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Showing 1 to 12 of 149 entries
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Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold.

Biomedicines

Keely NO, Carr M, Yassin B, Ana G, Lloyd DG, Zisterer D, Meegan MJ.
PMID: 28536383
Biomedicines. 2016 Jul 20;4(3). doi: 10.3390/biomedicines4030015.

Nuclear-receptors are often overexpressed in tumours and can thereby be used as targets when designing novel selective chemotherapeutic agents. To date, many conjugates incorporating an estrogen receptor (ER) ligand have been synthesised in order to direct chemical agents to...

Microbial shifts in the aging mouse gut.

Microbiome

Langille MG, Meehan CJ, Koenig JE, Dhanani AS, Rose RA, Howlett SE, Beiko RG.
PMID: 25520805
Microbiome. 2014 Dec 05;2(1):50. doi: 10.1186/s40168-014-0050-9. eCollection 2014.

BACKGROUND: The changes that occur in the microbiome of aging individuals are unclear, especially in light of the imperfect correlation of frailty with age. Studies in older human subjects have reported subtle effects, but these results may be confounded...

Lower Back Symptoms in Adolescent Soccer Players: Predictors of Functional Recovery.

Orthopaedic journal of sports medicine

Shah T, Cloke DJ, Rushton S, Shirley MD, Deehan DJ.
PMID: 26535318
Orthop J Sports Med. 2014 Apr 17;2(4):2325967114529703. doi: 10.1177/2325967114529703. eCollection 2014 Apr.

BACKGROUND: There are little published data on factors relating to low back pain in the younger athletic population.HYPOTHESIS: Independent predictors of recovery and return to participation in sports could be determined by event analysis, which investigates the impacts of...

Phenylalkylamine abuse among opiate addicts attending a methadone treatment programme in the Republic of Ireland.

Addiction biology

Kavanagh P, Dunne J, Feely J, Maguire R, Corrigan D, Keating JJ, Meegan MJ, Clancy JM, Burdett J.
PMID: 11341858
Addict Biol. 2001 Apr;6(2):177-181. doi: 10.1080/13556210020040262.

Since the early 1990s ring-substituted derivatives of amphetamine have been abused widely in the Republic of Ireland. The main ring-substituted amphetamines being abused include methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA) and methylenedioxyethamphetamine (MDEA). A newer illicit synthetic analogue, which has been...

CAPILLARY PERMEABILITY IN RELATION TO ACUTE ANOXIA AND TO VENOUS OXYGEN SATURATION.

The Journal of clinical investigation

Henry J, Goodman J, Meehan J, Frankel R.
PMID: 16695513
J Clin Invest. 1947 Nov;26(6):1119-29. doi: 10.1172/JCI101904.

No abstract available.

Spectroscopic determination of sulphate in the presence of excess of nitrate and nitrite.

Talanta

Meehan BJ, Tariq SA.
PMID: 18961401
Talanta. 1973 Nov;20(11):1215-7. doi: 10.1016/0039-9140(73)80085-2.

The KBr pellet technique has been used for the determination of alkali metal sulphate in the presence of large excesses of nitrate and nitrite by measuring the absorption of the sulphate at 619 cm(-1). The sulphate can be determined...

Recent advances in estrogen receptor antagonists.

IDrugs : the investigational drugs journal

Lloyd DG, Meegan MJ.
PMID: 16096926
IDrugs. 2000 Jun;3(6):632-42.

No abstract available.

Regulation and utilization of microsin promoter turn on in a chromosomal fusion.

Biotechnology and bioengineering

Meehan AJ, Minkley EG, Domach MM.
PMID: 18600797
Biotechnol Bioeng. 1991 Oct 05;38(7):719-26. doi: 10.1002/bit.260380705.

Prior work has demonstrated that the microsin antibiotics are produced by enteric bacteria when the growth medium is depleted of nutrients. Because the control loci could have biotechnical potential, and general stress-response phenomena are of importance to understanding how...

Mental health problems in children with prader-willi syndrome.

Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

Skokauskas N, Sweeny E, Meehan J, Gallagher L.
PMID: 22876265
J Can Acad Child Adolesc Psychiatry. 2012 Aug;21(3):194-203.

BACKGROUND: Prader-Willi Syndrome (PWS) is a genetically determined neurodevelopmental disorder, which occurs in approximately one in 22000 births.AIMS: This study aimed to investigate psychiatric characteristics of children diagnosed with PWS compared with an age-, gender- and IQ-matched control group....

Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness.

Metabolites

Ward C, Meehan J, Gray M, Kunkler IH, Langdon SP, Argyle DJ, Barkham M, Dufour G.
PMID: 29439394
Metabolites. 2018 Feb 10;8(1). doi: 10.3390/metabo8010013.

Carbonic anhydrase IX has been under intensive investigation as a therapeutic target in cancer. Studies demonstrate that this enzyme has a key role in pH regulation in cancer cells, allowing these cells to adapt to the adverse conditions of...

Generalizing the Network Scale-Up Method: A New Estimator for the Size of Hidden Populations.

Sociological methodology

Feehan DM, Salganik MJ.
PMID: 29375167
Sociol Methodol. 2016 Aug;46(1):153-186. doi: 10.1177/0081175016665425. Epub 2016 Sep 20.

The network scale-up method enables researchers to estimate the size of hidden populations, such as drug injectors and sex workers, using sampled social network data. The basic scale-up estimator offers advantages over other size estimation techniques, but it depends...

Special Issue "Anticancer Drugs".

Pharmaceuticals (Basel, Switzerland)

Meegan MJ, O'Boyle NM.
PMID: 31527393
Pharmaceuticals (Basel). 2019 Sep 16;12(3). doi: 10.3390/ph12030134.

The focus of this Special Issue of

Showing 1 to 12 of 149 entries