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Tandem buildup of complexity of aromatic molecules through multiple successive electrophile generation in one pot, controlled by varying the reaction temperature.

Organic & biomolecular chemistry

Sumita A, Otani Y, Ohwada T.
PMID: 26699842
Org Biomol Chem. 2016 Feb 07;14(5):1680-93. doi: 10.1039/c5ob02240a.

While some sequential electrophilic aromatic substitution reactions, known as tandem/domino/cascade reactions, have been reported for the construction of aromatic single skeletons, one of the most interesting and challenging possibilities remains the one-pot build-up of a complex aromatic molecule from...

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Sumita A, Otani Y, Ohwada T. Tandem buildup of complexity of aromatic molecules through multiple successive electrophile generation in one pot, controlled by varying the reaction temperature. Org Biomol Chem. 2016;14(5):1680-93doi: 10.1039/c5ob02240a.
Sumita, A., Otani, Y., & Ohwada, T. (2016). Tandem buildup of complexity of aromatic molecules through multiple successive electrophile generation in one pot, controlled by varying the reaction temperature. Organic & biomolecular chemistry, 14(5), 1680-93. https://doi.org/10.1039/c5ob02240a
Sumita, Akinari, et al. "Tandem buildup of complexity of aromatic molecules through multiple successive electrophile generation in one pot, controlled by varying the reaction temperature." Organic & biomolecular chemistry vol. 14,5 (2016): 1680-93. doi: https://doi.org/10.1039/c5ob02240a
Sumita A, Otani Y, Ohwada T. Tandem buildup of complexity of aromatic molecules through multiple successive electrophile generation in one pot, controlled by varying the reaction temperature. Org Biomol Chem. 2016 Feb 07;14(5):1680-93. doi: 10.1039/c5ob02240a. PMID: 26699842.
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Stage IV intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type.

Clinical journal of gastroenterology

Ohtaka M, Sato T, Kobayashi S, Sueki R, Yamaguchi T, Uetake T, Ohtsuka H, Iwao N, Kirito K, Enomoto N.
PMID: 26181449
Clin J Gastroenterol. 2013 Apr;6(2):127-33. doi: 10.1007/s12328-013-0374-1. Epub 2013 Mar 20.

A 45-year-old woman with no symptoms underwent upper gastrointestinal endoscopy. A discolored area was noted at the greater curvature of the gastric upper body. Endoscopic ultrasonography demonstrated thickening of the second sonographic layer indicating that the depth of invasion...

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Ohtaka M, Sato T, Kobayashi S, et al. Stage IV intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type. Clin J Gastroenterol. 2013;6(2):127-33doi: 10.1007/s12328-013-0374-1.
Ohtaka, M., Sato, T., Kobayashi, S., Sueki, R., Yamaguchi, T., Uetake, T., Ohtsuka, H., Iwao, N., Kirito, K., & Enomoto, N. (2013). Stage IV intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type. Clinical journal of gastroenterology, 6(2), 127-33. https://doi.org/10.1007/s12328-013-0374-1
Ohtaka, Masahiko, et al. "Stage IV intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type." Clinical journal of gastroenterology vol. 6,2 (2013): 127-33. doi: https://doi.org/10.1007/s12328-013-0374-1
Ohtaka M, Sato T, Kobayashi S, Sueki R, Yamaguchi T, Uetake T, Ohtsuka H, Iwao N, Kirito K, Enomoto N. Stage IV intramucosal gastric marginal zone B cell lymphoma of mucosa-associated lymphoid tissue type. Clin J Gastroenterol. 2013 Apr;6(2):127-33. doi: 10.1007/s12328-013-0374-1. Epub 2013 Mar 20. PMID: 26181449.
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Complete remission of gastric plasmacytoma following eradication of "Candidatus Helicobacter heilmannii".

Clinical journal of gastroenterology

Ohtaka M, Tatsumi A, Fukasawa M, Yamaguchi T, Uetake T, Ohtsuka H, Sato T, Enomoto N, Watanabe H, Mitani K.
PMID: 26182161
Clin J Gastroenterol. 2012 Apr;5(2):158-63. doi: 10.1007/s12328-012-0287-4. Epub 2012 Feb 18.

This is the first case report of gastric plasmacytoma associated with "Candidatus Helicobacter heilmannii" ('H. heilmannii') infection. The patient was a 40-year-old woman with epigastric discomfort. Upper gastrointestinal endoscopy demonstrated a white granular lesion on the wall of the...

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Ohtaka M, Tatsumi A, Fukasawa M, et al. Complete remission of gastric plasmacytoma following eradication of "Candidatus Helicobacter heilmannii". Clin J Gastroenterol. 2012;5(2):158-63doi: 10.1007/s12328-012-0287-4.
Ohtaka, M., Tatsumi, A., Fukasawa, M., Yamaguchi, T., Uetake, T., Ohtsuka, H., Sato, T., Enomoto, N., Watanabe, H., & Mitani, K. (2012). Complete remission of gastric plasmacytoma following eradication of "Candidatus Helicobacter heilmannii". Clinical journal of gastroenterology, 5(2), 158-63. https://doi.org/10.1007/s12328-012-0287-4
Ohtaka, Masahiko, et al. "Complete remission of gastric plasmacytoma following eradication of "Candidatus Helicobacter heilmannii"." Clinical journal of gastroenterology vol. 5,2 (2012): 158-63. doi: https://doi.org/10.1007/s12328-012-0287-4
Ohtaka M, Tatsumi A, Fukasawa M, Yamaguchi T, Uetake T, Ohtsuka H, Sato T, Enomoto N, Watanabe H, Mitani K. Complete remission of gastric plasmacytoma following eradication of "Candidatus Helicobacter heilmannii". Clin J Gastroenterol. 2012 Apr;5(2):158-63. doi: 10.1007/s12328-012-0287-4. Epub 2012 Feb 18. PMID: 26182161.
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Enhanced heterologous production of eicosapentaenoic acid in Escherichia coli cells that co-express eicosapentaenoic acid biosynthesis pfa genes and foreign DNA fragments including a high-performance catalase gene, vktA.

Biotechnology letters

Orikasa Y, Ito Y, Nishida T, Watanabe K, Morita N, Ohwada T, Yumoto I, Okuyama H.
PMID: 27519303
Biotechnol Lett. 2007 May;29(5):811-2. doi: 10.1007/s10529-007-9343-4.

No abstract available.

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Orikasa Y, Ito Y, Nishida T, et al. Enhanced heterologous production of eicosapentaenoic acid in Escherichia coli cells that co-express eicosapentaenoic acid biosynthesis pfa genes and foreign DNA fragments including a high-performance catalase gene, vktA. Biotechnol Lett. 2007;29(5):811-2doi: 10.1007/s10529-007-9343-4.
Orikasa, Y., Ito, Y., Nishida, T., Watanabe, K., Morita, N., Ohwada, T., Yumoto, I., & Okuyama, H. (2007). Enhanced heterologous production of eicosapentaenoic acid in Escherichia coli cells that co-express eicosapentaenoic acid biosynthesis pfa genes and foreign DNA fragments including a high-performance catalase gene, vktA. Biotechnology letters, 29(5), 811-2. https://doi.org/10.1007/s10529-007-9343-4
Orikasa, Yoshitake, et al. "Enhanced heterologous production of eicosapentaenoic acid in Escherichia coli cells that co-express eicosapentaenoic acid biosynthesis pfa genes and foreign DNA fragments including a high-performance catalase gene, vktA." Biotechnology letters vol. 29,5 (2007): 811-2. doi: https://doi.org/10.1007/s10529-007-9343-4
Orikasa Y, Ito Y, Nishida T, Watanabe K, Morita N, Ohwada T, Yumoto I, Okuyama H. Enhanced heterologous production of eicosapentaenoic acid in Escherichia coli cells that co-express eicosapentaenoic acid biosynthesis pfa genes and foreign DNA fragments including a high-performance catalase gene, vktA. Biotechnol Lett. 2007 May;29(5):811-2. doi: 10.1007/s10529-007-9343-4. PMID: 27519303.
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An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils.

Molecular therapy. Methods & clinical development

Lin HT, Masaki H, Yamaguchi T, Wada T, Yachie A, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H, Otsu M.
PMID: 26682238
Mol Ther Methods Clin Dev. 2015 Dec 09;2:15046. doi: 10.1038/mtm.2015.46. eCollection 2015.

For the treatment of monogenetic hematological disorders, restoration of transgene expression in affected cell populations is generally considered to have beneficial effects. However, X-linked chronic granulomatous disease (XCGD) is unique since the appearance of functional neutrophils in the peripheral...

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Lin HT, Masaki H, Yamaguchi T, et al. An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils. Mol Ther Methods Clin Dev. 2015;2:15046doi: 10.1038/mtm.2015.46.
Lin, H. T., Masaki, H., Yamaguchi, T., Wada, T., Yachie, A., Nishimura, K., Ohtaka, M., Nakanishi, M., Nakauchi, H., & Otsu, M. (2015). An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils. Molecular therapy. Methods & clinical development, 215046. https://doi.org/10.1038/mtm.2015.46
Lin, Huan-Ting, et al. "An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils." Molecular therapy. Methods & clinical development vol. 2 (2015): 15046. doi: https://doi.org/10.1038/mtm.2015.46
Lin HT, Masaki H, Yamaguchi T, Wada T, Yachie A, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H, Otsu M. An assessment of the effects of ectopic gp91phox expression in XCGD iPSC-derived neutrophils. Mol Ther Methods Clin Dev. 2015 Dec 09;2:15046. doi: 10.1038/mtm.2015.46. eCollection 2015. PMID: 26682238; PMCID: PMC4674005.
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Effect of a Dynamic Air Cushion on the Development of Leg Edema during Wheelchair Sitting.

Journal of physical therapy science

Murata J, Murata S, Ohyama M, Kogo H, Matsubara S.
PMID: 25013295
J Phys Ther Sci. 2014 Jun;26(6):911-3. doi: 10.1589/jpts.26.911. Epub 2014 Jun 30.

[Purpose] To clarify how a novel dynamic cushion affects the leg edema evoked by wheelchair sitting, we measured the changes in leg volume induced during wheelchair sitting with the dynamic air cushion or a static cushion. [Subjects and Methods]...

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Murata J, Murata S, Ohyama M, et al. Effect of a Dynamic Air Cushion on the Development of Leg Edema during Wheelchair Sitting. J Phys Ther Sci. 2014;26(6):911-3doi: 10.1589/jpts.26.911.
Murata, J., Murata, S., Ohyama, M., Kogo, H., & Matsubara, S. (2014). Effect of a Dynamic Air Cushion on the Development of Leg Edema during Wheelchair Sitting. Journal of physical therapy science, 26(6), 911-3. https://doi.org/10.1589/jpts.26.911
Murata, Jun, et al. "Effect of a Dynamic Air Cushion on the Development of Leg Edema during Wheelchair Sitting." Journal of physical therapy science vol. 26,6 (2014): 911-3. doi: https://doi.org/10.1589/jpts.26.911
Murata J, Murata S, Ohyama M, Kogo H, Matsubara S. Effect of a Dynamic Air Cushion on the Development of Leg Edema during Wheelchair Sitting. J Phys Ther Sci. 2014 Jun;26(6):911-3. doi: 10.1589/jpts.26.911. Epub 2014 Jun 30. PMID: 25013295; PMCID: PMC4085220.
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A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils.

Blood

Shibakura M, Koyama T, Ohsawa M, Kamiyama R, Hirosawa S.
PMID: 9427733
Blood. 1998 Jan 15;91(2):724b-725.

No abstract available.

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Shibakura M, Koyama T, Ohsawa M, et al. A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils. Blood. 1998;91(2):724b-725
Shibakura, M., Koyama, T., Ohsawa, M., Kamiyama, R., & Hirosawa, S. (1998). A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils. Blood, 91(2), 724b-725.
Shibakura, et al. "A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils." Blood vol. 91,2 (1998): 724b-725.
Shibakura M, Koyama T, Ohsawa M, Kamiyama R, Hirosawa S. A Retinoic Acid Receptor-alpha (RARalpha) Selective Agonist Modulates Procoagulant Activity of Acute Promyelocytic Cells and Induces Their Differentiation Into Neutrophils. Blood. 1998 Jan 15;91(2):724b-725. PMID: 9427733.
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Two-dimensional incommensurately modulated structure of (Sr0.13Ca0. 87)2CoSi2O7 crystals.

Acta crystallographica. Section B, Structural science

Bagautdinov B, Hagiya K, Kusaka K, Ohmasa M, Iishi K.
PMID: 11006557
Acta Crystallogr B. 2000 Oct;56:811-21. doi: 10.1107/S0108768100006716. Epub 2000 Oct 01.

The incommensurate structure of (Sr(0.13)Ca(0.87))(2)CoSi(2)O(7) at room temperature has been determined from single-crystal X-ray diffraction data. The compound has a non-centrosymmetric tetragonal basic cell of a = 7.8743 (4) and c = 5.0417 (2) A with the space group...

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Bagautdinov B, Hagiya K, Kusaka K, et al. Two-dimensional incommensurately modulated structure of (Sr0.13Ca0. 87)2CoSi2O7 crystals. Acta Crystallogr B. 2000;56:811-21doi: 10.1107/S0108768100006716.
Bagautdinov, B., Hagiya, K., Kusaka, K., Ohmasa, M., & Iishi, K. (2000). Two-dimensional incommensurately modulated structure of (Sr0.13Ca0. 87)2CoSi2O7 crystals. Acta crystallographica. Section B, Structural science, 56811-21. https://doi.org/10.1107/S0108768100006716
Bagautdinov, B, et al. "Two-dimensional incommensurately modulated structure of (Sr0.13Ca0. 87)2CoSi2O7 crystals." Acta crystallographica. Section B, Structural science vol. 56 (2000): 811-21. doi: https://doi.org/10.1107/S0108768100006716
Bagautdinov B, Hagiya K, Kusaka K, Ohmasa M, Iishi K. Two-dimensional incommensurately modulated structure of (Sr0.13Ca0. 87)2CoSi2O7 crystals. Acta Crystallogr B. 2000 Oct;56:811-21. doi: 10.1107/S0108768100006716. Epub 2000 Oct 01. PMID: 11006557.
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Stereoselectivity of superacid-catalyzed Pictet-Spengler cyclization reactions.

Organic letters

Nakamura S, Tanaka M, Taniguchi T, Uchiyama M, Ohwada T.
PMID: 12790535
Org Lett. 2003 Jun 12;5(12):2087-90. doi: 10.1021/ol034526a.

[reaction: see text] High stereoselectivities were found in a wide range of superacid-catalyzed Pictet-Spengler cyclization reactions. Particularly in the cases of 2-alkyl-N-benzylidene-2-phenethylamines, an enhanced stereoselectivity was observed under the superacid conditions as compared with the corresponding weak acid (TFA)-catalyzed...

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Nakamura S, Tanaka M, Taniguchi T, et al. Stereoselectivity of superacid-catalyzed Pictet-Spengler cyclization reactions. Org Lett. 2003;5(12):2087-90doi: 10.1021/ol034526a.
Nakamura, S., Tanaka, M., Taniguchi, T., Uchiyama, M., & Ohwada, T. (2003). Stereoselectivity of superacid-catalyzed Pictet-Spengler cyclization reactions. Organic letters, 5(12), 2087-90. https://doi.org/10.1021/ol034526a
Nakamura, Satoshi, et al. "Stereoselectivity of superacid-catalyzed Pictet-Spengler cyclization reactions." Organic letters vol. 5,12 (2003): 2087-90. doi: https://doi.org/10.1021/ol034526a
Nakamura S, Tanaka M, Taniguchi T, Uchiyama M, Ohwada T. Stereoselectivity of superacid-catalyzed Pictet-Spengler cyclization reactions. Org Lett. 2003 Jun 12;5(12):2087-90. doi: 10.1021/ol034526a. PMID: 12790535.
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Development of a gallium-doped germanium far-infrared photoconductor direct hybrid two-dimensional array.

Applied optics

Fujiwara M, Hirao T, Kawada M, Shibai H, Matsuura S, Kaneda H, Patrashin M, Nakagawa T.
PMID: 12716158
Appl Opt. 2003 Apr 20;42(12):2166-73. doi: 10.1364/ao.42.002166.

To our knowledge, we are the first to successfully report a direct hybrid two-dimensional (2D) detector array in the far-infrared region. Gallium-doped germanium (Ge:Ga) has been used extensively to produce sensitive far-infrared detectors with a cutoff wavelength of approximately...

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Fujiwara M, Hirao T, Kawada M, et al. Development of a gallium-doped germanium far-infrared photoconductor direct hybrid two-dimensional array. Appl Opt. 2003;42(12):2166-73doi: 10.1364/ao.42.002166.
Fujiwara, M., Hirao, T., Kawada, M., Shibai, H., Matsuura, S., Kaneda, H., Patrashin, M., & Nakagawa, T. (2003). Development of a gallium-doped germanium far-infrared photoconductor direct hybrid two-dimensional array. Applied optics, 42(12), 2166-73. https://doi.org/10.1364/ao.42.002166
Fujiwara, Mikio, et al. "Development of a gallium-doped germanium far-infrared photoconductor direct hybrid two-dimensional array." Applied optics vol. 42,12 (2003): 2166-73. doi: https://doi.org/10.1364/ao.42.002166
Fujiwara M, Hirao T, Kawada M, Shibai H, Matsuura S, Kaneda H, Patrashin M, Nakagawa T. Development of a gallium-doped germanium far-infrared photoconductor direct hybrid two-dimensional array. Appl Opt. 2003 Apr 20;42(12):2166-73. doi: 10.1364/ao.42.002166. PMID: 12716158.
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Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis.

Hepatology research : the official journal of the Japan Society of Hepatology

Murata M, Miyoshi Y, Ohsawa M, Shibata K, Ohta T, Imai Y, Nishikawa M, Iwao K, Tateishi H, Shimano T, Kobayashi T, Nakamura Y.
PMID: 11551833
Hepatol Res. 2001 Oct;21(2):126-135. doi: 10.1016/s1386-6346(01)00116-4.

Hepatocellular carcinomas (HCCs) are thought to develop as well-differentiated tumors and progress to less-differentiated tumors. However, the genetic changes underlying the development and progression of HCCs are not well understood. Recent studies have shown frequent beta-catenin gene activation in...

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Murata M, Miyoshi Y, Ohsawa M, et al. Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis. Hepatol Res. 2001;21(2):126-135doi: 10.1016/s1386-6346(01)00116-4.
Murata, M., Miyoshi, Y., Ohsawa, M., Shibata, K., Ohta, T., Imai, Y., Nishikawa, M., Iwao, K., Tateishi, H., Shimano, T., Kobayashi, T., & Nakamura, Y. (2001). Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis. Hepatology research : the official journal of the Japan Society of Hepatology, 21(2), 126-135. https://doi.org/10.1016/s1386-6346(01)00116-4
Murata, M, et al. "Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis." Hepatology research : the official journal of the Japan Society of Hepatology vol. 21,2 (2001): 126-135. doi: https://doi.org/10.1016/s1386-6346(01)00116-4
Murata M, Miyoshi Y, Ohsawa M, Shibata K, Ohta T, Imai Y, Nishikawa M, Iwao K, Tateishi H, Shimano T, Kobayashi T, Nakamura Y. Accumulation of beta-catenin in the cytoplasm and the nuclei during the early hepatic tumorigenesis. Hepatol Res. 2001 Oct;21(2):126-135. doi: 10.1016/s1386-6346(01)00116-4. PMID: 11551833.
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Radical cytoreductive surgery combined with platinums-carboplatin and cisplatin chemotherapy for advanced ovarian cancer.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Suzuki M, Ohwara M, Sekiguchi I, Sato I.
PMID: 11240743
Int J Gynecol Cancer. 1999 Jan;9(1):54-60. doi: 10.1046/j.1525-1438.1999.09890.x.

In an attempt to improve the therapeutic outcome for patients with advanced ovarian cancer, primary radical cytoreductive surgery consisting of hysterectomy, bilateral salpingo-oophorectomy, omentectomy and retroperitoneal lymph node resection, with optimal cytoreduction in case of metastatic lesions, was followed...

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Suzuki M, Ohwara M, Sekiguchi I, et al. Radical cytoreductive surgery combined with platinums-carboplatin and cisplatin chemotherapy for advanced ovarian cancer. Int J Gynecol Cancer. 1999;9(1):54-60doi: 10.1046/j.1525-1438.1999.09890.x.
Suzuki, M., Ohwara, M., Sekiguchi, I., & Sato, I. (1999). Radical cytoreductive surgery combined with platinums-carboplatin and cisplatin chemotherapy for advanced ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 9(1), 54-60. https://doi.org/10.1046/j.1525-1438.1999.09890.x
Suzuki, M., et al. "Radical cytoreductive surgery combined with platinums-carboplatin and cisplatin chemotherapy for advanced ovarian cancer." International journal of gynecological cancer : official journal of the International Gynecological Cancer Society vol. 9,1 (1999): 54-60. doi: https://doi.org/10.1046/j.1525-1438.1999.09890.x
Suzuki M, Ohwara M, Sekiguchi I, Sato I. Radical cytoreductive surgery combined with platinums-carboplatin and cisplatin chemotherapy for advanced ovarian cancer. Int J Gynecol Cancer. 1999 Jan;9(1):54-60. doi: 10.1046/j.1525-1438.1999.09890.x. PMID: 11240743.
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Showing 1 to 12 of 452 entries