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The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP).

Frontiers in pharmacology

Loi B, Sahai MA, De Luca MA, Shiref H, Opacka-Juffry J.
PMID: 32670057
Front Pharmacol. 2020 Jun 05;11:806. doi: 10.3389/fphar.2020.00806. eCollection 2020.

Stimulant drugs, including novel psychoactive substances (NPS, formerly "legal highs") have addictive potential which their users may not realize. Stimulants increase extracellular dopamine levels in the brain, including the reward and addiction pathways, through interacting with dopamine transporter (DAT)....

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Loi B, Sahai MA, De Luca MA, et al. The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP). Front Pharmacol. 2020;11:806doi: 10.3389/fphar.2020.00806.
Loi, B., Sahai, M. A., De Luca, M. A., Shiref, H., & Opacka-Juffry, J. (2020). The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP). Frontiers in pharmacology, 11806. https://doi.org/10.3389/fphar.2020.00806
Loi, Barbara, et al. "The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP)." Frontiers in pharmacology vol. 11 (2020): 806. doi: https://doi.org/10.3389/fphar.2020.00806
Loi B, Sahai MA, De Luca MA, Shiref H, Opacka-Juffry J. The Role of Dopamine in the Stimulant Characteristics of Novel Psychoactive Substances (NPS)-Neurobiological and Computational Assessment Using the Case of Desoxypipradrol (2-DPMP). Front Pharmacol. 2020 Jun 05;11:806. doi: 10.3389/fphar.2020.00806. eCollection 2020. PMID: 32670057; PMCID: PMC7289955.
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Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice.

IBRO neuroscience reports

Carneiro-Nascimento S, Powell W, Uebel M, Buerge M, Sigrist H, Patterson M, Pryce CR, Opacka-Juffry J.
PMID: 33861815
IBRO Neurosci Rep. 2021 Feb 03;10:8-16. doi: 10.1016/j.ibneur.2020.11.001. eCollection 2021 Jun.

Serotonin (5-HT), via its receptors expressed in discrete brain regions, modulates aversion and reward processing and is implicated in various psychiatric disorders including depression. Stressful experiences affect central serotonergic activity and act as a risk factor for depression; this...

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Carneiro-Nascimento S, Powell W, Uebel M, et al. Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice. IBRO Neurosci Rep. 2021;10:8-16doi: 10.1016/j.ibneur.2020.11.001.
Carneiro-Nascimento, S., Powell, W., Uebel, M., Buerge, M., Sigrist, H., Patterson, M., Pryce, C. R., & Opacka-Juffry, J. (2021). Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice. IBRO neuroscience reports, 108-16. https://doi.org/10.1016/j.ibneur.2020.11.001
Carneiro-Nascimento, Simone, et al. "Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice." IBRO neuroscience reports vol. 10 (2021): 8-16. doi: https://doi.org/10.1016/j.ibneur.2020.11.001
Carneiro-Nascimento S, Powell W, Uebel M, Buerge M, Sigrist H, Patterson M, Pryce CR, Opacka-Juffry J. Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice. IBRO Neurosci Rep. 2021 Feb 03;10:8-16. doi: 10.1016/j.ibneur.2020.11.001. eCollection 2021 Jun. PMID: 33861815; PMCID: PMC8019833.
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Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines.

Brain sciences

Sahai MA, Davidson C, Dutta N, Opacka-Juffry J.
PMID: 29642450
Brain Sci. 2018 Apr 07;8(4). doi: 10.3390/brainsci8040063.

Novel psychoactive substances (NPS) may have unsuspected addiction potential through possessing stimulant properties. Stimulants normally act at the dopamine transporter (DAT) and thus increase dopamine (DA) availability in the brain, including nucleus accumbens, within the reward and addiction pathway....

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Sahai MA, Davidson C, Dutta N, et al. Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines. Brain Sci. 2018;8(4)doi: 10.3390/brainsci8040063.
Sahai, M. A., Davidson, C., Dutta, N., & Opacka-Juffry, J. (2018). Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines. Brain sciences, 8(4), . https://doi.org/10.3390/brainsci8040063
Sahai, Michelle A, et al. "Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines." Brain sciences vol. 8,4 (2018). doi: https://doi.org/10.3390/brainsci8040063
Sahai MA, Davidson C, Dutta N, Opacka-Juffry J. Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter-In Silico and In Vitro Exploration of Dissociative Diarylethylamines. Brain Sci. 2018 Apr 07;8(4). doi: 10.3390/brainsci8040063. PMID: 29642450; PMCID: PMC5924399.
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Electroencephalography (EEG) Measures of Neural Connectivity in the Assessment of Brain Responses to Salient Auditory Stimuli in Patients with Disorders of Consciousness.

Frontiers in psychology

Lord V, Opacka-Juffry J.
PMID: 27047424
Front Psychol. 2016 Mar 22;7:397. doi: 10.3389/fpsyg.2016.00397. eCollection 2016.

No abstract available.

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Lord V, Opacka-Juffry J. Electroencephalography (EEG) Measures of Neural Connectivity in the Assessment of Brain Responses to Salient Auditory Stimuli in Patients with Disorders of Consciousness. Front Psychol. 2016;7:397doi: 10.3389/fpsyg.2016.00397.
Lord, V., & Opacka-Juffry, J. (2016). Electroencephalography (EEG) Measures of Neural Connectivity in the Assessment of Brain Responses to Salient Auditory Stimuli in Patients with Disorders of Consciousness. Frontiers in psychology, 7397. https://doi.org/10.3389/fpsyg.2016.00397
Lord, Victoria, and Opacka-Juffry, Jolanta. "Electroencephalography (EEG) Measures of Neural Connectivity in the Assessment of Brain Responses to Salient Auditory Stimuli in Patients with Disorders of Consciousness." Frontiers in psychology vol. 7 (2016): 397. doi: https://doi.org/10.3389/fpsyg.2016.00397
Lord V, Opacka-Juffry J. Electroencephalography (EEG) Measures of Neural Connectivity in the Assessment of Brain Responses to Salient Auditory Stimuli in Patients with Disorders of Consciousness. Front Psychol. 2016 Mar 22;7:397. doi: 10.3389/fpsyg.2016.00397. eCollection 2016. PMID: 27047424; PMCID: PMC4801887.
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Coexistence of Gonadotrophin-Releasing Hormone and Galanin: Immunohisto-chemical and Functional Studies.

Journal of neuroendocrinology

Coen CW, Montagnese C, Opacka-Juffry J.
PMID: 19210372
J Neuroendocrinol. 1990 Apr 01;2(2):107-11. doi: 10.1111/j.1365-2826.1990.tb00839.x.

Our observation of galanin-immunoreactive perikarya with morphological characteristics strikingly similar to those containing gorvadotrophin-releasmg hormone (GnRH) led us to undertake double-label immunohistochemical studies on the distribution of these peptides. A considerable proportion of GnRH-containing perikarya in the rat preoptic...

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Coen CW, Montagnese C, Opacka-Juffry J. Coexistence of Gonadotrophin-Releasing Hormone and Galanin: Immunohisto-chemical and Functional Studies. J Neuroendocrinol. 1990;2(2):107-11doi: 10.1111/j.1365-2826.1990.tb00839.x.
Coen, C. W., Montagnese, C., & Opacka-Juffry, J. (1990). Coexistence of Gonadotrophin-Releasing Hormone and Galanin: Immunohisto-chemical and Functional Studies. Journal of neuroendocrinology, 2(2), 107-11. https://doi.org/10.1111/j.1365-2826.1990.tb00839.x
Coen, C W, et al. "Coexistence of Gonadotrophin-Releasing Hormone and Galanin: Immunohisto-chemical and Functional Studies." Journal of neuroendocrinology vol. 2,2 (1990): 107-11. doi: https://doi.org/10.1111/j.1365-2826.1990.tb00839.x
Coen CW, Montagnese C, Opacka-Juffry J. Coexistence of Gonadotrophin-Releasing Hormone and Galanin: Immunohisto-chemical and Functional Studies. J Neuroendocrinol. 1990 Apr 01;2(2):107-11. doi: 10.1111/j.1365-2826.1990.tb00839.x. PMID: 19210372.
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Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine.

Neuronal signaling

Sahai MA, Opacka-Juffry J.
PMID: 34888062
Neuronal Signal. 2021 Nov 17;5(4):NS20210006. doi: 10.1042/NS20210006. eCollection 2021 Dec.

Drug misuse is a significant social and public health problem worldwide. Misused substances exert their neurobehavioural effects through changing neural signalling within the brain, many of them leading to substance dependence and addiction in the longer term. Among drugs...

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Sahai MA, Opacka-Juffry J. Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine. Neuronal Signal. 2021;5(4):NS20210006doi: 10.1042/NS20210006.
Sahai, M. A., & Opacka-Juffry, J. (2021). Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine. Neuronal signaling, 5(4), NS20210006. https://doi.org/10.1042/NS20210006
Sahai, Michelle A, and Opacka-Juffry, Jolanta. "Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine." Neuronal signaling vol. 5,4 (2021): NS20210006. doi: https://doi.org/10.1042/NS20210006
Sahai MA, Opacka-Juffry J. Molecular mechanisms of action of stimulant novel psychoactive substances that target the high-affinity transporter for dopamine. Neuronal Signal. 2021 Nov 17;5(4):NS20210006. doi: 10.1042/NS20210006. eCollection 2021 Dec. PMID: 34888062; PMCID: PMC8630395.
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Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice.

Neurobiology of stress

Bergamini G, Mechtersheimer J, Azzinnari D, Sigrist H, Buerge M, Dallmann R, Freije R, Kouraki A, Opacka-Juffry J, Seifritz E, Ferger B, Suter T, Pryce CR.
PMID: 29888303
Neurobiol Stress. 2018 Feb 02;8:42-56. doi: 10.1016/j.ynstr.2018.01.004. eCollection 2018 Feb.

Psychosocial stress is a major risk factor for depression, stress leads to peripheral and central immune activation, immune activation is associated with blunted dopamine (DA) neural function, DA function underlies reward interest, and reduced reward interest is a core...

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Bergamini G, Mechtersheimer J, Azzinnari D, et al. Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice. Neurobiol Stress. 2018;8:42-56doi: 10.1016/j.ynstr.2018.01.004.
Bergamini, G., Mechtersheimer, J., Azzinnari, D., Sigrist, H., Buerge, M., Dallmann, R., Freije, R., Kouraki, A., Opacka-Juffry, J., Seifritz, E., Ferger, B., Suter, T., & Pryce, C. R. (2018). Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice. Neurobiology of stress, 842-56. https://doi.org/10.1016/j.ynstr.2018.01.004
Bergamini, Giorgio, et al. "Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice." Neurobiology of stress vol. 8 (2018): 42-56. doi: https://doi.org/10.1016/j.ynstr.2018.01.004
Bergamini G, Mechtersheimer J, Azzinnari D, Sigrist H, Buerge M, Dallmann R, Freije R, Kouraki A, Opacka-Juffry J, Seifritz E, Ferger B, Suter T, Pryce CR. Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice. Neurobiol Stress. 2018 Feb 02;8:42-56. doi: 10.1016/j.ynstr.2018.01.004. eCollection 2018 Feb. PMID: 29888303; PMCID: PMC5991330.
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Showing 1 to 7 of 7 entries