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Showing 1 to 12 of 188 entries
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Recent genomic advances in schizophrenia.

Clinical genetics

Doherty JL, O'Donovan MC, Owen MJ.
PMID: 21895634
Clin Genet. 2012 Feb;81(2):103-9. doi: 10.1111/j.1399-0004.2011.01773.x. Epub 2011 Oct 05.

Recent studies have supported the hypothesis based upon expectations from population genetics that the high heritability of schizophrenia reflects a combination of relatively common alleles of small effect and rare alleles some with relatively large effects. Genome-wide association studies...

How reliable is internet-based self-reported identity, socio-demographic and obesity measures in European adults?.

Genes & nutrition

Celis-Morales C, Livingstone KM, Woolhead C, Forster H, O'Donovan CB, Macready AL, Fallaize R, Marsaux CFM, Tsirigoti L, Efstathopoulou E, Moschonis G, Navas-Carretero S, San-Cristobal R, Kolossa S, Klein UL, Hallmann J, Godlewska M, Surwiłło A, Drevon CA, Bouwman J, Grimaldi K, Parnell LD, Manios Y, Traczyk I, Gibney ER, Brennan L, Walsh MC, Lovegrove JA, Martinez JA, Daniel H, Saris WHM, Gibney M, Mathers JC.
PMID: 26143178
Genes Nutr. 2015 Sep;10(5):28. doi: 10.1007/s12263-015-0476-0. Epub 2015 Jul 05.

UNLABELLED: In e-health intervention studies, there are concerns about the reliability of internet-based, self-reported (SR) data and about the potential for identity fraud. This study introduced and tested a novel procedure for assessing the validity of internet-based, SR identity...

The physical working capacity of male adolescents in Ireland.

Irish journal of medical science

Watson AW, O'Donovan DJ.
PMID: 27517261
Ir J Med Sci. 1976 Dec;145(1):383. doi: 10.1007/BF02938977.

The physical working capacity (PWC) of 303 male adolescents was measured using the PWC170 test. The changes in PWC with age were similar to those reported by other workers; the PWC of male adolescents in Ireland appears to be...

Localization of interictal epileptiform activity using magnetoencephalography with synthetic aperture magnetometry in patients with a vagus nerve stimulator.

Frontiers in neurology

Stapleton-Kotloski JR, Kotloski RJ, Boggs JA, Popli G, O'Donovan CA, Couture DE, Cornell C, Godwin DW.
PMID: 25505894
Front Neurol. 2014 Nov 27;5:244. doi: 10.3389/fneur.2014.00244. eCollection 2014.

Magnetoencephalography (MEG) provides useful and non-redundant information in the evaluation of patients with epilepsy, and in particular, during the pre-surgical evaluation of pharmaco-resistant epilepsy. Vagus nerve stimulation (VNS) is a common treatment for pharmaco-resistant epilepsy. However, interpretation of MEG...

Common alleles contribute to schizophrenia in CNV carriers.

Molecular psychiatry

Tansey KE, Rees E, Linden DE, Ripke S, Chambert KD, Moran JL, McCarroll SA, Holmans P, Kirov G, Walters J, Owen MJ, O'Donovan MC.
PMID: 26643540
Mol Psychiatry. 2016 Aug;21(8):1153. doi: 10.1038/mp.2015.170. Epub 2015 Dec 08.

No abstract available.

A clinical survey of cortisone therapy.

Journal of the Irish Medical Association

O'DONOVAN DK.
PMID: 13011490
J Ir Med Assoc. 1952 Dec;31(186):343-8.

No abstract available.

New findings from genetic association studies of schizophrenia.

Journal of human genetics

Williams HJ, Owen MJ, O'Donovan MC.
PMID: 19158819
J Hum Genet. 2009 Jan;54(1):9-14. doi: 10.1038/jhg.2008.7. Epub 2009 Jan 09.

In the past 20 years, association studies of schizophrenia have evolved from analyses in lesser than 100 subjects of one or two markers in candidate genes to systematic analyses of association at a genome-wide level in samples of thousands...

De novo mutation in schizophrenia.

Schizophrenia bulletin

Rees E, Kirov G, O'Donovan MC, Owen MJ.
PMID: 22451492
Schizophr Bull. 2012 May;38(3):377-81. doi: 10.1093/schbul/sbs047. Epub 2012 Mar 26.

Several studies in the last 5 years have shown that newly arising (de novo) mutations contribute to the genetics of schizophrenia (SZ). This will replenish genetic variants removed by natural selection and could, in part, explain why SZ prevalence...

Current Pharmacological Management in Juvenile Huntington's Disease.

PLoS currents

Robertson L, Santini H, O'Donovan KL, Squitieri F, Barker RA, Rakowicz M, Landwehrmeyer GB, Quarrell O.
PMID: 22474619
PLoS Curr. 2012 Feb 15;4:RRN1304. doi: 10.1371/currents.RRN1304.

BACKGROUND: The clinical presentation of Juvenile Huntington's Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management.AIM: To survey the current use of pharmacological treatments for JHD.METHODS: Patients were identified through the HD...

Current Pharmacological Management in Juvenile Huntington's Disease.

PLoS currents

Robertson L, Santini H, O'Donovan KL, Squitieri F, Barker RA, Rakowicz M, Landwehrmeyer GB, Quarrell O.
PMID: 22474619
PLoS Curr. 2012 Feb 15;4:RRN1304. doi: 10.1371/currents.RRN1304.

BACKGROUND: The clinical presentation of Juvenile Huntington's Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management.AIM: To survey the current use of pharmacological treatments for JHD.METHODS: Patients were identified through the HD...

Current Pharmacological Management in Juvenile Huntington's Disease.

PLoS currents

Robertson L, Santini H, O'Donovan KL, Squitieri F, Barker RA, Rakowicz M, Landwehrmeyer GB, Quarrell O.
PMID: 22474619
PLoS Curr. 2012 Feb 15;4:RRN1304. doi: 10.1371/currents.RRN1304.

SUMMARY BACKGROUND: The clinical presentation of Juvenile Huntington's Disease (JHD) can be very different from adult-onset HD with little evidence to guide symptomatic management.AIM: To survey the current use of pharmacological treatments for JHD.METHODS: Patients were identified through the...

Spatial correlations in polydisperse, frictionless, two-dimensional packings.

Physical review. E, Statistical, nonlinear, and soft matter physics

O'Donovan CB, Möbius ME.
PMID: 21928939
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Aug;84(2):020302. doi: 10.1103/PhysRevE.84.020302. Epub 2011 Aug 29.

We investigate next-nearest-neighbor correlations of the contact number in simulations of polydisperse, frictionless packings in two dimensions. We find that disks with few contacting neighbors are predominantly in contact with disks that have many neighbors and vice versa at...

Showing 1 to 12 of 188 entries