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Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis.

Frontiers in psychiatry

Collin G, Bauer CCC, Anteraper SA, Gabrieli JDE, Molokotos E, Mesholam-Gately R, Thermenos HW, Seidman LJ, Keshavan MS, Shenton ME, Whitfield-Gabrieli S.
PMID: 33633608
Front Psychiatry. 2021 Feb 09;12:613142. doi: 10.3389/fpsyt.2021.613142. eCollection 2021.

Patients with schizophrenia spectrum disorders show disturbances in self-referential processing and associated neural circuits including the default mode network (DMN). These disturbances may precede the onset of psychosis and may underlie early social and emotional problems. In this study,...

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Collin G, Bauer CCC, Anteraper SA, et al. Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis. Front Psychiatry. 2021;12:613142doi: 10.3389/fpsyt.2021.613142.
Collin, G., Bauer, C. C. C., Anteraper, S. A., Gabrieli, J. D. E., Molokotos, E., Mesholam-Gately, R., Thermenos, H. W., Seidman, L. J., Keshavan, M. S., Shenton, M. E., & Whitfield-Gabrieli, S. (2021). Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis. Frontiers in psychiatry, 12613142. https://doi.org/10.3389/fpsyt.2021.613142
Collin, Guusje, et al. "Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis." Frontiers in psychiatry vol. 12 (2021): 613142. doi: https://doi.org/10.3389/fpsyt.2021.613142
Collin G, Bauer CCC, Anteraper SA, Gabrieli JDE, Molokotos E, Mesholam-Gately R, Thermenos HW, Seidman LJ, Keshavan MS, Shenton ME, Whitfield-Gabrieli S. Hyperactivation of Posterior Default Mode Network During Self-Referential Processing in Children at Familial High-Risk for Psychosis. Front Psychiatry. 2021 Feb 09;12:613142. doi: 10.3389/fpsyt.2021.613142. eCollection 2021. PMID: 33633608; PMCID: PMC7900488.
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What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families.

Schizophrenia research

Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI.
PMID: 34864440
Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01.

No abstract available.

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Keshavan MS, Davis B, Friedman-Yakoobian M, et al. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021;239:92-94doi: 10.1016/j.schres.2021.10.009.
Keshavan, M. S., Davis, B., Friedman-Yakoobian, M., & Mesholam-Gately, R. I. (2021). What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophrenia research, 23992-94. https://doi.org/10.1016/j.schres.2021.10.009
Keshavan, Matcheri S, et al. "What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families." Schizophrenia research vol. 239 (2021): 92-94. doi: https://doi.org/10.1016/j.schres.2021.10.009
Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01. PMID: 34864440.
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What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families.

Schizophrenia research

Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI.
PMID: 34864440
Schizophr Res. 2022 Jan;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01.

No abstract available.

Cite
Keshavan MS, Davis B, Friedman-Yakoobian M, et al. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021;239:92-94doi: 10.1016/j.schres.2021.10.009.
Keshavan, M. S., Davis, B., Friedman-Yakoobian, M., & Mesholam-Gately, R. I. (2022). What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophrenia research, 23992-94. https://doi.org/10.1016/j.schres.2021.10.009
Keshavan, Matcheri S, et al. "What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families." Schizophrenia research vol. 239 (2022): 92-94. doi: https://doi.org/10.1016/j.schres.2021.10.009
Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2022 Jan;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01. PMID: 34864440.
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What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families.

Schizophrenia research

Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI.
PMID: 34864440
Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01.

No abstract available.

Cite
Keshavan MS, Davis B, Friedman-Yakoobian M, et al. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021;239:92-94doi: 10.1016/j.schres.2021.10.009.
Keshavan, M. S., Davis, B., Friedman-Yakoobian, M., & Mesholam-Gately, R. I. (2021). What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophrenia research, 23992-94. https://doi.org/10.1016/j.schres.2021.10.009
Keshavan, Matcheri S, et al. "What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families." Schizophrenia research vol. 239 (2021): 92-94. doi: https://doi.org/10.1016/j.schres.2021.10.009
Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01. PMID: 34864440.
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Functional connectivity associated with improvement in emotion management after cognitive enhancement therapy in early-course schizophrenia.

Psychological medicine

Guimond S, Ling G, Drodge J, Matheson H, Wojtalik JA, Lopez B, Collin G, Brady R, Mesholam-Gately RI, Thermenos H, Eack SM, Keshavan MS.
PMID: 33183362
Psychol Med. 2020 Nov 13;1-10. doi: 10.1017/S0033291720004110. Epub 2020 Nov 13.

BACKGROUND: The ability to manage emotions is an important social-cognitive domain impaired in schizophrenia and linked to functional outcome. The goal of our study was to examine the impact of cognitive enhancement therapy (CET) on the ability to manage...

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Guimond S, Ling G, Drodge J, et al. Functional connectivity associated with improvement in emotion management after cognitive enhancement therapy in early-course schizophrenia. Psychol Med. 2020;1-10doi: 10.1017/S0033291720004110.
Guimond, S., Ling, G., Drodge, J., Matheson, H., Wojtalik, J. A., Lopez, B., Collin, G., Brady, R., Mesholam-Gately, R. I., Thermenos, H., Eack, S. M., & Keshavan, M. S. (2020). Functional connectivity associated with improvement in emotion management after cognitive enhancement therapy in early-course schizophrenia. Psychological medicine, 1-10. https://doi.org/10.1017/S0033291720004110
Guimond, Synthia, et al. "Functional connectivity associated with improvement in emotion management after cognitive enhancement therapy in early-course schizophrenia." Psychological medicine vol. (2020): 1-10. doi: https://doi.org/10.1017/S0033291720004110
Guimond S, Ling G, Drodge J, Matheson H, Wojtalik JA, Lopez B, Collin G, Brady R, Mesholam-Gately RI, Thermenos H, Eack SM, Keshavan MS. Functional connectivity associated with improvement in emotion management after cognitive enhancement therapy in early-course schizophrenia. Psychol Med. 2020 Nov 13;1-10. doi: 10.1017/S0033291720004110. Epub 2020 Nov 13. PMID: 33183362.
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What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families.

Schizophrenia research

Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI.
PMID: 34864440
Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01.

No abstract available.

Cite
Keshavan MS, Davis B, Friedman-Yakoobian M, et al. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021;239:92-94doi: 10.1016/j.schres.2021.10.009.
Keshavan, M. S., Davis, B., Friedman-Yakoobian, M., & Mesholam-Gately, R. I. (2021). What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophrenia research, 23992-94. https://doi.org/10.1016/j.schres.2021.10.009
Keshavan, Matcheri S, et al. "What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families." Schizophrenia research vol. 239 (2021): 92-94. doi: https://doi.org/10.1016/j.schres.2021.10.009
Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01. PMID: 34864440.
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What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families.

Schizophrenia research

Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI.
PMID: 34864440
Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01.

No abstract available.

Cite
Keshavan MS, Davis B, Friedman-Yakoobian M, et al. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021;239:92-94doi: 10.1016/j.schres.2021.10.009.
Keshavan, M. S., Davis, B., Friedman-Yakoobian, M., & Mesholam-Gately, R. I. (2021). What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophrenia research, 23992-94. https://doi.org/10.1016/j.schres.2021.10.009
Keshavan, Matcheri S, et al. "What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families." Schizophrenia research vol. 239 (2021): 92-94. doi: https://doi.org/10.1016/j.schres.2021.10.009
Keshavan MS, Davis B, Friedman-Yakoobian M, Mesholam-Gately RI. What is my diagnosis, Doc?: Discussing psychosis diagnosis with patients and families. Schizophr Res. 2021 Dec 01;239:92-94. doi: 10.1016/j.schres.2021.10.009. Epub 2021 Dec 01. PMID: 34864440.
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Elucidating the relationship between white matter structure, demographic, and clinical variables in schizophrenia-a multicenter harmonized diffusion tensor imaging study.

Molecular psychiatry

Seitz-Holland J, Cetin-Karayumak S, Wojcik JD, Lyall A, Levitt J, Shenton ME, Pasternak O, Westin CF, Baxi M, Kelly S, Mesholam-Gately R, Vangel M, Pearlson G, Tamminga CA, Sweeney JA, Clementz BA, Schretlen D, Viher PV, Stegmayer K, Walther S, Lee J, Crow T, James A, Voineskos A, Buchanan RW, Szeszko PR, Malhotra AK, Rathi Y, Keshavan M, Kubicki M.
PMID: 33483689
Mol Psychiatry. 2021 Sep;26(9):5357-5370. doi: 10.1038/s41380-021-01018-z. Epub 2021 Jan 22.

White matter (WM) abnormalities are repeatedly demonstrated across the schizophrenia time-course. However, our understanding of how demographic and clinical variables interact, influence, or are dependent on WM pathologies is limited. The most well-known barriers to progress are heterogeneous findings...

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Seitz-Holland J, Cetin-Karayumak S, Wojcik JD, et al. Elucidating the relationship between white matter structure, demographic, and clinical variables in schizophrenia-a multicenter harmonized diffusion tensor imaging study. Mol Psychiatry. 2021;26(9):5357-5370doi: 10.1038/s41380-021-01018-z.
Seitz-Holland, J., Cetin-Karayumak, S., Wojcik, J. D., Lyall, A., Levitt, J., Shenton, M. E., Pasternak, O., Westin, C. F., Baxi, M., Kelly, S., Mesholam-Gately, R., Vangel, M., Pearlson, G., Tamminga, C. A., Sweeney, J. A., Clementz, B. A., Schretlen, D., Viher, P. V., Stegmayer, K., Walther, S., Lee, J., Crow, T., James, A., Voineskos, A., Buchanan, R. W., Szeszko, P. R., Malhotra, A. K., Rathi, Y., Keshavan, M., & Kubicki, M. (2021). Elucidating the relationship between white matter structure, demographic, and clinical variables in schizophrenia-a multicenter harmonized diffusion tensor imaging study. Molecular psychiatry, 26(9), 5357-5370. https://doi.org/10.1038/s41380-021-01018-z
Seitz-Holland, Johanna, et al. "Elucidating the relationship between white matter structure, demographic, and clinical variables in schizophrenia-a multicenter harmonized diffusion tensor imaging study." Molecular psychiatry vol. 26,9 (2021): 5357-5370. doi: https://doi.org/10.1038/s41380-021-01018-z
Seitz-Holland J, Cetin-Karayumak S, Wojcik JD, Lyall A, Levitt J, Shenton ME, Pasternak O, Westin CF, Baxi M, Kelly S, Mesholam-Gately R, Vangel M, Pearlson G, Tamminga CA, Sweeney JA, Clementz BA, Schretlen D, Viher PV, Stegmayer K, Walther S, Lee J, Crow T, James A, Voineskos A, Buchanan RW, Szeszko PR, Malhotra AK, Rathi Y, Keshavan M, Kubicki M. Elucidating the relationship between white matter structure, demographic, and clinical variables in schizophrenia-a multicenter harmonized diffusion tensor imaging study. Mol Psychiatry. 2021 Sep;26(9):5357-5370. doi: 10.1038/s41380-021-01018-z. Epub 2021 Jan 22. PMID: 33483689; PMCID: PMC8329919.
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The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures.

Schizophrenia research. Cognition

Kraus MS, Gold JM, Barch DM, Walker TM, Chun CA, Buchanan RW, Csernansky JG, Goff DC, Green MF, Jarskog LF, Javitt DC, Kimhy D, Lieberman JA, McEvoy JP, Mesholam-Gately RI, Seidman LJ, Ball MP, Kern RS, McMahon RP, Robinson J, Marder SR, Keefe RSE.
PMID: 31832342
Schizophr Res Cogn. 2019 Oct 31;19:100161. doi: 10.1016/j.scog.2019.100161. eCollection 2020 Mar.

In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests...

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Kraus MS, Gold JM, Barch DM, et al. The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures. Schizophr Res Cogn. 2019;19:100161doi: 10.1016/j.scog.2019.100161.
Kraus, M. S., Gold, J. M., Barch, D. M., Walker, T. M., Chun, C. A., Buchanan, R. W., Csernansky, J. G., Goff, D. C., Green, M. F., Jarskog, L. F., Javitt, D. C., Kimhy, D., Lieberman, J. A., McEvoy, J. P., Mesholam-Gately, R. I., Seidman, L. J., Ball, M. P., Kern, R. S., McMahon, R. P., Robinson, J., Marder, S. R., & Keefe, R. S. E. (2020). The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures. Schizophrenia research. Cognition, 19100161. https://doi.org/10.1016/j.scog.2019.100161
Kraus, Michael S, et al. "The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures." Schizophrenia research. Cognition vol. 19 (2020): 100161. doi: https://doi.org/10.1016/j.scog.2019.100161
Kraus MS, Gold JM, Barch DM, Walker TM, Chun CA, Buchanan RW, Csernansky JG, Goff DC, Green MF, Jarskog LF, Javitt DC, Kimhy D, Lieberman JA, McEvoy JP, Mesholam-Gately RI, Seidman LJ, Ball MP, Kern RS, McMahon RP, Robinson J, Marder SR, Keefe RSE. The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures. Schizophr Res Cogn. 2019 Oct 31;19:100161. doi: 10.1016/j.scog.2019.100161. eCollection 2020 Mar. PMID: 31832342; PMCID: PMC6889798.
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Confirmatory Efficacy of Cognitive Enhancement Therapy for Early Schizophrenia: Results From a Multisite Randomized Trial.

Psychiatric services (Washington, D.C.)

Wojtalik JA, Mesholam-Gately RI, Hogarty SS, Greenwald DP, Litschge MY, Sandoval LR, Shashidhar G, Guimond S, Keshavan MS, Eack SM.
PMID: 34470506
Psychiatr Serv. 2021 Sep 02;appips202000552. doi: 10.1176/appi.ps.202000552. Epub 2021 Sep 02.

OBJECTIVE: Cognitive enhancement therapy (CET) is an 18-month comprehensive cognitive remediation intervention designed to improve cognition and functioning among patients with schizophrenia. The current study sought to confirm previously observed benefits of CET on cognitive and behavioral outcomes in...

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Wojtalik JA, Mesholam-Gately RI, Hogarty SS, et al. Confirmatory Efficacy of Cognitive Enhancement Therapy for Early Schizophrenia: Results From a Multisite Randomized Trial. Psychiatr Serv. 2021;appips202000552doi: 10.1176/appi.ps.202000552.
Wojtalik, J. A., Mesholam-Gately, R. I., Hogarty, S. S., Greenwald, D. P., Litschge, M. Y., Sandoval, L. R., Shashidhar, G., Guimond, S., Keshavan, M. S., & Eack, S. M. (2021). Confirmatory Efficacy of Cognitive Enhancement Therapy for Early Schizophrenia: Results From a Multisite Randomized Trial. Psychiatric services (Washington, D.C.), appips202000552. https://doi.org/10.1176/appi.ps.202000552
Wojtalik, Jessica A, et al. "Confirmatory Efficacy of Cognitive Enhancement Therapy for Early Schizophrenia: Results From a Multisite Randomized Trial." Psychiatric services (Washington, D.C.) vol. (2021): appips202000552. doi: https://doi.org/10.1176/appi.ps.202000552
Wojtalik JA, Mesholam-Gately RI, Hogarty SS, Greenwald DP, Litschge MY, Sandoval LR, Shashidhar G, Guimond S, Keshavan MS, Eack SM. Confirmatory Efficacy of Cognitive Enhancement Therapy for Early Schizophrenia: Results From a Multisite Randomized Trial. Psychiatr Serv. 2021 Sep 02;appips202000552. doi: 10.1176/appi.ps.202000552. Epub 2021 Sep 02. PMID: 34470506.
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Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically.

Frontiers in psychiatry

Brady RO, Beermann A, Nye M, Eack SM, Mesholam-Gately R, Keshavan MS, Lewandowski KE.
PMID: 33329111
Front Psychiatry. 2020 Nov 04;11:573002. doi: 10.3389/fpsyt.2020.573002. eCollection 2020.

No abstract available.

Cite
Brady RO, Beermann A, Nye M, et al. Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically. Front Psychiatry. 2020;11:573002doi: 10.3389/fpsyt.2020.573002.
Brady, R. O., Beermann, A., Nye, M., Eack, S. M., Mesholam-Gately, R., Keshavan, M. S., & Lewandowski, K. E. (2020). Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically. Frontiers in psychiatry, 11573002. https://doi.org/10.3389/fpsyt.2020.573002
Brady, Roscoe O, et al. "Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically." Frontiers in psychiatry vol. 11 (2020): 573002. doi: https://doi.org/10.3389/fpsyt.2020.573002
Brady RO, Beermann A, Nye M, Eack SM, Mesholam-Gately R, Keshavan MS, Lewandowski KE. Cerebellar-Cortical Connectivity Is Linked to Social Cognition Trans-Diagnostically. Front Psychiatry. 2020 Nov 04;11:573002. doi: 10.3389/fpsyt.2020.573002. eCollection 2020. PMID: 33329111; PMCID: PMC7672118.
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Altered working memory-related brain activity in children at familial high risk for psychosis: A preliminary study.

Schizophrenia research

van Gool KCA, Collin G, Bauer CCC, Molokotos E, Mesholam-Gately RI, Thermenos HW, Seidman LJ, Gabrieli JDE, Whitfield-Gabrieli S, Keshavan MS.
PMID: 35032903
Schizophr Res. 2022 Jan 12;240:186-192. doi: 10.1016/j.schres.2021.12.030. Epub 2022 Jan 12.

BACKGROUND: Schizophrenia spectrum disorders are heritable illnesses that usually manifest in early adulthood but are increasingly viewed as neurodevelopmental disorders. Functional magnetic resonance imaging (fMRI) studies show altered brain activity during performance of working memory (WM) tasks in both...

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van Gool KCA, Collin G, Bauer CCC, et al. Altered working memory-related brain activity in children at familial high risk for psychosis: A preliminary study. Schizophr Res. 2022;240:186-192doi: 10.1016/j.schres.2021.12.030.
van Gool, K. C. A., Collin, G., Bauer, C. C. C., Molokotos, E., Mesholam-Gately, R. I., Thermenos, H. W., Seidman, L. J., Gabrieli, J. D. E., Whitfield-Gabrieli, S., & Keshavan, M. S. (2022). Altered working memory-related brain activity in children at familial high risk for psychosis: A preliminary study. Schizophrenia research, 240186-192. https://doi.org/10.1016/j.schres.2021.12.030
van Gool, Kevin C A, et al. "Altered working memory-related brain activity in children at familial high risk for psychosis: A preliminary study." Schizophrenia research vol. 240 (2022): 186-192. doi: https://doi.org/10.1016/j.schres.2021.12.030
van Gool KCA, Collin G, Bauer CCC, Molokotos E, Mesholam-Gately RI, Thermenos HW, Seidman LJ, Gabrieli JDE, Whitfield-Gabrieli S, Keshavan MS. Altered working memory-related brain activity in children at familial high risk for psychosis: A preliminary study. Schizophr Res. 2022 Jan 12;240:186-192. doi: 10.1016/j.schres.2021.12.030. Epub 2022 Jan 12. PMID: 35032903.
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