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Showing 1 to 12 of 17 entries
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VARIATIONAL LEVEL-SET WITH GAUSSIAN SHAPE MODEL FOR CELL SEGMENTATION.

Proceedings. International Conference on Image Processing

Gelas A, Mosaliganti K, Gouaillard A, Souhait L, Noche R, Obholzer N, Megason SG.
PMID: 21738904
Proc Int Conf Image Proc. 2009;1089-1092. doi: 10.1109/ICIP.2009.5413463.

In analysis of microscopy based images, a major challenge lies in splitting apart cells that appear to overlap because they are too densely packed. This task is complicated by the physics of the image acquisition that causes large variations...

An experimental search strategy retrieves more precise results than PubMed and Google for questions about medical interventions.

PeerJ

Badgett RG, Dylla DP, Megison SD, Harmon EG.
PMID: 25922798
PeerJ. 2015 Apr 23;3:e913. doi: 10.7717/peerj.913. eCollection 2015.

Objective. We compared the precision of a search strategy designed specifically to retrieve randomized controlled trials (RCTs) and systematic reviews of RCTs with search strategies designed for broader purposes. Methods. We designed an experimental search strategy that automatically revised...

Inguinal prolapse of a retroperitoneal lymphovascular malformation.

Urology case reports

Trivedi HM, Megison S, Peters CA.
PMID: 34381693
Urol Case Rep. 2021 Jul 24;39:101786. doi: 10.1016/j.eucr.2021.101786. eCollection 2021 Nov.

Abdominal lymphovascular malformations (ALMs) are rare cystic masses that can present with nonspecific symptoms. We present a case of a 7-month-old boy who, during an uncomplicated communicating hydrocele repair, was found to have an incidental large, prolapsed mesenteric abdominal...

Esophagus-Like Bronchus: A Noncommunicating Bronchopulmonary Foregut Malformation.

International journal of surgical pathology

Weon JL, Megison S, Timmons CF, Rakheja D.
PMID: 33709821
Int J Surg Pathol. 2021 Dec;29(8):847-849. doi: 10.1177/10668969211002255. Epub 2021 Mar 12.

We describe a previously unreported bronchopulmonary foregut malformation wherein a segment of a bronchus of the lower lobe of the left lung in a 4-year-old girl was entirely esophageal in structure. No communication was identified between the tracheobronchial tree...

FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo.

Translational oncology

Gillory LA, Stewart JE, Megison ML, Nabers HC, Mroczek-Musulman E, Beierle EA.
PMID: 23544173
Transl Oncol. 2013 Apr;6(2):206-15. doi: 10.1593/tlo.12505. Epub 2013 Apr 01.

Hepatoblastoma is the most frequently diagnosed liver tumor of childhood, and children with advanced, metastatic or relapsed disease have a disease-free survival rate under 50%. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is important in many...

Durable Clinical Response to Larotrectinib in an Adolescent Patient With an Undifferentiated Sarcoma Harboring an .

JCO precision oncology

Wu LW, Pavlock T, Patterson A, Post A, Ambrose C, Rajaram V, Pavlick DC, Cooke M, Miller VA, Albacker LA, Ali SM, Smith S, Cox MC, Martin A, Megison S, Laetsch TW.
PMID: 32913990
JCO Precis Oncol. 2018 Aug 02;2. doi: 10.1200/PO.18.00101. eCollection 2018.

No abstract available.

A novel deep learning-based 3D cell segmentation framework for future image-based disease detection.

Scientific reports

Wang A, Zhang Q, Han Y, Megason S, Hormoz S, Mosaliganti KR, Lam JCK, Li VOK.
PMID: 35013443
Sci Rep. 2022 Jan 10;12(1):342. doi: 10.1038/s41598-021-04048-3.

Cell segmentation plays a crucial role in understanding, diagnosing, and treating diseases. Despite the recent success of deep learning-based cell segmentation methods, it remains challenging to accurately segment densely packed cells in 3D cell membrane images. Existing approaches also...

A novel deep learning-based 3D cell segmentation framework for future image-based disease detection.

Scientific reports

Wang A, Zhang Q, Han Y, Megason S, Hormoz S, Mosaliganti KR, Lam JCK, Li VOK.
PMID: 35013443
Sci Rep. 2022 Jan 10;12(1):342. doi: 10.1038/s41598-021-04048-3.

Cell segmentation plays a crucial role in understanding, diagnosing, and treating diseases. Despite the recent success of deep learning-based cell segmentation methods, it remains challenging to accurately segment densely packed cells in 3D cell membrane images. Existing approaches also...

Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis.

Cell

Munjal A, Hannezo E, Tsai TY, Mitchison TJ, Megason SG.
PMID: 34942099
Cell. 2021 Dec 22;184(26):6313-6325.e18. doi: 10.1016/j.cell.2021.11.025.

How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) that extend and fuse to form the hubs of each canal. We find that...

Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis.

Cell

Munjal A, Hannezo E, Tsai TY, Mitchison TJ, Megason SG.
PMID: 34942099
Cell. 2021 Dec 22;184(26):6313-6325.e18. doi: 10.1016/j.cell.2021.11.025.

How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) that extend and fuse to form the hubs of each canal. We find that...

Uni-traveling-carrier variable confinement waveguide photodiodes.

Optics express

Klamkin J, Madison SM, Oakley DC, Napoleone A, O'Donnell FJ, Sheehan M, Missaggia LJ, Caissie JM, Plant JJ, Juodawlkis PW.
PMID: 21643278
Opt Express. 2011 May 23;19(11):10199-205. doi: 10.1364/OE.19.010199.

Uni-traveling-carrier waveguide photodiodes (PDs) with a variable optical confinement mode size transformer are demonstrated. The optical mode is large at the input for minimal front-end saturation and the mode transforms as the light propagates so that the absorption profile...

ANISOTROPIC PLATE DIFFUSION FILTERING FOR DETECTION OF CELL MEMBRANES IN 3D MICROSCOPY IMAGES.

Proceedings. IEEE International Symposium on Biomedical Imaging

Mosaliganti K, Janoos F, Gelas A, Noche R, Obholzer N, Machiraju R, Megason SG.
PMID: 21766060
Proc IEEE Int Symp Biomed Imaging. 2010;588-591. doi: 10.1109/ISBI.2010.5490110.

We propose an anisotropic diffusion method to denoise and aid the reconstruction of planar objects in three-dimensional images. The contribution of this paper is the development of a planarity function characterizing plate-like structures using an image Hessian's eigensystem. We...

Showing 1 to 12 of 17 entries