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Showing 1 to 7 of 7 entries
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Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention.

Journal of pharmaceutical innovation

Gong T, Zhang W, Parniak MA, Graebing PW, Moncla B, Gupta P, Empey KM, Rohan LC.
PMID: 28983328
J Pharm Innov. 2017 Jun;12(2):142-154. doi: 10.1007/s12247-017-9274-0. Epub 2017 Mar 03.

PURPOSE: 5-chloro-3-[phenylsulfonyl] indole-2-carboxamide (CSIC) is a highly potent non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 which has been shown to have a more desirable resistance profile than other NNRTIs in development as HIV prevention strategies. This work involves generation...

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Gong T, Zhang W, Parniak MA, et al. Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention. J Pharm Innov. 2017;12(2):142-154doi: 10.1007/s12247-017-9274-0.
Gong, T., Zhang, W., Parniak, M. A., Graebing, P. W., Moncla, B., Gupta, P., Empey, K. M., & Rohan, L. C. (2017). Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention. Journal of pharmaceutical innovation, 12(2), 142-154. https://doi.org/10.1007/s12247-017-9274-0
Gong, Tiantian, et al. "Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention." Journal of pharmaceutical innovation vol. 12,2 (2017): 142-154. doi: https://doi.org/10.1007/s12247-017-9274-0
Gong T, Zhang W, Parniak MA, Graebing PW, Moncla B, Gupta P, Empey KM, Rohan LC. Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention. J Pharm Innov. 2017 Jun;12(2):142-154. doi: 10.1007/s12247-017-9274-0. Epub 2017 Mar 03. PMID: 28983328; PMCID: PMC5624728.
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Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission.

Drug delivery and translational research

Akil A, Parniak MA, Dezzuitti CS, Moncla BJ, Cost MR, Li M, Rohan LC.
PMID: 22708075
Drug Deliv Transl Res. 2011 Jun 01;1(3):209-222. doi: 10.1007/s13346-011-0022-6.

Dapivirine, a non-nucleoside reverse transcriptase inhibitor, is a potent and promising anti-HIV molecule. It is currently being investigated for use as a vaginal microbicide in two dosage forms, a semi-solid gel and a silicone elastomer ring. Quick-dissolving films are...

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Akil A, Parniak MA, Dezzuitti CS, et al. Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission. Drug Deliv Transl Res. 2011;1(3):209-222doi: 10.1007/s13346-011-0022-6.
Akil, A., Parniak, M. A., Dezzuitti, C. S., Moncla, B. J., Cost, M. R., Li, M., & Rohan, L. C. (2011). Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission. Drug delivery and translational research, 1(3), 209-222. https://doi.org/10.1007/s13346-011-0022-6
Akil, Ayman, et al. "Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission." Drug delivery and translational research vol. 1,3 (2011): 209-222. doi: https://doi.org/10.1007/s13346-011-0022-6
Akil A, Parniak MA, Dezzuitti CS, Moncla BJ, Cost MR, Li M, Rohan LC. Development and Characterization of a Vaginal Film Containing Dapivirine, a Non- nucleoside Reverse Transcriptase Inhibitor (NNRTI), for prevention of HIV-1 sexual transmission. Drug Deliv Transl Res. 2011 Jun 01;1(3):209-222. doi: 10.1007/s13346-011-0022-6. PMID: 22708075; PMCID: PMC3375737.
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Degradation of naturally occurring and engineered antimicrobial peptides by proteases.

Advances in bioscience and biotechnology (Print)

Moncla BJ, Pryke K, Rohan LC, Graebing PW.
PMID: 22611520
Adv Biosci Biotechnol. 2011 Dec;2(6):404-408. doi: 10.4236/abb.2011.26059.

We hypothesized that current antimicrobial peptides should be susceptible to proteolytic digestion. The antimicrobial peptides: Griffithinsin, RC-101, LL-37, LSA-5, PSC-RANTES and DJ007 were degraded by commercially available proteases. Two different species of anaerobic vaginal flora, Prevotella bivia and Porphyromonas...

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Moncla BJ, Pryke K, Rohan LC, et al. Degradation of naturally occurring and engineered antimicrobial peptides by proteases. Adv Biosci Biotechnol. 2011;2(6):404-408doi: 10.4236/abb.2011.26059.
Moncla, B. J., Pryke, K., Rohan, L. C., & Graebing, P. W. (2011). Degradation of naturally occurring and engineered antimicrobial peptides by proteases. Advances in bioscience and biotechnology (Print), 2(6), 404-408. https://doi.org/10.4236/abb.2011.26059
Moncla, Bernard J, et al. "Degradation of naturally occurring and engineered antimicrobial peptides by proteases." Advances in bioscience and biotechnology (Print) vol. 2,6 (2011): 404-408. doi: https://doi.org/10.4236/abb.2011.26059
Moncla BJ, Pryke K, Rohan LC, Graebing PW. Degradation of naturally occurring and engineered antimicrobial peptides by proteases. Adv Biosci Biotechnol. 2011 Dec;2(6):404-408. doi: 10.4236/abb.2011.26059. PMID: 22611520; PMCID: PMC3354962.
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IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign.

Molecular syndromology

Desmyter L, Ghassibe M, Revencu N, Boute O, Lees M, François G, Verellen-Dumoulin C, Sznajer Y, Moncla A, Benateau H, Claes K, Devriendt K, Mathieu M, Van Maldergem L, Addor MC, Drouin-Garraud V, Mortier G, Bouma M, Dieux-Coeslier A, Genevieve D, Goldenberg A, Gozu A, Makrythanasis P, McEntagart U, Sanchez A, Vilain C, Vermeer S, Connell F, Verheij J, Manouvrier S, Pierquin G, Odent S, Holder-Espinasse M, Vincent-Delorme C, Gillerot Y, Vanwijck R, Bayet B, Vikkula M.
PMID: 21045959
Mol Syndromol. 2010;1(2):67-74. doi: 10.1159/000313786. Epub 2010 Jun 09.

Van der Woude syndrome (VWS), caused by dominant IRF6 mutation, is the most common cleft syndrome. In 15% of the patients, lip pits are absent and the phenotype mimics isolated clefts. Therefore, we hypothesized that some of the families...

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Desmyter L, Ghassibe M, Revencu N, et al. IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign. Mol Syndromol. 2010;1(2):67-74doi: 10.1159/000313786.
Desmyter, L., Ghassibe, M., Revencu, N., Boute, O., Lees, M., François, G., Verellen-Dumoulin, C., Sznajer, Y., Moncla, A., Benateau, H., Claes, K., Devriendt, K., Mathieu, M., Van Maldergem, L., Addor, M. C., Drouin-Garraud, V., Mortier, G., Bouma, M., Dieux-Coeslier, A., Genevieve, D., Goldenberg, A., Gozu, A., Makrythanasis, P., McEntagart, U., Sanchez, A., Vilain, C., Vermeer, S., Connell, F., Verheij, J., Manouvrier, S., Pierquin, G., Odent, S., Holder-Espinasse, M., Vincent-Delorme, C., Gillerot, Y., Vanwijck, R., Bayet, B., & Vikkula, M. (2010). IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign. Molecular syndromology, 1(2), 67-74. https://doi.org/10.1159/000313786
Desmyter, L, et al. "IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign." Molecular syndromology vol. 1,2 (2010): 67-74. doi: https://doi.org/10.1159/000313786
Desmyter L, Ghassibe M, Revencu N, Boute O, Lees M, François G, Verellen-Dumoulin C, Sznajer Y, Moncla A, Benateau H, Claes K, Devriendt K, Mathieu M, Van Maldergem L, Addor MC, Drouin-Garraud V, Mortier G, Bouma M, Dieux-Coeslier A, Genevieve D, Goldenberg A, Gozu A, Makrythanasis P, McEntagart U, Sanchez A, Vilain C, Vermeer S, Connell F, Verheij J, Manouvrier S, Pierquin G, Odent S, Holder-Espinasse M, Vincent-Delorme C, Gillerot Y, Vanwijck R, Bayet B, Vikkula M. IRF6 Screening of Syndromic and a priori Non-Syndromic Cleft Lip and Palate Patients: Identification of a New Type of Minor VWS Sign. Mol Syndromol. 2010;1(2):67-74. doi: 10.1159/000313786. Epub 2010 Jun 09. PMID: 21045959; PMCID: PMC2941841.
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Correction for Dinis et al., Deep Sequencing Reveals Potential Antigenic Variants at Low Frequencies in Influenza A Virus-Infected Humans.

Journal of virology

Dinis JM, Florek NW, Fatola OO, Moncla LH, Mutschler JP, Charlier OK, Meece JK, Belongia EA, Friedrich TC.
PMID: 27520946
J Virol. 2016 Aug 12;90(17):8029. doi: 10.1128/JVI.01041-16. Print 2016 Sep 01.

No abstract available.

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Dinis JM, Florek NW, Fatola OO, et al. Correction for Dinis et al., Deep Sequencing Reveals Potential Antigenic Variants at Low Frequencies in Influenza A Virus-Infected Humans. J Virol. 2016;90(17):8029doi: 10.1128/JVI.01041-16.
Dinis, J. M., Florek, N. W., Fatola, O. O., Moncla, L. H., Mutschler, J. P., Charlier, O. K., Meece, J. K., Belongia, E. A., & Friedrich, T. C. (2016). Correction for Dinis et al., Deep Sequencing Reveals Potential Antigenic Variants at Low Frequencies in Influenza A Virus-Infected Humans. Journal of virology, 90(17), 8029. https://doi.org/10.1128/JVI.01041-16
Dinis, Jorge M, et al. "Correction for Dinis et al., Deep Sequencing Reveals Potential Antigenic Variants at Low Frequencies in Influenza A Virus-Infected Humans." Journal of virology vol. 90,17 (2016): 8029. doi: https://doi.org/10.1128/JVI.01041-16
Dinis JM, Florek NW, Fatola OO, Moncla LH, Mutschler JP, Charlier OK, Meece JK, Belongia EA, Friedrich TC. Correction for Dinis et al., Deep Sequencing Reveals Potential Antigenic Variants at Low Frequencies in Influenza A Virus-Infected Humans. J Virol. 2016 Aug 12;90(17):8029. doi: 10.1128/JVI.01041-16. Print 2016 Sep 01. PMID: 27520946; PMCID: PMC4988149.
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Cryptic transmission of SARS-CoV-2 in Washington State.

medRxiv : the preprint server for health sciences

Bedford T, Greninger AL, Roychoudhury P, Starita LM, Famulare M, Huang ML, Nalla A, Pepper G, Reinhardt A, Xie H, Shrestha L, Nguyen TN, Adler A, Brandstetter E, Cho S, Giroux D, Han PD, Fay K, Frazar CD, Ilcisin M, Lacombe K, Lee J, Kiavand A, Richardson M, Sibley TR, Truong M, Wolf CR, Nickerson DA, Rieder MJ, Englund JA, Hadfield J, Hodcroft EB, Huddleston J, Moncla LH, Müller NF, Neher RA, Deng X, Gu W, Federman S, Chiu C, Duchin J, Gautom R, Melly G, Hiatt B, Dykema P, Lindquist S, Queen K, Tao Y, Uehara A, Tong S, MacCannell D, Armstrong GL, Baird GS, Chu HY, Shendure J, Jerome KR.
PMID: 32511596
medRxiv. 2020 Apr 06; doi: 10.1101/2020.04.02.20051417.

Following its emergence in Wuhan, China, in late November or early December 2019, the SARS-CoV-2 virus has rapidly spread throughout the world. On March 11, 2020, the World Health Organization declared Coronavirus Disease 2019 (COVID-19) a pandemic. Genome sequencing...

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Bedford T, Greninger AL, Roychoudhury P, et al. Cryptic transmission of SARS-CoV-2 in Washington State. medRxiv. 2020;doi: 10.1101/2020.04.02.20051417.
Bedford, T., Greninger, A. L., Roychoudhury, P., Starita, L. M., Famulare, M., Huang, M. L., Nalla, A., Pepper, G., Reinhardt, A., Xie, H., Shrestha, L., Nguyen, T. N., Adler, A., Brandstetter, E., Cho, S., Giroux, D., Han, P. D., Fay, K., Frazar, C. D., Ilcisin, M., Lacombe, K., Lee, J., Kiavand, A., Richardson, M., Sibley, T. R., Truong, M., Wolf, C. R., Nickerson, D. A., Rieder, M. J., Englund, J. A., Hadfield, J., Hodcroft, E. B., Huddleston, J., Moncla, L. H., Müller, N. F., Neher, R. A., Deng, X., Gu, W., Federman, S., Chiu, C., Duchin, J., Gautom, R., Melly, G., Hiatt, B., Dykema, P., Lindquist, S., Queen, K., Tao, Y., Uehara, A., Tong, S., MacCannell, D., Armstrong, G. L., Baird, G. S., Chu, H. Y., Shendure, J., & Jerome, K. R. (2020). Cryptic transmission of SARS-CoV-2 in Washington State. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.04.02.20051417
Bedford, Trevor, et al. "Cryptic transmission of SARS-CoV-2 in Washington State." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.04.02.20051417
Bedford T, Greninger AL, Roychoudhury P, Starita LM, Famulare M, Huang ML, Nalla A, Pepper G, Reinhardt A, Xie H, Shrestha L, Nguyen TN, Adler A, Brandstetter E, Cho S, Giroux D, Han PD, Fay K, Frazar CD, Ilcisin M, Lacombe K, Lee J, Kiavand A, Richardson M, Sibley TR, Truong M, Wolf CR, Nickerson DA, Rieder MJ, Englund JA, Hadfield J, Hodcroft EB, Huddleston J, Moncla LH, Müller NF, Neher RA, Deng X, Gu W, Federman S, Chiu C, Duchin J, Gautom R, Melly G, Hiatt B, Dykema P, Lindquist S, Queen K, Tao Y, Uehara A, Tong S, MacCannell D, Armstrong GL, Baird GS, Chu HY, Shendure J, Jerome KR. Cryptic transmission of SARS-CoV-2 in Washington State. medRxiv. 2020 Apr 06; doi: 10.1101/2020.04.02.20051417. PMID: 32511596; PMCID: PMC7276023.
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Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State.

medRxiv : the preprint server for health sciences

Müller NF, Wagner C, Frazar CD, Roychoudhury P, Lee J, Moncla LH, Pelle B, Richardson M, Ryke E, Xie H, Shrestha L, Addetia A, Rachleff VM, Lieberman NAP, Huang ML, Gautom R, Melly G, Hiatt B, Dykema P, Adler A, Brandstetter E, Han PD, Fay K, Llcisin M, Lacombe K, Sibley TR, Truong M, Wolf CR, Boeckh M, Englund JA, Famulare M, Lutz BR, Rieder MJ, Thompson M, Duchin JS, Starita LM, Chu HY, Shendure J, Jerome KR, Lindquist S, Greninger AL, Nickerson DA, Bedford T.
PMID: 33024981
medRxiv. 2020 Sep 30; doi: 10.1101/2020.09.30.20204230.

The rapid spread of SARS-CoV-2 has gravely impacted societies around the world. Outbreaks in different parts of the globe are shaped by repeated introductions of new lineages and subsequent local transmission of those lineages. Here, we sequenced 3940 SARS-CoV-2...

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Müller NF, Wagner C, Frazar CD, et al. Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State. medRxiv. 2020;doi: 10.1101/2020.09.30.20204230.
Müller, N. F., Wagner, C., Frazar, C. D., Roychoudhury, P., Lee, J., Moncla, L. H., Pelle, B., Richardson, M., Ryke, E., Xie, H., Shrestha, L., Addetia, A., Rachleff, V. M., Lieberman, N. A. P., Huang, M. L., Gautom, R., Melly, G., Hiatt, B., Dykema, P., Adler, A., Brandstetter, E., Han, P. D., Fay, K., Llcisin, M., Lacombe, K., Sibley, T. R., Truong, M., Wolf, C. R., Boeckh, M., Englund, J. A., Famulare, M., Lutz, B. R., Rieder, M. J., Thompson, M., Duchin, J. S., Starita, L. M., Chu, H. Y., Shendure, J., Jerome, K. R., Lindquist, S., Greninger, A. L., Nickerson, D. A., & Bedford, T. (2020). Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2020.09.30.20204230
Müller, Nicola F, et al. "Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State." medRxiv : the preprint server for health sciences vol. (2020). doi: https://doi.org/10.1101/2020.09.30.20204230
Müller NF, Wagner C, Frazar CD, Roychoudhury P, Lee J, Moncla LH, Pelle B, Richardson M, Ryke E, Xie H, Shrestha L, Addetia A, Rachleff VM, Lieberman NAP, Huang ML, Gautom R, Melly G, Hiatt B, Dykema P, Adler A, Brandstetter E, Han PD, Fay K, Llcisin M, Lacombe K, Sibley TR, Truong M, Wolf CR, Boeckh M, Englund JA, Famulare M, Lutz BR, Rieder MJ, Thompson M, Duchin JS, Starita LM, Chu HY, Shendure J, Jerome KR, Lindquist S, Greninger AL, Nickerson DA, Bedford T. Viral genomes reveal patterns of the SARS-CoV-2 outbreak in Washington State. medRxiv. 2020 Sep 30; doi: 10.1101/2020.09.30.20204230. PMID: 33024981; PMCID: PMC7536883.
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