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Showing 1 to 12 of 439 entries
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RRx-001-Induced Tumor Necrosis and Immune Cell Infiltration in an EGFR Mutation-Positive NSCLC with Resistance to EGFR Tyrosine Kinase Inhibitors: A Case Report.

Case reports in oncology

Brzezniak C, Schmitz BA, Peterson PG, Degesys A, Oronsky BT, Scicinski JJ, Caroen SZ, Carter CA.
PMID: 26933418
Case Rep Oncol. 2016 Jan 15;9(1):45-50. doi: 10.1159/000443605. eCollection 2016.

We present the case of a 49-year-old male with metastatic epidermal growth factor receptor (EGFR) mutation-positive adenocarcinoma of the lung that continues to outlive stage IV diagnosis of non-small cell lung cancer after treatment with RRx-001, an experimental anticancer...

Intravenous zoledronate for osteoporosis: less might be more.

Therapeutic advances in musculoskeletal disease

Grey A.
PMID: 27493690
Ther Adv Musculoskelet Dis. 2016 Aug;8(4):119-23. doi: 10.1177/1759720X16650866. Epub 2016 May 19.

Annual administration of 5 mg intravenous zoledronate is moderately effective in reducing fracture risk in older adults, decreasing the relative risk of clinical fracture by 33%. However, almost 10 years after its approval for use in clinical practice there...

Estimation of Time Period for Effective Human Inhalational Anthrax Treatment Including Antitoxin Therapy.

PLoS currents

Rubinson L, Corey A, Hanfling D.
PMID: 28856066
PLoS Curr. 2017 Jul 28;9. doi: 10.1371/currents.outbreaks.7896c43f69838f17ce1c2c372e79d55d.

INTRODUCTION: Infrequent natural human inhalational anthrax cases coupled with high bioterrorism risk have brought about use of animal models to serve as the basis for approval of novel treatments. For inhalational anthrax, protective antigen (PA) drives much of the...

Validation of a quantitative phosphorus loss assessment tool.

Journal of environmental quality

White MJ, Storm DE, Smolen MD, Busteed PR, Zhang H, Fox GA.
PMID: 25602555
J Environ Qual. 2014 Jan;43(1):224-34. doi: 10.2134/jeq2011.0434.

Pasture Phosphorus Management Plus (PPM Plus) is a tool that allows nutrient management and conservation planners to evaluate phosphorus (P) loss from agricultural fields. This tool uses a modified version of the widely used Soil and Water Assessment Tool...

Aerobic Capacity is Related to Repeated Sprint Ability with Sprint Distances Less Than 40 Meters.

International journal of exercise science

Sanders GJ, Turner Z, Boos B, Peacock CA, Peveler W, Lipping A.
PMID: 28344734
Int J Exerc Sci. 2017 Mar 01;10(2):197-204. eCollection 2017.

Research is inconclusive regarding the association between aerobic fitness (objectively measured VO

Layered Bi2Se3 nanoplate/polyvinylidene fluoride composite based n-type thermoelectric fabrics.

ACS applied materials & interfaces

Dun C, Hewitt CA, Huang H, Xu J, Montgomery DS, Nie W, Jiang Q, Carroll DL.
PMID: 25798653
ACS Appl Mater Interfaces. 2015 Apr 08;7(13):7054-9. doi: 10.1021/acsami.5b00514. Epub 2015 Mar 27.

In this study, we report the fabrication of n-type flexible thermoelectric fabrics using layered Bi2Se3 nanoplate/polyvinylidene fluoride (PVDF) composites as the thermoelectric material. These composites exhibit room temperature Seebeck coefficient and electrical conductivity values of -80 μV K(-1) and...

The AMP-Dependent Protein Kinase (AMPK) Activator A-769662 Causes Arterial Relaxation by Reducing Cytosolic Free Calcium Independently of an Increase in AMPK Phosphorylation.

Frontiers in pharmacology

Huang Y, Smith CA, Chen G, Sharma B, Miner AS, Barbee RW, Ratz PH.
PMID: 29093683
Front Pharmacol. 2017 Oct 18;8:756. doi: 10.3389/fphar.2017.00756. eCollection 2017.

Although recent studies reveal that activation of the metabolic and Ca

Effect of an herbal/botanical supplement on recovery from delayed onset muscle soreness: a randomized placebo-controlled trial.

Journal of the International Society of Sports Nutrition

Rynders CA, Weltman JY, Rynders SD, Patrie J, McKnight J, Katch FI, Hertel J, Weltman A.
PMID: 24966805
J Int Soc Sports Nutr. 2014 Jun 13;11:27. doi: 10.1186/1550-2783-11-27. eCollection 2014.

BACKGROUND: We examined the effects of a proprietary herbal/botanical supplement (StemSport, Stemtech, San Clemente, CA.) suggested to increase circulating stem cells, decrease inflammation, and attenuate exercise induced muscle damage on recovery from delayed onset muscle soreness (DOMS).METHODS: Sixteen subjects...

Impact of Caregiving for Patients with Alzheimer's Disease and Dementia on Psychiatric and Clinical Comorbidities in Brazil.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Goren A, Novick D, Barros BR, Laks J, Dueñas H, Kahle-Wrobleski K.
PMID: 27200965
Value Health. 2014 Nov;17(7):A402. doi: 10.1016/j.jval.2014.08.921. Epub 2014 Oct 26.

No abstract available.

Ovarian Torsion in the Third Trimester of Pregnancy Leading to Iatrogenic Preterm Delivery.

Case reports in obstetrics and gynecology

Vlachodimitropoulou Koumoutsea E, Gupta M, Hollingworth A, Gorry A.
PMID: 27066282
Case Rep Obstet Gynecol. 2016;2016:8426270. doi: 10.1155/2016/8426270. Epub 2016 Mar 15.

Ovarian torsion in the third trimester of pregnancy leading to a midline laparotomy and caesarean section for the delivery of a preterm baby is an uncommon event. As the woman is likely to present with nonspecific symptoms of lower...

Novel segmental proxy measures for estimating weight and height in healthy school children aged 11-18 years.

Clinical nutrition ESPEN

Carey A, McCarthy H, Gill J, Thompson A, McNulty H.
PMID: 28531548
Clin Nutr ESPEN. 2015 Oct;10(5):e211. doi: 10.1016/j.clnesp.2015.03.078. Epub 2015 Aug 28.

No abstract available.

Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001.

Case reports in oncology

Carter CA, Schmitz B, Peterson PG, Quinn M, Degesys A, Jenkins J, Oronsky B, Scicinski J, Caroen S, Reid TR, Cabrales P, Brzezniak C.
PMID: 27065848
Case Rep Oncol. 2016 Mar 10;9(1):164-70. doi: 10.1159/000444633. eCollection 2016.

Neuroendocrine tumors (NETs) are grouped together as a single class on the basis of histologic appearance, immunoreactivity for the neuroendocrine markers chromogranin A and synaptophysin, and potential secretion of hormones, neurotransmitters, neuromodulators and neuropeptides. Nevertheless, despite these common characteristics,...

Showing 1 to 12 of 439 entries