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Showing 1 to 12 of 19 entries
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Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial.

Lancet (London, England)

Lazarus R, Baos S, Cappel-Porter H, Carson-Stevens A, Clout M, Culliford L, Emmett SR, Garstang J, Gbadamoshi L, Hallis B, Harris RA, Hutton D, Jacobsen N, Joyce K, Kaminski R, Libri V, Middleditch A, McCullagh L, Moran E, Phillipson A, Price E, Ryan J, Thirard R, Todd R, Snape MD, Tucker D, Williams RL, Nguyen-Van-Tam JS, Finn A, Rogers CA.
PMID: 34774197
Lancet. 2021 Nov 11; doi: 10.1016/S0140-6736(21)02329-1. Epub 2021 Nov 11.

BACKGROUND: Concomitant administration of COVID-19 and influenza vaccines could reduce burden on health-care systems. We aimed to assess the safety of concomitant administration of ChAdOx1 or BNT162b2 plus an age-appropriate influenza vaccine.METHODS: In this multicentre, randomised, controlled, phase 4...

A higher-protein nut-based snack product suppresses glycaemia and decreases glycaemic response to co-ingested carbohydrate in an overweight prediabetic Asian Chinese cohort: the Tū Ora postprandial RCT.

Journal of nutritional science

Lu LW, Silvestre MP, Sequeira IR, Plank LD, Foster M, Middleditch N, Acevedo-Fani A, Hollingsworth KG, Poppitt SD.
PMID: 34094511
J Nutr Sci. 2021 Apr 23;10:e30. doi: 10.1017/jns.2021.20. eCollection 2021.

Nut-based products may aid low-glycaemic dietary strategies that are important for diabetes prevention in populations at increased risk of dysglycaemia, such as Asian Chinese. This randomised cross-over trial assessed the postprandial glycaemic response (0-120 min) of a higher-protein nut-based...

Utility of the .

ACS omega

Lin B, Daniels BJ, Middleditch MJ, Furkert DP, Brimble MA, Bong J, Stephens JM, Loomes KM.
PMID: 32337448
ACS Omega. 2020 Apr 08;5(15):8858-8866. doi: 10.1021/acsomega.0c00486. eCollection 2020 Apr 21.

Manuka honey is a premium food product with unique antimicrobial bioactivity. Concerns with mislabeled manuka honey require robust assays to determine authenticity. Lepteridine is a

Mass spectra of prostaglandins: II. Trimethylsilyl and alkyloxime-trimethylsilyl derivatives of prostaglandins B1 and B2.

Lipids

Middleditch BS, Desiderio DM.
PMID: 27519877
Lipids. 1973 May;8(5):267-70. doi: 10.1007/BF02531903.

The mass spectra of the trimethylsilyl ester trimethylsilyl ether derivatives of prostaglandins B1 and B2, and of theirO-ethyl andO-methyl oximes are reported and discussed. The high resolution spectra of these compounds are also considered. These spectra are compared with...

Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial.

Lancet (London, England)

Lazarus R, Baos S, Cappel-Porter H, Carson-Stevens A, Clout M, Culliford L, Emmett SR, Garstang J, Gbadamoshi L, Hallis B, Harris RA, Hutton D, Jacobsen N, Joyce K, Kaminski R, Libri V, Middleditch A, McCullagh L, Moran E, Phillipson A, Price E, Ryan J, Thirard R, Todd R, Snape MD, Tucker D, Williams RL, Nguyen-Van-Tam JS, Finn A, Rogers CA.
PMID: 34774197
Lancet. 2021 Dec 18;398(10318):2277-2287. doi: 10.1016/S0140-6736(21)02329-1. Epub 2021 Nov 11.

BACKGROUND: Concomitant administration of COVID-19 and influenza vaccines could reduce burden on health-care systems. We aimed to assess the safety of concomitant administration of ChAdOx1 or BNT162b2 plus an age-appropriate influenza vaccine.METHODS: In this multicentre, randomised, controlled, phase 4...

Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial.

Lancet (London, England)

Lazarus R, Baos S, Cappel-Porter H, Carson-Stevens A, Clout M, Culliford L, Emmett SR, Garstang J, Gbadamoshi L, Hallis B, Harris RA, Hutton D, Jacobsen N, Joyce K, Kaminski R, Libri V, Middleditch A, McCullagh L, Moran E, Phillipson A, Price E, Ryan J, Thirard R, Todd R, Snape MD, Tucker D, Williams RL, Nguyen-Van-Tam JS, Finn A, Rogers CA.
PMID: 34774197
Lancet. 2021 Dec 18;398(10318):2277-2287. doi: 10.1016/S0140-6736(21)02329-1. Epub 2021 Nov 11.

BACKGROUND: Concomitant administration of COVID-19 and influenza vaccines could reduce burden on health-care systems. We aimed to assess the safety of concomitant administration of ChAdOx1 or BNT162b2 plus an age-appropriate influenza vaccine.METHODS: In this multicentre, randomised, controlled, phase 4...

Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial.

Lancet (London, England)

Lazarus R, Baos S, Cappel-Porter H, Carson-Stevens A, Clout M, Culliford L, Emmett SR, Garstang J, Gbadamoshi L, Hallis B, Harris RA, Hutton D, Jacobsen N, Joyce K, Kaminski R, Libri V, Middleditch A, McCullagh L, Moran E, Phillipson A, Price E, Ryan J, Thirard R, Todd R, Snape MD, Tucker D, Williams RL, Nguyen-Van-Tam JS, Finn A, Rogers CA.
PMID: 34774197
Lancet. 2021 Dec 18;398(10318):2277-2287. doi: 10.1016/S0140-6736(21)02329-1. Epub 2021 Nov 11.

BACKGROUND: Concomitant administration of COVID-19 and influenza vaccines could reduce burden on health-care systems. We aimed to assess the safety of concomitant administration of ChAdOx1 or BNT162b2 plus an age-appropriate influenza vaccine.METHODS: In this multicentre, randomised, controlled, phase 4...

Itaconate is a covalent inhibitor of the .

RSC medicinal chemistry

Kwai BXC, Collins AJ, Middleditch MJ, Sperry J, Bashiri G, Leung IKH.
PMID: 34046597
RSC Med Chem. 2020 Oct 19;12(1):57-61. doi: 10.1039/d0md00301h. eCollection 2021 Jan 01.

Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of

Characterization of proteomic changes in cardiac mitochondria in streptozotocin-diabetic rats using iTRAQ™ isobaric tags.

Proteomics. Clinical applications

Jüllig M, Hickey AJ, Middleditch MJ, Crossman DJ, Lee SC, Cooper GJ.
PMID: 21136708
Proteomics Clin Appl. 2007 Jun;1(6):565-76. doi: 10.1002/prca.200600831.

Diabetes now affects more than 5% of the world's population and heart failure is the most common cause of death amongst diabetic patients. Accumulating evidence supports a view that myocardial mitochondrial structural and functional changes are central to the...

Towards energetically viable asymmetric deprotonations: selectivity at more elevated temperatures with C2-symmetric magnesium bisamides.

Chemical communications (Cambridge, England)

Bennie LS, Kerr WJ, Middleditch M, Watson AJ.
PMID: 21243164
Chem Commun (Camb). 2011 Feb 28;47(8):2264-6. doi: 10.1039/c0cc04939e. Epub 2011 Jan 18.

A novel chiral magnesium bisamide has enabled the development of effective asymmetric deprotonation protocols at substantially more elevated temperatures. This new, structurally simple, C(2)-symmetric magnesium complex displays excellent levels of asymmetric efficiency and energy reduction in the synthesis of...

The application of eDNA for monitoring of the Great Crested Newt in the UK.

Ecology and evolution

Rees HC, Bishop K, Middleditch DJ, Patmore JR, Maddison BC, Gough KC.
PMID: 25505530
Ecol Evol. 2014 Nov;4(21):4023-32. doi: 10.1002/ece3.1272. Epub 2014 Sep 30.

Current ecological surveys for great crested newts are time-consuming and expensive and can only be carried out within a short survey window. Additional survey methods which would facilitate the detection of rare or protected species such as the great...

Artifacts in chromatography: an overview.

Journal of chromatographic science

Middleditch BS, Zlatkis A.
PMID: 3323218
J Chromatogr Sci. 1987 Dec;25(12):547-51. doi: 10.1093/chromsci/25.12.547.

A brief overview of the field of analytical artifacts is provided, with examples of solvent impurities, stabilizers, polymer additives, and problems relating to Teflon, glassware, and laboratory contaminants.

Showing 1 to 12 of 19 entries