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Showing 1 to 12 of 16 entries
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PHYSICAL INDETERMINACY AND PHILOSOPHICAL SOPHICAL DETERMINISM.

Science (New York, N.Y.)

McKeehan LW.
PMID: 17802329
Science. 1935 May 24;81(2108):514. doi: 10.1126/science.81.2108.514.

No abstract available.

Excerpta medica usage.

Bulletin of the Medical Library Association

McKeehan NC.
PMID: 16017820
Bull Med Libr Assoc. 1982 Jul;70(3):336.

No abstract available.

Correction to: Abnormalities of Aspiration and Swallowing Function in Survivors of Acute Respiratory Failure.

Dysphagia

Langmore SE, Krisciunas GP, Warner H, White SD, Dvorkin D, Fink D, McNally E, Scheel R, Higgins C, Levitt JE, McKeehan J, Deane S, Siner JM, Vojnik R, Moss M.
PMID: 33635374
Dysphagia. 2021 Oct;36(5):842-853. doi: 10.1007/s00455-020-10226-8.

No abstract available.

The Crystal Structure of Beryllium and of Beryllium Oxide.

Proceedings of the National Academy of Sciences of the United States of America

McKeehan LW.
PMID: 16586895
Proc Natl Acad Sci U S A. 1922 Sep;8(9):270-4. doi: 10.1073/pnas.8.9.270.

No abstract available.

Spatial and temporal localization of FGF receptors in Xenopus laevis.

Roux's archives of developmental biology : the official organ of the EDBO

Ding XY, McKeehan WL, Xu J, Grunz H.
PMID: 28305851
Rouxs Arch Dev Biol. 1992 Oct;201(6):334-339. doi: 10.1007/BF00365120.

Mesoderm formation is a result of cell-cell interactions between the vegetal and animal hemisphere and is thought to be mediated by inducing peptide growth factors including members of the FGF and TGFβ superfamilies. Our immunochemical study analyses the distribution...

Human iPSC-derived cardiomyocytes and pyridyl-phenyl mexiletine analogs.

Bioorganic & medicinal chemistry letters

Johnson M, Gomez-Galeno J, Ryan D, Okolotowicz K, McKeithan WL, Sampson KJ, Kass RS, Mercola M, Cashman JR.
PMID: 34062251
Bioorg Med Chem Lett. 2021 Aug 15;46:128162. doi: 10.1016/j.bmcl.2021.128162. Epub 2021 May 29.

In the United States, approximately one million individuals are hospitalized every year for arrhythmias, making arrhythmias one of the top causes of healthcare expenditures. Mexiletine is currently used as an antiarrhythmic drug but has limitations. The purpose of this...

Human-induced pluripotent stem cell-derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs.

Pharmacology research & perspectives

Gomez-Galeno J, Okolotowicz K, Johnson M, McKeithan WL, Mercola M, Cashman JR.
PMID: 34327875
Pharmacol Res Perspect. 2021 Aug;9(4):e00828. doi: 10.1002/prp2.828.

Prolongation of the cardiac action potential (AP) and early after depolarizations (EADs) are electrical anomalies of cardiomyocytes that can lead to lethal arrhythmias and are potential liabilities for existing drugs and drug candidates in development. For example, long QT...

Stressed Liver and Muscle Call on Adipocytes with FGF21.

Frontiers in endocrinology

Luo Y, McKeehan WL.
PMID: 24385972
Front Endocrinol (Lausanne). 2013 Dec 18;4:194. doi: 10.3389/fendo.2013.00194.

Fibroblast growth factor 21 (FGF21) is an emerging regulator of local and systemic metabolic homeostasis. Treatment with pharmacological levels of FGF21 alleviates obesity and associated metabolic diseases including diabetes. However, beyond anti-obesogenic effects, the normal roles and underlying mechanisms...

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.

Frontiers in physiology

McKeithan WL, Savchenko A, Yu MS, Cerignoli F, Bruyneel AAN, Price JH, Colas AR, Miller EW, Cashman JR, Mercola M.
PMID: 29075196
Front Physiol. 2017 Oct 11;8:766. doi: 10.3389/fphys.2017.00766. eCollection 2017.

The ability to produce unlimited numbers of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) harboring disease and patient-specific gene variants creates a new paradigm for modeling congenital heart diseases (CHDs) and predicting proarrhythmic liabilities of drug candidates. However,...

REAPPEARANCE OF AN ANCIENT ABSURDITY REGARDING MAGNETS.

Science (New York, N.Y.)

McKeehan LW.
PMID: 17777229
Science. 1940 Mar 29;91(2361):314. doi: 10.1126/science.91.2361.314.

No abstract available.

X RAY CRYSTALLOMETRY: X-RAY WAVE LENGTHS, SPACE-LATTICE DIMENSIONS AND ATOMIC MASSES.

Science (New York, N.Y.)

McKeehan LW.
PMID: 17791565
Science. 1922 Dec 29;56(1461):757-9. doi: 10.1126/science.56.1461.757.

No abstract available.

Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations.

Cancer & metabolism

Luo Y, Yang C, Ye M, Jin C, Abbruzzese JL, Lee MH, Yeung SC, McKeehan WL.
PMID: 24279986
Cancer Metab. 2013 Nov 25;1(1):21. doi: 10.1186/2049-3002-1-21.

BACKGROUND: Endocrine FGF21 and FGF19 target adipocytes and hepatocytes through betaKlotho (KLB) and FGFR tyrosine kinases effecting glucose, lipid and energy metabolism. Both factors alleviate obesity and metabolic abnormalities which are contributing factors to breast tumor progression. Genomic manipulation...

Showing 1 to 12 of 16 entries