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Showing 1 to 12 of 69 entries
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Transcriptomic and Ectoine Analysis of Halotolerant .

Frontiers in microbiology

Han J, Gao QX, Zhang YG, Li L, Mohamad OAA, Rao MPN, Xiao M, Hozzein WN, Alkhalifah DHM, Tao Y, Li WJ.
PMID: 29651284
Front Microbiol. 2018 Mar 29;9:618. doi: 10.3389/fmicb.2018.00618. eCollection 2018.

The genus

Improving risk prediction for pancreatic cancer in symptomatic patients: a Saudi Arabian study.

Cancer management and research

Ahmed AE, Alzahrani FS, Gharawi AM, Alammary SA, Almijmaj FH, Alhusayni FM, McClish DK, Al-Jahdali H, Olayan AAA, Jazieh AR.
PMID: 30464598
Cancer Manag Res. 2018 Oct 25;10:4981-4986. doi: 10.2147/CMAR.S173666. eCollection 2018.

BACKGROUND: Imaging tests used in our center are usually inadequate to confirm the high risk for pancreatic cancer. We aimed to use a combination of potential predictors including imaging tests to quantify the risk of pancreatic cancer and evaluate...

Evaluation of the Antimicrobial Activity of Endophytic Bacterial Populations From Chinese Traditional Medicinal Plant Licorice and Characterization of the Bioactive Secondary Metabolites Produced by .

Frontiers in microbiology

Mohamad OAA, Li L, Ma JB, Hatab S, Xu L, Guo JW, Rasulov BA, Liu YH, Hedlund BP, Li WJ.
PMID: 29867835
Front Microbiol. 2018 May 09;9:924. doi: 10.3389/fmicb.2018.00924. eCollection 2018.

Endophytic bacteria associated with medicinal plants possess unique strategies that enhance growth and suvival of host plants, many of which are mediated by distinctive secondary metabolites. These bacteria and their secondary metabolites are important subjects for both basic and...

Scorpion Venom-Functionalized Quercetin Phytosomes for Breast Cancer Management: In Vitro Response Surface Optimization and Anticancer Activity against MCF-7 Cells.

Polymers

Alhakamy NA, Fahmy UA, Eldin SMB, Ahmed OAA, Aldawsari HM, Okbazghi SZ, Alfaleh MA, Abdulaal WH, Alamoudi AJ, Mady FM.
PMID: 35012116
Polymers (Basel). 2021 Dec 27;14(1). doi: 10.3390/polym14010093.

Breast cancer is a dangerous type of cancer in women. Quercetin (QRT), a naturally occurring flavonoid, has wide biological effects including antioxidant, anticarcinogenic, anti-inflammatory, antiallergic, and antiviral activities. The anticancer activity is considered the most valuable effect of QRT...

Evaluation of the Antiviral Activity of Sitagliptin-Glatiramer Acetate Nano-Conjugates against SARS-CoV-2 Virus.

Pharmaceuticals (Basel, Switzerland)

Alhakamy NA, Ahmed OAA, Ibrahim TS, Aldawsari HM, Eljaaly K, Fahmy UA, Alaofi AL, Caraci F, Caruso G.
PMID: 33668390
Pharmaceuticals (Basel). 2021 Feb 24;14(3). doi: 10.3390/ph14030178.

The outbreak of the COVID-19 pandemic in China has become an urgent health and economic challenge. There is a current race for developing strategies to treat and/or prevent COVID-19 worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the...

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1.

Pharmacological research

Eid BG, Alhakamy NA, Fahmy UA, Ahmed OAA, Md S, Abdel-Naim AB, Caruso G, Caraci F.
PMID: 34801680
Pharmacol Res. 2021 Nov 19;175:105993. doi: 10.1016/j.phrs.2021.105993. Epub 2021 Nov 19.

A dysregulation of the wound healing process can lead to the development of various intractable ulcers or excessive scar formation. Therefore it is essential to identify novel pharmacological strategies to promote wound healing and restore the mechanical integrity of...

Transdermal Film Loaded with Avanafil Ultra-deformable Nanovesicles to Enhance its Percutaneous Absorption and Bioavailability.

AAPS PharmSciTech

Al-Hejaili OD, Alamoudi AA, Ahmed OAA, El-Say KM.
PMID: 34984577
AAPS PharmSciTech. 2022 Jan 04;23(1):46. doi: 10.1208/s12249-021-02195-4.

The in vitro dissolution of Avanafil (AVA) is the rate-limiting step for its bioavailability. Also, it undergoes the first-pass metabolism, and its absorption is altered significantly in the presence of food. So, our study aimed to overcome the previous...

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1.

Pharmacological research

Eid BG, Alhakamy NA, Fahmy UA, Ahmed OAA, Md S, Abdel-Naim AB, Caruso G, Caraci F.
PMID: 34801680
Pharmacol Res. 2021 Nov 19;175:105993. doi: 10.1016/j.phrs.2021.105993. Epub 2021 Nov 19.

A dysregulation of the wound healing process can lead to the development of various intractable ulcers or excessive scar formation. Therefore it is essential to identify novel pharmacological strategies to promote wound healing and restore the mechanical integrity of...

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1.

Pharmacological research

Eid BG, Alhakamy NA, Fahmy UA, Ahmed OAA, Md S, Abdel-Naim AB, Caruso G, Caraci F.
PMID: 34801680
Pharmacol Res. 2021 Nov 19;175:105993. doi: 10.1016/j.phrs.2021.105993. Epub 2021 Nov 19.

A dysregulation of the wound healing process can lead to the development of various intractable ulcers or excessive scar formation. Therefore it is essential to identify novel pharmacological strategies to promote wound healing and restore the mechanical integrity of...

Phyto-Phospholipid Conjugated Scorpion Venom Nanovesicles as Promising Carrier That Improves Efficacy of Thymoquinone against Adenocarcinoma Human Alveolar Basal Epithelial Cells.

Pharmaceutics

Asfour HZ, Fahmy UA, Alharbi WS, Almehmady AM, Alamoudi AJ, Tima S, Mansouri RA, Omar UM, Ahmed OAA, Zakai SA, Aldarmahi AA, Bagalagel A, Diri R, Alhakamy NA.
PMID: 34959424
Pharmaceutics. 2021 Dec 13;13(12). doi: 10.3390/pharmaceutics13122144.

Lung cancer is a dangerous type of cancer in men and the third leading cause of cancer-related death in women, behind breast and colorectal cancers. Thymoquinone (THQ), a main compound in black seed essential oils, has a variety of...

The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats.

PloS one

Abdel-Rahman RF, Fayed HM, Asaad GF, Ogaly HA, Hessin AF, Salama AAA, Abd El-Rahman SS, Arbid MS, Mohamed MAE.
PMID: 34965258
PLoS One. 2021 Dec 29;16(12):e0260130. doi: 10.1371/journal.pone.0260130. eCollection 2021.

The objective of the current study is to investigate the effect of rice bran oil (RBO) on hepatic fibrosis as a characteristic response to persistent liver injuries. Rats were randomly allocated into five groups: the negative control group, thioacetamide...

Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells.

Pharmaceutics

Alhakamy NA, A Fahmy U, Badr-Eldin SM, Ahmed OAA, Asfour HZ, Aldawsari HM, Algandaby MM, Eid BG, Abdel-Naim AB, Awan ZA, K Alruwaili N, Mohamed AI.
PMID: 32290412
Pharmaceutics. 2020 Apr 11;12(4). doi: 10.3390/pharmaceutics12040346.

Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for their potential in drug delivery of cytotoxic agents. Thus,...

Showing 1 to 12 of 69 entries