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Showing 1 to 12 of 53 entries
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Optimized Prediction of Extreme Treatment Outcomes in Ovarian Cancer.

Cancer informatics

Misganaw B, Ahsen E, Singh N, Baggerly KA, Unruh A, White MA, Vidyasagar M.
PMID: 27034613
Cancer Inform. 2016 Mar 21;14:45-55. doi: 10.4137/CIN.S30803. eCollection 2015.

Ovarian cancer is the fifth leading cause of death among female cancers. Front-line therapy for ovarian cancer is platinum-based chemotherapy. However, the response of patients is highly nonuniform. The TCGA database of serous ovarian carcinomas shows that ~10% of...

Understanding job satisfaction and motivation among nurses in public health facilities of Ethiopia: a cross-sectional study.

BMC nursing

Ayalew F, Kibwana S, Shawula S, Misganaw E, Abosse Z, van Roosmalen J, Stekelenburg J, Kim YM, Teshome M, Mariam DW.
PMID: 31636508
BMC Nurs. 2019 Oct 15;18:46. doi: 10.1186/s12912-019-0373-8. eCollection 2019.

BACKGROUND: Poor job conditions and limited resources are reducing job satisfaction and motivation among nurses in low-income countries, which may affect the quality of services and attrition rates. The objective of this study was to examine job satisfaction, motivation...

Proceedings from the CIH-LMU 2021 Symposium: "Global Health Perspectives: Climate Change & Migration".

BMC proceedings

Lutchmun W, Ablorde A, Chang HW, Froeschl G, Misganaw E, Sapkota BP, Scholze S, Singo J, Hoffaeller L.
PMID: 34645438
BMC Proc. 2021 Oct 12;15:21. doi: 10.1186/s12919-021-00225-4.

Climate change shapes human migration through the interaction of environmental changes with political, social, economic, and demographic drivers of mobility. Low-and middle-income countries bear the brunt of the health impacts of climate change and migration, despite their overall low...

Quality of Same-Day Sputum Smears Microscopy and Presumptive Tuberculosis Patients Drop-out at Health Facilities of Addis Ababa, Ethiopia.

Tuberculosis and respiratory diseases

Taddese BD, Misganaw AS.
PMID: 31905436
Tuberc Respir Dis (Seoul). 2020 Jan;83(1):89-95. doi: 10.4046/trd.2019.0029.

BACKGROUND: Same-day sputum microcopy is recommended in areas where sputum smear microscopy external quality assessment (EQA) is effectively implemented and sturdy. In Addis Ababa, the status of EQA and drop-out of same-day sputum smear microcopy has not yet been...

GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models.

Diabetes

Borner T, Geisler CE, Fortin SM, Cosgrove R, Alsina-Fernandez J, Dogra M, Doebley S, Sanchez-Navarro MJ, Leon RM, Gaisinsky J, White A, Bamezai A, Ghidewon MY, Grill HJ, Crist RC, Reiner BC, Ai M, Samms RJ, De Jonghe BC, Hayes MR.
PMID: 34380697
Diabetes. 2021 Nov;70(11):2545-2553. doi: 10.2337/db21-0459. Epub 2021 Aug 11.

Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. Patient compliance and maximal efficacy of GLP-1 therapeutics are limited by adverse side effects, including nausea and emesis. In three different species...

Effect of Feeding Improved Grass Hays and .

Animals : an open access journal from MDPI

Mekuriaw S, Tsunekawa A, Ichinohe T, Tegegne F, Haregeweyn N, Kobayashi N, Tassew A, Mekuriaw Y, Walie M, Tsubo M, Okuro T, Meshesha DT, Meseret M, Sam L, Fievez V.
PMID: 32545346
Animals (Basel). 2020 Jun 11;10(6). doi: 10.3390/ani10061021.

The nutritionally imbalanced poor-quality diet feeding is the major constraint of dairy production in tropical regions. Hence, alternative high-quality roughage-based diets are required to improve milk yield and reduce methane emission (CH4). Thus, we tested the effects of feeding...

Wound Healing Effect of .

Clinical pharmacology : advances and applications

Alemu BK, Misganaw D, Mengistu G.
PMID: 33408534
Clin Pharmacol. 2020 Dec 31;12:213-222. doi: 10.2147/CPAA.S288394. eCollection 2020.

METHODS: The crude extract was prepared as 5% and 10% w/w ointments for topical use in mice. Wound contraction and epithelialization period were determined in excision and infected models, whereas tensile strength was determined in an incision model. Besides,...

Mechanism of Action of .

ACS omega

Girma MB, Ball HS, Wang X, Brothers RC, Jackson ER, Meyers MJ, Dowd CS, Couch RD.
PMID: 34722963
ACS Omega. 2021 Oct 15;6(42):27630-27639. doi: 10.1021/acsomega.1c01711. eCollection 2021 Oct 26.

Malaria is a global health threat that requires immediate attention. Malaria is caused by the protozoan parasite

Nickel-catalyzed amination of aryl carbamates and sequential site-selective cross-couplings.

Chemical science

Mesganaw T, Silberstein AL, Ramgren SD, Fine Nathel NF, Hong X, Liu P, Garg NK.
PMID: 31105924
Chem Sci. 2011 Sep 01;2(9):1766-1771. doi: 10.1039/c1sc00230a. Epub 2011 Jun 09.

We report the amination of aryl carbamates using nickel-catalysis. The methodology is broad in scope with respect to both coupling partners and delivers aminated products in synthetically useful yields. Computational studies provide the full catalytic cycle of this transformation,...

Exploration of the interrupted Fischer indolization reaction.

Tetrahedron

Schammel AW, Boal BW, Zu L, Mesganaw T, Garg NK.
PMID: 20798890
Tetrahedron. 2010 Jun 26;66(26):4687-4695. doi: 10.1016/j.tet.2010.02.050.

A convergent method to access the fused indoline ring system present in a multitude of bioactive molecules has been developed. The strategy involves the condensation of hydrazines with latent aldehydes to ultimately deliver indoline-containing products by way of an...

How useful are complete blood count and reticulocyte reports to clinicians in Addis Ababa hospitals, Ethiopia?.

BMC hematology

Birhaneselassie M, Birhanu A, Gebremedhin A, Tsegaye A.
PMID: 24325971
BMC Hematol. 2013 Dec 11;13(1):11. doi: 10.1186/2052-1839-13-11.

BACKGROUND: Complete blood count (CBC) and reticulocyte (Retics) are routine hematology tests useful for the differential diagnosis of anemia and other medical conditions. However, it has been presumed that they are not used as regular as they should be...

Preparative Synthesis of Highly Substituted Tetrahydropyridines via a Rh(I)-Catalyzed C-H Functionalization Sequence.

Organic process research & development

Mesganaw T, Ellman JA.
PMID: 25288872
Org Process Res Dev. 2014 Sep 19;18(9):1105-1109. doi: 10.1021/op500225c. Epub 2014 Aug 29.

We report a Rh(I)-catalyzed C-H activation/alkenylation/electrocyclization cascade and subsequent reduction for the synthesis of highly substituted tetrahydropyridines. These products can be accessed on a gram scale with low catalyst loadings and at high reaction concentrations. Additionally, a modified Rh-catalyst,...

Showing 1 to 12 of 53 entries