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Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.

ACS medicinal chemistry letters

Tong Y, Torrent M, Florjancic AS, Bromberg KD, Buchanan FG, Ferguson DC, Johnson EF, Lasko LM, Maag D, Merta PJ, Olson AM, Osterling DJ, Soni N, Shoemaker AR, Penning TD.
PMID: 25589931
ACS Med Chem Lett. 2014 Aug 06;6(1):58-62. doi: 10.1021/ml5002745. eCollection 2015 Jan 08.

Aided by molecular modeling, compounds with a pyrimidine-based tricyclic scaffold were designed and confirmed to inhibit Wee1 kinase. Structure-activity studies identified key pharmacophores at the aminoaryl and halo-benzene regions responsible for binding affinity with sub-nM K i values. The...

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Tong Y, Torrent M, Florjancic AS, et al. Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett. 2014;6(1):58-62doi: 10.1021/ml5002745.
Tong, Y., Torrent, M., Florjancic, A. S., Bromberg, K. D., Buchanan, F. G., Ferguson, D. C., Johnson, E. F., Lasko, L. M., Maag, D., Merta, P. J., Olson, A. M., Osterling, D. J., Soni, N., Shoemaker, A. R., & Penning, T. D. (2015). Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS medicinal chemistry letters, 6(1), 58-62. https://doi.org/10.1021/ml5002745
Tong, Yunsong, et al. "Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase." ACS medicinal chemistry letters vol. 6,1 (2015): 58-62. doi: https://doi.org/10.1021/ml5002745
Tong Y, Torrent M, Florjancic AS, Bromberg KD, Buchanan FG, Ferguson DC, Johnson EF, Lasko LM, Maag D, Merta PJ, Olson AM, Osterling DJ, Soni N, Shoemaker AR, Penning TD. Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase. ACS Med Chem Lett. 2014 Aug 06;6(1):58-62. doi: 10.1021/ml5002745. eCollection 2015 Jan 08. PMID: 25589931; PMCID: PMC4291713.
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Bare Metal Stents Versus Drug Eluting Stents: Where Do We Stand in 2015?.

Current treatment options in cardiovascular medicine

Meraj PM, Jauhar R, Singh A.
PMID: 26154294
Curr Treat Options Cardiovasc Med. 2015 Aug;17(8):393. doi: 10.1007/s11936-015-0393-y.

OPINION STATEMENT: The development of bare metal stent (BMS) was a major advancement over plain old balloon angioplasty (POBA) in the management of symptomatic coronary artery disease. BMS prevented restenosis by attenuating early arterial recoil and contraction; both seen...

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Meraj PM, Jauhar R, Singh A. Bare Metal Stents Versus Drug Eluting Stents: Where Do We Stand in 2015?. Curr Treat Options Cardiovasc Med. 2015;17(8):393doi: 10.1007/s11936-015-0393-y.
Meraj, P. M., Jauhar, R., & Singh, A. (2015). Bare Metal Stents Versus Drug Eluting Stents: Where Do We Stand in 2015?. Current treatment options in cardiovascular medicine, 17(8), 393. https://doi.org/10.1007/s11936-015-0393-y
Meraj, Perwaiz M, et al. "Bare Metal Stents Versus Drug Eluting Stents: Where Do We Stand in 2015?." Current treatment options in cardiovascular medicine vol. 17,8 (2015): 393. doi: https://doi.org/10.1007/s11936-015-0393-y
Meraj PM, Jauhar R, Singh A. Bare Metal Stents Versus Drug Eluting Stents: Where Do We Stand in 2015?. Curr Treat Options Cardiovasc Med. 2015 Aug;17(8):393. doi: 10.1007/s11936-015-0393-y. PMID: 26154294.
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Tailored nurse navigation for women treated for breast cancer: Design and rationale for a pilot randomized controlled trial.

Acta oncologica (Stockholm, Sweden)

Envold Bidstrup P, Mertz BG, Kroman N, Andersson M, Mathiesen UB, Vibe-Petersen J, Dalton SO, Johansen C.
PMID: 27219356
Acta Oncol. 2016 Sep - Oct;55(9):1239-1243. doi: 10.3109/0284186X.2016.1167957. Epub 2016 May 24.

No abstract available.

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Envold Bidstrup P, Mertz BG, Kroman N, et al. Tailored nurse navigation for women treated for breast cancer: Design and rationale for a pilot randomized controlled trial. Acta Oncol. 2016;55(9):1239-1243doi: 10.3109/0284186X.2016.1167957.
Envold Bidstrup, P., Mertz, B. G., Kroman, N., Andersson, M., Mathiesen, U. B., Vibe-Petersen, J., Dalton, S. O., & Johansen, C. (2016). Tailored nurse navigation for women treated for breast cancer: Design and rationale for a pilot randomized controlled trial. Acta oncologica (Stockholm, Sweden), 55(9), 1239-1243. https://doi.org/10.3109/0284186X.2016.1167957
Envold Bidstrup, Pernille, et al. "Tailored nurse navigation for women treated for breast cancer: Design and rationale for a pilot randomized controlled trial." Acta oncologica (Stockholm, Sweden) vol. 55,9 (2016): 1239-1243. doi: https://doi.org/10.3109/0284186X.2016.1167957
Envold Bidstrup P, Mertz BG, Kroman N, Andersson M, Mathiesen UB, Vibe-Petersen J, Dalton SO, Johansen C. Tailored nurse navigation for women treated for breast cancer: Design and rationale for a pilot randomized controlled trial. Acta Oncol. 2016 Sep - Oct;55(9):1239-1243. doi: 10.3109/0284186X.2016.1167957. Epub 2016 May 24. PMID: 27219356.
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Inhibition of ion accumulation in maize roots by abscisic acid.

Planta

Shaner DL, Mertz SM, Arntzen CJ.
PMID: 24435924
Planta. 1975 Jan;122(1):79-90. doi: 10.1007/BF00385407.

An inhibition of root growth, a decrease in the amount of potassium (as (86)Rb) and phosphate ((32)P) accumulation by the root, and a partial depolarization of transmembrane electropotential were observed to develop with a similar time course and to...

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Shaner DL, Mertz SM, Arntzen CJ. Inhibition of ion accumulation in maize roots by abscisic acid. Planta. 1975;122(1):79-90doi: 10.1007/BF00385407.
Shaner, D. L., Mertz, S. M., & Arntzen, C. J. (1975). Inhibition of ion accumulation in maize roots by abscisic acid. Planta, 122(1), 79-90. https://doi.org/10.1007/BF00385407
Shaner, D L, et al. "Inhibition of ion accumulation in maize roots by abscisic acid." Planta vol. 122,1 (1975): 79-90. doi: https://doi.org/10.1007/BF00385407
Shaner DL, Mertz SM, Arntzen CJ. Inhibition of ion accumulation in maize roots by abscisic acid. Planta. 1975 Jan;122(1):79-90. doi: 10.1007/BF00385407. PMID: 24435924.
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Diagnosis of diseases of children in Ancient India.

Journal of the Indian Medical Association

MEHTA PM.
PMID: 13549755
J Indian Med Assoc. 1958 May 16;30(10):320-2.

No abstract available.

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MEHTA PM. Diagnosis of diseases of children in Ancient India. J Indian Med Assoc. 1958;30(10):320-2
MEHTA, P. M. (1958). Diagnosis of diseases of children in Ancient India. Journal of the Indian Medical Association, 30(10), 320-2.
MEHTA, P M. "Diagnosis of diseases of children in Ancient India." Journal of the Indian Medical Association vol. 30,10 (1958): 320-2.
MEHTA PM. Diagnosis of diseases of children in Ancient India. J Indian Med Assoc. 1958 May 16;30(10):320-2. PMID: 13549755.
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Psychiatric examinations of offenders: a specialized service.

The Psychiatric quarterly

MERTZ P.
PMID: 13245875
Psychiatr Q. 1955 Apr;29(2):179-92. doi: 10.1007/BF01567448.

No abstract available.

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MERTZ P. Psychiatric examinations of offenders: a specialized service. Psychiatr Q. 1955;29(2):179-92doi: 10.1007/BF01567448.
MERTZ, P. (1955). Psychiatric examinations of offenders: a specialized service. The Psychiatric quarterly, 29(2), 179-92. https://doi.org/10.1007/BF01567448
MERTZ, P. "Psychiatric examinations of offenders: a specialized service." The Psychiatric quarterly vol. 29,2 (1955): 179-92. doi: https://doi.org/10.1007/BF01567448
MERTZ P. Psychiatric examinations of offenders: a specialized service. Psychiatr Q. 1955 Apr;29(2):179-92. doi: 10.1007/BF01567448. PMID: 13245875.
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[Origin, essence and development of the idea of science--I: Antiquity--. a synopsis over two and a half millenia].

Versicherungsmedizin

Mertz DP.
PMID: 15224509
Versicherungsmedizin. 2004 Jun 01;56(2):87-92.

No abstract available.

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Mertz DP. Ursprung, Wesen und Werdegang der Idee der Wissenschaft--I. Teil: Antike--Eine Synopsis über zweieinhalb Jahrtausende. [Origin, essence and development of the idea of science--I: Antiquity--. a synopsis over two and a half millenia]. Versicherungsmedizin. 2004;56(2):87-92
Mertz, D. P. (2004). Ursprung, Wesen und Werdegang der Idee der Wissenschaft--I. Teil: Antike--Eine Synopsis über zweieinhalb Jahrtausende. [Origin, essence and development of the idea of science--I: Antiquity--. a synopsis over two and a half millenia]. Versicherungsmedizin, 56(2), 87-92.
Mertz, D P. "Ursprung, Wesen und Werdegang der Idee der Wissenschaft--I. Teil: Antike--Eine Synopsis über zweieinhalb Jahrtausende." [Origin, essence and development of the idea of science--I: Antiquity--. a synopsis over two and a half millenia]. Versicherungsmedizin vol. 56,2 (2004): 87-92.
Mertz DP. Ursprung, Wesen und Werdegang der Idee der Wissenschaft--I. Teil: Antike--Eine Synopsis über zweieinhalb Jahrtausende. [Origin, essence and development of the idea of science--I: Antiquity--. a synopsis over two and a half millenia]. Versicherungsmedizin. 2004 Jun 01;56(2):87-92. German. PMID: 15224509.
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[What holds the European Union together and where does its borders lie? (I)].

Versicherungsmedizin

Mertz DP.
PMID: 16392382
Versicherungsmedizin. 2005 Dec 01;57(4):192-4.

No abstract available.

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Mertz DP. Was hält die Europäische Union (EU) zusammen und wo liegen ihre Grenzen? (I). [What holds the European Union together and where does its borders lie? (I)]. Versicherungsmedizin. 2005;57(4):192-4
Mertz, D. P. (2005). Was hält die Europäische Union (EU) zusammen und wo liegen ihre Grenzen? (I). [What holds the European Union together and where does its borders lie? (I)]. Versicherungsmedizin, 57(4), 192-4.
Mertz, D P. "Was hält die Europäische Union (EU) zusammen und wo liegen ihre Grenzen? (I)." [What holds the European Union together and where does its borders lie? (I)]. Versicherungsmedizin vol. 57,4 (2005): 192-4.
Mertz DP. Was hält die Europäische Union (EU) zusammen und wo liegen ihre Grenzen? (I). [What holds the European Union together and where does its borders lie? (I)]. Versicherungsmedizin. 2005 Dec 01;57(4):192-4. German. PMID: 16392382.
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Kerr effect tomography for nonintrusive spatially resolved measurements of asymmetric electric field distributions.

Applied optics

Hertz HM.
PMID: 18231274
Appl Opt. 1986 Mar 15;25(6):914. doi: 10.1364/ao.25.000914.

No abstract available.

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Hertz HM. Kerr effect tomography for nonintrusive spatially resolved measurements of asymmetric electric field distributions. Appl Opt. 1986;25(6):914doi: 10.1364/ao.25.000914.
Hertz, H. M. (1986). Kerr effect tomography for nonintrusive spatially resolved measurements of asymmetric electric field distributions. Applied optics, 25(6), 914. https://doi.org/10.1364/ao.25.000914
Hertz, H M. "Kerr effect tomography for nonintrusive spatially resolved measurements of asymmetric electric field distributions." Applied optics vol. 25,6 (1986): 914. doi: https://doi.org/10.1364/ao.25.000914
Hertz HM. Kerr effect tomography for nonintrusive spatially resolved measurements of asymmetric electric field distributions. Appl Opt. 1986 Mar 15;25(6):914. doi: 10.1364/ao.25.000914. PMID: 18231274.
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Compact x-ray microscope for the water window based on a high brightness laser plasma source.

Optics express

Legall H, Blobel G, Stiel H, Sandner W, Seim C, Takman P, Martz DH, Selin M, Vogt U, Hertz HM, Esser D, Sipma H, Luttmann J, Höfer M, Hoffmann HD, Yulin S, Feigl T, Rehbein S, Guttmann P, Schneider G, Wiesemann U, Wirtz M, Diete W.
PMID: 23038387
Opt Express. 2012 Jul 30;20(16):18362-9. doi: 10.1364/OE.20.018362.

We present a laser plasma based x-ray microscope for the water window employing a high-average power laser system for plasma generation. At 90 W laser power a brightness of 7.4 x 10(11) photons/(s x sr x μm(2)) was measured...

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Legall H, Blobel G, Stiel H, et al. Compact x-ray microscope for the water window based on a high brightness laser plasma source. Opt Express. 2012;20(16):18362-9doi: 10.1364/OE.20.018362.
Legall, H., Blobel, G., Stiel, H., Sandner, W., Seim, C., Takman, P., Martz, D. H., Selin, M., Vogt, U., Hertz, H. M., Esser, D., Sipma, H., Luttmann, J., Höfer, M., Hoffmann, H. D., Yulin, S., Feigl, T., Rehbein, S., Guttmann, P., Schneider, G., Wiesemann, U., Wirtz, M., & Diete, W. (2012). Compact x-ray microscope for the water window based on a high brightness laser plasma source. Optics express, 20(16), 18362-9. https://doi.org/10.1364/OE.20.018362
Legall, H, et al. "Compact x-ray microscope for the water window based on a high brightness laser plasma source." Optics express vol. 20,16 (2012): 18362-9. doi: https://doi.org/10.1364/OE.20.018362
Legall H, Blobel G, Stiel H, Sandner W, Seim C, Takman P, Martz DH, Selin M, Vogt U, Hertz HM, Esser D, Sipma H, Luttmann J, Höfer M, Hoffmann HD, Yulin S, Feigl T, Rehbein S, Guttmann P, Schneider G, Wiesemann U, Wirtz M, Diete W. Compact x-ray microscope for the water window based on a high brightness laser plasma source. Opt Express. 2012 Jul 30;20(16):18362-9. doi: 10.1364/OE.20.018362. PMID: 23038387.
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Potent and selective inhibitors of CDPK1 from .

ACS medicinal chemistry letters

Zhang Z, Ojo KK, Vidadala R, Huang W, Geiger JA, Scheele S, Choi R, Reid MC, Keyloun KR, Rivas K, Siddaramaiah LK, Comess KM, Robinson KP, Merta PJ, Kifle L, Hol WG, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E.
PMID: 24494061
ACS Med Chem Lett. 2014 Jan 09;5(1):40-44. doi: 10.1021/ml400315s.

5-Aminopyrazole-4-carboxamide was used as an alternative scaffold to substitute for the pyrazolopyrimidine of a known "bumped kinase inhibitor" to create selective inhibitors of calcium-dependent protein kinase-1 from both

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Zhang Z, Ojo KK, Vidadala R, et al. Potent and selective inhibitors of CDPK1 from . ACS Med Chem Lett. 2014;5(1):40-44doi: 10.1021/ml400315s.
Zhang, Z., Ojo, K. K., Vidadala, R., Huang, W., Geiger, J. A., Scheele, S., Choi, R., Reid, M. C., Keyloun, K. R., Rivas, K., Siddaramaiah, L. K., Comess, K. M., Robinson, K. P., Merta, P. J., Kifle, L., Hol, W. G., Parsons, M., Merritt, E. A., Maly, D. J., Verlinde, C. L., Van Voorhis, W. C., & Fan, E. (2014). Potent and selective inhibitors of CDPK1 from . ACS medicinal chemistry letters, 5(1), 40-44. https://doi.org/10.1021/ml400315s
Zhang, Zhongsheng, et al. "Potent and selective inhibitors of CDPK1 from ." ACS medicinal chemistry letters vol. 5,1 (2014): 40-44. doi: https://doi.org/10.1021/ml400315s
Zhang Z, Ojo KK, Vidadala R, Huang W, Geiger JA, Scheele S, Choi R, Reid MC, Keyloun KR, Rivas K, Siddaramaiah LK, Comess KM, Robinson KP, Merta PJ, Kifle L, Hol WG, Parsons M, Merritt EA, Maly DJ, Verlinde CL, Van Voorhis WC, Fan E. Potent and selective inhibitors of CDPK1 from . ACS Med Chem Lett. 2014 Jan 09;5(1):40-44. doi: 10.1021/ml400315s. PMID: 24494061; PMCID: PMC3908674.
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Long-term Outcomes of 2-Level Total Disc Replacement Using ProDisc-L: Nine- to 10-Year Follow-up.

Spine

Balderston JR, Gertz ZM, McIntosh T, Balderston RA.
PMID: 29504961
Spine (Phila Pa 1976). 2014 May 15;39(11):906-910. doi: 10.1097/BRS.0000000000000148.

STUDY DESIGN: A prospective clinical data analysis.OBJECTIVE: To determine the long-term clinical success of 2-level total disc replacement (TDR) in patients with degenerative disc disease.SUMMARY OF BACKGROUND DATA: Early successful clinical results of 2-level TDR have been reported. Few...

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Balderston JR, Gertz ZM, McIntosh T, et al. Long-term Outcomes of 2-Level Total Disc Replacement Using ProDisc-L: Nine- to 10-Year Follow-up. Spine (Phila Pa 1976). 2014;39(11):906-910doi: 10.1097/BRS.0000000000000148.
Balderston, J. R., Gertz, Z. M., McIntosh, T., & Balderston, R. A. (2014). Long-term Outcomes of 2-Level Total Disc Replacement Using ProDisc-L: Nine- to 10-Year Follow-up. Spine, 39(11), 906-910. https://doi.org/10.1097/BRS.0000000000000148
Balderston, Jessica R, et al. "Long-term Outcomes of 2-Level Total Disc Replacement Using ProDisc-L: Nine- to 10-Year Follow-up." Spine vol. 39,11 (2014): 906-910. doi: https://doi.org/10.1097/BRS.0000000000000148
Balderston JR, Gertz ZM, McIntosh T, Balderston RA. Long-term Outcomes of 2-Level Total Disc Replacement Using ProDisc-L: Nine- to 10-Year Follow-up. Spine (Phila Pa 1976). 2014 May 15;39(11):906-910. doi: 10.1097/BRS.0000000000000148. PMID: 29504961.
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Showing 1 to 12 of 167 entries