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Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, .

EJNMMI research

Mikkola K, Yim CB, Lehtiniemi P, Kauhanen S, Tarkia M, Tolvanen T, Nuutila P, Solin O.
PMID: 27957723
EJNMMI Res. 2016 Dec;6(1):91. doi: 10.1186/s13550-016-0243-2. Epub 2016 Dec 13.

BACKGROUND: Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer in the kidneys. This study aimed to develop a novel...

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Mikkola K, Yim CB, Lehtiniemi P, et al. Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, . EJNMMI Res. 2016;6(1):91doi: 10.1186/s13550-016-0243-2.
Mikkola, K., Yim, C. B., Lehtiniemi, P., Kauhanen, S., Tarkia, M., Tolvanen, T., Nuutila, P., & Solin, O. (2016). Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, . EJNMMI research, 6(1), 91. https://doi.org/10.1186/s13550-016-0243-2
Mikkola, Kirsi, et al. "Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, ." EJNMMI research vol. 6,1 (2016): 91. doi: https://doi.org/10.1186/s13550-016-0243-2
Mikkola K, Yim CB, Lehtiniemi P, Kauhanen S, Tarkia M, Tolvanen T, Nuutila P, Solin O. Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, . EJNMMI Res. 2016 Dec;6(1):91. doi: 10.1186/s13550-016-0243-2. Epub 2016 Dec 13. PMID: 27957723; PMCID: PMC5153397.
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Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage.

Cartilage

Kulmala KA, Pulkkinen HJ, Rieppo L, Tiitu V, Kiviranta I, Brünott A, Brommer H, van Weeren R, Brama PA, Mikkola MT, Korhonen RK, Jurvelin JS, Töyräs J.
PMID: 26069636
Cartilage. 2012 Jul;3(3):235-44. doi: 10.1177/1947603511424173.

OBJECTIVE: Contrast-enhanced computed tomography (CECT) has been introduced for the evaluation of cartilage integrity. Furthermore, CECT enables imaging of the structure and density of subchondral bone. In this laboratory study, we investigate the potential of microCECT to simultaneously image...

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Kulmala KA, Pulkkinen HJ, Rieppo L, et al. Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage. Cartilage. 2012;3(3):235-44doi: 10.1177/1947603511424173.
Kulmala, K. A., Pulkkinen, H. J., Rieppo, L., Tiitu, V., Kiviranta, I., Brünott, A., Brommer, H., van Weeren, R., Brama, P. A., Mikkola, M. T., Korhonen, R. K., Jurvelin, J. S., & Töyräs, J. (2012). Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage. Cartilage, 3(3), 235-44. https://doi.org/10.1177/1947603511424173
Kulmala, K A M, et al. "Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage." Cartilage vol. 3,3 (2012): 235-44. doi: https://doi.org/10.1177/1947603511424173
Kulmala KA, Pulkkinen HJ, Rieppo L, Tiitu V, Kiviranta I, Brünott A, Brommer H, van Weeren R, Brama PA, Mikkola MT, Korhonen RK, Jurvelin JS, Töyräs J. Contrast-Enhanced Micro-Computed Tomography in Evaluation of Spontaneous Repair of Equine Cartilage. Cartilage. 2012 Jul;3(3):235-44. doi: 10.1177/1947603511424173. PMID: 26069636; PMCID: PMC4297117.
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Adsorption of an Isocyanurate Silane on E-Glass Fibers from Ethanol and Toluene.

Journal of colloid and interface science

Norström AE, Mikkola PJ, Matisons JG, Rosenholm JB.
PMID: 11071744
J Colloid Interface Sci. 2000 Dec 01;232(1):149-155. doi: 10.1006/jcis.2000.7198.

Isocyanurate silane was adsorbed onto E-glass fibers from toluene and ethanol in order to gain a better understanding of the surface processes at the silane-glass interface of composite materials. Use of DRIFT (diffuse reflectance infrared Fourier transform spectroscopy), XPS...

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Norström AE, Mikkola PJ, Matisons JG, et al. Adsorption of an Isocyanurate Silane on E-Glass Fibers from Ethanol and Toluene. J Colloid Interface Sci. 2000;232(1):149-155doi: 10.1006/jcis.2000.7198.
Norström, A. E., Mikkola, P. J., Matisons, J. G., & Rosenholm, J. B. (2000). Adsorption of an Isocyanurate Silane on E-Glass Fibers from Ethanol and Toluene. Journal of colloid and interface science, 232(1), 149-155. https://doi.org/10.1006/jcis.2000.7198
Norström, et al. "Adsorption of an Isocyanurate Silane on E-Glass Fibers from Ethanol and Toluene." Journal of colloid and interface science vol. 232,1 (2000): 149-155. doi: https://doi.org/10.1006/jcis.2000.7198
Norström AE, Mikkola PJ, Matisons JG, Rosenholm JB. Adsorption of an Isocyanurate Silane on E-Glass Fibers from Ethanol and Toluene. J Colloid Interface Sci. 2000 Dec 01;232(1):149-155. doi: 10.1006/jcis.2000.7198. PMID: 11071744.
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Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm.

Organic & biomolecular chemistry

Zhang Z, Mikkola S, Lönnberg H.
PMID: 12929370
Org Biomol Chem. 2003 Mar 07;1(5):854-8. doi: 10.1039/b210663a.

A practical and reproducible route for the preparation of 1,4,7,10,13,16,19-heptaazacyclohenicosane (1), 1,4,7,10,13,16-hexaazacyclooctadecane (2), and 1,4,7,10,13,17-hexaazacycloicosane (3) bearing a single N-(2-aminoethyl) pendant arm has been developed. Richman-Atkins cyclization in the presence of caesium carbonate was applied to construct the macrocycle...

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Zhang Z, Mikkola S, Lönnberg H. Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm. Org Biomol Chem. 2003;1(5):854-8doi: 10.1039/b210663a.
Zhang, Z., Mikkola, S., & Lönnberg, H. (2003). Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm. Organic & biomolecular chemistry, 1(5), 854-8. https://doi.org/10.1039/b210663a
Zhang, Zhibo, et al. "Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm." Organic & biomolecular chemistry vol. 1,5 (2003): 854-8. doi: https://doi.org/10.1039/b210663a
Zhang Z, Mikkola S, Lönnberg H. Preparation of hexaaza and heptaaza macrocycles functionalized with a single aminoalkyl pendant arm. Org Biomol Chem. 2003 Mar 07;1(5):854-8. doi: 10.1039/b210663a. PMID: 12929370.
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Enhanced sludge dewatering based on the application of high-power ultrasonic vibration.

Ultrasonics

Mobaraki M, Semken RS, Mikkola A, Pyrhönen J.
PMID: 29257985
Ultrasonics. 2018 Mar;84:438-445. doi: 10.1016/j.ultras.2017.12.002. Epub 2017 Dec 08.

Interest in producing heat and power using municipal wastewater sewage sludge as a fuel is increasing worldwide. Since its water content is initially high, sludge must be dewatered and further dried if it is to serve as an effective...

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Mobaraki M, Semken RS, Mikkola A, et al. Enhanced sludge dewatering based on the application of high-power ultrasonic vibration. Ultrasonics. 2017;84:438-445doi: 10.1016/j.ultras.2017.12.002.
Mobaraki, M., Semken, R. S., Mikkola, A., & Pyrhönen, J. (2018). Enhanced sludge dewatering based on the application of high-power ultrasonic vibration. Ultrasonics, 84438-445. https://doi.org/10.1016/j.ultras.2017.12.002
Mobaraki, Mojtaba, et al. "Enhanced sludge dewatering based on the application of high-power ultrasonic vibration." Ultrasonics vol. 84 (2018): 438-445. doi: https://doi.org/10.1016/j.ultras.2017.12.002
Mobaraki M, Semken RS, Mikkola A, Pyrhönen J. Enhanced sludge dewatering based on the application of high-power ultrasonic vibration. Ultrasonics. 2018 Mar;84:438-445. doi: 10.1016/j.ultras.2017.12.002. Epub 2017 Dec 08. PMID: 29257985.
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MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of .

Oncotarget

Roth SA, Hald ØH, Fuchs S, Løkke C, Mikkola I, Flægstad T, Schulte J, Einvik C.
PMID: 29719597
Oncotarget. 2018 Apr 06;9(26):18160-18179. doi: 10.18632/oncotarget.24793. eCollection 2018 Apr 06.

Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are...

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Roth SA, Hald ØH, Fuchs S, et al. MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of . Oncotarget. 2018;9(26):18160-18179doi: 10.18632/oncotarget.24793.
Roth, S. A., Hald, �. �. H., Fuchs, S., Løkke, C., Mikkola, I., Flægstad, T., Schulte, J., & Einvik, C. (2018). MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of . Oncotarget, 9(26), 18160-18179. https://doi.org/10.18632/oncotarget.24793
Roth, Sarah Andrea, et al. "MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of ." Oncotarget vol. 9,26 (2018): 18160-18179. doi: https://doi.org/10.18632/oncotarget.24793
Roth SA, Hald ØH, Fuchs S, Løkke C, Mikkola I, Flægstad T, Schulte J, Einvik C. MicroRNA-193b-3p represses neuroblastoma cell growth via downregulation of . Oncotarget. 2018 Apr 06;9(26):18160-18179. doi: 10.18632/oncotarget.24793. eCollection 2018 Apr 06. PMID: 29719597; PMCID: PMC5915064.
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Intermolecular interactions upon carbon dioxide capture in deep-eutectic solvents.

Physical chemistry chemical physics : PCCP

Shukla SK, Mikkola JP.
PMID: 30229246
Phys Chem Chem Phys. 2018 Oct 03;20(38):24591-24601. doi: 10.1039/c8cp03724h.

Herein we report the CO2 uptake in potential deep-eutectic solvents (DESs) formed between hydrogen bond acceptors (HBAs) such as monoethanolammonium chloride ([MEA·Cl]), 1-methylimidazolium chloride ([HMIM·Cl]) and tetra-n-butylammonium bromide ([TBAB]) and hydrogen bond donors (HBDs) like ethylenediamine ([EDA]), diethylenetriamine ([DETA]),...

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Shukla SK, Mikkola JP. Intermolecular interactions upon carbon dioxide capture in deep-eutectic solvents. Phys Chem Chem Phys. 2018;20(38):24591-24601doi: 10.1039/c8cp03724h.
Shukla, S. K., & Mikkola, J. P. (2018). Intermolecular interactions upon carbon dioxide capture in deep-eutectic solvents. Physical chemistry chemical physics : PCCP, 20(38), 24591-24601. https://doi.org/10.1039/c8cp03724h
Shukla, Shashi Kant, and Mikkola, Jyri-Pekka. "Intermolecular interactions upon carbon dioxide capture in deep-eutectic solvents." Physical chemistry chemical physics : PCCP vol. 20,38 (2018): 24591-24601. doi: https://doi.org/10.1039/c8cp03724h
Shukla SK, Mikkola JP. Intermolecular interactions upon carbon dioxide capture in deep-eutectic solvents. Phys Chem Chem Phys. 2018 Oct 03;20(38):24591-24601. doi: 10.1039/c8cp03724h. PMID: 30229246.
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Effect of structural training on surgical outcomes of residents' first operative laparoscopy: a randomized controlled trial.

Surgical endoscopy

Jokinen E, Mikkola TS, Härkki P.
PMID: 30656454
Surg Endosc. 2019 Nov;33(11):3688-3695. doi: 10.1007/s00464-018-06657-y. Epub 2019 Jan 17.

BACKGROUND: Gynecological surgery and resident education have changed during recent decades, thus impacting surgical training. Training on simulators must begin before operating on patients. The objective of this study was to evaluate the effect of a simple curriculum on...

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Jokinen E, Mikkola TS, Härkki P. Effect of structural training on surgical outcomes of residents' first operative laparoscopy: a randomized controlled trial. Surg Endosc. 2019;33(11):3688-3695doi: 10.1007/s00464-018-06657-y.
Jokinen, E., Mikkola, T. S., & Härkki, P. (2019). Effect of structural training on surgical outcomes of residents' first operative laparoscopy: a randomized controlled trial. Surgical endoscopy, 33(11), 3688-3695. https://doi.org/10.1007/s00464-018-06657-y
Jokinen, Ewa, et al. "Effect of structural training on surgical outcomes of residents' first operative laparoscopy: a randomized controlled trial." Surgical endoscopy vol. 33,11 (2019): 3688-3695. doi: https://doi.org/10.1007/s00464-018-06657-y
Jokinen E, Mikkola TS, Härkki P. Effect of structural training on surgical outcomes of residents' first operative laparoscopy: a randomized controlled trial. Surg Endosc. 2019 Nov;33(11):3688-3695. doi: 10.1007/s00464-018-06657-y. Epub 2019 Jan 17. PMID: 30656454; PMCID: PMC6795620.
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An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

Hetemäki I, Kääriäinen S, Alho P, Mikkola J, Savolainen-Kopra C, Ikonen N, Nohynek H, Lyytikäinen O.
PMID: 34328076
Euro Surveill. 2021 Jul;26(30). doi: 10.2807/1560-7917.ES.2021.26.30.2100636.

An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) spread from one inpatient in a secondary care hospital to three primary care facilities, resulting in 58 infections including 18 deaths in patients and 45 infections in healthcare workers (HCW)....

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Hetemäki I, Kääriäinen S, Alho P, et al. An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021. Euro Surveill. 2021;26(30)doi: 10.2807/1560-7917.ES.2021.26.30.2100636.
Hetemäki, I., Kääriäinen, S., Alho, P., Mikkola, J., Savolainen-Kopra, C., Ikonen, N., Nohynek, H., & Lyytikäinen, O. (2021). An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 26(30), . https://doi.org/10.2807/1560-7917.ES.2021.26.30.2100636
Hetemäki, Iivo, et al. "An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021." Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin vol. 26,30 (2021). doi: https://doi.org/10.2807/1560-7917.ES.2021.26.30.2100636
Hetemäki I, Kääriäinen S, Alho P, Mikkola J, Savolainen-Kopra C, Ikonen N, Nohynek H, Lyytikäinen O. An outbreak caused by the SARS-CoV-2 Delta variant (B.1.617.2) in a secondary care hospital in Finland, May 2021. Euro Surveill. 2021 Jul;26(30). doi: 10.2807/1560-7917.ES.2021.26.30.2100636. PMID: 34328076; PMCID: PMC8323455.
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CHRONIC LIMB THREATENING ISCHEMIA AND DIABETES MELLITUS: THE SEVERITY OF TIBIAL ATHEROSCLEROSIS AND OUTCOME AFTER INFRAPOPLITEAL REVASCULARIZATION.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

Koivunen V, Juonala M, Mikkola K, Hakovirta HH.
PMID: 33225841
Scand J Surg. 2020 Nov 23;1457496920968679. doi: 10.1177/1457496920968679. Epub 2020 Nov 23.

BACKGROUND AND AIMS: Diabetes mellitus associates with poor outcomes in chronic limb threatening ischemia but data on different hypoglycemic regimens and outcomes are lacking. We analyzed insulin-treated diabetes mellitus, non-insulin-treated diabetes mellitus, and patients without diabetes mellitus.MATERIALS AND METHODS:...

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Koivunen V, Juonala M, Mikkola K, et al. CHRONIC LIMB THREATENING ISCHEMIA AND DIABETES MELLITUS: THE SEVERITY OF TIBIAL ATHEROSCLEROSIS AND OUTCOME AFTER INFRAPOPLITEAL REVASCULARIZATION. Scand J Surg. 2020;1457496920968679doi: 10.1177/1457496920968679.
Koivunen, V., Juonala, M., Mikkola, K., & Hakovirta, H. H. (2020). CHRONIC LIMB THREATENING ISCHEMIA AND DIABETES MELLITUS: THE SEVERITY OF TIBIAL ATHEROSCLEROSIS AND OUTCOME AFTER INFRAPOPLITEAL REVASCULARIZATION. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society, 1457496920968679. https://doi.org/10.1177/1457496920968679
Koivunen, V, et al. "CHRONIC LIMB THREATENING ISCHEMIA AND DIABETES MELLITUS: THE SEVERITY OF TIBIAL ATHEROSCLEROSIS AND OUTCOME AFTER INFRAPOPLITEAL REVASCULARIZATION." Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society vol. (2020): 1457496920968679. doi: https://doi.org/10.1177/1457496920968679
Koivunen V, Juonala M, Mikkola K, Hakovirta HH. CHRONIC LIMB THREATENING ISCHEMIA AND DIABETES MELLITUS: THE SEVERITY OF TIBIAL ATHEROSCLEROSIS AND OUTCOME AFTER INFRAPOPLITEAL REVASCULARIZATION. Scand J Surg. 2020 Nov 23;1457496920968679. doi: 10.1177/1457496920968679. Epub 2020 Nov 23. PMID: 33225841.
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SO.

Chemical reviews

Konwar LJ, Mäki-Arvela P, Mikkola JP.
PMID: 31589024
Chem Rev. 2019 Nov 27;119(22):11576-11630. doi: 10.1021/acs.chemrev.9b00199. Epub 2019 Oct 07.

The "sulfonated carbons" are a new class of metal-free solid protonic acids characterized by their unique carbon structure and Brønsted acidity (-

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Konwar LJ, Mäki-Arvela P, Mikkola JP. SO. Chem Rev. 2019;119(22):11576-11630doi: 10.1021/acs.chemrev.9b00199.
Konwar, L. J., Mäki-Arvela, P., & Mikkola, J. P. (2019). SO. Chemical reviews, 119(22), 11576-11630. https://doi.org/10.1021/acs.chemrev.9b00199
Konwar, Lakhya Jyoti, et al. "SO." Chemical reviews vol. 119,22 (2019): 11576-11630. doi: https://doi.org/10.1021/acs.chemrev.9b00199
Konwar LJ, Mäki-Arvela P, Mikkola JP. SO. Chem Rev. 2019 Nov 27;119(22):11576-11630. doi: 10.1021/acs.chemrev.9b00199. Epub 2019 Oct 07. PMID: 31589024.
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Mental, Physical and Social Functioning in Independently Living Senior House Residents and Community-Dwelling Older Adults.

International journal of environmental research and public health

Lahti AM, Mikkola TM, Salonen M, Wasenius N, Sarvimäki A, Eriksson JG, von Bonsdorff MB.
PMID: 34886019
Int J Environ Res Public Health. 2021 Nov 23;18(23). doi: 10.3390/ijerph182312299.

Senior houses provide social interaction and support, potentially supporting older people's physical and mental functioning. Few studies have investigated functioning of senior house residents. The aim was to compare functioning between senior house residents and community-dwelling older adults in...

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Lahti AM, Mikkola TM, Salonen M, et al. Mental, Physical and Social Functioning in Independently Living Senior House Residents and Community-Dwelling Older Adults. Int J Environ Res Public Health. 2021;18(23)doi: 10.3390/ijerph182312299.
Lahti, A. M., Mikkola, T. M., Salonen, M., Wasenius, N., Sarvimäki, A., Eriksson, J. G., & von Bonsdorff, M. B. (2021). Mental, Physical and Social Functioning in Independently Living Senior House Residents and Community-Dwelling Older Adults. International journal of environmental research and public health, 18(23), . https://doi.org/10.3390/ijerph182312299
Lahti, Anna-Maria, et al. "Mental, Physical and Social Functioning in Independently Living Senior House Residents and Community-Dwelling Older Adults." International journal of environmental research and public health vol. 18,23 (2021). doi: https://doi.org/10.3390/ijerph182312299
Lahti AM, Mikkola TM, Salonen M, Wasenius N, Sarvimäki A, Eriksson JG, von Bonsdorff MB. Mental, Physical and Social Functioning in Independently Living Senior House Residents and Community-Dwelling Older Adults. Int J Environ Res Public Health. 2021 Nov 23;18(23). doi: 10.3390/ijerph182312299. PMID: 34886019; PMCID: PMC8657393.
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