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Showing 1 to 12 of 45 entries
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A multivariate analysis of factors affecting psychological performance.

The Johns Hopkins medical journal

Welcher DW, Mellits ED, Hardy JB.
PMID: 5099324
Johns Hopkins Med J. 1971 Jul;129(1):19-35.

No abstract available.

Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

Science translational medicine

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.
PMID: 25080479
Sci Transl Med. 2014 Jul 30;6(247):247rt1. doi: 10.1126/scitranslmed.3009995.

No abstract available.

Agrobacterium-Mediated Transformation of Fusarium oxysporum: An Efficient Tool for Insertional Mutagenesis and Gene Transfer.

Phytopathology

Mullins ED, Chen X, Romaine P, Raina R, Geiser DM, Kang S.
PMID: 18944391
Phytopathology. 2001 Feb;91(2):173-80. doi: 10.1094/PHYTO.2001.91.2.173.

ABSTRACT Agrobacterium tumefaciens-mediated transformation (ATMT) has long been used to transfer genes to a wide variety of plants and has also served as an efficient tool for insertional mutagenesis. In this paper, we report the construction of four novel...

Construction of Novel Spiroisoxazolines via Intramolecular Cyclization/Methylation.

Tetrahedron letters

Ellis ED, Xu J, Valente EJ, Hamme AT.
PMID: 20160942
Tetrahedron Lett. 2009 Sep 30;50(39):5516-5519. doi: 10.1016/j.tetlet.2009.07.095.

Improved yields for the syntheses of a variety of spiroisoxazolines were achieved through intramolecular cyclization/methylation reactions of functionalized 5,5-disubstituted isoxazolines in one reaction vessel. Aromatic ring containing nitrile oxides and disubstituted geminal alkenes reacted in a 1,3-dipolar fashion to...

Sex-specific lung cancer risk among radiation workers in the million-person study and patients TB-Fluoroscopy.

International journal of radiation biology

Boice JD, Ellis ED, Golden AP, Zablotska LB, Mumma MT, Cohen SS.
PMID: 30614747
Int J Radiat Biol. 2019 Jan 07;1-12. doi: 10.1080/09553002.2018.1547441. Epub 2019 Jan 07.

BACKGROUND: The study of Japanese atomic bomb survivors, exposed briefly to radiation, finds the risk of radiation-induced lung cancer to be nearly three times greater for women than for men. Because protection standards for astronauts are based on individual...

New insights into B cells as antigen presenting cells.

Current opinion in immunology

Ghosh D, Jiang W, Mukhopadhyay D, Mellins ED.
PMID: 34242927
Curr Opin Immunol. 2021 Jun;70:129-137. doi: 10.1016/j.coi.2021.06.003. Epub 2021 Jul 06.

In addition to their role as antibody producing cells, B cells make a critical contribution to adaptive immune responses by functioning as professional antigen-presenting cells (APC). Distinctive features of B cells as APC include the expression of the B...

Mortality among workers at the Los Alamos National Laboratory, 1943-2017.

International journal of radiation biology

Boice JD, Cohen SS, Mumma MT, Golden AP, Howard SC, Girardi DJ, Ellis ED, Bellamy MB, Dauer LT, Samuels C, Eckerman KF, Leggett RW.
PMID: 34047625
Int J Radiat Biol. 2021 Jun 21;1-28. doi: 10.1080/09553002.2021.1917784. Epub 2021 Jun 21.

BACKGROUND: During World War II (WWII), the Manhattan Engineering District established a secret laboratory in the mountains of northern New Mexico. The mission was to design, construct and test the first atomic weapon, nicknamed 'The Gadget' that was detonated...

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity.

Science translational medicine

Chakraborty S, Gonzalez JC, Sievers BL, Mallajosyula V, Chakraborty S, Dubey M, Ashraf U, Cheng BY, Kathale N, Tran KQT, Scallan C, Sinnott A, Cassidy A, Chen ST, Gelbart T, Gao F, Golan Y, Ji X, Kim-Schulze S, Prahl M, Gaw SL, Gnjatic S, Marron TU, Merad M, Arunachalam PS, Boyd SD, Davis MM, Holubar M, Khosla C, Maecker HT, Maldonado Y, Mellins ED, Nadeau KC, Pulendran B, Singh U, Subramanian A, Utz PJ, Sherwood R, Zhang S, Jagannathan P, Tan GS, Wang TT.
PMID: 35040666
Sci Transl Med. 2022 Jan 18;eabm7853. doi: 10.1126/scitranslmed.abm7853. Epub 2022 Jan 18.

A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two prospective cohorts, early non-neutralizing, afucosylated IgG antibodies specific to severe acute respiratory syndrome coronavirus...

Response to: 'Successful treatment of plasma exchange for refractory systemic juvenile idiopathic arthritis complicated with macrophage activation syndrome and severe lung disease' by Sato .

Annals of the rheumatic diseases

Saper VE, Chen G, Guillerman RP, Khatri P, Cron RQ, Mellins ED.
PMID: 32317313
Ann Rheum Dis. 2020 Apr 21; doi: 10.1136/annrheumdis-2020-217426. Epub 2020 Apr 21.

No abstract available.

Severe delayed hypersensitivity reactions to IL-1 and IL-6 inhibitors link to common HLA-DRB1*15 alleles.

Annals of the rheumatic diseases

Saper VE, Ombrello MJ, Tremoulet AH, Montero-Martin G, Prahalad S, Canna S, Shimizu C, Deutsch G, Tan SY, Remmers EF, Monos D, Hahn T, Phadke OK, Cassidy E, Ferguson I, Mallajosyula V, Xu J, Rosa Duque JS, Chua GT, Ghosh D, Szymanski AM, Rubin D, Burns JC, Tian L, Fernandez-Vina MA, Mellins ED, Hollenbach JA.
PMID: 34789453
Ann Rheum Dis. 2021 Nov 17; doi: 10.1136/annrheumdis-2021-220578. Epub 2021 Nov 17.

OBJECTIVES: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe, delayed hypersensitivity reaction (DHR). We observed DRESS to inhibitors of interleukin 1 (IL-1) or IL-6 in a small group of patients with Still's disease with atypical lung...

Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin.

Virulence

Al-Beltagi S, Goulding LV, Chang DKE, Mellits KH, Hayes CJ, Gershkovich P, Coleman CM, Chang KC.
PMID: 34793280
Virulence. 2021 Dec;12(1):2946-2956. doi: 10.1080/21505594.2021.2006960.

The struggle to control the COVID-19 pandemic is made challenging by the emergence of virulent SARS-CoV-2 variants. To gain insight into their replication dynamics, emergent Alpha (A), Beta (B) and Delta (D) SARS-CoV-2 variants were assessed for their infection...

Development of gfp Vectors for Expression in Listeria monocytogenes and Other Low G+C Gram Positive Bacteria.

Microbial ecology

Qazi SN, Rees CE, Mellits KH, Hill PJ.
PMID: 12032603
Microb Ecol. 2001 Feb;41(4):301-309. doi: 10.1007/s002480000091.

The gfp (green fluorescent protein) gene has previously been used to construct a variety of reporter plasmids for Gram-positive bacteria for bacterial localization and gene expression studies. When a native red-shifted gfp variant (gfp3) was cloned into an expression...

Showing 1 to 12 of 45 entries