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Showing 1 to 9 of 9 entries
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Efficacy and safety of Syferol-IHP for the treatment of peptic ulcer disease: a pilot, double-blind randomized trial.

Clinical and experimental gastroenterology

Eleje GU, Ogbunugafor HA, Emegoakor CD, Okoye EI, Ezejiofor OI, Chukwurah SN, Ikechebelu JI, Nchinda GW, Ugochukwu CG, Nnaji-Ihedinmah LI, Okoye FBC, Eneh FU, Onwukamuche ME, Esimone CO.
PMID: 30679917
Clin Exp Gastroenterol. 2019 Jan 15;12:21-30. doi: 10.2147/CEG.S178179. eCollection 2019.

BACKGROUND: To our knowledge, there is no prior randomized study on the utility of Syferol-IHP (blend of virgin coconut oil and AIM: This study determined the efficacy and safety of Syferol-IHP as adjunct to conventional triple therapy for the...

Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and .

Journal of medicinal chemistry

Horatscheck A, Andrijevic A, Nchinda AT, Le Manach C, Paquet T, Khonde LP, Dam J, Pawar K, Taylor D, Lawrence N, Brunschwig C, Gibhard L, Njoroge M, Reader J, van der Watt M, Wicht K, de Sousa ACC, Okombo J, Maepa K, Egan TJ, Birkholtz LM, Basarab GS, Wittlin S, Fish PV, Street LJ, Duffy J, Chibale K.
PMID: 33508187
J Med Chem. 2021 Feb 11;64(3):1762. doi: 10.1021/acs.jmedchem.1c00064. Epub 2021 Jan 28.

No abstract available.

Evaluation of a collaborative model for successful implementation of a National CD4 enumeration EQA program in Cameroon.

Scientific reports

Sagnia B, Kiazyk S, Meyers AFA, Plews M, Diallo TO, Sosso SM, Ambada G, Kamgaing R, Nji N, Sandstrom P, Ball BT, Nchinda G, Ndjolo A.
PMID: 34078982
Sci Rep. 2021 Jun 02;11(1):11536. doi: 10.1038/s41598-021-91015-7.

Participation in an EQA program is critical to the quality assurance process. Reliable and precise CD4 T-cells enumeration are essential to improve the clinical management of patients by evaluating the disease progression and by monitoring the effectiveness of ART...

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Antimicrobial agents and chemotherapy

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.
PMID: 30355750
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.01941-18. Print 2018 Nov.

No abstract available.

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.

ACS omega

Mueller R, Reddy V, Nchinda AT, Mebrahtu F, Taylor D, Lawrence N, Tanner L, Barnabe M, Eyermann CJ, Zou B, Kondreddi RR, Lakshminarayana SB, Rottmann M, Street LJ, Chibale K.
PMID: 32258933
ACS Omega. 2020 Mar 17;5(12):6967-6982. doi: 10.1021/acsomega.0c00327. eCollection 2020 Mar 31.

A phenotypic whole cell high-throughput screen against the asexual blood and liver stages of the malaria parasite identified a benzimidazole chemical series. Among the hits were the antiemetic benzimidazole drug Lerisetron

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Antimicrobial agents and chemotherapy

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.
PMID: 29941635
Antimicrob Agents Chemother. 2018 Aug 27;62(9). doi: 10.1128/AAC.00012-18. Print 2018 Sep.

The 2-aminopyridine MMV048 was the first drug candidate inhibiting

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in .

Journal of medicinal chemistry

Khonde LP, Müller R, Boyle GA, Reddy V, Nchinda AT, Eyermann CJ, Fienberg S, Singh V, Myrick A, Abay E, Njoroge M, Lawrence N, Su Q, Myers TG, Boshoff HIM, Barry CE, Sirgel FA, van Helden PD, Massoudi LM, Robertson GT, Lenaerts AJ, Basarab GS, Ghorpade SR, Chibale K.
PMID: 34414766
J Med Chem. 2021 Sep 09;64(17):12790-12807. doi: 10.1021/acs.jmedchem.1c00837. Epub 2021 Aug 20.

Phenotypic whole cell high-throughput screening of a ∼150,000 diverse set of compounds against

Global Assessment of Dengue Virus-Specific CD4.

Frontiers in immunology

Grifoni A, Angelo MA, Lopez B, O'Rourke PH, Sidney J, Cerpas C, Balmaseda A, Silveira CGT, Maestri A, Costa PR, Durbin AP, Diehl SA, Phillips E, Mallal S, De Silva AD, Nchinda G, Nkenfou C, Collins MH, de Silva AM, Lim MQ, Macary PA, Tatullo F, Solomon T, Satchidanandam V, Desai A, Ravi V, Coloma J, Turtle L, Rivino L, Kallas EG, Peters B, Harris E, Sette A, Weiskopf D.
PMID: 29081779
Front Immunol. 2017 Oct 13;8:1309. doi: 10.3389/fimmu.2017.01309. eCollection 2017.

BACKGROUND: Dengue is a major public health problem worldwide. Assessment of adaptive immunity is important to understanding immunopathology and to define correlates of protection against dengue virus (DENV). To enable global assessment of CD4METHODS: HLA class II epitopes in...

The Effect of Antiretroviral Naïve HIV-1 Infection on the Ability of Natural Killer Cells to Produce IFN-γ upon Exposure to Plasmodium falciparum-Infected Erythrocytes.

Biomedicine hub

Sake CS, Ngu L, Ambada G, Chedjou JP, Nji N, Tchadji JC, Lissom A, Tchouangueu TF, Djukouo L, Njambe G, Garcia R, Gutierrez A, Bopda Waffo A, Park CG, Mbacham W, Etoa FX, Nchinda GW.
PMID: 31988903
Biomed Hub. 2017 Apr 21;2(1):1-13. doi: 10.1159/000467386. eCollection 2017.

BACKGROUND: In sub-Saharan Africa, intense perennial METHOD: Magnetically sorted NK cells from antiretroviral naïve HIV-1-infected people were tested for their ability to respond to iRBC following in vitro coculture. NK cell IFN-γ production after coculture was measured through multiparametric...

Showing 1 to 9 of 9 entries