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Showing 1 to 12 of 21 entries
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Artificial intelligence predicts delirium following cardiac surgery: A case study.

Journal of clinical anesthesia

Fliegenschmidt J, Hulde N, Preising MG, Ruggeri S, Szymanowski R, Meesseman L, Sun H, von Dossow V.
PMID: 34333447
J Clin Anesth. 2021 Dec;75:110473. doi: 10.1016/j.jclinane.2021.110473. Epub 2021 Jul 29.

Delirium is a highly relevant complication of surgical interventions. Current research indicates that despite increased awareness for delirium, it is often overlooked. We implemented an AI-based tool to monitor delirium in cardiac surgery patients in our specialist clinic. This...

Clinical practices underlie COVID-19 patient respiratory microbiome composition and its interactions with the host.

Nature communications

Lloréns-Rico V, Gregory AC, Van Weyenbergh J, Jansen S, Van Buyten T, Qian J, Braz M, Menezes SM, Van Mol P, Vanderbeke L, Dooms C, Gunst J, Hermans G, Meersseman P, Wauters E, Neyts J, Lambrechts D, Wauters J, Raes J.
PMID: 34716338
Nat Commun. 2021 Oct 29;12(1):6243. doi: 10.1038/s41467-021-26500-8.

Understanding the pathology of COVID-19 is a global research priority. Early evidence suggests that the respiratory microbiome may be playing a role in disease progression, yet current studies report contradictory results. Here, we examine potential confounders in COVID-19 respiratory...

Case Report of Gastrointestinal Bleeding in an Adult with Chronic Visceral Acid Sphingomyelinase Deficiency.

Case reports in gastrointestinal medicine

Cassiman D, Libbrecht L, Meersseman W, Wilmer A.
PMID: 31080679
Case Rep Gastrointest Med. 2019 Apr 04;2019:9613457. doi: 10.1155/2019/9613457. eCollection 2019.

INTRODUCTION: Acid sphingomyelinase deficiency (ASMD, also known as Niemann-Pick Type A and Type B disease) is a rare, inherited metabolic disorder. Liver-related issues, including cirrhosis and variceal haemorrhage, are a leading cause of early mortality in individuals with chronic...

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza.

JCI insight

Cambier S, Metzemaekers M, de Carvalho AC, Nooyens A, Jacobs C, Vanderbeke L, Malengier-Devlies B, Gouwy M, Heylen E, Meersseman P, Hermans G, Wauters E, Wilmer A, Schols D, Matthys P, Opdenakker G, Marques RE, Wauters J, Vandooren J, Proost P.
PMID: 34793331
JCI Insight. 2022 Jan 11;7(1). doi: 10.1172/jci.insight.155055.

Neutrophils are recognized as important circulating effector cells in the pathophysiology of severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs is incompletely understood. Here, we collected bronchoalveolar lavage (BAL) fluids and parallel blood samples of...

Atypical response to bacterial co-infection and persistent neutrophilic broncho-alveolar inflammation distinguish critical COVID-19 from influenza.

JCI insight

Cambier S, Metzemaekers M, Carvalho AC, Nooyens A, Jacobs C, Vanderbeke L, Malengier-Devlies B, Gouwy M, Heylen E, Meersseman P, Hermans G, Wauters E, Wilmer A, Consortium C, Schols D, Matthys P, Opdenakker G, Marques RE, Wauters J, Vandooren J, Proost P.
PMID: 34793331
JCI Insight. 2021 Nov 18; doi: 10.1172/jci.insight.155055. Epub 2021 Nov 18.

Neutrophils are recognized as important circulating effector cells in the pathophysiology of severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs is incompletely understood. Here, we collected broncho-alveolar lavage (BAL) fluids and parallel blood samples of...

Patents vs patients 1-0: The case of chenodeoxycholic acid.

Journal of inherited metabolic disease

Briké SM, Meersseman W, Cassiman D.
PMID: 34599614
J Inherit Metab Dis. 2021 Oct 02; doi: 10.1002/jimd.12443. Epub 2021 Oct 02.

Profit-driven games with the availability and prices of chenodeoxycholic acid led to the discontinuation of proper treatment for this cerebrotendinous xanthomatosis patient with disastrous consequences to his health.

Intensive care management of acute-on-chronic liver failure.

Journal of hepatology

Bernal W, Karvellas C, Saliba F, Saner FH, Meersseman P.
PMID: 34039487
J Hepatol. 2021 Jul;75:S163-S177. doi: 10.1016/j.jhep.2020.10.024.

The syndrome of acute-on-chronic liver failure combines deterioration of liver function in a patient with chronic liver disease, with the development of extrahepatic organ failure and high short-term mortality. Its successful management demands a rapid and coherent response to...

Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function.

Infection and drug resistance

Gijsen M, Elkayal O, Annaert P, Van Daele R, Meersseman P, Debaveye Y, Wauters J, Dreesen E, Spriet I.
PMID: 35035223
Infect Drug Resist. 2022 Jan 08;15:53-62. doi: 10.2147/IDR.S343264. eCollection 2022.

PURPOSE: Critically ill patients with preserved or increased renal function have been shown to be at risk of underexposure to meropenem. Although many meropenem population pharmacokinetic (PK) models have been published, there is no large prospective population PK study...

Porphyria: awareness is the key to diagnosis!.

Acta clinica Belgica

Heymans B, Meersseman W.
PMID: 33938396
Acta Clin Belg. 2021 May 03;1-7. doi: 10.1080/17843286.2021.1918876. Epub 2021 May 03.

Porphyrias are disorders of the haem biosynthesis which are encountered infrequently and which often present themselves atypically as a combination of gastrointestinal, neurologic and/or dermatologic symptoms. Although they are primarily caused by enzyme defects, inheritance patterns are mostly not...

Correction to: A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico study.

Trials

Vanassche T, Engelen MM, Van Thillo Q, Wauters J, Gunst J, Wouters C, Vandenbriele C, Rex S, Liesenborghs L, Wilmer A, Meersseman P, Van den Berghe G, Dauwe D, Verbeke G, Thomeer M, Fivez T, Mesotten D, Ruttens D, Heytens L, Dapper I, Tuyls S, De Tavernier B, Verhamme P.
PMID: 33375932
Trials. 2020 Dec 29;21(1):1033. doi: 10.1186/s13063-020-04991-y.

No abstract available.

A Large Retrospective Assessment of Voriconazole Exposure in Patients Treated with Extracorporeal Membrane Oxygenation.

Microorganisms

Van Daele R, Bekkers B, Lindfors M, Broman LM, Schauwvlieghe A, Rijnders B, Hunfeld NGM, Juffermans NP, Taccone FS, Coimbra Sousa CA, Jacquet LM, Laterre PF, Nulens E, Grootaert V, Lyster H, Reed A, Patel B, Meersseman P, Debaveye Y, Wauters J, Vandenbriele C, Spriet I.
PMID: 34361978
Microorganisms. 2021 Jul 20;9(7). doi: 10.3390/microorganisms9071543.

BACKGROUND: Voriconazole is one of the first-line therapies for invasive pulmonary aspergillosis. Drug concentrations might be significantly influenced by the use of extracorporeal membrane oxygenation (ECMO). We aimed to assess the effect of ECMO on voriconazole exposure in a...

Liver Fibrosis Associated with Iron Accumulation Due to Long-Term Heme-Arginate Treatment in Acute Intermittent Porphyria: A Case Series.

JIMD reports

Willandt B, Langendonk JG, Biermann K, Meersseman W, D'Heygere F, George C, Verslype C, Monbaliu D, Cassiman D.
PMID: 26093628
JIMD Rep. 2016;25:77-81. doi: 10.1007/8904_2015_458. Epub 2015 Jun 21.

Acute intermittent porphyria (AIP) is an autosomal dominant disorder of heme biosynthesis due to a mutation in the porphobilinogen deaminase gene. The mutation causes a deficiency in the porphobilinogen deaminase enzyme, thereby causing an accumulation of heme precursors (δ-aminolevulinic...

Showing 1 to 12 of 21 entries