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Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress.

iScience

Sanchez M, Lin Y, Yang CC, McQuary P, Rosa Campos A, Aza Blanc P, Wolf DA.
PMID: 31627132
iScience. 2019 Oct 25;20:466-480. doi: 10.1016/j.isci.2019.09.031. Epub 2019 Sep 26.

The cellular stress response triggers a cascade of events leading to transcriptional reprogramming and a transient inhibition of global protein synthesis, which is thought to be mediated by phosphorylation of eukaryotic initiation factor-2α (eIF2α). Using mouse embryonic fibroblasts (MEFs)...

Total Protein Staining is Superior to Classical or Tissue-Specific Protein Staining for Standardization of Protein Biomarkers in Heterogeneous Tissue Samples.

Gene reports

Bettencourt JW, McLaury AR, Limberg AK, Vargas-Hernandez JS, Bayram B, Owen AR, Berry DJ, Sanchez-Sotelo J, Morrey ME, van Wijnen AJ, Abdel MP.
PMID: 32377595
Gene Rep. 2020 Jun;19. doi: 10.1016/j.genrep.2020.100641. Epub 2020 Mar 06.

Protein detection techniques such as western blotting and ELISA rely on housekeeping proteins as standards for sample normalization. However, clinical or animal tissue specimens are heterogeneous due to presence of contaminating cell types and tissues (e.g., blood vessels and...

Anti-fibrotic effects of the antihistamine ketotifen in a rabbit model of arthrofibrosis.

Bone & joint research

Tibbo ME, Limberg AK, Salib CG, Turner TW, McLaury AR, Jay AG, Bettencourt JW, Carter JM, Bolon B, Berry DJ, Morrey ME, Sanchez-Sotelo J, van Wijnen AJ, Abdel MP.
PMID: 32728431
Bone Joint Res. 2020 Jul 23;9(6):302-310. doi: 10.1302/2046-3758.96.BJR-2019-0272.R2. eCollection 2020 Jun.

AIMS: Arthrofibrosis is a relatively common complication after joint injuries and surgery, particularly in the knee. The present study used a previously described and validated rabbit model to assess the biomechanical, histopathological, and molecular effects of the mast cell...

Showing 1 to 3 of 3 entries