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Showing 1 to 12 of 93 entries
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Medical sciences (Basel, Switzerland)

García-Carrasco B, Fernandez-Dacosta R, Dávalos A, Ordovás JM, Rodriguez-Casado A.
PMID: 29083390
Med Sci (Basel). 2015 Jun 11;3(2):38-54. doi: 10.3390/medsci3020038.

Adipose tissue dysfunction constitutes a primary defect in obesity and might link this disease to severe chronic health problems. We aimed to evaluate the antioxidant activity of three extracts from

Environmental chemicals and DNA methylation in adults: a systematic review of the epidemiologic evidence.

Clinical epigenetics

Ruiz-Hernandez A, Kuo CC, Rentero-Garrido P, Tang WY, Redon J, Ordovas JM, Navas-Acien A, Tellez-Plaza M.
PMID: 25984247
Clin Epigenetics. 2015 Apr 29;7:55. doi: 10.1186/s13148-015-0055-7. eCollection 2015.

Current evidence supports the notion that environmental exposures are associated with DNA-methylation and expression changes that can impact human health. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between environmental chemicals with DNA...

Dietary lipids modulate the expression of miR-107, a miRNA that regulates the circadian system.

Molecular nutrition & food research

Daimiel-Ruiz L, Klett-Mingo M, Konstantinidou V, Micó V, Aranda JF, García B, Martínez-Botas J, Dávalos A, Fernández-Hernando C, Ordovás JM.
PMID: 26387852
Mol Nutr Food Res. 2015 Sep;59(9):1865-78. doi: 10.1002/mnfr.201570094.

SCOPE: The increased prevalence of cardiovascular diseases (CVDs) has been hypothesized to be the result of an increased exposure to a host of atherogenic environmental factors, paramount among them being unhealthy dietary habits. Long-chain n-3 polyunsaturated fatty acids (PUFAs)...

Circumscribed Ciliochoroidal Effusion Presenting as an Acute Angle Closure Attack.

Journal of ophthalmic & vision research

Lipa RK, Sánchez ME, Ordovas CA, Aragües AR, Borque CG.
PMID: 28299016
J Ophthalmic Vis Res. 2017 Jan-Mar;12(1):117-119. doi: 10.4103/jovr.jovr_99_14.

PURPOSE: To report a case of choroidal effusion probably caused by angiotensin receptor II blocker.CASE REPORT: A 52-year-old man with aplastic anemia and high blood pressure who developed unilateral acute angle closure glaucoma after receiving oral cyclosporine and angiotensin...

[Integrating environment and disease into "omic" analysis].

Revista espanola de cardiologia

Ordovás JM.
PMID: 19709532
Rev Esp Cardiol. 2009 Jun;62:17-22. doi: 10.1016/s0300-8932(09)72118-9.

New techniques grouped together under the general term of "omic" techniques are bringing about a revolution in biological research, as can be clearly seen in the case of genomics. However, environmental factors (such as lifestyle, socioeconomic context and diet)...

HDL cholesterol: second annual meeting metabolic pathways and drug development.

IDrugs : the investigational drugs journal

Ordovas JM.
PMID: 16012892
IDrugs. 2001 May;4(5):529-32.

No abstract available.

TCF7L2 polymorphisms and inflammatory markers before and after treatment with fenofibrate.

Diabetology & metabolic syndrome

Kabagambe EK, Glasser SP, Ordovas JM, Warodomwichit D, Tsai MY, Hopkins PN, Borecki IB, Wojczynski M, Arnett DK.
PMID: 19825152
Diabetol Metab Syndr. 2009 Oct 12;1(1):16. doi: 10.1186/1758-5996-1-16.

BACKGROUND: Inflammation is implicated in causing diabetes. We tested whether transcription factor 7 like-2 (TCF7L2) gene polymorphisms (rs12255372 and rs7903146), consistently associated with type 2 diabetes, are associated with plasma concentrations of inflammatory markers before and after three weeks...

Functional genomic and epidemiological studies reveal novel genes regulating cholesterol metabolism.

Genome medicine

Richardson K, Ordovas JM.
PMID: 19863771
Genome Med. 2009 Oct 27;1(10):96. doi: 10.1186/gm96.

Elevated plasma cholesterol is a heritable trait and a risk factor for the development of cardiovascular disease. Although several major biochemical pathways regulating cholesterol metabolism have been identified, questions regarding the details of this regulation remain. In fact, common...

CardioGxE, a catalog of gene-environment interactions for cardiometabolic traits.

BioData mining

Parnell LD, Blokker BA, Dashti HS, Nesbeth PD, Cooper BE, Ma Y, Lee YC, Hou R, Lai CQ, Richardson K, Ordovás JM.
PMID: 25368670
BioData Min. 2014 Oct 26;7:21. doi: 10.1186/1756-0381-7-21. eCollection 2014.

BACKGROUND: Genetic understanding of complex traits has developed immensely over the past decade but remains hampered by incomplete descriptions of contribution to phenotypic variance. Gene-environment (GxE) interactions are one of these contributors and in the guise of diet and...

Corrigendum: Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.

Human molecular genetics

Sayols-Baixeras S, Subirana I, Lluis-Ganella C, Civeira F, Roquer J, Do AN, Absher D, Cenarro A, Muñoz D, Soriano-Tárraga C, Jiménez-Conde J, Ordovas JM, Senti M, Aslibekyan S, Marrugat J, Arnett DK, Elosua R.
PMID: 30541122
Hum Mol Genet. 2019 Apr 15;28(8):1402. doi: 10.1093/hmg/ddy417.

No abstract available.

Cardiac MRI T2* in Liver Transplant Candidates: Application and Performance of a Novel Imaging Technique to Identify Patients at Risk for Poor Posttransplant Cardiac Outcomes.

Transplantation direct

Lewin SM, Kallianos K, Nevah MI, Zhao S, Fix OK, Brooks GC, De Marco T, Qasim AN, Ordovas KG, Mehta N.
PMID: 30046653
Transplant Direct. 2018 Jun 08;4(7):e363. doi: 10.1097/TXD.0000000000000803. eCollection 2018 Jul.

BACKGROUND: In end-stage liver disease, alterations in iron metabolism can lead to iron overload and development of iron overload cardiomyopathy. In liver transplant candidates, evaluation for cardiac iron overload and dysfunction can help to identify candidates at increased risk...

Gene Expression and Fatty Acid Profiling in .

Frontiers in genetics

Dervishi E, González-Calvo L, Blanco M, Joy M, Sarto P, Martin-Hernandez R, Ordovás JM, Serrano M, Calvo JH.
PMID: 31737049
Front Genet. 2019 Oct 31;10:1070. doi: 10.3389/fgene.2019.01070. eCollection 2019.

A better understanding of gene expression and metabolic pathways in response to a feeding system is critical for identifying key physiological processes and genes associated with polyunsaturated fatty acid (PUFA) content in lamb meat. The main objective of this...

Showing 1 to 12 of 93 entries