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Showing 1 to 12 of 40 entries
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Enriched biodiversity data as a resource and service.

Biodiversity data journal

Vos RA, Biserkov JV, Balech B, Beard N, Blissett M, Brenninkmeijer C, van Dooren T, Eades D, Gosline G, Groom QJ, Hamann TD, Hettling H, Hoehndorf R, Holleman A, Hovenkamp P, Kelbert P, King D, Kirkup D, Lammers Y, DeMeulemeester T, Mietchen D, Miller JA, Mounce R, Nicolson N, Page R, Pawlik A, Pereira S, Penev L, Richards K, Sautter G, Shorthouse DP, Tähtinen M, Weiland C, Williams AR, Sierra S.
PMID: 25057255
Biodivers Data J. 2014 Jun 16;(2):e1125. doi: 10.3897/BDJ.2.e1125. eCollection 2014.

BACKGROUND: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source "data enrichment" workflows, they are increasingly being represented in a...

A framework for extending trial design to facilitate missing data sensitivity analyses.

BMC medical research methodology

Mason AJ, Grieve RD, Richards-Belle A, Mouncey PR, Harrison DA, Carpenter JR.
PMID: 32183708
BMC Med Res Methodol. 2020 Mar 17;20(1):66. doi: 10.1186/s12874-020-00930-2.

BACKGROUND: Missing data are an inevitable challenge in Randomised Controlled Trials (RCTs), particularly those with Patient Reported Outcome Measures. Methodological guidance suggests that to avoid incorrect conclusions, studies should undertake sensitivity analyses which recognise that data may be 'missing...

Development of platforms for functional characterization and production of phenazines using a multi-chassis approach via CRAGE.

Metabolic engineering

Ke J, Zhao Z, Coates CR, Hadjithomas M, Kuftin A, Louie K, Weller D, Thomashow L, Mouncey NJ, Northen TR, Yoshikuni Y.
PMID: 34890798
Metab Eng. 2021 Dec 08;69:188-197. doi: 10.1016/j.ymben.2021.11.012. Epub 2021 Dec 08.

Phenazines (Phzs), a family of chemicals with a phenazine backbone, are secondary metabolites with diverse properties such as antibacterial, anti-fungal, or anticancer activity. The core derivatives of phenazine, phenazine-1-carboxylic acid (PCA) and phenazine-1,6-dicarboxylic acid (PDC), are themselves precursors for...

Correction to: COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland.

Intensive care medicine

Richards-Belle A, Orzechowska I, Gould DW, Thomas K, Doidge JC, Mouncey PR, Christian MD, Shankar-Hari M, Harrison DA, Rowan KM.
PMID: 34061211
Intensive Care Med. 2021 Jun;47(6):731-732. doi: 10.1007/s00134-021-06413-2.

No abstract available.

Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial.

Journal of the Intensive Care Society

Richards-Belle A, Mouncey PR, Grieve RD, Harrison DA, Sadique MZ, Henry D, Whitman C, Camsooksai J, Gordon AC, Young JD, Rowan KM, Lamontagne F.
PMID: 34093727
J Intensive Care Soc. 2020 Nov;21(4):281-282. doi: 10.1177/1751143720971433. Epub 2020 Dec 08.

Vasodilatory shock is common in critically ill patients and vasopressors are a mainstay of therapy. A meta-analysis suggested that use of a higher, as opposed to a lower, mean arterial pressure target to guide titration of vasopressor therapy, could...

Development of platforms for functional characterization and production of phenazines using a multi-chassis approach via CRAGE.

Metabolic engineering

Ke J, Zhao Z, Coates CR, Hadjithomas M, Kuftin A, Louie K, Weller D, Thomashow L, Mouncey NJ, Northen TR, Yoshikuni Y.
PMID: 34890798
Metab Eng. 2021 Dec 08;69:188-197. doi: 10.1016/j.ymben.2021.11.012. Epub 2021 Dec 08.

Phenazines (Phzs), a family of chemicals with a phenazine backbone, are secondary metabolites with diverse properties such as antibacterial, anti-fungal, or anticancer activity. The core derivatives of phenazine, phenazine-1-carboxylic acid (PCA) and phenazine-1,6-dicarboxylic acid (PDC), are themselves precursors for...

Retrospective analysis of the population dynamics and racing outcomes of the 2014 and 2015 UK and Ireland Thoroughbred foal crops.

The Veterinary record

Arango-Sabogal JC, Mouncey R, de Mestre AM, Verheyen K.
PMID: 33870524
Vet Rec. 2021 Sep;189(5):e298. doi: 10.1002/vetr.298. Epub 2021 Apr 18.

BACKGROUND: Up-to-date figures on early losses of Thoroughbreds from the racing industry can inform strategies to improve retention and incentivise traceability of Thoroughbreds during this early life period.METHODS: Data on Thoroughbred mares bred in 2013-2014 and training, racing and...

Author Correction: A genomic catalog of Earth's microbiomes.

Nature biotechnology

Nayfach S, Roux S, Seshadri R, Udwary D, Varghese N, Schulz F, Wu D, Paez-Espino D, Chen IM, Huntemann M, Palaniappan K, Ladau J, Mukherjee S, Reddy TBK, Nielsen T, Kirton E, Faria JP, Edirisinghe JN, Henry CS, Jungbluth SP, Chivian D, Dehal P, Wood-Charlson EM, Arkin AP, Tringe SG, Visel A, Woyke T, Mouncey NJ, Ivanova NN, Kyrpides NC, Eloe-Fadrosh EA.
PMID: 33795890
Nat Biotechnol. 2021 Apr;39(4):521. doi: 10.1038/s41587-021-00898-4.

No abstract available.

Recent developments in scholarly publishing to improve research practices in the life sciences.

Emerging topics in life sciences

Eglen SJ, Mounce R, Gatto L, Currie AM, Nobis Y, Calvo‐Ferrer JR.
PMID: 33530668
Emerg Top Life Sci. 2018 Dec 21;2(6):775-778. doi: 10.1042/ETLS20180172.

We outline recent developments in scholarly publishing that we think will improve the working environment and career prospects for life scientists. Most prominently, we discuss two key developments. (1) Life scientists are now embracing a preprint culture leading to...

Comparative effectiveness of common treatments for new-onset atrial fibrillation within the ICU: Accounting for physiological status.

Journal of critical care

Bedford JP, Johnson A, Redfern O, Gerry S, Doidge J, Harrison D, Rajappan K, Rowan K, Young JD, Mouncey P, Watkinson PJ.
PMID: 34798373
J Crit Care. 2021 Nov 16;67:149-156. doi: 10.1016/j.jcrc.2021.11.005. Epub 2021 Nov 16.

BACKGROUND: New-onset atrial fibrillation (NOAF) is common in patients on an intensive care unit (ICU). Evidence guiding treatments is limited, though recent reports suggest beta blocker (BB) therapy is associated with reduced mortality.METHODS: We conducted a multicentre cohort study...

Pharmacological and non-pharmacological treatments and outcomes for new-onset atrial fibrillation in ICU patients: the CAFE scoping review and database analyses.

Health technology assessment (Winchester, England)

Bedford J, Drikite L, Corbett M, Doidge J, Ferrando-Vivas P, Johnson A, Rajappan K, Mouncey P, Harrison D, Young D, Rowan K, Watkinson P.
PMID: 34847987
Health Technol Assess. 2021 Nov;25(71):1-174. doi: 10.3310/hta25710.

BACKGROUND: New-onset atrial fibrillation occurs in around 10% of adults treated in an intensive care unit. New-onset atrial fibrillation may lead to cardiovascular instability and thromboembolism, and has been independently associated with increased length of hospital stay and mortality....

Development of platforms for functional characterization and production of phenazines using a multi-chassis approach via CRAGE.

Metabolic engineering

Ke J, Zhao Z, Coates CR, Hadjithomas M, Kuftin A, Louie K, Weller D, Thomashow L, Mouncey NJ, Northen TR, Yoshikuni Y.
PMID: 34890798
Metab Eng. 2021 Dec 07; doi: 10.1016/j.ymben.2021.11.012. Epub 2021 Dec 07.

Phenazines (Phzs), a family of chemicals with a phenazine backbone, are secondary metabolites with diverse properties such as antibacterial, anti-fungal, or anticancer activity. The core derivatives of phenazine, phenazine-1-carboxylic acid (PCA) and phenazine-1,6-dicarboxylic acid (PDC), are themselves precursors for...

Showing 1 to 12 of 40 entries