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Surrogate endpoints: a basis for a rational approach.

European journal of clinical pharmacology

Boissel JP, Collet JP, Moleur P, Haugh M.
PMID: 1425885
Eur J Clin Pharmacol. 1992;43(3):235-44. doi: 10.1007/BF02333016.

In clinical trials, the clinical endpoint is often replaced by an intermediate endpoint, known in some instances as a "surrogate" endpoint. The reasons for the substitution are often both practical and financial. At present, no theoretical basis or practical...

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Boissel JP, Collet JP, Moleur P, et al. Surrogate endpoints: a basis for a rational approach. Eur J Clin Pharmacol. 1992;43(3):235-44doi: 10.1007/BF02333016.
Boissel, J. P., Collet, J. P., Moleur, P., & Haugh, M. (1992). Surrogate endpoints: a basis for a rational approach. European journal of clinical pharmacology, 43(3), 235-44. https://doi.org/10.1007/BF02333016
Boissel, J P, et al. "Surrogate endpoints: a basis for a rational approach." European journal of clinical pharmacology vol. 43,3 (1992): 235-44. doi: https://doi.org/10.1007/BF02333016
Boissel JP, Collet JP, Moleur P, Haugh M. Surrogate endpoints: a basis for a rational approach. Eur J Clin Pharmacol. 1992;43(3):235-44. doi: 10.1007/BF02333016. PMID: 1425885.
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Effects of past copper contamination and soil structure on copper leaching from soil.

Journal of environmental quality

Paradelo M, Moldrup P, Arthur E, Naveed M, Holmstrup M, López-Periago JE, de Jonge LW.
PMID: 25602425
J Environ Qual. 2013 Nov;42(6):1852-62. doi: 10.2134/jeq2013.05.0209.

Copper contamination affects biological, chemical, and physical soil properties and associated ecological functions. Changes in soil pore organization as a result of Cu contamination can dramatically affect flow and contaminant transport in polluted soils. This study assessed the influence...

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Paradelo M, Moldrup P, Arthur E, et al. Effects of past copper contamination and soil structure on copper leaching from soil. J Environ Qual. 2013;42(6):1852-62doi: 10.2134/jeq2013.05.0209.
Paradelo, M., Moldrup, P., Arthur, E., Naveed, M., Holmstrup, M., López-Periago, J. E., & de Jonge, L. W. (2013). Effects of past copper contamination and soil structure on copper leaching from soil. Journal of environmental quality, 42(6), 1852-62. https://doi.org/10.2134/jeq2013.05.0209
Paradelo, Marcos, et al. "Effects of past copper contamination and soil structure on copper leaching from soil." Journal of environmental quality vol. 42,6 (2013): 1852-62. doi: https://doi.org/10.2134/jeq2013.05.0209
Paradelo M, Moldrup P, Arthur E, Naveed M, Holmstrup M, López-Periago JE, de Jonge LW. Effects of past copper contamination and soil structure on copper leaching from soil. J Environ Qual. 2013 Nov;42(6):1852-62. doi: 10.2134/jeq2013.05.0209. PMID: 25602425.
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[Virological investigations in connection with 1957 poliomyelitis epidemiology in Hungary].

Orvosi hetilap

FOLDES P, SZERI I, BANOS Z.
PMID: 13823707
Orv Hetil. 1960 Feb 28;101:301-4.

No abstract available.

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FOLDES P, SZERI I, BANOS Z. [Virological investigations in connection with 1957 poliomyelitis epidemiology in Hungary]. Orv Hetil. 1960;101:301-4
FOLDES, P., SZERI, I., & BANOS, Z. (1960). [Virological investigations in connection with 1957 poliomyelitis epidemiology in Hungary]. Orvosi hetilap, 101301-4.
FOLDES, P, et al. "[Virological investigations in connection with 1957 poliomyelitis epidemiology in Hungary]." Orvosi hetilap vol. 101 (1960): 301-4.
FOLDES P, SZERI I, BANOS Z. [Virological investigations in connection with 1957 poliomyelitis epidemiology in Hungary]. Orv Hetil. 1960 Feb 28;101:301-4. Hungarian. PMID: 13823707.
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Extraction study of algal pigments in river bed sediments by applying factorial designs.

Talanta

Devesa R, Moldes A, Díaz-Fierros F, Barral MT.
PMID: 19071796
Talanta. 2007 Jun 15;72(4):1546-51. doi: 10.1016/j.talanta.2007.02.006. Epub 2007 Feb 15.

Phytopigment content of river bed sediments changes in response to different concentrations of available nutrients and results in a useful descriptor of their trophic state and environmental quality. In this work three incomplete factorial designs of experiments were carried...

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Devesa R, Moldes A, Díaz-Fierros F, et al. Extraction study of algal pigments in river bed sediments by applying factorial designs. Talanta. 2007;72(4):1546-51doi: 10.1016/j.talanta.2007.02.006.
Devesa, R., Moldes, A., Díaz-Fierros, F., & Barral, M. T. (2007). Extraction study of algal pigments in river bed sediments by applying factorial designs. Talanta, 72(4), 1546-51. https://doi.org/10.1016/j.talanta.2007.02.006
Devesa, R, et al. "Extraction study of algal pigments in river bed sediments by applying factorial designs." Talanta vol. 72,4 (2007): 1546-51. doi: https://doi.org/10.1016/j.talanta.2007.02.006
Devesa R, Moldes A, Díaz-Fierros F, Barral MT. Extraction study of algal pigments in river bed sediments by applying factorial designs. Talanta. 2007 Jun 15;72(4):1546-51. doi: 10.1016/j.talanta.2007.02.006. Epub 2007 Feb 15. PMID: 19071796.
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Stimulant effect of nitrite on the activation of benzo[a]pyrene-7,8-dihydrodiol in human polymorphonuclear leucocytes.

Toxicology in vitro : an international journal published in association with BIBRA

Constantin D, Wallin A, Moldéus P, Jernström B.
PMID: 20692968
Toxicol In Vitro. 1994 Aug;8(4):593-5. doi: 10.1016/0887-2333(94)90024-8.

Addition of sodium nitrite to human polymorphonuclear leucocytes (PMNs), previously treated with phorbol myristate acetate (PMA), significantly stimulates the activation of (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP-7,8-diol) to products that covalently bind to extracellular DNA and cellular proteins. The reactive metabolites formed from...

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Constantin D, Wallin A, Moldéus P, et al. Stimulant effect of nitrite on the activation of benzo[a]pyrene-7,8-dihydrodiol in human polymorphonuclear leucocytes. Toxicol In Vitro. 1994;8(4):593-5doi: 10.1016/0887-2333(94)90024-8.
Constantin, D., Wallin, A., Moldéus, P., & Jernström, B. (1994). Stimulant effect of nitrite on the activation of benzo[a]pyrene-7,8-dihydrodiol in human polymorphonuclear leucocytes. Toxicology in vitro : an international journal published in association with BIBRA, 8(4), 593-5. https://doi.org/10.1016/0887-2333(94)90024-8
Constantin, D, et al. "Stimulant effect of nitrite on the activation of benzo[a]pyrene-7,8-dihydrodiol in human polymorphonuclear leucocytes." Toxicology in vitro : an international journal published in association with BIBRA vol. 8,4 (1994): 593-5. doi: https://doi.org/10.1016/0887-2333(94)90024-8
Constantin D, Wallin A, Moldéus P, Jernström B. Stimulant effect of nitrite on the activation of benzo[a]pyrene-7,8-dihydrodiol in human polymorphonuclear leucocytes. Toxicol In Vitro. 1994 Aug;8(4):593-5. doi: 10.1016/0887-2333(94)90024-8. PMID: 20692968.
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Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Gott D, Leblanc JC, Smeraldi C, Tard A, Castle L.
PMID: 32626247
EFSA J. 2019 Mar 08;17(3):e05621. doi: 10.2903/j.efsa.2019.5621. eCollection 2019 Mar.

The present scientific opinion deals with the evaluation of the safety of the food additive ethyl lauroyl arginate (E 243) in the light of a new interpretation of the available toxicological data and with respect to the proposed changes...

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, Younes M, Aquilina G, et al. Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use. EFSA J. 2019;17(3):e05621doi: 10.2903/j.efsa.2019.5621.
, Younes, M., Aquilina, G., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gürtler, R., Gundert-Remy, U., Husøy, T., Mennes, W., Moldeus, P., Oskarsson, A., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Gott, D., Leblanc, J. C., Smeraldi, C., Tard, A., & Castle, L. (2019). Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use. EFSA journal. European Food Safety Authority, 17(3), e05621. https://doi.org/10.2903/j.efsa.2019.5621
, et al. "Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use." EFSA journal. European Food Safety Authority vol. 17,3 (2019): e05621. doi: https://doi.org/10.2903/j.efsa.2019.5621
, Younes M, Aquilina G, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gürtler R, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Gott D, Leblanc JC, Smeraldi C, Tard A, Castle L. Safety of ethyl lauroyl arginate (E 243) as a food additive in the light of the new information provided and the proposed extension of use. EFSA J. 2019 Mar 08;17(3):e05621. doi: 10.2903/j.efsa.2019.5621. eCollection 2019 Mar. PMID: 32626247; PMCID: PMC7009305.
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Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carfì M, Vianello G, Mennes W.
PMID: 32626370
EFSA J. 2019 Jul 17;17(7):e05750. doi: 10.2903/j.efsa.2019.5750. eCollection 2019 Jul.

The Panel on Food Additives and Flavourings (FAF Panel) of the European Food Safety Authority was requested to evaluate the genotoxic potential of the flavouring substances from subgroup 1.2.1 of FGE.19 in the Flavouring Group Evaluation 204 (FGE.204). In...

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19. EFSA J. 2019;17(7):e05750doi: 10.2903/j.efsa.2019.5750.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Gürtler, R., Husøy, T., Moldeus, P., Oskarsson, A., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Benigni, R., Bolognesi, C., Chipman, K., Cordelli, E., Degen, G., Marzin, D., Svendsen, C., Carfì, M., Vianello, G., & Mennes, W. (2019). Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19. EFSA journal. European Food Safety Authority, 17(7), e05750. https://doi.org/10.2903/j.efsa.2019.5750
, et al. "Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19." EFSA journal. European Food Safety Authority vol. 17,7 (2019): e05750. doi: https://doi.org/10.2903/j.efsa.2019.5750
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Moldeus P, Oskarsson A, Shah R, Waalkens-Berendsen I, Wölfle D, Benigni R, Bolognesi C, Chipman K, Cordelli E, Degen G, Marzin D, Svendsen C, Carfì M, Vianello G, Mennes W. Scientific Opinion on Flavouring Group Evaluation 204 Revision 1 (FGE.204Rev1): consideration of genotoxicity data on representatives for 17 monounsaturated, aliphatic, α,β-unsaturated ketones and precursors from chemical subgroup 1.2.1 of FGE.19. EFSA J. 2019 Jul 17;17(7):e05750. doi: 10.2903/j.efsa.2019.5750. eCollection 2019 Jul. PMID: 32626370; PMCID: PMC7009293.
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Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Carfì M, Vianello G, Gürtler R.
PMID: 32625707
EFSA J. 2018 Oct 19;16(10):e05422. doi: 10.2903/j.efsa.2018.5422. eCollection 2018 Oct.

The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of 74 flavouring substances from subgroup 1.1.1 of FGE.19 in the Flavouring Group Evaluation 200 Revision 1 (FGE.200 Rev1)....

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19. EFSA J. 2018;16(10):e05422doi: 10.2903/j.efsa.2018.5422.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Husøy, T., Mennes, W., Moldeus, P., Oskarsson, A., Rainieri, S., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Binderup, M. L., Bolognesi, C., Marcon, F., Marzin, D., Mosesso, P., Carfì, M., Vianello, G., & Gürtler, R. (2018). Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19. EFSA journal. European Food Safety Authority, 16(10), e05422. https://doi.org/10.2903/j.efsa.2018.5422
, et al. "Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19." EFSA journal. European Food Safety Authority vol. 16,10 (2018): e05422. doi: https://doi.org/10.2903/j.efsa.2018.5422
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Carfì M, Vianello G, Gürtler R. Scientific Opinion on Flavouring Group Evaluation 200, Revision 1 (FGE.200 Rev.1): 74 α,β-unsaturated aliphatic aldehydes and precursors from chemical subgroup 1.1.1 of FGE.19. EFSA J. 2018 Oct 19;16(10):e05422. doi: 10.2903/j.efsa.2018.5422. eCollection 2018 Oct. PMID: 32625707; PMCID: PMC7009627.
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Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19.

EFSA journal. European Food Safety Authority

, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Anastassiadou M, Carfì M, Vianello G, Gürtler R.
PMID: 32625708
EFSA J. 2018 Oct 17;16(10):e05423. doi: 10.2903/j.efsa.2018.5423. eCollection 2018 Oct.

The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to consider in this revision 2 of Flavouring Group Evaluation 201, the additional data on genotoxicity submitted by the Industry on two substances, 2-methylpent-2-enal...

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, Younes M, Aquilina G, et al. Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19. EFSA J. 2018;16(10):e05423doi: 10.2903/j.efsa.2018.5423.
, Younes, M., Aquilina, G., Castle, L., Engel, K. H., Fowler, P., Frutos Fernandez, M. J., Fürst, P., Gundert-Remy, U., Husøy, T., Mennes, W., Moldeus, P., Oskarsson, A., Rainieri, S., Shah, R., Waalkens-Berendsen, I., Wölfle, D., Binderup, M. L., Bolognesi, C., Marcon, F., Marzin, D., Mosesso, P., Anastassiadou, M., Carfì, M., Vianello, G., & Gürtler, R. (2018). Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19. EFSA journal. European Food Safety Authority, 16(10), e05423. https://doi.org/10.2903/j.efsa.2018.5423
, et al. "Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19." EFSA journal. European Food Safety Authority vol. 16,10 (2018): e05423. doi: https://doi.org/10.2903/j.efsa.2018.5423
, Younes M, Aquilina G, Castle L, Engel KH, Fowler P, Frutos Fernandez MJ, Fürst P, Gundert-Remy U, Husøy T, Mennes W, Moldeus P, Oskarsson A, Rainieri S, Shah R, Waalkens-Berendsen I, Wölfle D, Binderup ML, Bolognesi C, Marcon F, Marzin D, Mosesso P, Anastassiadou M, Carfì M, Vianello G, Gürtler R. Scientific Opinion on Flavouring Group Evaluation 201 Revision 2 (FGE.201Rev2): 2-alkylated, aliphatic, acyclic alpha,beta-unsaturated aldehydes and precursors, with or without additional double-bonds, from chemical subgroup 1.1.2 of FGE.19. EFSA J. 2018 Oct 17;16(10):e05423. doi: 10.2903/j.efsa.2018.5423. eCollection 2018 Oct. PMID: 32625708; PMCID: PMC7009377.
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Re-evaluation of gellan gum (E 418) as food additive.

EFSA journal. European Food Safety Authority

, Younes M, Aggett P, Aguilar F, Crebelli R, Filipic M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Brimer L, Mosesso P, Christodoulidou A, Cascio C, Tard A, Lodi F, Dusemund B.
PMID: 32625935
EFSA J. 2018 Jun 20;16(6):e05296. doi: 10.2903/j.efsa.2018.5296. eCollection 2018 Jun.

The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of gellan gum (E 418) as a food additive. Following the conceptual framework for the risk assessment of certain food...

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, Younes M, Aggett P, et al. Re-evaluation of gellan gum (E 418) as food additive. EFSA J. 2018;16(6):e05296doi: 10.2903/j.efsa.2018.5296.
, Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Filipic, M., Frutos, M. J., Galtier, P., Gott, D., Gundert-Remy, U., Kuhnle, G. G., Lambré, C., Leblanc, J. C., Lillegaard, I. T., Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Woutersen, R. A., Wright, M., Brimer, L., Mosesso, P., Christodoulidou, A., Cascio, C., Tard, A., Lodi, F., & Dusemund, B. (2018). Re-evaluation of gellan gum (E 418) as food additive. EFSA journal. European Food Safety Authority, 16(6), e05296. https://doi.org/10.2903/j.efsa.2018.5296
, et al. "Re-evaluation of gellan gum (E 418) as food additive." EFSA journal. European Food Safety Authority vol. 16,6 (2018): e05296. doi: https://doi.org/10.2903/j.efsa.2018.5296
, Younes M, Aggett P, Aguilar F, Crebelli R, Filipic M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Brimer L, Mosesso P, Christodoulidou A, Cascio C, Tard A, Lodi F, Dusemund B. Re-evaluation of gellan gum (E 418) as food additive. EFSA J. 2018 Jun 20;16(6):e05296. doi: 10.2903/j.efsa.2018.5296. eCollection 2018 Jun. PMID: 32625935; PMCID: PMC7009714.
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Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171).

EFSA journal. European Food Safety Authority

, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Wright M, Lodi F, Rincon AM, Smeraldi C, Woutersen RA.
PMID: 32625996
EFSA J. 2018 Jul 04;16(7):e05366. doi: 10.2903/j.efsa.2018.5366. eCollection 2018 Jul.

The European Commission requested EFSA to carry out a scientific evaluation on four studies on the potential toxicity of titanium dioxide (TiO

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, Younes M, Aggett P, et al. Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171). EFSA J. 2018;16(7):e05366doi: 10.2903/j.efsa.2018.5366.
, Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Dusemund, B., Filipič, M., Frutos, M. J., Galtier, P., Gott, D., Gundert-Remy, U., Kuhnle, G. G., Lambré, C., Leblanc, J. C., Lillegaard, I. T., Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Wright, M., Lodi, F., Rincon, A. M., Smeraldi, C., & Woutersen, R. A. (2018). Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171). EFSA journal. European Food Safety Authority, 16(7), e05366. https://doi.org/10.2903/j.efsa.2018.5366
, et al. "Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171)." EFSA journal. European Food Safety Authority vol. 16,7 (2018): e05366. doi: https://doi.org/10.2903/j.efsa.2018.5366
, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Lambré C, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Wright M, Lodi F, Rincon AM, Smeraldi C, Woutersen RA. Evaluation of four new studies on the potential toxicity of titanium dioxide used as a food additive (E 171). EFSA J. 2018 Jul 04;16(7):e05366. doi: 10.2903/j.efsa.2018.5366. eCollection 2018 Jul. PMID: 32625996; PMCID: PMC7009373.
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Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives.

EFSA journal. European Food Safety Authority

, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Boon P, Gürtler R, Mosesso P, Parent-Massin D, Tobback P, Chrysafidis D, Rincon AM, Tard A, Lambré C.
PMID: 32626019
EFSA J. 2018 Aug 02;16(8):e05375. doi: 10.2903/j.efsa.2018.5375. eCollection 2018 Aug.

The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of calcium silicate (E 552), magnesium silicate (E 553a) and talc (E 553b) when used as food additives. In...

Cite
, Younes M, Aggett P, et al. Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives. EFSA J. 2018;16(8):e05375doi: 10.2903/j.efsa.2018.5375.
, Younes, M., Aggett, P., Aguilar, F., Crebelli, R., Dusemund, B., Filipič, M., Frutos, M. J., Galtier, P., Gott, D., Gundert-Remy, U., Kuhnle, G. G., Leblanc, J. C., Lillegaard, I. T., Moldeus, P., Mortensen, A., Oskarsson, A., Stankovic, I., Waalkens-Berendsen, I., Woutersen, R. A., Wright, M., Boon, P., Gürtler, R., Mosesso, P., Parent-Massin, D., Tobback, P., Chrysafidis, D., Rincon, A. M., Tard, A., & Lambré, C. (2018). Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives. EFSA journal. European Food Safety Authority, 16(8), e05375. https://doi.org/10.2903/j.efsa.2018.5375
, et al. "Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives." EFSA journal. European Food Safety Authority vol. 16,8 (2018): e05375. doi: https://doi.org/10.2903/j.efsa.2018.5375
, Younes M, Aggett P, Aguilar F, Crebelli R, Dusemund B, Filipič M, Frutos MJ, Galtier P, Gott D, Gundert-Remy U, Kuhnle GG, Leblanc JC, Lillegaard IT, Moldeus P, Mortensen A, Oskarsson A, Stankovic I, Waalkens-Berendsen I, Woutersen RA, Wright M, Boon P, Gürtler R, Mosesso P, Parent-Massin D, Tobback P, Chrysafidis D, Rincon AM, Tard A, Lambré C. Re-evaluation of calcium silicate (E 552), magnesium silicate (E 553a(i)), magnesium trisilicate (E 553a(ii)) and talc (E 553b) as food additives. EFSA J. 2018 Aug 02;16(8):e05375. doi: 10.2903/j.efsa.2018.5375. eCollection 2018 Aug. PMID: 32626019; PMCID: PMC7009349.
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