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HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.

ACS medicinal chemistry letters

Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E.
PMID: 22662288
ACS Med Chem Lett. 2012 Apr 03;3(5):402-406. doi: 10.1021/ml300038t.

We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo-acids bind to the active site Mg(2+)/Asp...

Cite
Zhang Y, Fu-Yang Lin, Li K, et al. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett. 2012;3(5):402-406doi: 10.1021/ml300038t.
Zhang, Y., Fu-Yang Lin, Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V., & Oldfield, E. (2012). HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS medicinal chemistry letters, 3(5), 402-406. https://doi.org/10.1021/ml300038t
Zhang, Yonghui, et al. "HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis." ACS medicinal chemistry letters vol. 3,5 (2012): 402-406. doi: https://doi.org/10.1021/ml300038t
Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett. 2012 Apr 03;3(5):402-406. doi: 10.1021/ml300038t. PMID: 22662288; PMCID: PMC3363326.
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Conditioned soils reveal plant-selected microbial communities that impact plant drought response.

Scientific reports

Monohon SJ, Manter DK, Vivanco JM.
PMID: 34707132
Sci Rep. 2021 Oct 27;11(1):21153. doi: 10.1038/s41598-021-00593-z.

Rhizobacterial communities can contribute to plant trait expression and performance, including plant tolerance against abiotic stresses such as drought. The conditioning of microbial communities related to disease resistance over generations has been shown to develop suppressive soils which aid...

Cite
Monohon SJ, Manter DK, Vivanco JM. Conditioned soils reveal plant-selected microbial communities that impact plant drought response. Sci Rep. 2021;11(1):21153doi: 10.1038/s41598-021-00593-z.
Monohon, S. J., Manter, D. K., & Vivanco, J. M. (2021). Conditioned soils reveal plant-selected microbial communities that impact plant drought response. Scientific reports, 11(1), 21153. https://doi.org/10.1038/s41598-021-00593-z
Monohon, Samantha J, et al. "Conditioned soils reveal plant-selected microbial communities that impact plant drought response." Scientific reports vol. 11,1 (2021): 21153. doi: https://doi.org/10.1038/s41598-021-00593-z
Monohon SJ, Manter DK, Vivanco JM. Conditioned soils reveal plant-selected microbial communities that impact plant drought response. Sci Rep. 2021 Oct 27;11(1):21153. doi: 10.1038/s41598-021-00593-z. PMID: 34707132; PMCID: PMC8551274.
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Plantazolicin is an ultra-narrow spectrum antibiotic that targets the .

ACS infectious diseases

Molohon KJ, Saint-Vincent PMB, Park S, Doroghazi JR, Maxson T, Hershfield JR, Flatt KM, Schroeder NE, Ha T, Mitchell DA.
PMID: 27152321
ACS Infect Dis. 2016 Mar 10;2(3):207-220. doi: 10.1021/acsinfecdis.5b00115. Epub 2015 Dec 23.

Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from

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Molohon KJ, Saint-Vincent PMB, Park S, et al. Plantazolicin is an ultra-narrow spectrum antibiotic that targets the . ACS Infect Dis. 2015;2(3):207-220doi: 10.1021/acsinfecdis.5b00115.
Molohon, K. J., Saint-Vincent, P. M. B., Park, S., Doroghazi, J. R., Maxson, T., Hershfield, J. R., Flatt, K. M., Schroeder, N. E., Ha, T., & Mitchell, D. A. (2016). Plantazolicin is an ultra-narrow spectrum antibiotic that targets the . ACS infectious diseases, 2(3), 207-220. https://doi.org/10.1021/acsinfecdis.5b00115
Molohon, Katie J, et al. "Plantazolicin is an ultra-narrow spectrum antibiotic that targets the ." ACS infectious diseases vol. 2,3 (2016): 207-220. doi: https://doi.org/10.1021/acsinfecdis.5b00115
Molohon KJ, Saint-Vincent PMB, Park S, Doroghazi JR, Maxson T, Hershfield JR, Flatt KM, Schroeder NE, Ha T, Mitchell DA. Plantazolicin is an ultra-narrow spectrum antibiotic that targets the . ACS Infect Dis. 2016 Mar 10;2(3):207-220. doi: 10.1021/acsinfecdis.5b00115. Epub 2015 Dec 23. PMID: 27152321; PMCID: PMC4852872.
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Conditioned soils reveal plant-selected microbial communities that impact plant drought response.

Scientific reports

Monohon SJ, Manter DK, Vivanco JM.
PMID: 34707132
Sci Rep. 2021 Oct 27;11(1):21153. doi: 10.1038/s41598-021-00593-z.

Rhizobacterial communities can contribute to plant trait expression and performance, including plant tolerance against abiotic stresses such as drought. The conditioning of microbial communities related to disease resistance over generations has been shown to develop suppressive soils which aid...

Cite
Monohon SJ, Manter DK, Vivanco JM. Conditioned soils reveal plant-selected microbial communities that impact plant drought response. Sci Rep. 2021;11(1):21153doi: 10.1038/s41598-021-00593-z.
Monohon, S. J., Manter, D. K., & Vivanco, J. M. (2021). Conditioned soils reveal plant-selected microbial communities that impact plant drought response. Scientific reports, 11(1), 21153. https://doi.org/10.1038/s41598-021-00593-z
Monohon, Samantha J, et al. "Conditioned soils reveal plant-selected microbial communities that impact plant drought response." Scientific reports vol. 11,1 (2021): 21153. doi: https://doi.org/10.1038/s41598-021-00593-z
Monohon SJ, Manter DK, Vivanco JM. Conditioned soils reveal plant-selected microbial communities that impact plant drought response. Sci Rep. 2021 Oct 27;11(1):21153. doi: 10.1038/s41598-021-00593-z. PMID: 34707132; PMCID: PMC8551274.
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Showing 1 to 4 of 4 entries