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Electric-field-induced shape transition of nematic tactoids.

Physical review. E

Metselaar L, Dozov I, Antonova K, Belamie E, Davidson P, Yeomans JM, Doostmohammadi A.
PMID: 28950460
Phys Rev E. 2017 Aug;96(2):022706. doi: 10.1103/PhysRevE.96.022706. Epub 2017 Aug 09.

The occurrence of new textures of liquid crystals is an important factor in tuning their optical and photonics properties. Here, we show, both experimentally and by numerical computation, that under an electric field chitin tactoids (i.e., nematic droplets) can...

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Metselaar L, Dozov I, Antonova K, et al. Electric-field-induced shape transition of nematic tactoids. Phys Rev E. 2017;96(2):022706doi: 10.1103/PhysRevE.96.022706.
Metselaar, L., Dozov, I., Antonova, K., Belamie, E., Davidson, P., Yeomans, J. M., & Doostmohammadi, A. (2017). Electric-field-induced shape transition of nematic tactoids. Physical review. E, 96(2), 022706. https://doi.org/10.1103/PhysRevE.96.022706
Metselaar, Luuk, et al. "Electric-field-induced shape transition of nematic tactoids." Physical review. E vol. 96,2 (2017): 022706. doi: https://doi.org/10.1103/PhysRevE.96.022706
Metselaar L, Dozov I, Antonova K, Belamie E, Davidson P, Yeomans JM, Doostmohammadi A. Electric-field-induced shape transition of nematic tactoids. Phys Rev E. 2017 Aug;96(2):022706. doi: 10.1103/PhysRevE.96.022706. Epub 2017 Aug 09. PMID: 28950460.
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Selective binding and easy separation of C70 by nanoscale self-assembled capsules.

Angewandte Chemie (International ed. in English)

Huerta E, Metselaar GA, Fragoso A, Santos E, Bo C, de Mendoza J.
PMID: 17031895
Angew Chem Int Ed Engl. 2007;46(1):202-5. doi: 10.1002/anie.200603223.

No abstract available.

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Huerta E, Metselaar GA, Fragoso A, et al. Selective binding and easy separation of C70 by nanoscale self-assembled capsules. Angew Chem Int Ed Engl. 2007;46(1):202-5doi: 10.1002/anie.200603223.
Huerta, E., Metselaar, G. A., Fragoso, A., Santos, E., Bo, C., & de Mendoza, J. (2007). Selective binding and easy separation of C70 by nanoscale self-assembled capsules. Angewandte Chemie (International ed. in English), 46(1), 202-5. https://doi.org/10.1002/anie.200603223
Huerta, Elisa, et al. "Selective binding and easy separation of C70 by nanoscale self-assembled capsules." Angewandte Chemie (International ed. in English) vol. 46,1 (2007): 202-5. doi: https://doi.org/10.1002/anie.200603223
Huerta E, Metselaar GA, Fragoso A, Santos E, Bo C, de Mendoza J. Selective binding and easy separation of C70 by nanoscale self-assembled capsules. Angew Chem Int Ed Engl. 2007;46(1):202-5. doi: 10.1002/anie.200603223. PMID: 17031895.
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On the Gaseous Exchange of Ammonia between Leaves and the Environment: Determination of the Ammonia Compensation Point.

Plant physiology

Farquhar GD, Firth PM, Wetselaar R, Weir B.
PMID: 16661507
Plant Physiol. 1980 Oct;66(4):710-4. doi: 10.1104/pp.66.4.710.

Whole shoots of Phaseolus vulgaris L. and other species were exposed to a range of partial pressures of gaseous ammonia in air and the resulting fluxes were measured. Net uptake is linear with partial pressure in the range 5...

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Farquhar GD, Firth PM, Wetselaar R, et al. On the Gaseous Exchange of Ammonia between Leaves and the Environment: Determination of the Ammonia Compensation Point. Plant Physiol. 1980;66(4):710-4doi: 10.1104/pp.66.4.710.
Farquhar, G. D., Firth, P. M., Wetselaar, R., & Weir, B. (1980). On the Gaseous Exchange of Ammonia between Leaves and the Environment: Determination of the Ammonia Compensation Point. Plant physiology, 66(4), 710-4. https://doi.org/10.1104/pp.66.4.710
Farquhar, G D, et al. "On the Gaseous Exchange of Ammonia between Leaves and the Environment: Determination of the Ammonia Compensation Point." Plant physiology vol. 66,4 (1980): 710-4. doi: https://doi.org/10.1104/pp.66.4.710
Farquhar GD, Firth PM, Wetselaar R, Weir B. On the Gaseous Exchange of Ammonia between Leaves and the Environment: Determination of the Ammonia Compensation Point. Plant Physiol. 1980 Oct;66(4):710-4. doi: 10.1104/pp.66.4.710. PMID: 16661507; PMCID: PMC440708.
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X-ray spectroscopic and diffraction study of the structure of the active species in the Ni(II)-catalyzed polymerization of isocyanides.

Chemphyschem : a European journal of chemical physics and physical chemistry

Metselaar GA, Schwartz E, de Gelder R, Feiters MC, Nikitenko S, Smolentsev G, Yalovega GE, Soldatov AV, Cornelissen JJ, Rowan AE, Nolte RJ.
PMID: 17647252
Chemphyschem. 2007 Aug 24;8(12):1850-6. doi: 10.1002/cphc.200700251.

The structure of the active complex in the Ni-catalyzed polymerization of isocyanides to give polyisocyanides is investigated. It is shown by X-ray absorption spectroscopy (XAS), including EXAFS (extended X-ray absorption fine structure) and XANES (X-ray absorption near edge structure),...

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Metselaar GA, Schwartz E, de Gelder R, et al. X-ray spectroscopic and diffraction study of the structure of the active species in the Ni(II)-catalyzed polymerization of isocyanides. Chemphyschem. 2007;8(12):1850-6doi: 10.1002/cphc.200700251.
Metselaar, G. A., Schwartz, E., de Gelder, R., Feiters, M. C., Nikitenko, S., Smolentsev, G., Yalovega, G. E., Soldatov, A. V., Cornelissen, J. J., Rowan, A. E., & Nolte, R. J. (2007). X-ray spectroscopic and diffraction study of the structure of the active species in the Ni(II)-catalyzed polymerization of isocyanides. Chemphyschem : a European journal of chemical physics and physical chemistry, 8(12), 1850-6. https://doi.org/10.1002/cphc.200700251
Metselaar, Gerald A, et al. "X-ray spectroscopic and diffraction study of the structure of the active species in the Ni(II)-catalyzed polymerization of isocyanides." Chemphyschem : a European journal of chemical physics and physical chemistry vol. 8,12 (2007): 1850-6. doi: https://doi.org/10.1002/cphc.200700251
Metselaar GA, Schwartz E, de Gelder R, Feiters MC, Nikitenko S, Smolentsev G, Yalovega GE, Soldatov AV, Cornelissen JJ, Rowan AE, Nolte RJ. X-ray spectroscopic and diffraction study of the structure of the active species in the Ni(II)-catalyzed polymerization of isocyanides. Chemphyschem. 2007 Aug 24;8(12):1850-6. doi: 10.1002/cphc.200700251. PMID: 17647252.
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Topological states in chiral active matter: Dynamic blue phases and active half-skyrmions.

The Journal of chemical physics

Metselaar L, Doostmohammadi A, Yeomans JM.
PMID: 30769984
J Chem Phys. 2019 Feb 14;150(6):064909. doi: 10.1063/1.5085282.

We numerically study the dynamics of two-dimensional blue phases in active chiral liquid crystals. We show that introducing contractile activity results in stabilised blue phases, while small extensile activity generates ordered but dynamic blue phases characterised by coherently moving...

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Metselaar L, Doostmohammadi A, Yeomans JM. Topological states in chiral active matter: Dynamic blue phases and active half-skyrmions. J Chem Phys. 2019;150(6):064909doi: 10.1063/1.5085282.
Metselaar, L., Doostmohammadi, A., & Yeomans, J. M. (2019). Topological states in chiral active matter: Dynamic blue phases and active half-skyrmions. The Journal of chemical physics, 150(6), 064909. https://doi.org/10.1063/1.5085282
Metselaar, Luuk, et al. "Topological states in chiral active matter: Dynamic blue phases and active half-skyrmions." The Journal of chemical physics vol. 150,6 (2019): 064909. doi: https://doi.org/10.1063/1.5085282
Metselaar L, Doostmohammadi A, Yeomans JM. Topological states in chiral active matter: Dynamic blue phases and active half-skyrmions. J Chem Phys. 2019 Feb 14;150(6):064909. doi: 10.1063/1.5085282. PMID: 30769984.
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Development and characterization of liposomal formulation of bortezomib.

International journal of pharmaceutics: X

Deshantri AK, Metselaar JM, Zagkou S, Storm G, Mandhane SN, Fens MHAM, Schiffelers RM.
PMID: 31517276
Int J Pharm X. 2019 Mar 23;1:100011. doi: 10.1016/j.ijpx.2019.100011. eCollection 2019 Dec.

Bortezomib is a proteasome inhibitor used for the treatment of multiple myeloma. The poor pharmacokinetic profile and off-target adverse effects provide a strong incentive to develop drug delivery systems for bortezomib. In the past, liposomal encapsulation has been proven...

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Deshantri AK, Metselaar JM, Zagkou S, et al. Development and characterization of liposomal formulation of bortezomib. Int J Pharm X. 2019;1:100011doi: 10.1016/j.ijpx.2019.100011.
Deshantri, A. K., Metselaar, J. M., Zagkou, S., Storm, G., Mandhane, S. N., Fens, M. H. A. M., & Schiffelers, R. M. (2019). Development and characterization of liposomal formulation of bortezomib. International journal of pharmaceutics: X, 1100011. https://doi.org/10.1016/j.ijpx.2019.100011
Deshantri, Anil K, et al. "Development and characterization of liposomal formulation of bortezomib." International journal of pharmaceutics: X vol. 1 (2019): 100011. doi: https://doi.org/10.1016/j.ijpx.2019.100011
Deshantri AK, Metselaar JM, Zagkou S, Storm G, Mandhane SN, Fens MHAM, Schiffelers RM. Development and characterization of liposomal formulation of bortezomib. Int J Pharm X. 2019 Mar 23;1:100011. doi: 10.1016/j.ijpx.2019.100011. eCollection 2019 Dec. PMID: 31517276; PMCID: PMC6733293.
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A pilot study on the use of prednisolone-encapsulated liposomes for the treatment of moderate-to-severe Graves' orbitopathy with reduced systemic steroid exposure.

Acta ophthalmologica

Detiger SE, Kremer TM, A S H Dalm V, de Keizer ROB, Wubbels RJ, Metselaar JM, van Hagen PM, Peeters RP, Paridaens D.
PMID: 33423386
Acta Ophthalmol. 2021 Nov;99(7):797-804. doi: 10.1111/aos.14751. Epub 2021 Jan 10.

PURPOSE: To demonstrate that long-circulating PEGylated liposomal prednisolone is a safe and effective therapy in patients with active moderate-to-severe Graves' orbitopathy.METHODS: Open-label, proof-of-concept, multicentre pilot study. Ten patients with moderate-to-severe Graves's orbitopathy, who were euthyroid for at least three...

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Detiger SE, Kremer TM, A S H Dalm V, et al. A pilot study on the use of prednisolone-encapsulated liposomes for the treatment of moderate-to-severe Graves' orbitopathy with reduced systemic steroid exposure. Acta Ophthalmol. 2021;99(7):797-804doi: 10.1111/aos.14751.
Detiger, S. E., Kremer, T. M., A S H Dalm, V., de Keizer, R. O. B., Wubbels, R. J., Metselaar, J. M., van Hagen, P. M., Peeters, R. P., & Paridaens, D. (2021). A pilot study on the use of prednisolone-encapsulated liposomes for the treatment of moderate-to-severe Graves' orbitopathy with reduced systemic steroid exposure. Acta ophthalmologica, 99(7), 797-804. https://doi.org/10.1111/aos.14751
Detiger, Sanne E, et al. "A pilot study on the use of prednisolone-encapsulated liposomes for the treatment of moderate-to-severe Graves' orbitopathy with reduced systemic steroid exposure." Acta ophthalmologica vol. 99,7 (2021): 797-804. doi: https://doi.org/10.1111/aos.14751
Detiger SE, Kremer TM, A S H Dalm V, de Keizer ROB, Wubbels RJ, Metselaar JM, van Hagen PM, Peeters RP, Paridaens D. A pilot study on the use of prednisolone-encapsulated liposomes for the treatment of moderate-to-severe Graves' orbitopathy with reduced systemic steroid exposure. Acta Ophthalmol. 2021 Nov;99(7):797-804. doi: 10.1111/aos.14751. Epub 2021 Jan 10. PMID: 33423386.
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Intravenous pegylated liposomal prednisolone outperforms intramuscular methylprednisolone in treating rheumatoid arthritis flares: A randomized controlled clinical trial.

Journal of controlled release : official journal of the Controlled Release Society

Metselaar JM, Middelink LM, Wortel CH, Bos R, van Laar JM, Vonkeman HE, Westhovens R, Lammers T, Yao SL, Kothekar M, Raut A, Bijlsma JWJ.
PMID: 34896445
J Control Release. 2021 Dec 10;341:548-554. doi: 10.1016/j.jconrel.2021.12.007. Epub 2021 Dec 10.

Glucocorticoids (GCs) are potent anti-inflammatory drugs but their use is limited by systemic exposure leading to toxicity. Targeted GC delivery to sites of inflammation via encapsulation in long-circulating liposomes may improve the therapeutic index. We performed a randomized, double-blind,...

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Metselaar JM, Middelink LM, Wortel CH, et al. Intravenous pegylated liposomal prednisolone outperforms intramuscular methylprednisolone in treating rheumatoid arthritis flares: A randomized controlled clinical trial. J Control Release. 2021;341:548-554doi: 10.1016/j.jconrel.2021.12.007.
Metselaar, J. M., Middelink, L. M., Wortel, C. H., Bos, R., van Laar, J. M., Vonkeman, H. E., Westhovens, R., Lammers, T., Yao, S. L., Kothekar, M., Raut, A., & Bijlsma, J. W. J. (2021). Intravenous pegylated liposomal prednisolone outperforms intramuscular methylprednisolone in treating rheumatoid arthritis flares: A randomized controlled clinical trial. Journal of controlled release : official journal of the Controlled Release Society, 341548-554. https://doi.org/10.1016/j.jconrel.2021.12.007
Metselaar, Josbert M, et al. "Intravenous pegylated liposomal prednisolone outperforms intramuscular methylprednisolone in treating rheumatoid arthritis flares: A randomized controlled clinical trial." Journal of controlled release : official journal of the Controlled Release Society vol. 341 (2021): 548-554. doi: https://doi.org/10.1016/j.jconrel.2021.12.007
Metselaar JM, Middelink LM, Wortel CH, Bos R, van Laar JM, Vonkeman HE, Westhovens R, Lammers T, Yao SL, Kothekar M, Raut A, Bijlsma JWJ. Intravenous pegylated liposomal prednisolone outperforms intramuscular methylprednisolone in treating rheumatoid arthritis flares: A randomized controlled clinical trial. J Control Release. 2021 Dec 10;341:548-554. doi: 10.1016/j.jconrel.2021.12.007. Epub 2021 Dec 10. PMID: 34896445.
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An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer.

Pharmacology research & perspectives

Vrouwe JPM, Kamerling IMC, van Esdonk MJ, Metselaar JM, Stuurman FE, van der Pluijm G, Burggraaf J, Osanto S.
PMID: 34414692
Pharmacol Res Perspect. 2021 Oct;9(5):e00845. doi: 10.1002/prp2.845.

Dexamethasone has antitumor activity in metastatic castration resistant prostate cancer (mCRPC). We aimed to investigate intravenous liposome-encapsulated dexamethasone disodium phosphate (liposomal dexamethasone) administration in mCRPC patients. In this exploratory first-in-man study, patients in part A received a starting dose...

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Vrouwe JPM, Kamerling IMC, van Esdonk MJ, et al. An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer. Pharmacol Res Perspect. 2021;9(5):e00845doi: 10.1002/prp2.845.
Vrouwe, J. P. M., Kamerling, I. M. C., van Esdonk, M. J., Metselaar, J. M., Stuurman, F. E., van der Pluijm, G., Burggraaf, J., & Osanto, S. (2021). An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer. Pharmacology research & perspectives, 9(5), e00845. https://doi.org/10.1002/prp2.845
Vrouwe, Josephina P M, et al. "An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer." Pharmacology research & perspectives vol. 9,5 (2021): e00845. doi: https://doi.org/10.1002/prp2.845
Vrouwe JPM, Kamerling IMC, van Esdonk MJ, Metselaar JM, Stuurman FE, van der Pluijm G, Burggraaf J, Osanto S. An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer. Pharmacol Res Perspect. 2021 Oct;9(5):e00845. doi: 10.1002/prp2.845. PMID: 34414692; PMCID: PMC8377443.
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Topology and Morphology of Self-Deforming Active Shells.

Physical review letters

Metselaar L, Yeomans JM, Doostmohammadi A.
PMID: 31809098
Phys Rev Lett. 2019 Nov 15;123(20):208001. doi: 10.1103/PhysRevLett.123.208001.

We present a generic framework for modeling three-dimensional deformable shells of active matter that captures the orientational dynamics of the active particles and hydrodynamic interactions on the shell and with the surrounding environment. We find that the cross talk...

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Metselaar L, Yeomans JM, Doostmohammadi A. Topology and Morphology of Self-Deforming Active Shells. Phys Rev Lett. 2019;123(20):208001doi: 10.1103/PhysRevLett.123.208001.
Metselaar, L., Yeomans, J. M., & Doostmohammadi, A. (2019). Topology and Morphology of Self-Deforming Active Shells. Physical review letters, 123(20), 208001. https://doi.org/10.1103/PhysRevLett.123.208001
Metselaar, Luuk, et al. "Topology and Morphology of Self-Deforming Active Shells." Physical review letters vol. 123,20 (2019): 208001. doi: https://doi.org/10.1103/PhysRevLett.123.208001
Metselaar L, Yeomans JM, Doostmohammadi A. Topology and Morphology of Self-Deforming Active Shells. Phys Rev Lett. 2019 Nov 15;123(20):208001. doi: 10.1103/PhysRevLett.123.208001. PMID: 31809098.
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Measurement properties of the PBC-40 and PBC-27: a Dutch validation study.

BMJ open gastroenterology

de Veer RC, da Silva G, van Hooff MC, Harms MH, Metselaar HJ, Willemse J, Utomo E, van der Meer AJ.
PMID: 34916226
BMJ Open Gastroenterol. 2021 Dec;8(1). doi: 10.1136/bmjgast-2021-000758.

OBJECTIVE: Patients with primary biliary cholangitis (PBC) have an impaired health-related quality of life (HRQoL). Practice guidelines recommend evaluating the HRQoL in all patients with PBC. The aim of this study was to assess the reliability and validity of...

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de Veer RC, da Silva G, van Hooff MC, et al. Measurement properties of the PBC-40 and PBC-27: a Dutch validation study. BMJ Open Gastroenterol. 2021;8(1)doi: 10.1136/bmjgast-2021-000758.
de Veer, R. C., da Silva, G., van Hooff, M. C., Harms, M. H., Metselaar, H. J., Willemse, J., Utomo, E., & van der Meer, A. J. (2021). Measurement properties of the PBC-40 and PBC-27: a Dutch validation study. BMJ open gastroenterology, 8(1), . https://doi.org/10.1136/bmjgast-2021-000758
de Veer, Rozanne C, et al. "Measurement properties of the PBC-40 and PBC-27: a Dutch validation study." BMJ open gastroenterology vol. 8,1 (2021). doi: https://doi.org/10.1136/bmjgast-2021-000758
de Veer RC, da Silva G, van Hooff MC, Harms MH, Metselaar HJ, Willemse J, Utomo E, van der Meer AJ. Measurement properties of the PBC-40 and PBC-27: a Dutch validation study. BMJ Open Gastroenterol. 2021 Dec;8(1). doi: 10.1136/bmjgast-2021-000758. PMID: 34916226.
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Nomenclature of magnetic, incommensurate, composition-changed morphotropic, polytype, transient-structural and quasicrystalline phases undergoing phase transitions. II. Report of an IUCr Working Group on Phase Transition Nomenclature.

Acta crystallographica. Section A, Foundations of crystallography

Tolédano JC, Berry RS, Brown PJ, Glazer AM, Metselaar R, Pandey D, Perez-Mato JM, Roth RS, Abrahams SC.
PMID: 11526310
Acta Crystallogr A. 2001 Sep;57:614-26. doi: 10.1107/s0108767301006821. Epub 2001 Sep 01.

A general nomenclature applicable to the phases that form in any sequence of transitions in the solid state has been recommended by an IUCr Working Group [Acta Cryst. (1998). A54, 1028-1033]. The six-field notation of the first Report, hereafter...

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Tolédano JC, Berry RS, Brown PJ, et al. Nomenclature of magnetic, incommensurate, composition-changed morphotropic, polytype, transient-structural and quasicrystalline phases undergoing phase transitions. II. Report of an IUCr Working Group on Phase Transition Nomenclature. Acta Crystallogr A. 2001;57:614-26doi: 10.1107/s0108767301006821.
Tolédano, J. C., Berry, R. S., Brown, P. J., Glazer, A. M., Metselaar, R., Pandey, D., Perez-Mato, J. M., Roth, R. S., & Abrahams, S. C. (2001). Nomenclature of magnetic, incommensurate, composition-changed morphotropic, polytype, transient-structural and quasicrystalline phases undergoing phase transitions. II. Report of an IUCr Working Group on Phase Transition Nomenclature. Acta crystallographica. Section A, Foundations of crystallography, 57614-26. https://doi.org/10.1107/s0108767301006821
Tolédano, J C, et al. "Nomenclature of magnetic, incommensurate, composition-changed morphotropic, polytype, transient-structural and quasicrystalline phases undergoing phase transitions. II. Report of an IUCr Working Group on Phase Transition Nomenclature." Acta crystallographica. Section A, Foundations of crystallography vol. 57 (2001): 614-26. doi: https://doi.org/10.1107/s0108767301006821
Tolédano JC, Berry RS, Brown PJ, Glazer AM, Metselaar R, Pandey D, Perez-Mato JM, Roth RS, Abrahams SC. Nomenclature of magnetic, incommensurate, composition-changed morphotropic, polytype, transient-structural and quasicrystalline phases undergoing phase transitions. II. Report of an IUCr Working Group on Phase Transition Nomenclature. Acta Crystallogr A. 2001 Sep;57:614-26. doi: 10.1107/s0108767301006821. Epub 2001 Sep 01. PMID: 11526310.
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