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Showing 1 to 12 of 356 entries
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Biological treatment in systemic juvenile idiopathic arthritis: achievement of inactive disease or clinical remission on a first, second or third biological agent.

RMD open

Woerner A, Uettwiller F, Melki I, Mouy R, Wouters C, Bader-Meunier B, Quartier P.
PMID: 26509061
RMD Open. 2015 Apr 30;1(1):e000036. doi: 10.1136/rmdopen-2014-000036. eCollection 2015.

OBJECTIVES: To analyse the effect of biological agents (BAs) in terms of achieving inactive disease (ID) or clinical remission (CR) in patients with systemic juvenile idiopathic arthritis (SJIA), to describe effects of switching or discontinuing a BA and to...

Role of innate immune response in non-alcoholic Fatty liver disease: metabolic complications and therapeutic tools.

Frontiers in immunology

Meli R, Mattace Raso G, Calignano A.
PMID: 24795720
Front Immunol. 2014 Apr 23;5:177. doi: 10.3389/fimmu.2014.00177. eCollection 2014.

Non-alcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, both in adults and children. It is characterized by an aberrant lipid storage in hepatocytes, named hepatic steatosis. Simple steatosis remains a benign process in most...

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice.

Molecular metabolism

D'Agostino G, Cristiano C, Lyons DJ, Citraro R, Russo E, Avagliano C, Russo R, Raso GM, Meli R, De Sarro G, Heisler LK, Calignano A.
PMID: 26137440
Mol Metab. 2015 May 02;4(7):528-36. doi: 10.1016/j.molmet.2015.04.005. eCollection 2015 Jul.

BACKGROUND/OBJECTIVES: Nuclear peroxisome proliferator activated receptor-α (PPAR-α) plays a fundamental role in the regulation of lipid homeostasis and is the target of medications used to treat dyslipidemia. However, little is known about the role of PPAR-α in mouse behavior.METHODS:...

Discrete Mixed-Valence Metal Chains: Iridium Pyridonate Blues The generous financial support from DGES and MCyT-PNI (Projects PB98-641 and BQU2000-1170) is gratefully acknowledged. .

Angewandte Chemie (International ed. in English)

Tejel C, Ciriano MA, Villarroya BE, Gelpi R, López JA, Lahoz FJ, Oro LA.
PMID: 12404501
Angew Chem Int Ed Engl. 2001 Nov 05;40(21):4084-4086.

No abstract available.

Age-associated changes in quantitative ultrasonometry (QUS) of the os calcis in Lebanese women-assessment of a Lebanese reference population.

Journal of musculoskeletal & neuronal interactions

Wehbe J, Cortbaoui C, Chidiac RM, Nehme A, Melki R, Bedran F, Atallah P, Cooper C, Hadji P, Maalouf G.
PMID: 15758346
J Musculoskelet Neuronal Interact. 2003 Sep;3(3):232-9.

OBJECTIVE: This study was aimed to assess age changes in quantitative ultrasonometry (QUS) in a large sample of Lebanese women to determine a Lebanese reference population.DESIGN: Cross-sectional study.SUBJECTS AND METHODS: Broadband ultrasound attenuation (BUA) and speed of sound (SOS)...

Production and efficacy of an attenuated live vaccine against contagious ovine ecthyma.

Veterinaria italiana

Mercante MT, Lelli R, Ronchi GF, Pini A.
PMID: 20405450
Vet Ital. 2008 Jul-Sep;44(3):537-42, 543-7.

Contagious ecthyma is caused by the orf virus, a member of the family Poxviridae, genus Parapoxvirus. Morbidity in affected sheep flocks is approximately 100%, while mortality varies between 1% and 10%. A live attenuated vaccine was produced by the...

A Web-based geographic information system for the management of animal disease epidemics.

Veterinaria italiana

Savini L, Weiss C, Colangeli P, Conte A, Ippoliti C, Lelli R, Santucci U.
PMID: 20422556
Vet Ital. 2007 Jul-Sep;43(3):761-72.

Outbreaks of highly contagious animal diseases severely affect the global economy, seriously disrupting domestic economies and the international trade of livestock and animal commodities. Italy has a series of contingency plans for the management of outbreaks of all major...

Reaction of chlorosulfonyl isocyanate with fluorosubstituted alkenes: evidence of a concerted pathway.

The Journal of organic chemistry

Shellhamer DF, Davenport KJ, Hassler DM, Hickle KR, Thorpe JJ, Vandenbroek DJ, Heasley VL, Boatz JA, Reingold AL, Moore CE.
PMID: 20964338
J Org Chem. 2010 Nov 19;75(22):7913-6. doi: 10.1021/jo101240s. Epub 2010 Oct 21.

Concerted reactions are indicated for the electrophilic addition of chlorosulfonyl isocyanate with monofluoroalkenes. A vinyl fluorine atom on an alkene raises the energy of a stepwise transition state more than the energy of the competing concerted pathway. This energy...

The interaction of Hsc70 protein with fibrillar α-Synuclein and its therapeutic potential in Parkinson's disease.

Communicative & integrative biology

Pemberton S, Melki R.
PMID: 22482021
Commun Integr Biol. 2012 Jan 01;5(1):94-5. doi: 10.4161/cib.18483.

We recently described the effect of the constitutively expressed chaperone, Hsc70 protein, on α‑Synuclein aggregation, a phenomenon associated with Parkinson disease. In vitro, Hsc70 binds to soluble α‑Syn and slows down its assembly into fibrils. Hsc70 also binds fibrillar...

Mapping and morphometric analysis of synapses and spines on fusiform cells in the dorsal cochlear nucleus.

Frontiers in systems neuroscience

Salloum RH, Chen G, Velet L, Manzoor NF, Elkin R, Kidd GJ, Coughlin J, Yurosko C, Bou-Anak S, Azadi S, Gohlsch S, Schneider H, Kaltenbach JA.
PMID: 25294990
Front Syst Neurosci. 2014 Sep 23;8:167. doi: 10.3389/fnsys.2014.00167. eCollection 2014.

Fusiform cells are the main integrative units of the mammalian dorsal cochlear nucleus (DCN), collecting and processing inputs from auditory and other sources before transmitting information to higher levels of the auditory system. Despite much previous work describing these...

A neural network simulation of hallucinated "voices" and associated speech perception impairments in schizophrenic patients.

Journal of cognitive neuroscience

Hoffman RE, Rapaport J, Ameli R, McGlashan TH, Harcherik D, Servan-Schreiber D.
PMID: 23961906
J Cogn Neurosci. 1995;7(4):479-96. doi: 10.1162/jocn.1995.7.4.479.

The mechanism of hallucinated speech, a symptom commonly reported by schizophrenic patients, is unknown. The hypothesis that these hallucinations arise from pathologically altered working memory underlying speech perception was explored. A neural network computer simulation of contextually guided sequential...

Periodic perturbation of chemical oscillators: entrainment and induced synchronization.

Chemistry (Weinheim an der Bergstrasse, Germany)

Makki R, Muñuzuri AP, Perez-Mercader J.
PMID: 25214439
Chemistry. 2014 Oct 27;20(44):14213-7. doi: 10.1002/chem.201403647. Epub 2014 Sep 11.

It is well known that a large number of catalyst-carrying beads immersed in an oscillatory chemical medium (Belousov-Zhabotinsky reaction) display collective oscillatory behavior. Using a light sensitive version of BZ, we show that this collective behavior can be entrained...

Showing 1 to 12 of 356 entries