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Showing 1 to 12 of 191 entries
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Medical resource utilization and costs associated with autosomal dominant polycystic kidney disease in the USA: a retrospective matched cohort analysis of private insurer data.

ClinicoEconomics and outcomes research : CEOR

Knight T, Schaefer C, Krasa H, Oberdhan D, Chapman A, Perrone RD.
PMID: 25759590
Clinicoecon Outcomes Res. 2015 Feb 20;7:123-32. doi: 10.2147/CEOR.S75523. eCollection 2015.

BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) results in kidney cyst development and enlargement, resulting in chronic kidney disease (CKD) leading to renal failure. This study sought to determine if ADPKD patients in the early stages of CKD contribute...

The Effect of Mir-451 Upregulation on Erythroid Lineage Differentiation of Murine Embryonic Stem Cells.

Cell journal

Obeidi N, Pourfathollah AA, Soleimani M, Nikougoftar Zarif M, Kouhkan F.
PMID: 27540521
Cell J. 2016 Jul-Sep;18(2):165-78. doi: 10.22074/cellj.2016.4311. Epub 2016 May 30.

OBJECTIVE: MicroRNAs (miRNAs) are small endogenous non-coding regulatory RNAs that control mRNAs post-transcriptionally. Several mouse stem cells miRNAs are cloned differentially regulated in different hematopoietic lineages, suggesting their possible role in hematopoietic lineage differentiation. Recent studies have shown that...

Ceramide and the regulation of apoptosis and the stress response.

Trends in cardiovascular medicine

Perry DK, Obeid LM, Hannun YA.
PMID: 21232290
Trends Cardiovasc Med. 1996 Jul;6(5):158-62. doi: 10.1016/1050-1738(96)00044-8.

The process of apoptosis or programmed cell death has been the subject of intense study due to the realization of its importance in a wide variety of biological and pathological conditions, including development, ischemia, cancer, and neurodegenerative disorders. Although...

Prevalence of herpes simplex virus types 1 and 2 and associated sociodemographic variables in pregnant women attending king fahd hospital of the university.

Journal of family & community medicine

Obeid OE.
PMID: 23012136
J Family Community Med. 2007 Jan;14(1):3-7.

OBJECTIVES: The risk factors associated with herpes simplex virus (HSV) seropositivity in pregnant women in Saudi Arabia are not known. This study was aimed at identifying the sociodemographic variables associated with seroprevalence of HSV-1 and HSV-2 in pregnant women...

A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.

FEBS open bio

Carroll BL, Bonica J, Shamseddine AA, Hannun YA, Obeid LM.
PMID: 29321954
FEBS Open Bio. 2017 Dec 08;8(1):27-40. doi: 10.1002/2211-5463.12344. eCollection 2018 Jan.

Sphingosine kinase 1 (SK1) is a lipid kinase whose activity produces sphingosine 1-phosphate, a prosurvival lipid associated with proliferation, angiogenesis, and invasion. SK1 overexpression has been observed in numerous cancers. Recent studies have demonstrated that SK1 proteolysis occurs downstream...

A survey of practices for the use of electronic health records to support research recruitment.

Journal of clinical and translational science

Obeid JS, Beskow LM, Rape M, Gouripeddi R, Black RA, Cimino JJ, Embi PJ, Weng C, Marnocha R, Buse JB.
PMID: 29657859
J Clin Transl Sci. 2017 Aug;1(4):246-252. doi: 10.1017/cts.2017.301.

Electronic health records (EHRs) provide great promise for identifying cohorts and enhancing research recruitment. Such approaches are sorely needed, but there are few descriptions in the literature of prevailing practices to guide their use. A multidisciplinary workgroup was formed...

Treatment of children and adolescents with avoidant/restrictive food intake disorder: a case series examining the feasibility of family therapy and adjunctive treatments.

Journal of eating disorders

Spettigue W, Norris ML, Santos A, Obeid N.
PMID: 30123505
J Eat Disord. 2018 Aug 03;6:20. doi: 10.1186/s40337-018-0205-3. eCollection 2018.

BACKGROUND: To date, little research has examined the effectiveness of either modified Family-Based Therapy or psychopharmacological treatments for patients diagnosed with avoidant/restrictive food intake disorder (ARFID), and there is little evidence to guide clinicians treating children and adolescents with...

Bismuth oxyhalides: synthesis, structure and photoelectrochemical activity.

Chemical science

Bhachu DS, Moniz SJA, Sathasivam S, Scanlon DO, Walsh A, Bawaked SM, Mokhtar M, Obaid AY, Parkin IP, Tang J, Carmalt CJ.
PMID: 30155131
Chem Sci. 2016 Aug 01;7(8):4832-4841. doi: 10.1039/c6sc00389c. Epub 2016 Mar 09.

We report the synthesis and photoelectrochemical assessment of phase pure tetragonal matlockite structured BiOX (where X = Cl, Br, I) films. The materials were deposited using aerosol-assisted chemical vapour deposition. The measured optical bandgaps of the oxyhalides, supported by...

Review of Clinical Outcome Assessments in Pediatric Attention-Deficit/Hyperactivity Disorder.

Neuropsychiatric disease and treatment

Markowitz JT, Oberdhan D, Ciesluk A, Rams A, Wigal SB.
PMID: 32669845
Neuropsychiatr Dis Treat. 2020 Jul 01;16:1619-1643. doi: 10.2147/NDT.S248685. eCollection 2020.

PURPOSE: Various clinical outcome assessments (COAs) are used in clinical research to assess and monitor treatment efficacy in pediatric attention-deficit/hyperactivity disorder (ADHD) trials. It is unclear whether the concepts assessed are those that are important to patients and their...

Research participation preferences as expressed through a patient portal: implications of demographic characteristics.

JAMIA open

Obeid JS, Shoaibi A, Oates JC, Habrat ML, Hughes-Halbert C, Lenert LA.
PMID: 30474076
JAMIA Open. 2018 Oct;1(2):202-209. doi: 10.1093/jamiaopen/ooy034. Epub 2018 Aug 16.

OBJECTIVE: As patient portals are increasingly used for research recruitment, it is important to examine the demographic makeup of research registries that are populated via portals and the factors that influence participation in these registries.METHODS: We examined the response...

The effect of diabetes mellitus on the shear bond strength of composite resin to dentin and enamel.

Odontology

Saghiri MA, Obeidi A, Nath D, Morgano SM.
PMID: 34318336
Odontology. 2022 Jan;110(1):92-98. doi: 10.1007/s10266-021-00641-0. Epub 2021 Jul 27.

Diabetes mellitus might be linked to the deterioration of certain physical properties of dentin and enamel. This study aimed to determine the effect of two types of diabetes on the shear bond strength of enamel and dentin, by using...

Myeloid Cell Infiltration Correlates With Prognosis in Cholangiocarcinoma and Varies Based on Tumor Location.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Kunk PR, Dougherty SC, Lynch K, Whitehair R, Meneveau M, Obeid JM, Winters K, Ju JY, Stelow EB, Bauer TW, Slingluff CL, Rahma OE.
PMID: 34191790
J Immunother. 2021 Sep 01;44(7):254-263. doi: 10.1097/CJI.0000000000000378.

Cholangiocarcinoma (CC) is an uncommon malignancy with increasing incidence and dismal prognosis. We conducted a comprehensive analysis of the CC tumor immune microenvironment (TIME) based on tumor location to identify therapeutic targets. We hypothesized that the TIME of CC...

Showing 1 to 12 of 191 entries