCE: Obesity, diabetes, and hypertension are common comorbidities in patients with severe COVID-19, yet little is known about the risk of acute respiratory distress syndrome (ARDS) or death in patients with COVID-19 and metabolic syndrome.OBJECTIVE: To determine whether metabolic...

Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19.

JAMA network open

Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R.
PMID: 34935924
JAMA Netw Open. 2021 Dec 01;4(12):e2140568. doi: 10.1001/jamanetworkopen.2021.40568.

IMPORTANCE: Obesity, diabetes, and hypertension are common comorbidities in patients with severe COVID-19, yet little is known about the risk of acute respiratory distress syndrome (ARDS) or death in patients with COVID-19 and metabolic syndrome.OBJECTIVE: To determine whether metabolic...

Erratum. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes 2019;68.

Diabetes

Zhang Y, Parajuli KR, Fava GE, Gupta R, Xu W, Nguyen LU, Zakaria AF, Fonseca VA, Wang H, Mauvais-Jarvis F, Sloop KW, Wu H.
PMID: 31843952
Diabetes. 2020 Feb;69(2):267-268. doi: 10.2337/db20-er02c. Epub 2019 Dec 16.

No abstract available.

Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.

Cell reports

Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R.
PMID: 34644565
Cell Rep. 2021 Oct 12;37(2):109813. doi: 10.1016/j.celrep.2021.109813.

A heterozygous missense mutation of the islet β cell-enriched MAFA transcription factor (p.Ser64Phe [S64F]) is found in patients with adult-onset β cell dysfunction (diabetes or insulinomatosis), with men more prone to diabetes than women. This mutation engenders increased stability...

Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19.

JAMA network open

Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R.
PMID: 34935924
JAMA Netw Open. 2021 Dec 01;4(12):e2140568. doi: 10.1001/jamanetworkopen.2021.40568.

IMPORTANCE: Obesity, diabetes, and hypertension are common comorbidities in patients with severe COVID-19, yet little is known about the risk of acute respiratory distress syndrome (ARDS) or death in patients with COVID-19 and metabolic syndrome.OBJECTIVE: To determine whether metabolic...

Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19.

JAMA network open

Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R.
PMID: 34935924
JAMA Netw Open. 2021 Dec 01;4(12):e2140568. doi: 10.1001/jamanetworkopen.2021.40568.

IMPORTANCE: Obesity, diabetes, and hypertension are common comorbidities in patients with severe COVID-19, yet little is known about the risk of acute respiratory distress syndrome (ARDS) or death in patients with COVID-19 and metabolic syndrome.OBJECTIVE: To determine whether metabolic...

Conjugated Estrogens and Bazedoxifene Improve .

Journal of the Endocrine Society

Lovre D, Peacock E, Katalenich B, Moreau C, Xu B, Tate C, Utzschneider KM, Gautier JF, Fonseca V, Mauvais-Jarvis F.
PMID: 31384719
J Endocr Soc. 2019 Jun 06;3(8):1583-1594. doi: 10.1210/js.2019-00074. eCollection 2019 Aug 01.

CONTEXT: Studies suggest that menopausal hormone therapy (MHT) prevents type 2 diabetes (T2D). The combination of conjugated estrogens (CE) with the selective estrogen receptor modulator bazedoxifene (BZA) is an MHT that improves obesity and T2D in preclinical models of...

Showing 1 to 12 of 30 entries