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Showing 1 to 12 of 32 entries
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Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing.

Genome medicine

O'Rawe J, Jiang T, Sun G, Wu Y, Wang W, Hu J, Bodily P, Tian L, Hakonarson H, Johnson WE, Wei Z, Wang K, Lyon GJ.
PMID: 23537139
Genome Med. 2013 Mar 27;5(3):28. doi: 10.1186/gm432. eCollection 2013.

BACKGROUND: To facilitate the clinical implementation of genomic medicine by next-generation sequencing, it will be critically important to obtain accurate and consistent variant calls on personal genomes. Multiple software tools for variant calling are available, but it is unclear...

Recent Insights into Corticostriatal Circuit Mechanisms underlying Habits: Invited review for Current Opinions in Behavioral Sciences.

Current opinion in behavioral sciences

O'Hare J, Calakos N, Yin HH.
PMID: 29450220
Curr Opin Behav Sci. 2018 Apr;20:40-46. doi: 10.1016/j.cobeha.2017.10.001. Epub 2017 Oct 27.

Habits have been studied for decades, but it was not until recent years that experiments began to elucidate the underlying cellular and circuit mechanisms. The latest experiments have been enabled by advances in cell-type specific monitoring and manipulation of...

Adaptive stimulus selection for consolidation in the hippocampus.

Nature

Terada S, Geiller T, Liao Z, O'Hare J, Vancura B, Losonczy A.
PMID: 34880499
Nature. 2022 Jan;601(7892):240-244. doi: 10.1038/s41586-021-04118-6. Epub 2021 Dec 08.

Associative memories guide behavioural adaptation by binding together outcome-predictive sensory stimuli

Beyond Implicit Bias to Explicit Action.

JAMA ophthalmology

Knight OJ, Mike EV, Elam AR.
PMID: 34673886
JAMA Ophthalmol. 2021 Dec 01;139(12):1283-1284. doi: 10.1001/jamaophthalmol.2021.4320.

No abstract available.

Treatment of glioblastoma with re-purposed renin-angiotensin system modulators: Results of a phase I clinical trial.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

O'Rawe M, Wickremesekera AC, Pandey R, Young D, Sim D, FitzJohn T, Burgess C, Kaye AH, Tan ST.
PMID: 34929651
J Clin Neurosci. 2021 Dec 04;95:48-54. doi: 10.1016/j.jocn.2021.11.023. Epub 2021 Dec 04.

Glioblastoma is the most common and most aggressive primary brain cancer in adults. Standard treatment of glioblastoma consisting of maximal safe resection, adjuvant radiotherapy and chemotherapy with temozolomide, results in an overall median survival of 14.6 months. The aggressive...

Understanding the Origins of Problem Geomagnetic Storms Associated with "Stealth" Coronal Mass Ejections.

Space science reviews

Nitta NV, Mulligan T, Kilpua EKJ, Lynch BJ, Mierla M, O'Kane J, Pagano P, Palmerio E, Pomoell J, Richardson IR, Rodriguez L, Rouillard AP, Sinha S, Srivastava N, Talpeanu DC, Yardley SL, Zhukov AN.
PMID: 34789949
Space Sci Rev. 2021;217(8):82. doi: 10.1007/s11214-021-00857-0. Epub 2021 Nov 03.

Geomagnetic storms are an important aspect of space weather and can result in significant impacts on space- and ground-based assets. The majority of strong storms are associated with the passage of interplanetary coronal mass ejections (ICMEs) in the near-Earth...

Reducing INDEL calling errors in whole genome and exome sequencing data.

Genome medicine

Fang H, Wu Y, Narzisi G, O'Rawe JA, Barrón LT, Rosenbaum J, Ronemus M, Iossifov I, Schatz MC, Lyon GJ.
PMID: 25426171
Genome Med. 2014 Oct 28;6(10):89. doi: 10.1186/s13073-014-0089-z. eCollection 2014.

BACKGROUND: INDELs, especially those disrupting protein-coding regions of the genome, have been strongly associated with human diseases. However, there are still many errors with INDEL variant calling, driven by library preparation, sequencing biases, and algorithm artifacts.METHODS: We characterized whole...

The Dissociative Experiences Scale.

Irish journal of psychological medicine

Lewis CA, Dorahy MJ, O'Rawe B, O'Rawe A.
PMID: 30290518
Ir J Psychol Med. 2006 Sep;23(3):121-122. doi: 10.1017/S0790966700009812.

No abstract available.

Political issues in internal medicine in Europe. A position paper.

European journal of internal medicine

, Bauer W, Schumm-Draeger PM, Koebberling J, Gjoerup T, Garcia Alegria JJ, Ferreira F, Higgens C, Kramer M, Licata G, Mittelman M, O'hare J, Unal S.
PMID: 15967343
Eur J Intern Med. 2005 Jun;16(3):214-217. doi: 10.1016/j.ejim.2005.02.003.

What will be the future of internal medicine in Europe? Because of rapidly growing concerns regarding the position of internal medicine in many European countries, the European Federation of Internal Medicine (EFIM) has established a working group to analyze...

"Early Trigger" Intravenous Vitamin K: Optimizing Target-Driven Care in Warfarinised Patients With Hip Fracture.

Geriatric orthopaedic surgery & rehabilitation

Diament M, MacLeod K, O'Hare J, Tate A, Eardley W.
PMID: 26623160
Geriatr Orthop Surg Rehabil. 2015 Dec;6(4):263-8. doi: 10.1177/2151458515595669.

Best practice tariff (BPT) was introduced as a financial incentive model to improve compliance with evidence-based care, such as operation for hip fracture within 36 hours of admission. We previously evaluated the impact of warfarin on patients with hip...

Treatment of glioblastoma with re-purposed renin-angiotensin system modulators: Results of a phase I clinical trial.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

O'Rawe M, Wickremesekera AC, Pandey R, Young D, Sim D, FitzJohn T, Burgess C, Kaye AH, Tan ST.
PMID: 34929651
J Clin Neurosci. 2021 Dec 04;95:48-54. doi: 10.1016/j.jocn.2021.11.023. Epub 2021 Dec 04.

Glioblastoma is the most common and most aggressive primary brain cancer in adults. Standard treatment of glioblastoma consisting of maximal safe resection, adjuvant radiotherapy and chemotherapy with temozolomide, results in an overall median survival of 14.6 months. The aggressive...

Treatment of glioblastoma with re-purposed renin-angiotensin system modulators: Results of a phase I clinical trial.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

O'Rawe M, Wickremesekera AC, Pandey R, Young D, Sim D, FitzJohn T, Burgess C, Kaye AH, Tan ST.
PMID: 34929651
J Clin Neurosci. 2021 Dec 04;95:48-54. doi: 10.1016/j.jocn.2021.11.023. Epub 2021 Dec 04.

Glioblastoma is the most common and most aggressive primary brain cancer in adults. Standard treatment of glioblastoma consisting of maximal safe resection, adjuvant radiotherapy and chemotherapy with temozolomide, results in an overall median survival of 14.6 months. The aggressive...

Showing 1 to 12 of 32 entries