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Showing 1 to 12 of 24 entries
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A critical review of brand and generic alendronate for the treatment of osteoporosis.

SpringerPlus

Brown JP, Davison KS, Olszynski WP, Beattie KA, Adachi JD.
PMID: 25674402
Springerplus. 2013 Oct 21;2:550. doi: 10.1186/2193-1801-2-550. eCollection 2013.

OBJECTIVE: Compare in vitro and in vivo characteristics and clinical outcomes of brand and generic alendronate.RESEARCH DESIGN AND METHODS: Relevant search terms were input into Medline ("alendronate" AND "generic" up to August 5, 2013) and any abstracts deemed possibly...

The development of a provincial multidisciplinary framework of consensus-based standards for Point of Care Ultrasound at the University of Saskatchewan.

The ultrasound journal

Olszynski P, Kim DJ, Ma IWY, Clunie M, Lambos P, Guzowski T, Butz M, Thoma B.
PMID: 31624937
Ultrasound J. 2019 Oct 17;11(1):28. doi: 10.1186/s13089-019-0142-7.

OBJECTIVES: The development and adoption of Point-of-Care Ultrasound (POCUS) across disciplines have created challenges and opportunities in implementing training and utilization standards. Within the context of a large, geographically disparate province, we sought to develop a multidisciplinary POCUS framework...

Chymase Dependent Pathway of Angiotensin II Generation and Rapeseed Derived Peptides for Antihypertensive Treatment of Spontaneously Hypertensive Rats.

Frontiers in pharmacology

Baranowska I, Gawrys O, Roszkowska-Chojecka MM, Badzynska B, Tymecka D, Olszynski KH, Kompanowska-Jezierska E.
PMID: 34079459
Front Pharmacol. 2021 May 17;12:658805. doi: 10.3389/fphar.2021.658805. eCollection 2021.

The contribution of chymase, one of the enzymes responsible for angiotensin II generation in non-ACE pathway, remains unclear in the development of hypertension. The aim of the study was to investigate chymase inhibition as potential antihypertensive therapy in spontaneously...

Does Point-of-care Ultrasonography Change Emergency Department Care Delivered to Hypotensive Patients When Categorized by Shock Type? A Post-Hoc Analysis of an International Randomized Controlled Trial from the SHoC-ED Investigators.

Cureus

Atkinson P, Hunter S, Banerjee A, Lewis D, Fraser J, Milne J, Diegelmann L, Lamprecht H, Stander M, Lussier D, Pham C, Peach M, Taylor L, Henneberry R, Howlett M, Mekwan J, Ramrattan B, Middleton J, Van Hoving DJ, Stoica G, French J, Olszynski P.
PMID: 31827989
Cureus. 2019 Nov 03;11(11):e6058. doi: 10.7759/cureus.6058.

Introduction Our previously reported randomized-controlled-trial of point-of-care ultrasound (PoCUS) for patients with undifferentiated hypotension in the emergency department (ED) showed no survival benefit with PoCUS. Here, we examine the data to see if PoCUS led to changes in the...

Sonography in Hypotension and Cardiac Arrest (SHoC): Rates of Abnormal Findings in Undifferentiated Hypotension and During Cardiac Arrest as a Basis for Consensus on a Hierarchical Point of Care Ultrasound Protocol.

Cureus

Milne J, Atkinson P, Lewis D, Fraser J, Diegelmann L, Olszynski P, Stander M, Lamprecht H.
PMID: 27190729
Cureus. 2016 Apr 08;8(4):e564. doi: 10.7759/cureus.564.

INTRODUCTION: Point of care ultrasound (PoCUS) has become an established tool in the initial management of patients with undifferentiated hypotension. Current established protocols (RUSH and ACES) were developed by expert user opinion, rather than objective, prospective data. PoCUS also...

A Randomized Clinical Trial of Aquatic versus Land Exercise to Improve Balance, Function, and Quality of Life in Older Women with Osteoporosis.

Physiotherapy Canada. Physiotherapie Canada

Arnold CM, Busch AJ, Schachter CL, Harrison EL, Olszynski WP.
PMID: 20145763
Physiother Can. 2008;60(4):296-306. doi: 10.3138/physio.60.4.296. Epub 2008 Nov 12.

PURPOSE: Despite the decreased gravitational loading that is experienced in an aquatic environment, little research has been conducted on this exercise medium for women with osteoporosis (OP). Aquatic exercise (AE) may improve function and balance, thus ultimately decreasing fall...

Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates.

Journal of osteoporosis

Olszynski WP, Adachi JD, Davison KS.
PMID: 25349772
J Osteoporos. 2014;2014:420451. doi: 10.1155/2014/420451. Epub 2014 Oct 02.

The objective of this study was to compare the disintegration times among Canadian-marketed brand (alendronate 70 mg, alendronate 70 mg plus vitamin D 5600 IU, and risedronate 35 mg) and generic (Novo-alendronate 70 mg and Apo-alendronate 70 mg) once-weekly...

Sonographic Findings of Left Ventricular Dysfunction to Predict Shock Type in Undifferentiated Hypotensive Patients: An Analysis From the Sonography in Hypotension and Cardiac Arrest in the Emergency Department (SHoC-ED) Study.

Cureus

Keefer S, Atkinson P, Chandra K, Henneberry RJ, Olszynski PA, Peach M, Diegelmann L, Lamprecht H, Stander M, Lussier D, Pham C, Milne J, Fraser J, Lewis D.
PMID: 34395137
Cureus. 2021 Jul 13;13(7):e16360. doi: 10.7759/cureus.16360. eCollection 2021 Jul.

Introduction Patients that present to the emergency department (ED) with undifferentiated hypotension have a high mortality rate. Hypotension can be divided into four categories: obstructive, hypovolemic, distributive, and cardiogenic. While it is possible to have overlapping or concomitant shock...

Use of a Simple Ultrasound Device to Identify the Optimal Area of Compression for Out-of-Hospital Cardiac Arrest.

Cureus

Olszynski PA, Bryce R, Hussain Q, Dunn S, Blondeau B, Atkinson P, Woods R.
PMID: 33489641
Cureus. 2021 Jan 19;13(1):e12785. doi: 10.7759/cureus.12785.

Background Despite automated defibrillation and compression-first resuscitation, out-of-hospital cardiac arrest (OHCA) survival remains low. Resuscitation guidelines recommend that chest compressions should be done over the lower half of the sternum, but evidence indicates that this is often associated with...

Correction to: Position statement: minimum archiving requirements for emergency medicine point‑of‑care ultrasound-a modified Delphi‑derived national consensus.

CJEM

Wong MKY, Olszynski P, Cheung WJ, Pageau P, Lewis D, Kwan C, Woo MY.
PMID: 33779942
CJEM. 2021 Jul;23(4):571. doi: 10.1007/s43678-021-00117-8.

No abstract available.

Does Point of Care Ultrasound Improve Resuscitation Markers in Undifferentiated Hypotension? An International Randomized Controlled Trial From The Sonography in Hypotension and Cardiac Arrest in the Emergency Department (SHoC-ED) Series.

Cureus

Atkinson P, Taylor L, Milne J, Diegelmann L, Lamprecht H, Stander M, Lussier D, Pham C, Henneberry RJ, Fraser J, Howlett M, Mekwan J, Ramrattan B, Middleton J, Van Hoving DJ, Peach M, Dahn T, Hurley S, MacSween K, Richardson L, Stoica G, Hunter S, Atkinson JP, Olszynski P, Banerjee A, Lewis D.
PMID: 32968565
Cureus. 2020 Aug 20;12(8):e9899. doi: 10.7759/cureus.9899.

Introduction Point of Care Ultrasound (PoCUS) protocols are commonly used to guide resuscitation for patients with undifferentiated hypotension, yet there is a paucity of evidence for any outcome benefit. We undertook an international multicenter randomized controlled trial (RCT) to...

Long-term effectiveness and safety of infliximab, golimumab and golimumab-IV in rheumatoid arthritis patients from a Canadian prospective observational registry.

BMC rheumatology

Rahman P, Baer P, Keystone E, Choquette D, Thorne C, Haraoui B, Chow A, Faraawi R, Olszynski W, Kelsall J, Rampakakis E, Lehman AJ, Nantel F.
PMID: 32968710
BMC Rheumatol. 2020 Sep 19;4:46. doi: 10.1186/s41927-020-00145-4. eCollection 2020.

BACKGROUND: Long-term clinical registries are essential tools to evaluate new therapies in a patient population that differs from those in randomized clinical trials. The objectives are to describe the profile of rheumatoid arthritis (RA) patients treated with anti-TNF agents...

Showing 1 to 12 of 24 entries