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Showing 1 to 12 of 56 entries
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Publisher Correction: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.

Nature medicine

Bolouri H, Farrar JE, Triche T, Ries RE, Lim EL, Alonzo TA, Ma Y, Moore R, Mungall AJ, Marra MA, Zhang J, Ma X, Liu Y, Liu Y, Auvil JMG, Davidsen TM, Gesuwan P, Hermida LC, Salhia B, Capone S, Ramsingh G, Zwaan CM, Noort S, Piccolo SR, Kolb EA, Gamis AS, Smith MA, Gerhard DS, Meshinchi S.
PMID: 30705421
Nat Med. 2019 Mar;25(3):530. doi: 10.1038/s41591-019-0369-7.

In the version of this article originally published, the color key in Fig. 1a was wrong. In the Cytogenetics key, the box over t(8;21) originally was green. It should have been red, matching the color of the sections of...

RNAIndel: discovering somatic coding indels from tumor RNA-Seq data.

Bioinformatics (Oxford, England)

Hagiwara K, Ding L, Edmonson MN, Rice SV, Newman S, Easton J, Dai J, Meshinchi S, Ries RE, Rusch M, Zhang J.
PMID: 31593214
Bioinformatics. 2020 Mar 01;36(5):1382-1390. doi: 10.1093/bioinformatics/btz753.

MOTIVATION: Reliable identification of expressed somatic insertions/deletions (indels) is an unmet need due to artifacts generated in PCR-based RNA-Seq library preparation and the lack of normal RNA-Seq data, presenting analytical challenges for discovery of somatic indels in tumor transcriptome.RESULTS:...

AML risk stratification models utilizing ELN-2017 guidelines and additional prognostic factors: a SWOG report.

Biomarker research

Pogosova-Agadjanyan EL, Moseley A, Othus M, Appelbaum FR, Chauncey TR, Chen IL, Erba HP, Godwin JE, Jenkins IC, Fang M, Huynh M, Kopecky KJ, List AF, Naru J, Radich JP, Stevens E, Willborg BE, Willman CL, Wood BL, Zhang Q, Meshinchi S, Stirewalt DL.
PMID: 32817791
Biomark Res. 2020 Aug 12;8:29. doi: 10.1186/s40364-020-00208-1. eCollection 2020.

BACKGROUND: The recently updated European LeukemiaNet risk stratification guidelines combine cytogenetic abnormalities and genetic mutations to provide the means to triage patients with acute myeloid leukemia for optimal therapies. Despite the identification of many prognostic factors, relatively few have...

A B-cell developmental gene regulatory network is activated in infant AML.

PloS one

Bolouri H, Ries R, Pardo L, Hylkema T, Zhou W, Smith JL, Leonti A, Loken M, Farrar JE, Triche TJ, Meshinchi S.
PMID: 34793513
PLoS One. 2021 Nov 18;16(11):e0259197. doi: 10.1371/journal.pone.0259197. eCollection 2021.

Infant Acute Myeloid Leukemia (AML) is a poorly-addressed, heterogeneous malignancy distinguished by surprisingly few mutations per patient but accompanied by myriad age-specific translocations. These characteristics make treatment of infant AML challenging. While infant AML is a relatively rare disease,...

Time to reconsider CD33 single nucleotide polymorphism in the response to gemtuzumab ozogamicin.

Haematologica

Lamba JK, Meshinchi S.
PMID: 34092060
Haematologica. 2021 Nov 01;106(11):2796-2798. doi: 10.3324/haematol.2021.279043.

No abstract available.

CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes.

Blood advances

Huang BJ, Smith JL, Wang YC, Taghizadeh K, Leonti AR, Ries RE, Liu Y, Kolekar P, Tarlock K, Gerbing R, Crowgey E, Furlan SN, Shaw TI, Hagiwara K, Wei L, Cooper TM, Gamis AS, Aplenc R, Kolb EA, Farrar JE, Triche T, Alonzo TA, Ma X, Meshinchi S.
PMID: 34547772
Blood Adv. 2021 Dec 14;5(23):4963-4968. doi: 10.1182/bloodadvances.2021004965.

No abstract available.

Estimation of upper and lower bounds of Gini coefficient by fuzzy data.

Data in brief

Ganjoei RA, Akbarifard H, Mashinchi M, Majid Jalaee Esfandabadi SA.
PMID: 32123714
Data Brief. 2020 Feb 14;29:105288. doi: 10.1016/j.dib.2020.105288. eCollection 2020 Apr.

The data presented in this paper are used to examine the uncertainty in macroeconomic variables and their impact on the Gini coefficient. Annual data for the period 2017 - 1996 are taken from the Bank of Iran website https://www.cbi.ir....

St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem.

Cancer discovery

McLeod C, Gout AM, Zhou X, Thrasher A, Rahbarinia D, Brady SW, Macias M, Birch K, Finkelstein D, Sunny J, Mudunuri R, Orr BA, Treadway M, Davidson B, Ard TK, Chiao A, Swistak A, Wiggins S, Foy S, Wang J, Sioson E, Wang S, Michael JR, Liu Y, Ma X, Patel A, Edmonson MN, Wilkinson MR, Frantz AM, Chang TC, Tian L, Lei S, Islam SMA, Meyer C, Thangaraj N, Tater P, Kandali V, Ma S, Nguyen T, Serang O, McGuire I, Robison N, Gentry D, Tang X, Palmer LE, Wu G, Suh E, Tanner L, McMurry J, Lear M, Pappo AS, Wang Z, Wilson CL, Cheng Y, Meshinchi S, Alexandrov LB, Weiss MJ, Armstrong GT, Robison LL, Yasui Y, Nichols KE, Ellison DW, Bangur C, Mullighan CG, Baker SJ, Dyer MA, Miller G, Newman S, Rusch M, Daly R, Perry K, Downing JR, Zhang J.
PMID: 33408242
Cancer Discov. 2021 May;11(5):1082-1099. doi: 10.1158/2159-8290.CD-20-1230. Epub 2021 Jan 06.

Effective data sharing is key to accelerating research to improve diagnostic precision, treatment efficacy, and long-term survival in pediatric cancer and other childhood catastrophic diseases. We present St. Jude Cloud (https://www.stjude.cloud), a cloud-based data-sharing ecosystem for accessing, analyzing, and...

Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research

Le Q, Castro S, Tang T, Loeb AM, Hylkema T, McKay CN, Perkins L, Srivastava S, Call L, Smith J, Leonti A, Ries R, Pardo L, Loken MR, Correnti C, Fiorenza S, Turtle CJ, Riddell S, Tarlock K, Meshinchi S.
PMID: 34380639
Clin Cancer Res. 2021 Oct 15;27(20):5718-5730. doi: 10.1158/1078-0432.CCR-21-1546. Epub 2021 Aug 11.

PURPOSE: We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent in normal hematopoiesis, providing a promising antigen for immunotherapeutic targeting that avoids hematopoietic toxicity. Given that T cells...

Stoichiometry and Structure of Poly(amidoamine) Dendrimer-Lipid Complexes.

ACS nano

Kelly CV, Liroff MG, Triplett LD, Leroueil PR, Mullen DG, Wallace JM, Meshinchi S, Baker JR, Orr BG, Banaszak Holl MM.
PMID: 19534489
ACS Nano. 2009 Jul 28;3(7):1886-96. doi: 10.1021/nn900173e. Epub 2009 Jun 17.

The energetics, stoichiometry, and structure of poly(amidoamine) (PAMAM) dendrimer-phospholipid interactions were measured with isothermal titration calorimetry (ITC), transmission electron microscopy (TEM), atomic force microscopy (AFM), dynamic light scattering (DLS), and molecular dynamics (MD) simulations. Dendrimers of sixth-generation and smaller...

Cytarabine dose reduction in patients with low-risk acute myeloid leukemia: A report from the Children's Oncology Group.

Pediatric blood & cancer

Getz KD, Alonzo TA, Sung L, Meshinchi S, Gerbing RB, Raimondi S, Hirsch B, Loken M, Brodersen LE, Kahwash S, Choi J, Kolb EA, Gamis A, Aplenc R.
PMID: 34472213
Pediatr Blood Cancer. 2022 Jan;69(1):e29313. doi: 10.1002/pbc.29313. Epub 2021 Sep 02.

BACKGROUND: The optimal number of chemotherapy courses for low-risk (LR) pediatric acute myeloid leukemia (AML) is not known.OBJECTIVE: To compare outcomes for four (21.6 g/mMETHODS: We compared relapse risk (RR), disease-free survival (DFS), and overall survival (OS), and the...

CD33_PGx6_Score Predicts Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia: A Report From the Children's Oncology Group.

JCO precision oncology

Chauhan L, Shin M, Wang YC, Loken M, Pollard J, Aplenc R, Hirsch BA, Raimondi S, Ries RE, Bernstein ID, Gamis AS, Alonzo TA, Meshinchi S, Lamba JK.
PMID: 32914031
JCO Precis Oncol. 2019 May 23;3. doi: 10.1200/PO.18.00387. eCollection 2019.

PURPOSE: The US Food and Drug Administration recently announced reapproval of gemtuzumab ozogamicin (GO) for treatment of CD33-positive acute myeloid leukemia (AML), thus opening up opportunities to develop strategies for effective use of GO. In light of our recent...

Showing 1 to 12 of 56 entries